FMO DATABASE

FMODB ID: 8N52Y

Calculation Name: 4K7K-A-Xray372

Preferred Name:

Target Type:

Ligand Name:

ligand 3-letter code:

PDB ID: 4K7K

Chain ID: A

ChEMBL ID:

UniProt ID: P77211

Base Structure: X-ray

Registration Date: 2023-09-26

Reference: C. Watanabe, N. Tani, K. Kamisaka, T. Honma et al., Interaction energy analysis of Apo structure dataset on FMODB, To be published.

DOI:

IFIE MAP

IFIE Diagram

Modeling method

Optimization	MOE:Amber10:EHT
Restraint	OptHSide
Protonation	MOE:Protonate 3D
Complement	MOE:Structure Preparation
Water	No
Procedure	Auto-FMO protocol ver. 2.20220422

FMO calculation

FMO method	FMO2-MP2/6-31G(d)
Fragmentation	Auto
Number of fragment	380
LigandCharge
Software	ABINIT-MP - Open Ver. 1 Rev. 23Q2 / 20200603(SMP)

Total energy (hartree)

FMO2-HF: Electronic energy	-5733731.862165
FMO2-HF: Nuclear repulsion	5586990.198281
FMO2-HF: Total energy	-146741.663883
FMO2-MP2: Total energy	-147176.559001

3D Structure

Snapshot

Ligand structure

Ligand Interaction

Ligand binding energy

IFIE [kcal/mol]	PIEDA [kcal/mol]				Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level.	ESElectro static interaction energy.	EXExchange-repulsion energy.	CT+mixCharge transfer and mixing terms energy.	DI(MP2)Dispersion energy.	q(I=>J)Charge transfer value from I to J fragments.
N/A	N/A	N/A	N/A	N/A	N/A

Interactive mode: IFIE and PIEDA for fragment #1(A:32:TYR)

Summations of interaction energy for fragment #1(A:32:TYR)

IFIE [kcal/mol]	PIEDA [kcal/mol]				Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level.	ESElectro static interaction energy.	EXExchange-repulsion energy.	CT+mixCharge transfer and mixing terms energy.	DI(MP2)Dispersion energy.	q(I=>J)Charge transfer value from I to J fragments.
-3.018	0.267	0.05	-1.144	-2.19	0.005

Interaction energy analysis for fragmet #1(A:32:TYR)

Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE

Single fragment	Multi fragments
	Fragment list

Charge [e] FCHARGE : 0 / q_Mulliken : 0.041 / q_NPA : 0.008

Distance from base fragment(s) [Å]

Dist

Interaction energy by IFIE and PIEDA
[kcal/mol]

| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >

Fragment charge [e]

FCHARGE q_Mulliken
q_NPA q(I=>J)

Residue

Res # RES

Sort

Graph Options

X Axis Label
Y Axis Max Y Axis Min
Display ES EX CT+mix DI(MP2)

