FMO DATABASE

FMODB ID: VR9L1

Calculation Name: 3KEY-A-Xray372

Preferred Name:

Target Type:

Ligand Name:

ligand 3-letter code:

PDB ID: 3KEY

Chain ID: A

ChEMBL ID:

UniProt ID: P38960

Base Structure: X-ray

Registration Date: 2023-06-19

Reference: C. Watanabe, N. Tani, K. Kamisaka, T. Honma et al., Interaction energy analysis of Apo structure dataset on FMODB, To be published.

DOI:

IFIE MAP

IFIE Diagram

Modeling method

Optimization	MOE:Amber10:EHT
Restraint	OptAll
Protonation	MOE:Protonate 3D
Complement	MOE:Structure Preparation
Water	No
Procedure	Auto-FMO protocol ver. 2.20220422

FMO calculation

FMO method	FMO2-MP2/6-31G(d)
Fragmentation	Auto
Number of fragment	175
LigandCharge
Software	ABINIT-MP - Open Ver. 1 Rev. 23Q2 / 20200603(SMP)

Total energy (hartree)

FMO2-HF: Electronic energy	-1824903.321116
FMO2-HF: Nuclear repulsion	1754637.585947
FMO2-HF: Total energy	-70265.735168
FMO2-MP2: Total energy	-70471.28361

3D Structure

Snapshot

Ligand structure

Ligand Interaction

Ligand binding energy

IFIE [kcal/mol]	PIEDA [kcal/mol]				Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level.	ESElectro static interaction energy.	EXExchange-repulsion energy.	CT+mixCharge transfer and mixing terms energy.	DI(MP2)Dispersion energy.	q(I=>J)Charge transfer value from I to J fragments.
N/A	N/A	N/A	N/A	N/A	N/A

Interactive mode: IFIE and PIEDA for fragment #1(A:312:ARG)

Summations of interaction energy for fragment #1(A:312:ARG)

IFIE [kcal/mol]	PIEDA [kcal/mol]				Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level.	ESElectro static interaction energy.	EXExchange-repulsion energy.	CT+mixCharge transfer and mixing terms energy.	DI(MP2)Dispersion energy.	q(I=>J)Charge transfer value from I to J fragments.
44.091	43.36	15.464	-7.405	-7.328	-0.073

Interaction energy analysis for fragmet #1(A:312:ARG)

Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE

Single fragment	Multi fragments
	Fragment list

Charge [e] FCHARGE : 1 / q_Mulliken : 0.978 / q_NPA : 0.969

Distance from base fragment(s) [Å]

Dist

Interaction energy by IFIE and PIEDA
[kcal/mol]

| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >

Fragment charge [e]

FCHARGE q_Mulliken
q_NPA q(I=>J)

Residue

Res # RES

Sort

Graph Options

X Axis Label
Y Axis Max Y Axis Min
Display ES EX CT+mix DI(MP2)

