| # | LOT_ID | Target | Assay_type | Assay_name | Value_type | Value | Unit | Relation | Value_comments | Conc_uM | Cell_line | Organism | Reference | Data_source | DB_ID | Memo |
|---|
| 1 | HG-0292673-0-00 |
hERG |
binding |
DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) |
Inhibition |
50 |
% |
< |
Not Active (inhibition < 50% @ 10 uM and thus dose-reponse curve not measured) |
10 |
HEK293 |
Homo sapiens |
DrugMatrix in vitro pharmacology data |
ChEMBL |
7641410 |
data from ChEMBL25 |
| 2 | HG-0292673-0-01 |
hERG |
binding |
Cerep binding IC50 Ki AB34864, [3H]Dofetilide |
IC50 |
10000 |
nM |
> |
|
|
HEK293 |
Homo sapiens |
|
RIKEN |
|
|
| 3 | HG-0292673-0-01 |
hERG |
patch clamp |
Cerep Autopatch IC50 RIK012116-1 |
IC50 |
10000 |
nM |
> |
|
|
HEK293 |
Homo sapiens |
|
RIKEN |
|
|
| 4 | HG-0292673-0-01 |
hERG |
patch clamp |
RIKEN Autopatch inhibition at 10uM |
inhibition |
16.1 |
% |
= |
|
10 |
HEK293 |
Homo sapiens |
|
RIKEN |
|
|
| 5 | HG-0292673-0-01 |
hERG |
patch clamp |
RIKEN Autopatch inhibition at 10uM |
inhibition |
-4.2 |
% |
= |
|
10 |
HEK293 |
Homo sapiens |
|
RIKEN |
|
|
| 6 | HG-0292673-0-01 |
Nav1.5 |
patch clamp |
Inhibition of recombinantly expressed NaV 1.5 channels on the Syncropatch 384 Patch clamp platform (Icagen) |
IC50 |
30000 |
nM |
> |
|
|
HEK293 |
Homo sapiens |
|
RIKEN |
|
|
| 7 | HG-0292673-0-00 |
hERG |
patch clamp |
hERG-U2OS cellular assay by FluxORTM thallium flux assay. PubChem AID:588834 |
Potency |
|
|
|
Phenotype:Inactive, Activity outcome:Inactive |
|
U2OS |
|
http://assay.nih.gov/htsws/rest/display/herg-trans-p2/NCGC00025267-05/39156575 |
PubChem_CID |
588834 |
Data from PubChem AID588834 by NCGC. Curve_Description: Compound QC:QC'd by SigmaAldrich |
| 8 | HG-0292673-0-00 |
hERG |
patch clamp |
hERG-U2OS cellular assay by FluxORTM thallium flux assay. PubChem AID:588834 |
Potency |
|
|
|
Phenotype:Inactive, Activity outcome:Inactive |
|
U2OS |
|
http://assay.nih.gov/htsws/rest/display/herg-trans-ntp-p2/AB08002000-01/39870185 |
PubChem_CID |
588834 |
Data from PubChem AID588834 by NCGC. Curve_Description: Compound QC:QC'd by NIEHS/NTP |
| 9 | HG-0292673-0-00 |
hERG |
patch clamp |
hERG inhibition(%) at 10uM by Ionworks Quattro (MDC, Sunnyvale, CA) in population patch clamp (PPC) mode |
inhibition |
-16.3721 |
% |
= |
|
10 |
CHO |
Homo sapiens |
PLoS One. 2015; 10(2): e0118324. |
hERG Central(PubChem_SID) |
|
Data from PLoS One. 2015; 10(2): e0118324 containing hERG Central data. hERG inhibition (%) at 1uM=13.5698% |