frag_NumFragment number.	ChainChain species.	Res #Residue number.	RES3-letter code of amino acid residue, ligand and solvent molecule.	FCHARGEFormal charge [e].	q_MullikenFragment charge evaluated by Mulliken charge [e].	q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e].	DISTDistance from Ligand [Å].	TotalIFIE at MP2 level [kcal/mol].	ESElectro static interaction energy by PIEDA [kcal/mol].	EXExchange-repulsion energy by PIEDA [kcal/mol].	CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol].	DI(MP2)Dispersion energy by PIEDA [kcal/mol].	q(I=>J)Charge transfer value from I to J fragmens [e].
3	A	34	ASN	0	0.011	-0.008	3.069	-3.268	-0.553	0.047	-1.049	-1.712	0.005
4	A	35	ALA	0	-0.003	0.012	3.740	-0.269	0.103	0.002	-0.070	-0.304	0.000
5	A	36	GLY	0	0.066	0.059	5.605	0.020	0.020	0.000	0.000	0.000	0.000
6	A	37	TRP	0	0.049	0.001	7.165	-0.311	-0.311	0.000	0.000	0.000	0.000
7	A	38	ARG	1	0.888	0.948	6.239	-0.461	-0.461	0.000	0.000	0.000	0.000
8	A	39	THR	0	-0.058	-0.039	8.774	0.006	0.006	0.000	0.000	0.000	0.000
9	A	40	PHE	0	-0.012	0.021	11.301	0.004	0.004	0.000	0.000	0.000	0.000
10	A	41	PHE	0	0.005	0.005	13.515	0.012	0.012	0.000	0.000	0.000	0.000
11	A	42	VAL	0	0.057	0.023	15.516	-0.031	-0.031	0.000	0.000	0.000	0.000
12	A	43	ASP	-1	-0.757	-0.891	18.058	0.054	0.054	0.000	0.000	0.000	0.000
13	A	44	ASN	0	0.006	-0.006	17.491	0.022	0.022	0.000	0.000	0.000	0.000
14	A	45	GLN	0	0.007	0.011	17.498	0.056	0.056	0.000	0.000	0.000	0.000
15	A	46	VAL	0	0.026	0.020	16.674	0.045	0.045	0.000	0.000	0.000	0.000
16	A	47	LYS	1	0.798	0.896	13.176	0.202	0.202	0.000	0.000	0.000	0.000
17	A	48	THR	0	-0.059	-0.027	13.381	0.083	0.083	0.000	0.000	0.000	0.000
18	A	49	LEU	0	0.035	0.017	15.016	0.071	0.071	0.000	0.000	0.000	0.000
19	A	50	ILE	0	-0.007	-0.001	10.928	0.073	0.073	0.000	0.000	0.000	0.000
20	A	51	SER	0	-0.032	-0.023	10.441	0.182	0.182	0.000	0.000	0.000	0.000
21	A	52	GLU	-1	-0.889	-0.948	11.462	0.518	0.518	0.000	0.000	0.000	0.000
22	A	53	ALA	0	0.042	0.018	14.291	0.047	0.047	0.000	0.000	0.000	0.000
23	A	54	LEU	0	-0.018	-0.010	7.518	0.071	0.071	0.000	0.000	0.000	0.000
24	A	55	VAL	0	-0.026	0.005	10.664	0.090	0.090	0.000	0.000	0.000	0.000
25	A	56	ASN	0	-0.013	-0.009	12.070	-0.045	-0.045	0.000	0.000	0.000	0.000
26	A	57	ASN	0	-0.095	-0.044	13.677	-0.181	-0.181	0.000	0.000	0.000	0.000
27	A	58	ARG	1	0.948	0.963	11.653	-0.613	-0.613	0.000	0.000	0.000	0.000
28	A	59	ASP	-1	-0.855	-0.915	12.258	0.762	0.762	0.000	0.000	0.000	0.000
29	A	60	LEU	0	0.079	0.028	10.723	-0.024	-0.024	0.000	0.000	0.000	0.000
30	A	61	ARG	1	0.880	0.924	14.754	-0.465	-0.465	0.000	0.000	0.000	0.000
31	A	62	MET	0	-0.001	-0.022	18.191	-0.060	-0.060	0.000	0.000	0.000	0.000
32	A	63	ALA	0	0.007	0.011	15.163	-0.050	-0.050	0.000	0.000	0.000	0.000
33	A	64	THR	0	-0.013	-0.012	17.186	-0.047	-0.047	0.000	0.000	0.000	0.000
34	A	65	LEU	0	-0.021	-0.013	19.290	-0.058	-0.058	0.000	0.000	0.000	0.000
35	A	66	LYS	1	0.882	0.956	18.367	-0.607	-0.607	0.000	0.000	0.000	0.000
36	A	67	VAL	0	0.021	0.019	17.908	-0.042	-0.042	0.000	0.000	0.000	0.000
37	A	68	GLN	0	-0.055	-0.019	21.120	-0.041	-0.041	0.000	0.000	0.000	0.000
38	A	69	GLU	-1	-0.906	-0.964	24.201	0.218	0.218	0.000	0.000	0.000	0.000
39	A	70	ALA	0	-0.012	-0.005	23.080	-0.024	-0.024	0.000	0.000	0.000	0.000
40	A	71	ARG	1	0.862	0.919	22.790	-0.303	-0.303	0.000	0.000	0.000	0.000
41	A	72	ALA	0	-0.010	0.005	26.303	-0.027	-0.027	0.000	0.000	0.000	0.000
42	A	73	GLN	0	0.001	-0.003	27.760	-0.006	-0.006	0.000	0.000	0.000	0.000
43	A	74	TYR	0	0.013	0.001	25.587	-0.021	-0.021	0.000	0.000	0.000	0.000
44	A	75	ARG	1	0.870	0.927	31.384	-0.142	-0.142	0.000	0.000	0.000	0.000
45	A	76	LEU	0	0.032	0.010	33.278	-0.007	-0.007	0.000	0.000	0.000	0.000
46	A	77	THR	0	-0.003	0.007	35.222	-0.008	-0.008	0.000	0.000	0.000	0.000
47	A	78	ASP	-1	-0.901	-0.919	36.340	0.106	0.106	0.000	0.000	0.000	0.000
48	A	79	ALA	0	-0.071	-0.040	37.343	-0.007	-0.007	0.000	0.000	0.000	0.000
49	A	80	ASP	-1	-0.799	-0.885	39.108	0.112	0.112	0.000	0.000	0.000	0.000
50	A	81	ARG	1	0.754	0.869	40.837	-0.101	-0.101	0.000	0.000	0.000	0.000