frag_NumFragment number.	ChainChain species.	Res #Residue number.	RES3-letter code of amino acid residue, ligand and solvent molecule.	FCHARGEFormal charge [e].	q_MullikenFragment charge evaluated by Mulliken charge [e].	q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e].	DISTDistance from Ligand [Å].	TotalIFIE at MP2 level [kcal/mol].	ESElectro static interaction energy by PIEDA [kcal/mol].	EXExchange-repulsion energy by PIEDA [kcal/mol].	CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol].	DI(MP2)Dispersion energy by PIEDA [kcal/mol].	q(I=>J)Charge transfer value from I to J fragmens [e].
3	A	314	SER	0	0.055	0.034	2.888	-11.556	-8.554	0.383	-1.609	-1.776	-0.005
4	A	315	ALA	0	0.074	0.040	4.962	-3.224	-3.224	0.000	0.000	0.000	0.000
5	A	316	LYS	1	0.874	0.917	5.863	25.282	25.282	0.000	0.000	0.000	0.000
6	A	317	SER	0	0.014	-0.002	6.516	1.557	1.557	0.000	0.000	0.000	0.000
7	A	318	ASN	0	-0.074	-0.033	1.920	-33.704	-37.731	15.082	-5.756	-5.299	-0.068
8	A	319	LEU	0	0.058	0.035	5.131	2.365	2.425	-0.001	-0.005	-0.054	0.000
9	A	320	MET	0	-0.013	-0.002	8.639	2.664	2.664	0.000	0.000	0.000	0.000
10	A	321	LEU	0	-0.029	-0.015	4.887	1.115	1.115	0.000	0.000	0.000	0.000
11	A	322	ILE	0	0.004	0.007	6.784	2.403	2.403	0.000	0.000	0.000	0.000
12	A	323	LEU	0	-0.014	-0.018	9.269	2.348	2.348	0.000	0.000	0.000	0.000
13	A	324	LEU	0	-0.025	-0.003	11.568	1.706	1.706	0.000	0.000	0.000	0.000
14	A	325	GLY	0	0.021	0.016	11.631	1.327	1.327	0.000	0.000	0.000	0.000
15	A	326	LEU	0	0.009	0.010	12.820	1.358	1.358	0.000	0.000	0.000	0.000
16	A	327	GLN	0	-0.027	-0.009	15.294	1.331	1.331	0.000	0.000	0.000	0.000
17	A	328	MET	0	-0.011	-0.001	18.219	0.769	0.769	0.000	0.000	0.000	0.000
18	A	329	LYS	1	0.984	0.986	19.741	10.797	10.797	0.000	0.000	0.000	0.000
19	A	330	GLU	-1	-0.850	-0.913	21.068	-12.007	-12.007	0.000	0.000	0.000	0.000
20	A	331	ILE	0	0.007	0.002	17.081	-0.158	-0.158	0.000	0.000	0.000	0.000
21	A	332	SER	0	0.065	0.026	20.784	-0.102	-0.102	0.000	0.000	0.000	0.000
22	A	333	ASN	0	0.045	0.000	19.176	-1.384	-1.384	0.000	0.000	0.000	0.000
23	A	334	SER	0	-0.003	-0.015	19.496	-0.467	-0.467	0.000	0.000	0.000	0.000
24	A	335	ASP	-1	-0.833	-0.880	20.411	-13.193	-13.193	0.000	0.000	0.000	0.000
25	A	336	LEU	0	0.001	0.004	13.702	-0.721	-0.721	0.000	0.000	0.000	0.000
26	A	337	TYR	0	-0.019	-0.012	15.252	-0.950	-0.950	0.000	0.000	0.000	0.000
27	A	338	LYS	1	0.847	0.911	16.829	13.008	13.008	0.000	0.000	0.000	0.000
28	A	339	LEU	0	-0.005	0.015	13.424	-0.153	-0.153	0.000	0.000	0.000	0.000
29	A	340	LYS	1	1.022	1.000	12.193	19.590	19.590	0.000	0.000	0.000	0.000
30	A	341	GLU	-1	-0.908	-0.942	8.054	-30.398	-30.398	0.000	0.000	0.000	0.000
31	A	342	VAL	0	0.028	0.010	8.629	-2.906	-2.906	0.000	0.000	0.000	0.000
32	A	343	ARG	1	0.871	0.919	10.471	17.199	17.199	0.000	0.000	0.000	0.000
33	A	344	SER	0	-0.020	-0.014	8.373	0.316	0.316	0.000	0.000	0.000	0.000
34	A	345	VAL	0	-0.050	-0.021	5.063	-1.736	-1.736	0.000	0.000	0.000	0.000