51	A	113	ALA	0	0.000	-0.008	23.077	-0.007	-0.007	0.000	0.000	0.000	0.000
52	A	114	SER	0	0.060	0.018	24.953	0.018	0.018	0.000	0.000	0.000	0.000
53	A	115	PHE	0	0.035	0.022	15.813	0.008	0.008	0.000	0.000	0.000	0.000
54	A	116	ASP	-1	-0.766	-0.889	21.438	0.360	0.360	0.000	0.000	0.000	0.000
55	A	117	LEU	0	-0.045	-0.018	22.408	0.010	0.010	0.000	0.000	0.000	0.000
56	A	118	ASP	-1	-0.859	-0.913	23.041	0.183	0.183	0.000	0.000	0.000	0.000
57	A	119	PHE	0	-0.005	0.005	17.298	0.009	0.009	0.000	0.000	0.000	0.000
58	A	120	PHE	0	0.020	-0.019	21.501	0.005	0.005	0.000	0.000	0.000	0.000
59	A	121	GLY	0	-0.051	-0.025	24.032	-0.011	-0.011	0.000	0.000	0.000	0.000
60	A	122	ARG	1	0.821	0.874	21.250	-0.288	-0.288	0.000	0.000	0.000	0.000
61	A	123	LEU	0	0.018	0.003	20.582	-0.009	-0.009	0.000	0.000	0.000	0.000
62	A	124	LYS	1	0.940	0.971	24.234	-0.230	-0.230	0.000	0.000	0.000	0.000
63	A	125	ASN	0	-0.103	-0.050	27.809	-0.022	-0.022	0.000	0.000	0.000	0.000
64	A	126	MET	0	-0.015	0.027	22.113	-0.008	-0.008	0.000	0.000	0.000	0.000
65	A	127	SER	0	-0.027	-0.051	27.676	0.006	0.006	0.000	0.000	0.000	0.000
66	A	128	GLU	-1	-0.727	-0.833	25.202	0.340	0.340	0.000	0.000	0.000	0.000
67	A	129	ALA	0	0.040	0.016	25.413	0.022	0.022	0.000	0.000	0.000	0.000
68	A	130	GLU	-1	-0.816	-0.866	24.658	0.221	0.221	0.000	0.000	0.000	0.000
69	A	131	ARG	1	0.772	0.864	22.554	-0.256	-0.256	0.000	0.000	0.000	0.000
70	A	132	GLN	0	-0.064	-0.042	20.796	0.040	0.040	0.000	0.000	0.000	0.000
71	A	133	ASN	0	-0.061	-0.019	19.834	0.024	0.024	0.000	0.000	0.000	0.000
72	A	134	TYR	0	0.036	0.013	18.314	0.052	0.052	0.000	0.000	0.000	0.000
73	A	135	LEU	0	-0.077	-0.066	15.793	0.005	0.005	0.000	0.000	0.000	0.000
74	A	136	ALA	0	0.012	0.016	15.075	0.072	0.072	0.000	0.000	0.000	0.000
75	A	137	THR	0	-0.073	-0.044	14.290	0.039	0.039	0.000	0.000	0.000	0.000
76	A	138	GLU	-1	-0.817	-0.916	7.660	0.990	0.990	0.000	0.000	0.000	0.000
77	A	139	GLU	-1	-0.774	-0.895	10.900	0.659	0.659	0.000	0.000	0.000	0.000
78	A	140	ALA	0	0.029	0.044	13.206	0.034	0.034	0.000	0.000	0.000	0.000
79	A	141	GLN	0	0.039	0.014	8.762	-0.093	-0.093	0.000	0.000	0.000	0.000
80	A	142	ARG	1	0.767	0.901	7.373	-0.727	-0.727	0.000	0.000	0.000	0.000
81	A	143	ALA	0	0.013	-0.012	10.329	-0.040	-0.040	0.000	0.000	0.000	0.000
82	A	144	VAL	0	-0.005	-0.004	12.905	-0.052	-0.052	0.000	0.000	0.000	0.000
83	A	145	HIS	0	-0.015	-0.003	7.030	0.265	0.265	0.000	0.000	0.000	0.000
84	A	146	ILE	0	-0.028	-0.016	10.698	-0.148	-0.148	0.000	0.000	0.000	0.000
85	A	147	LEU	0	-0.003	0.020	13.061	-0.111	-0.111	0.000	0.000	0.000	0.000
86	A	148	LEU	0	0.006	0.011	12.368	-0.095	-0.095	0.000	0.000	0.000	0.000
87	A	149	VAL	0	-0.021	-0.016	10.604	-0.109	-0.109	0.000	0.000	0.000	0.000
88	A	150	SER	0	-0.003	-0.001	13.790	-0.099	-0.099	0.000	0.000	0.000	0.000
89	A	151	ASN	0	-0.013	-0.034	17.071	-0.111	-0.111	0.000	0.000	0.000	0.000
90	A	152	VAL	0	0.015	0.026	15.531	-0.058	-0.058	0.000	0.000	0.000	0.000
91	A	153	ALA	0	-0.008	-0.010	16.937	-0.058	-0.058	0.000	0.000	0.000	0.000
92	A	154	GLN	0	0.001	-0.013	18.730	-0.050	-0.050	0.000	0.000	0.000	0.000
93	A	155	SER	0	-0.015	-0.018	21.454	-0.036	-0.036	0.000	0.000	0.000	0.000
94	A	156	TYR	0	-0.026	-0.021	20.936	-0.023	-0.023	0.000	0.000	0.000	0.000
95	A	157	PHE	0	0.005	-0.006	20.380	-0.027	-0.027	0.000	0.000	0.000	0.000
96	A	158	ASN	0	0.064	0.042	24.755	-0.030	-0.030	0.000	0.000	0.000	0.000
97	A	159	GLN	0	0.011	0.008	25.804	-0.015	-0.015	0.000	0.000	0.000	0.000
98	A	160	GLN	0	-0.029	-0.031	25.430	-0.029	-0.029	0.000	0.000	0.000	0.000
99	A	161	LEU	0	-0.005	0.010	28.118	-0.013	-0.013	0.000	0.000	0.000	0.000
100	A	162	ALA	0	0.039	0.019	30.423	-0.010	-0.010	0.000	0.000	0.000	0.000
101	A	163	TYR	0	-0.035	-0.043	28.179	-0.009	-0.009	0.000	0.000	0.000	0.000
102	A	164	ALA	0	-0.022	0.003	32.210	-0.008	-0.008	0.000	0.000	0.000	0.000
103	A	165	GLN	0	-0.007	-0.015	34.066	0.001	0.001	0.000	0.000	0.000	0.000
104	A	166	LEU	0	0.025	0.020	36.010	-0.005	-0.005	0.000	0.000	0.000	0.000
105	A	167	GLN	0	-0.027	-0.019	36.706	-0.001	-0.001	0.000	0.000	0.000	0.000
106	A	168	ILE	0	-0.002	-0.007	37.651	-0.005	-0.005	0.000	0.000	0.000	0.000