35	A	346	VAL	0	-0.021	-0.005	7.522	0.836	0.836	0.000	0.000	0.000	0.000
36	A	347	THR	0	0.004	-0.021	11.141	0.839	0.839	0.000	0.000	0.000	0.000
37	A	348	SER	0	-0.032	0.003	8.049	0.114	0.114	0.000	0.000	0.000	0.000
38	A	349	LEU	0	0.001	0.006	9.570	1.197	1.197	0.000	0.000	0.000	0.000
39	A	350	ALA	0	0.040	0.013	10.927	1.396	1.396	0.000	0.000	0.000	0.000
40	A	351	SER	0	-0.044	-0.034	12.351	1.277	1.277	0.000	0.000	0.000	0.000
41	A	352	PHE	0	0.001	0.015	12.273	0.672	0.672	0.000	0.000	0.000	0.000
42	A	353	LEU	0	-0.010	-0.021	14.220	1.092	1.092	0.000	0.000	0.000	0.000
43	A	354	PHE	0	0.003	-0.006	16.848	0.968	0.968	0.000	0.000	0.000	0.000
44	A	355	GLN	0	-0.034	-0.026	15.285	1.108	1.108	0.000	0.000	0.000	0.000
45	A	356	GLN	0	-0.051	-0.012	17.057	0.150	0.150	0.000	0.000	0.000	0.000
46	A	357	GLN	0	-0.030	0.000	19.838	0.753	0.753	0.000	0.000	0.000	0.000
47	A	358	ASN	0	0.018	0.011	23.008	0.223	0.223	0.000	0.000	0.000	0.000
48	A	359	VAL	0	0.044	0.012	26.158	0.045	0.045	0.000	0.000	0.000	0.000
49	A	360	GLY	0	0.021	0.013	28.927	0.292	0.292	0.000	0.000	0.000	0.000
50	A	361	VAL	0	-0.084	-0.033	25.451	0.138	0.138	0.000	0.000	0.000	0.000
51	A	362	MET	0	0.017	-0.001	25.794	-0.469	-0.469	0.000	0.000	0.000	0.000
52	A	363	LYS	1	0.855	0.930	22.358	13.432	13.432	0.000	0.000	0.000	0.000
53	A	364	SER	0	0.046	0.020	24.201	-0.278	-0.278	0.000	0.000	0.000	0.000
54	A	365	PHE	0	0.053	0.007	15.234	-0.211	-0.211	0.000	0.000	0.000	0.000
55	A	366	ASP	-1	-0.797	-0.882	19.146	-13.799	-13.799	0.000	0.000	0.000	0.000
56	A	367	SER	0	-0.012	0.002	20.369	-0.294	-0.294	0.000	0.000	0.000	0.000
57	A	368	LEU	0	0.037	0.015	17.946	-0.312	-0.312	0.000	0.000	0.000	0.000
58	A	369	GLU	-1	-0.804	-0.874	15.077	-19.475	-19.475	0.000	0.000	0.000	0.000
59	A	370	LYS	1	0.812	0.892	16.108	12.558	12.558	0.000	0.000	0.000	0.000
60	A	371	GLU	-1	-0.821	-0.877	18.376	-14.152	-14.152	0.000	0.000	0.000	0.000
61	A	372	ALA	0	0.021	0.000	13.043	-0.266	-0.266	0.000	0.000	0.000	0.000
62	A	373	PHE	0	-0.020	-0.013	13.658	-1.229	-1.229	0.000	0.000	0.000	0.000
63	A	374	ARG	1	0.896	0.921	14.803	14.473	14.473	0.000	0.000	0.000	0.000
64	A	375	ASP	-1	-0.802	-0.884	14.906	-16.790	-16.790	0.000	0.000	0.000	0.000
65	A	376	LEU	0	-0.079	-0.030	9.172	-0.559	-0.559	0.000	0.000	0.000	0.000
66	A	377	VAL	0	0.016	0.011	12.937	-0.426	-0.426	0.000	0.000	0.000	0.000
67	A	378	ASN	0	0.029	0.014	15.565	0.551	0.551	0.000	0.000	0.000	0.000
68	A	379	ARG	1	0.829	0.899	12.578	20.633	20.633	0.000	0.000	0.000	0.000
69	A	380	LEU	0	-0.020	-0.004	11.518	-0.063	-0.063	0.000	0.000	0.000	0.000
70	A	381	VAL	0	0.026	0.013	15.321	0.513	0.513	0.000	0.000	0.000	0.000
71	A	382	SER	0	-0.020	-0.012	18.689	0.714	0.714	0.000	0.000	0.000	0.000
72	A	383	GLN	0	-0.049	-0.009	14.534	-1.154	-1.154	0.000	0.000	0.000	0.000
73	A	384	GLY	0	0.082	0.030	18.753	0.104	0.104	0.000	0.000	0.000	0.000
74	A	385	LEU	0	-0.081	-0.030	13.742	0.014	0.014	0.000	0.000	0.000	0.000