107	A	169	ALA	0	0.018	0.017	40.240	-0.004	-0.004	0.000	0.000	0.000	0.000
108	A	170	GLU	-1	-0.902	-0.956	41.163	0.054	0.054	0.000	0.000	0.000	0.000
109	A	171	GLU	-1	-0.852	-0.882	40.934	0.019	0.019	0.000	0.000	0.000	0.000
110	A	172	THR	0	-0.037	-0.042	44.052	-0.004	-0.004	0.000	0.000	0.000	0.000
111	A	173	LEU	0	0.011	0.023	46.161	-0.002	-0.002	0.000	0.000	0.000	0.000
112	A	174	ARG	1	0.967	0.995	45.305	-0.024	-0.024	0.000	0.000	0.000	0.000
113	A	175	ASN	0	-0.052	-0.023	48.778	-0.001	-0.001	0.000	0.000	0.000	0.000
114	A	176	TYR	0	0.073	0.006	49.001	-0.003	-0.003	0.000	0.000	0.000	0.000
115	A	177	GLN	0	-0.008	-0.003	50.869	-0.001	-0.001	0.000	0.000	0.000	0.000
116	A	178	GLN	0	-0.033	-0.012	51.845	-0.001	-0.001	0.000	0.000	0.000	0.000
117	A	179	SER	0	-0.031	-0.017	54.689	-0.001	-0.001	0.000	0.000	0.000	0.000
118	A	180	TYR	0	0.027	0.014	56.284	-0.001	-0.001	0.000	0.000	0.000	0.000
119	A	181	ALA	0	0.004	-0.005	57.892	-0.001	-0.001	0.000	0.000	0.000	0.000
120	A	182	PHE	0	0.006	0.007	59.393	-0.001	-0.001	0.000	0.000	0.000	0.000
121	A	183	VAL	0	0.058	0.027	60.750	-0.001	-0.001	0.000	0.000	0.000	0.000
122	A	184	GLU	-1	-0.880	-0.934	62.285	0.018	0.018	0.000	0.000	0.000	0.000
123	A	185	LYS	1	0.861	0.929	61.675	-0.017	-0.017	0.000	0.000	0.000	0.000
124	A	186	GLN	0	0.011	-0.004	64.977	0.000	0.000	0.000	0.000	0.000	0.000
125	A	187	LEU	0	-0.025	-0.013	66.440	-0.001	-0.001	0.000	0.000	0.000	0.000
126	A	188	LEU	0	-0.075	-0.020	68.560	0.000	0.000	0.000	0.000	0.000	0.000
127	A	189	THR	0	-0.043	-0.023	70.756	0.000	0.000	0.000	0.000	0.000	0.000
128	A	190	GLY	0	-0.027	0.001	72.026	-0.001	-0.001	0.000	0.000	0.000	0.000
129	A	191	SER	0	-0.022	-0.020	68.179	-0.001	-0.001	0.000	0.000	0.000	0.000
130	A	192	SER	0	-0.011	-0.003	65.373	0.000	0.000	0.000	0.000	0.000	0.000
131	A	193	ASN	0	0.043	0.019	66.211	0.001	0.001	0.000	0.000	0.000	0.000
132	A	194	VAL	0	0.090	0.036	65.902	0.000	0.000	0.000	0.000	0.000	0.000
133	A	195	LEU	0	0.009	0.003	63.521	0.001	0.001	0.000	0.000	0.000	0.000
134	A	196	ALA	0	0.002	0.005	62.119	0.001	0.001	0.000	0.000	0.000	0.000
135	A	197	LEU	0	0.001	-0.002	60.935	0.001	0.001	0.000	0.000	0.000	0.000
136	A	198	GLU	-1	-0.882	-0.935	60.809	0.028	0.028	0.000	0.000	0.000	0.000
137	A	199	GLN	0	0.023	0.008	58.225	0.001	0.001	0.000	0.000	0.000	0.000
138	A	200	ALA	0	-0.022	-0.007	56.641	0.001	0.001	0.000	0.000	0.000	0.000
139	A	201	ARG	1	0.866	0.905	55.676	-0.024	-0.024	0.000	0.000	0.000	0.000
140	A	202	GLY	0	0.033	0.023	55.173	0.002	0.002	0.000	0.000	0.000	0.000
141	A	203	VAL	0	0.022	0.017	51.737	0.002	0.002	0.000	0.000	0.000	0.000
142	A	204	ILE	0	-0.023	0.017	50.597	0.002	0.002	0.000	0.000	0.000	0.000
143	A	205	GLU	-1	-0.822	-0.902	50.317	0.043	0.043	0.000	0.000	0.000	0.000
144	A	206	SER	0	-0.001	-0.004	49.052	0.003	0.003	0.000	0.000	0.000	0.000
145	A	207	THR	0	-0.069	-0.053	45.835	0.002	0.002	0.000	0.000	0.000	0.000
146	A	208	ARG	1	0.855	0.903	45.486	-0.038	-0.038	0.000	0.000	0.000	0.000
147	A	209	SER	0	-0.017	0.002	45.560	0.005	0.005	0.000	0.000	0.000	0.000
148	A	210	ASP	-1	-0.777	-0.878	41.598	0.062	0.062	0.000	0.000	0.000	0.000
149	A	211	ILE	0	0.035	0.028	41.026	0.005	0.005	0.000	0.000	0.000	0.000
150	A	212	ALA	0	0.009	0.011	40.424	0.006	0.006	0.000	0.000	0.000	0.000
151	A	213	LYS	1	0.789	0.880	38.813	-0.065	-0.065	0.000	0.000	0.000	0.000
152	A	214	ARG	1	0.740	0.832	36.059	-0.059	-0.059	0.000	0.000	0.000	0.000
153	A	215	GLN	0	-0.005	0.003	35.711	0.003	0.003	0.000	0.000	0.000	0.000
154	A	216	GLY	0	-0.003	0.000	35.891	0.008	0.008	0.000	0.000	0.000	0.000
155	A	217	GLU	-1	-0.747	-0.861	33.259	0.095	0.095	0.000	0.000	0.000	0.000
156	A	218	LEU	0	-0.020	-0.006	30.426	0.013	0.013	0.000	0.000	0.000	0.000
157	A	219	ALA	0	-0.038	-0.018	30.662	0.015	0.015	0.000	0.000	0.000	0.000
158	A	220	GLN	0	-0.030	-0.018	30.813	0.010	0.010	0.000	0.000	0.000	0.000
159	A	221	ALA	0	0.026	0.024	27.032	0.018	0.018	0.000	0.000	0.000	0.000
160	A	222	ASN	0	0.033	0.007	26.066	0.029	0.029	0.000	0.000	0.000	0.000
161	A	223	ASN	0	-0.017	0.004	26.359	0.032	0.032	0.000	0.000	0.000	0.000
162	A	224	ALA	0	0.026	0.021	24.422	0.023	0.023	0.000	0.000	0.000	0.000
163	A	225	LEU	0	-0.030	-0.024	21.182	0.040	0.040	0.000	0.000	0.000	0.000
164	A	226	GLN	0	-0.007	-0.009	21.629	0.041	0.041	0.000	0.000	0.000	0.000
165	A	227	LEU	0	-0.012	0.018	22.641	0.033	0.033	0.000	0.000	0.000	0.000
166	A	228	LEU	0	-0.041	-0.026	18.289	0.049	0.049	0.000	0.000	0.000	0.000
167	A	229	LEU	0	-0.053	-0.014	17.212	0.087	0.087	0.000	0.000	0.000	0.000
168	A	230	GLY	0	-0.012	-0.004	18.813	0.035	0.035	0.000	0.000	0.000	0.000
169	A	231	SER	0	-0.015	-0.029	20.977	-0.018	-0.018	0.000	0.000	0.000	0.000
170	A	232	TYR	0	-0.052	-0.025	20.638	-0.021	-0.021	0.000	0.000	0.000	0.000
171	A	233	GLY	0	0.051	0.053	20.904	0.002	0.002	0.000	0.000	0.000	0.000
172	A	234	LYS	1	0.886	0.941	21.645	-0.184	-0.184	0.000	0.000	0.000	0.000
173	A	235	LEU	0	0.020	0.013	22.665	0.007	0.007	0.000	0.000	0.000	0.000
174	A	236	PRO	0	-0.026	-0.008	22.553	-0.020	-0.020	0.000	0.000	0.000	0.000
175	A	237	GLN	0	0.016	0.009	25.305	0.009	0.009	0.000	0.000	0.000	0.000
176	A	238	ALA	0	0.053	0.030	27.799	0.003	0.003	0.000	0.000	0.000	0.000
177	A	239	GLN	0	-0.009	0.001	25.495	0.007	0.007	0.000	0.000	0.000	0.000
178	A	240	THR	0	-0.010	-0.009	28.710	-0.002	-0.002	0.000	0.000	0.000	0.000
179	A	241	VAL	0	0.011	0.007	29.861	-0.006	-0.006	0.000	0.000	0.000	0.000
180	A	242	ASN	0	0.013	0.001	31.152	0.002	0.002	0.000	0.000	0.000	0.000
181	A	243	SER	0	-0.003	-0.020	32.157	-0.002	-0.002	0.000	0.000	0.000	0.000
182	A	244	ASP	-1	-0.871	-0.924	33.950	-0.043	-0.043	0.000	0.000	0.000	0.000
183	A	245	SER	0	-0.093	-0.034	28.383	-0.011	-0.011	0.000	0.000	0.000	0.000
184	A	246	LEU	0	0.018	0.010	28.691	0.007	0.007	0.000	0.000	0.000	0.000
185	A	247	GLN	0	-0.034	0.007	28.334	-0.002	-0.002	0.000	0.000	0.000	0.000
186	A	248	SER	0	-0.023	0.008	23.419	-0.009	-0.009	0.000	0.000	0.000	0.000
187	A	249	VAL	0	0.017	0.013	19.352	-0.007	-0.007	0.000	0.000	0.000	0.000
188	A	250	LYS	1	0.912	0.951	21.077	0.243	0.243	0.000	0.000	0.000	0.000
189	A	251	LEU	0	0.006	0.013	17.469	-0.020	-0.020	0.000	0.000	0.000	0.000
190	A	252	PRO	0	0.005	0.009	14.013	0.034	0.034	0.000	0.000	0.000	0.000
191	A	253	ALA	0	0.035	0.027	17.090	0.029	0.029	0.000	0.000	0.000	0.000
192	A	254	GLY	0	-0.015	-0.002	18.085	-0.055	-0.055	0.000	0.000	0.000	0.000
193	A	255	LEU	0	-0.035	-0.005	12.981	-0.069	-0.069	0.000	0.000	0.000	0.000
194	A	256	SER	0	0.082	0.036	13.223	0.075	0.075	0.000	0.000	0.000	0.000
195	A	257	SER	0	0.033	-0.011	14.130	-0.052	-0.052	0.000	0.000	0.000	0.000
196	A	258	GLN	0	0.043	0.019	11.862	0.095	0.095	0.000	0.000	0.000	0.000
197	A	259	ILE	0	-0.034	0.000	8.953	0.002	0.002	0.000	0.000	0.000	0.000
198	A	260	LEU	0	0.021	0.008	11.239	0.091	0.091	0.000	0.000	0.000	0.000
199	A	261	LEU	0	-0.031	-0.010	11.243	0.093	0.093	0.000	0.000	0.000	0.000
200	A	262	GLN	0	-0.139	-0.055	8.024	-0.023	-0.023	0.000	0.000	0.000	0.000
201	A	263	ARG	1	0.782	0.842	10.447	0.117	0.117	0.000	0.000	0.000	0.000
202	A	264	PRO	0	0.023	0.009	13.290	-0.013	-0.013	0.000	0.000	0.000	0.000
203	A	265	ASP	-1	-0.790	-0.877	14.796	0.124	0.124	0.000	0.000	0.000	0.000
204	A	266	ILE	0	0.029	0.013	15.357	-0.027	-0.027	0.000	0.000	0.000	0.000
205	A	267	MET	0	-0.045	-0.001	10.002	0.010	0.010	0.000	0.000	0.000	0.000
206	A	268	GLU	-1	-0.805	-0.871	14.519	0.286	0.286	0.000	0.000	0.000	0.000
207	A	269	ALA	0	-0.025	-0.011	17.423	-0.024	-0.024	0.000	0.000	0.000	0.000
208	A	270	GLU	-1	-0.727	-0.815	14.606	-0.068	-0.068	0.000	0.000	0.000	0.000
209	A	271	HIS	0	-0.025	-0.010	15.173	-0.041	-0.041	0.000	0.000	0.000	0.000
210	A	272	ALA	0	-0.016	-0.010	17.897	-0.013	-0.013	0.000	0.000	0.000	0.000
211	A	273	LEU	0	0.011	0.002	20.373	-0.015	-0.015	0.000	0.000	0.000	0.000
212	A	274	MET	0	-0.019	-0.013	15.509	-0.010	-0.010	0.000	0.000	0.000	0.000
213	A	275	ALA	0	-0.028	0.002	20.503	-0.006	-0.006	0.000	0.000	0.000	0.000
214	A	276	ALA	0	-0.050	-0.014	22.840	-0.005	-0.005	0.000	0.000	0.000	0.000
215	A	277	ASN	0	-0.079	-0.051	23.796	-0.015	-0.015	0.000	0.000	0.000	0.000
216	A	278	ALA	0	0.001	0.013	22.160	-0.013	-0.013	0.000	0.000	0.000	0.000