75	A	386	ILE	0	-0.028	-0.012	15.697	-0.306	-0.306	0.000	0.000	0.000	0.000
76	A	387	GLY	0	0.035	0.021	18.806	0.393	0.393	0.000	0.000	0.000	0.000
77	A	388	LEU	0	-0.030	-0.023	21.514	-0.519	-0.519	0.000	0.000	0.000	0.000
78	A	389	LYS	1	0.797	0.900	23.868	12.348	12.348	0.000	0.000	0.000	0.000
79	A	390	ASP	-1	-0.745	-0.845	26.412	-9.857	-9.857	0.000	0.000	0.000	0.000
80	A	391	LYS	1	0.795	0.891	25.554	11.313	11.313	0.000	0.000	0.000	0.000
81	A	392	THR	0	-0.026	-0.026	28.429	0.010	0.010	0.000	0.000	0.000	0.000
82	A	393	SER	0	-0.056	-0.041	27.968	-0.062	-0.062	0.000	0.000	0.000	0.000
83	A	394	GLU	-1	-0.827	-0.896	23.356	-12.674	-12.674	0.000	0.000	0.000	0.000
84	A	395	THR	0	-0.004	-0.003	23.008	-0.811	-0.811	0.000	0.000	0.000	0.000
85	A	396	PHE	0	0.001	-0.016	18.884	0.101	0.101	0.000	0.000	0.000	0.000
86	A	397	ASP	-1	-0.827	-0.938	21.413	-12.639	-12.639	0.000	0.000	0.000	0.000
87	A	398	LEU	0	-0.005	-0.015	16.351	-0.605	-0.605	0.000	0.000	0.000	0.000
88	A	399	LEU	0	0.015	0.009	18.922	-0.476	-0.476	0.000	0.000	0.000	0.000
89	A	400	PRO	0	-0.006	0.006	20.119	-0.146	-0.146	0.000	0.000	0.000	0.000
90	A	401	LEU	0	0.024	0.016	13.139	-0.157	-0.157	0.000	0.000	0.000	0.000
91	A	402	LYS	1	0.870	0.925	16.589	16.399	16.399	0.000	0.000	0.000	0.000
92	A	403	ASN	0	0.026	0.015	18.567	-0.075	-0.075	0.000	0.000	0.000	0.000
93	A	404	LEU	0	-0.008	-0.002	18.231	0.185	0.185	0.000	0.000	0.000	0.000
94	A	405	PHE	0	0.007	-0.017	11.655	-0.554	-0.554	0.000	0.000	0.000	0.000
95	A	406	GLU	-1	-0.845	-0.903	17.402	-13.267	-13.267	0.000	0.000	0.000	0.000
96	A	407	TYR	0	-0.039	-0.020	20.641	0.698	0.698	0.000	0.000	0.000	0.000
97	A	408	ALA	0	0.015	0.001	17.267	0.390	0.390	0.000	0.000	0.000	0.000
98	A	409	GLU	-1	-0.842	-0.933	15.327	-19.033	-19.033	0.000	0.000	0.000	0.000
99	A	410	LYS	1	0.837	0.913	18.780	13.365	13.365	0.000	0.000	0.000	0.000
100	A	411	ARG	1	0.890	0.956	21.202	12.728	12.728	0.000	0.000	0.000	0.000
101	A	412	ILE	0	0.029	0.003	15.971	0.382	0.382	0.000	0.000	0.000	0.000
102	A	413	SER	0	0.028	0.019	20.177	0.697	0.697	0.000	0.000	0.000	0.000
103	A	414	VAL	0	-0.043	-0.027	22.311	0.407	0.407	0.000	0.000	0.000	0.000
104	A	415	LEU	0	0.014	0.004	21.336	0.364	0.364	0.000	0.000	0.000	0.000
105	A	416	MET	0	0.016	0.016	19.336	0.008	0.008	0.000	0.000	0.000	0.000
106	A	417	LYS	1	0.891	0.952	23.386	12.266	12.266	0.000	0.000	0.000	0.000
107	A	418	LEU	0	-0.027	-0.001	26.648	0.409	0.409	0.000	0.000	0.000	0.000
108	A	419	GLN	0	-0.042	-0.013	25.282	0.319	0.319	0.000	0.000	0.000	0.000
109	A	420	CYS	0	-0.018	-0.008	24.415	0.250	0.250	0.000	0.000	0.000	0.000
110	A	421	TYR	0	0.043	0.027	22.774	-0.605	-0.605	0.000	0.000	0.000	0.000
111	A	422	THR	0	0.001	-0.008	21.652	-0.413	-0.413	0.000	0.000	0.000	0.000
112	A	423	GLY	0	-0.001	-0.002	22.164	0.529	0.529	0.000	0.000	0.000	0.000
113	A	424	THR	0	-0.026	-0.012	22.073	-0.456	-0.456	0.000	0.000	0.000	0.000
114	A	425	VAL	0	-0.101	-0.052	20.790	0.271	0.271	0.000	0.000	0.000	0.000