217	A	279	ASN	0	-0.015	-0.011	21.321	-0.006	-0.006	0.000	0.000	0.000	0.000
218	A	280	ILE	0	0.056	0.018	15.701	-0.013	-0.013	0.000	0.000	0.000	0.000
219	A	281	GLY	0	-0.002	0.003	18.084	-0.017	-0.017	0.000	0.000	0.000	0.000
220	A	282	ALA	0	-0.003	-0.007	18.947	-0.014	-0.014	0.000	0.000	0.000	0.000
221	A	283	ALA	0	0.033	0.013	20.674	-0.001	-0.001	0.000	0.000	0.000	0.000
222	A	284	ARG	1	0.815	0.858	12.109	0.131	0.131	0.000	0.000	0.000	0.000
223	A	285	ALA	0	-0.032	-0.009	19.476	-0.012	-0.012	0.000	0.000	0.000	0.000
224	A	286	ALA	0	-0.031	0.002	21.692	0.000	0.000	0.000	0.000	0.000	0.000
225	A	287	PHE	0	0.003	-0.025	22.760	0.003	0.003	0.000	0.000	0.000	0.000
226	A	288	PHE	0	-0.011	0.000	15.449	0.011	0.011	0.000	0.000	0.000	0.000
227	A	289	PRO	0	-0.007	0.006	20.171	-0.028	-0.028	0.000	0.000	0.000	0.000
228	A	290	SER	0	-0.005	0.010	17.214	-0.034	-0.034	0.000	0.000	0.000	0.000
229	A	291	ILE	0	-0.018	-0.007	19.066	0.006	0.006	0.000	0.000	0.000	0.000
230	A	292	SER	0	0.023	0.033	18.230	-0.063	-0.063	0.000	0.000	0.000	0.000
231	A	293	LEU	0	0.006	0.011	16.215	0.049	0.049	0.000	0.000	0.000	0.000
232	A	294	THR	0	-0.018	-0.027	18.954	0.031	0.031	0.000	0.000	0.000	0.000
233	A	295	SER	0	-0.025	-0.033	21.224	-0.020	-0.020	0.000	0.000	0.000	0.000
234	A	296	GLY	0	0.040	0.019	22.762	-0.026	-0.026	0.000	0.000	0.000	0.000
235	A	297	ILE	0	-0.048	-0.021	24.039	-0.013	-0.013	0.000	0.000	0.000	0.000
236	A	298	SER	0	0.031	0.004	21.942	-0.027	-0.027	0.000	0.000	0.000	0.000
237	A	299	THR	0	0.027	0.026	22.969	0.014	0.014	0.000	0.000	0.000	0.000
238	A	300	ALA	0	0.092	0.041	23.796	-0.025	-0.025	0.000	0.000	0.000	0.000
239	A	301	SER	0	-0.051	-0.030	22.631	0.018	0.018	0.000	0.000	0.000	0.000
240	A	302	SER	0	0.063	0.019	24.867	0.015	0.015	0.000	0.000	0.000	0.000
241	A	303	ASP	-1	-0.861	-0.935	23.608	-0.227	-0.227	0.000	0.000	0.000	0.000
242	A	304	LEU	0	0.007	0.000	21.808	0.014	0.014	0.000	0.000	0.000	0.000
243	A	305	SER	0	-0.058	-0.042	24.673	0.022	0.022	0.000	0.000	0.000	0.000
244	A	306	SER	0	-0.049	-0.022	27.859	0.014	0.014	0.000	0.000	0.000	0.000
245	A	307	LEU	0	-0.011	0.011	23.631	0.010	0.010	0.000	0.000	0.000	0.000
246	A	308	PHE	0	-0.024	-0.005	25.515	0.014	0.014	0.000	0.000	0.000	0.000
247	A	309	ASN	0	-0.016	-0.002	30.710	-0.001	-0.001	0.000	0.000	0.000	0.000
248	A	310	ALA	0	0.038	0.006	34.466	0.002	0.002	0.000	0.000	0.000	0.000
249	A	311	SER	0	-0.059	-0.033	36.349	0.004	0.004	0.000	0.000	0.000	0.000
250	A	312	SER	0	0.026	0.007	36.318	0.006	0.006	0.000	0.000	0.000	0.000
251	A	313	GLY	0	-0.031	-0.004	32.755	0.006	0.006	0.000	0.000	0.000	0.000
252	A	314	MET	0	-0.015	-0.006	31.868	0.002	0.002	0.000	0.000	0.000	0.000
253	A	315	TRP	0	0.036	0.016	23.598	-0.008	-0.008	0.000	0.000	0.000	0.000
254	A	316	ASN	0	-0.003	-0.039	29.902	0.012	0.012	0.000	0.000	0.000	0.000
255	A	317	PHE	0	-0.049	-0.005	25.021	-0.002	-0.002	0.000	0.000	0.000	0.000
256	A	318	ILE	0	-0.001	0.003	28.821	0.011	0.011	0.000	0.000	0.000	0.000
257	A	319	PRO	0	0.001	0.022	26.989	-0.009	-0.009	0.000	0.000	0.000	0.000
258	A	320	LYS	1	0.844	0.900	28.172	0.088	0.088	0.000	0.000	0.000	0.000
259	A	321	ILE	0	0.009	0.000	27.926	-0.009	-0.009	0.000	0.000	0.000	0.000
260	A	322	GLU	-1	-0.851	-0.905	27.773	-0.093	-0.093	0.000	0.000	0.000	0.000
261	A	323	ILE	0	-0.036	-0.020	25.424	0.003	0.003	0.000	0.000	0.000	0.000
262	A	324	PRO	0	-0.006	-0.012	27.404	0.001	0.001	0.000	0.000	0.000	0.000
263	A	325	ILE	0	0.020	0.017	24.095	-0.002	-0.002	0.000	0.000	0.000	0.000
264	A	326	PHE	0	0.024	0.025	25.603	0.003	0.003	0.000	0.000	0.000	0.000
265	A	327	ASN	0	-0.032	-0.019	28.063	-0.001	-0.001	0.000	0.000	0.000	0.000
266	A	328	ALA	0	0.081	0.039	30.472	0.003	0.003	0.000	0.000	0.000	0.000
267	A	329	GLY	0	0.003	0.014	31.449	0.005	0.005	0.000	0.000	0.000	0.000
268	A	330	ARG	1	0.858	0.906	32.328	-0.033	-0.033	0.000	0.000	0.000	0.000
269	A	331	ASN	0	0.019	0.009	34.336	0.004	0.004	0.000	0.000	0.000	0.000
270	A	332	GLN	0	0.012	0.002	37.439	0.006	0.006	0.000	0.000	0.000	0.000
271	A	333	ALA	0	0.044	0.032	39.021	-0.001	-0.001	0.000	0.000	0.000	0.000
272	A	334	ASN	0	-0.028	-0.023	36.630	0.001	0.001	0.000	0.000	0.000	0.000
273	A	335	LEU	0	0.060	0.045	36.253	0.003	0.003	0.000	0.000	0.000	0.000
274	A	336	ASP	-1	-0.820	-0.912	36.090	0.024	0.024	0.000	0.000	0.000	0.000
275	A	337	ILE	0	-0.056	-0.028	34.486	0.002	0.002	0.000	0.000	0.000	0.000
276	A	338	ALA	0	0.013	-0.004	32.043	0.004	0.004	0.000	0.000	0.000	0.000
277	A	339	GLU	-1	-0.861	-0.928	31.482	0.012	0.012	0.000	0.000	0.000	0.000
278	A	340	ILE	0	-0.029	-0.008	32.480	0.000	0.000	0.000	0.000	0.000	0.000
279	A	341	ARG	1	0.870	0.926	28.909	-0.077	-0.077	0.000	0.000	0.000	0.000
280	A	342	GLN	0	0.036	0.029	28.145	0.001	0.001	0.000	0.000	0.000	0.000
281	A	343	GLN	0	-0.005	-0.004	28.377	0.003	0.003	0.000	0.000	0.000	0.000
282	A	344	GLN	0	0.029	0.014	29.349	0.005	0.005	0.000	0.000	0.000	0.000
283	A	345	SER	0	-0.029	-0.011	24.212	0.001	0.001	0.000	0.000	0.000	0.000
284	A	346	VAL	0	0.031	0.010	24.657	-0.001	-0.001	0.000	0.000	0.000	0.000
285	A	347	VAL	0	0.022	0.015	26.010	-0.004	-0.004	0.000	0.000	0.000	0.000
286	A	348	ASN	0	-0.042	-0.027	22.795	0.002	0.002	0.000	0.000	0.000	0.000
287	A	349	TYR	0	-0.053	-0.057	17.564	-0.005	-0.005	0.000	0.000	0.000	0.000
288	A	350	GLU	-1	-0.875	-0.950	22.597	-0.032	-0.032	0.000	0.000	0.000	0.000
289	A	351	GLN	0	-0.008	0.000	24.897	0.006	0.006	0.000	0.000	0.000	0.000
290	A	352	LYS	1	0.900	0.942	20.792	-0.109	-0.109	0.000	0.000	0.000	0.000
291	A	353	ILE	0	0.018	0.025	19.599	-0.007	-0.007	0.000	0.000	0.000	0.000
292	A	354	GLN	0	-0.037	-0.015	21.549	-0.005	-0.005	0.000	0.000	0.000	0.000
293	A	355	ASN	0	-0.028	-0.015	22.787	-0.010	-0.010	0.000	0.000	0.000	0.000
294	A	356	ALA	0	-0.002	0.010	18.649	0.000	0.000	0.000	0.000	0.000	0.000
295	A	357	PHE	0	-0.001	-0.021	18.978	-0.019	-0.019	0.000	0.000	0.000	0.000
296	A	358	LYS	1	0.859	0.920	21.952	0.000	0.000	0.000	0.000	0.000	0.000
297	A	359	GLU	-1	-0.814	-0.880	21.395	0.077	0.077	0.000	0.000	0.000	0.000
298	A	360	VAL	0	-0.004	-0.009	18.370	-0.006	-0.006	0.000	0.000	0.000	0.000
299	A	361	ALA	0	-0.007	-0.003	21.451	-0.012	-0.012	0.000	0.000	0.000	0.000
300	A	362	ASP	-1	-0.811	-0.894	24.731	-0.019	-0.019	0.000	0.000	0.000	0.000
301	A	363	ALA	0	0.009	0.006	22.598	0.003	0.003	0.000	0.000	0.000	0.000
302	A	364	LEU	0	-0.026	-0.020	20.811	-0.006	-0.006	0.000	0.000	0.000	0.000
303	A	365	ALA	0	-0.001	0.002	24.678	-0.002	-0.002	0.000	0.000	0.000	0.000
304	A	366	LEU	0	-0.009	0.004	27.428	0.002	0.002	0.000	0.000	0.000	0.000
305	A	367	ARG	1	0.785	0.863	21.080	0.152	0.152	0.000	0.000	0.000	0.000
306	A	368	GLN	0	-0.084	-0.042	26.949	-0.015	-0.015	0.000	0.000	0.000	0.000
307	A	369	SER	0	0.025	0.011	29.199	0.005	0.005	0.000	0.000	0.000	0.000
308	A	370	LEU	0	0.004	-0.001	28.731	0.004	0.004	0.000	0.000	0.000	0.000
309	A	371	ASN	0	0.051	0.008	26.385	0.014	0.014	0.000	0.000	0.000	0.000
310	A	372	ASP	-1	-0.840	-0.901	30.722	-0.077	-0.077	0.000	0.000	0.000	0.000
311	A	373	GLN	0	-0.055	-0.032	34.126	0.010	0.010	0.000	0.000	0.000	0.000
312	A	374	ILE	0	-0.007	-0.010	30.541	0.004	0.004	0.000	0.000	0.000	0.000
313	A	375	SER	0	-0.018	0.000	34.116	0.003	0.003	0.000	0.000	0.000	0.000
314	A	376	ALA	0	-0.043	-0.018	35.493	0.002	0.002	0.000	0.000	0.000	0.000
315	A	377	GLN	0	0.048	0.010	37.238	0.004	0.004	0.000	0.000	0.000	0.000
316	A	378	GLN	0	0.009	-0.006	32.983	-0.001	-0.001	0.000	0.000	0.000	0.000
317	A	379	ARG	1	0.964	0.992	38.061	0.052	0.052	0.000	0.000	0.000	0.000
318	A	380	TYR	0	-0.018	-0.011	41.096	0.000	0.000	0.000	0.000	0.000	0.000
319	A	381	LEU	0	0.043	0.016	38.526	0.002	0.002	0.000	0.000	0.000	0.000
320	A	382	ALA	0	0.036	0.027	41.169	0.002	0.002	0.000	0.000	0.000	0.000
321	A	383	SER	0	-0.025	-0.019	42.924	0.000	0.000	0.000	0.000	0.000	0.000
322	A	384	LEU	0	0.000	0.009	44.882	0.002	0.002	0.000	0.000	0.000	0.000
323	A	385	GLN	0	0.002	-0.005	40.162	0.000	0.000	0.000	0.000	0.000	0.000
324	A	386	ILE	0	-0.023	-0.002	45.954	0.002	0.002	0.000	0.000	0.000	0.000
325	A	387	THR	0	-0.048	-0.050	48.323	0.001	0.001	0.000	0.000	0.000	0.000
326	A	388	LEU	0	0.006	0.023	47.441	0.001	0.001	0.000	0.000	0.000	0.000
327	A	389	GLN	0	-0.006	-0.001	45.995	0.000	0.000	0.000	0.000	0.000	0.000
328	A	390	ARG	1	0.949	0.971	51.119	0.022	0.022	0.000	0.000	0.000	0.000
329	A	391	ALA	0	0.049	0.030	53.809	0.001	0.001	0.000	0.000	0.000	0.000
330	A	392	ARG	1	0.835	0.891	48.593	-0.002	-0.002	0.000	0.000	0.000	0.000
331	A	393	ALA	0	0.016	0.011	54.974	0.001	0.001	0.000	0.000	0.000	0.000
332	A	394	LEU	0	0.017	0.011	57.043	0.000	0.000	0.000	0.000	0.000	0.000
333	A	395	TYR	0	-0.004	0.010	57.815	0.001	0.001	0.000	0.000	0.000	0.000
334	A	396	GLN	0	-0.038	-0.019	56.851	0.002	0.002	0.000	0.000	0.000	0.000
335	A	397	HIS	0	-0.108	-0.059	60.301	-0.001	-0.001	0.000	0.000	0.000	0.000
336	A	398	GLY	0	-0.013	0.000	63.246	0.000	0.000	0.000	0.000	0.000	0.000
337	A	399	ALA	0	-0.041	-0.012	62.448	0.000	0.000	0.000	0.000	0.000	0.000
338	A	400	VAL	0	-0.033	-0.013	58.628	0.000	0.000	0.000	0.000	0.000	0.000
339	A	401	SER	0	0.013	-0.028	61.402	0.001	0.001	0.000	0.000	0.000	0.000
340	A	402	TYR	0	0.046	0.007	54.893	0.000	0.000	0.000	0.000	0.000	0.000
341	A	403	LEU	0	0.000	-0.005	57.181	0.000	0.000	0.000	0.000	0.000	0.000
342	A	404	GLU	-1	-0.811	-0.873	56.654	0.003	0.003	0.000	0.000	0.000	0.000
343	A	405	VAL	0	-0.048	-0.018	53.208	-0.001	-0.001	0.000	0.000	0.000	0.000
344	A	406	LEU	0	-0.049	-0.022	52.537	0.000	0.000	0.000	0.000	0.000	0.000
345	A	407	ASP	-1	-0.795	-0.885	51.783	0.009	0.009	0.000	0.000	0.000	0.000
346	A	408	ALA	0	0.018	0.010	51.546	0.000	0.000	0.000	0.000	0.000	0.000
347	A	409	GLU	-1	-0.835	-0.911	47.409	0.010	0.010	0.000	0.000	0.000	0.000
348	A	410	ARG	1	0.859	0.919	47.099	-0.012	-0.012	0.000	0.000	0.000	0.000
349	A	411	SER	0	0.017	0.016	46.900	0.001	0.001	0.000	0.000	0.000	0.000
350	A	412	LEU	0	-0.039	-0.009	43.166	-0.001	-0.001	0.000	0.000	0.000	0.000
351	A	413	PHE	0	-0.009	-0.013	42.832	0.000	0.000	0.000	0.000	0.000	0.000
352	A	414	ALA	0	0.058	0.029	41.947	0.002	0.002	0.000	0.000	0.000	0.000
353	A	415	THR	0	-0.003	-0.002	41.163	0.000	0.000	0.000	0.000	0.000	0.000
354	A	416	ARG	1	0.774	0.848	38.703	-0.018	-0.018	0.000	0.000	0.000	0.000
355	A	417	GLN	0	-0.002	-0.001	37.419	0.005	0.005	0.000	0.000	0.000	0.000
356	A	418	THR	0	-0.002	0.011	37.233	0.003	0.003	0.000	0.000	0.000	0.000
357	A	419	LEU	0	-0.031	-0.021	34.624	-0.001	-0.001	0.000	0.000	0.000	0.000
358	A	420	LEU	0	-0.013	-0.004	33.105	-0.003	-0.003	0.000	0.000	0.000	0.000
359	A	421	ASP	-1	-0.812	-0.896	32.225	0.047	0.047	0.000	0.000	0.000	0.000
360	A	422	LEU	0	-0.024	-0.007	32.370	0.002	0.002	0.000	0.000	0.000	0.000
361	A	423	ASN	0	0.020	0.002	27.735	-0.016	-0.016	0.000	0.000	0.000	0.000
362	A	424	TYR	0	-0.014	-0.013	27.006	-0.003	-0.003	0.000	0.000	0.000	0.000
363	A	425	ALA	0	0.018	0.006	27.572	0.008	0.008	0.000	0.000	0.000	0.000
364	A	426	ARG	1	0.831	0.901	24.102	0.033	0.033	0.000	0.000	0.000	0.000
365	A	427	GLN	0	-0.034	-0.015	23.954	-0.003	-0.003	0.000	0.000	0.000	0.000
366	A	428	VAL	0	0.024	0.015	23.057	0.010	0.010	0.000	0.000	0.000	0.000
367	A	429	ASN	0	-0.001	0.002	23.742	0.021	0.021	0.000	0.000	0.000	0.000
368	A	430	GLU	-1	-0.776	-0.885	20.320	-0.103	-0.103	0.000	0.000	0.000	0.000
369	A	431	ILE	0	-0.015	0.006	18.907	-0.004	-0.004	0.000	0.000	0.000	0.000
370	A	432	SER	0	-0.005	0.003	19.190	0.031	0.031	0.000	0.000	0.000	0.000
371	A	433	LEU	0	0.019	0.023	18.061	0.001	0.001	0.000	0.000	0.000	0.000
372	A	434	TYR	0	-0.022	-0.009	11.363	-0.024	-0.024	0.000	0.000	0.000	0.000
373	A	435	THR	0	-0.014	-0.049	15.226	0.040	0.040	0.000	0.000	0.000	0.000
374	A	436	ALA	0	-0.014	0.008	16.770	0.016	0.016	0.000	0.000	0.000	0.000
375	A	437	LEU	0	-0.021	-0.024	13.654	-0.032	-0.032	0.000	0.000	0.000	0.000
376	A	438	GLY	0	0.007	0.013	12.941	-0.067	-0.067	0.000	0.000	0.000	0.000
377	A	439	GLY	0	-0.013	-0.007	11.217	0.157	0.157	0.000	0.000	0.000	0.000
378	A	440	GLY	0	-0.029	-0.010	10.159	-0.077	-0.077	0.000	0.000	0.000	0.000
379	A	441	HIS	0	-0.020	-0.022	11.299	-0.087	-0.087	0.000	0.000	0.000	0.000
380	A	442	HIS	0	0.021	0.018	3.827	0.104	0.302	0.001	-0.025	-0.174	0.000

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Interactive mode: IFIE and PIEDA for fragment #1(A:32:TYR)