115	A	426	GLN	0	0.027	0.006	22.782	-0.192	-0.192	0.000	0.000	0.000	0.000
116	A	427	LEU	0	-0.001	-0.013	22.687	-0.191	-0.191	0.000	0.000	0.000	0.000
117	A	428	SER	0	0.042	0.006	24.827	-0.145	-0.145	0.000	0.000	0.000	0.000
118	A	429	HIS	0	0.013	0.019	27.133	0.005	0.005	0.000	0.000	0.000	0.000
119	A	430	VAL	0	-0.029	-0.012	22.150	-0.021	-0.021	0.000	0.000	0.000	0.000
120	A	431	GLN	0	-0.050	-0.027	25.469	0.326	0.326	0.000	0.000	0.000	0.000
121	A	432	GLU	-1	-0.876	-0.931	27.315	-9.518	-9.518	0.000	0.000	0.000	0.000
122	A	433	LYS	1	0.893	0.950	27.808	10.450	10.450	0.000	0.000	0.000	0.000
123	A	434	LEU	0	-0.058	-0.041	22.909	-0.041	-0.041	0.000	0.000	0.000	0.000
124	A	435	HIS	0	0.020	0.026	26.857	-0.157	-0.157	0.000	0.000	0.000	0.000
125	A	436	LEU	0	-0.038	-0.011	22.139	-0.221	-0.221	0.000	0.000	0.000	0.000
126	A	437	PRO	0	0.038	-0.007	25.667	-0.385	-0.385	0.000	0.000	0.000	0.000
127	A	438	TYR	0	0.003	0.006	24.235	0.002	0.002	0.000	0.000	0.000	0.000
128	A	439	ILE	0	-0.055	0.000	19.465	-0.498	-0.498	0.000	0.000	0.000	0.000
129	A	440	THR	0	0.048	0.026	19.249	0.214	0.214	0.000	0.000	0.000	0.000
130	A	441	THR	0	0.078	0.032	19.537	-0.729	-0.729	0.000	0.000	0.000	0.000
131	A	442	ASN	0	0.022	0.001	15.466	-0.542	-0.542	0.000	0.000	0.000	0.000
132	A	443	GLY	0	-0.009	0.000	14.696	-1.473	-1.473	0.000	0.000	0.000	0.000
133	A	444	ILE	0	0.024	0.011	15.637	-1.058	-1.058	0.000	0.000	0.000	0.000
134	A	445	VAL	0	0.024	0.010	12.248	-0.757	-0.757	0.000	0.000	0.000	0.000
135	A	446	ASP	-1	-0.784	-0.873	10.578	-28.607	-28.607	0.000	0.000	0.000	0.000
136	A	447	VAL	0	0.017	0.014	11.344	-1.860	-1.860	0.000	0.000	0.000	0.000
137	A	448	PHE	0	0.086	0.031	13.282	-0.425	-0.425	0.000	0.000	0.000	0.000
138	A	449	LYS	1	0.865	0.937	7.974	25.464	25.464	0.000	0.000	0.000	0.000
139	A	450	GLU	-1	-0.807	-0.898	6.947	-38.647	-38.647	0.000	0.000	0.000	0.000
140	A	451	CYS	0	-0.022	0.002	9.890	0.249	0.249	0.000	0.000	0.000	0.000
141	A	452	LEU	0	0.046	0.039	12.028	0.597	0.597	0.000	0.000	0.000	0.000
142	A	453	LYS	1	0.819	0.913	3.884	46.995	47.229	0.000	-0.035	-0.199	0.000
143	A	454	ARG	1	0.770	0.883	9.582	25.557	25.557	0.000	0.000	0.000	0.000
144	A	455	THR	0	0.012	-0.016	11.459	1.120	1.120	0.000	0.000	0.000	0.000
145	A	456	LYS	1	0.895	0.931	11.451	20.037	20.037	0.000	0.000	0.000	0.000
146	A	457	LYS	1	0.899	0.945	7.452	30.908	30.908	0.000	0.000	0.000	0.000
147	A	458	GLN	0	-0.027	-0.001	12.883	1.047	1.047	0.000	0.000	0.000	0.000
148	A	459	TYR	0	0.011	0.015	16.096	1.084	1.084	0.000	0.000	0.000	0.000
149	A	460	PRO	0	0.013	0.019	15.916	0.210	0.210	0.000	0.000	0.000	0.000
150	A	461	GLU	-1	-0.889	-0.952	17.634	-13.737	-13.737	0.000	0.000	0.000	0.000
151	A	462	VAL	0	-0.026	-0.024	20.308	0.570	0.570	0.000	0.000	0.000	0.000
152	A	463	LEU	0	-0.020	-0.013	15.073	0.190	0.190	0.000	0.000	0.000	0.000
153	A	464	LYS	1	0.859	0.929	16.451	12.446	12.446	0.000	0.000	0.000	0.000
154	A	465	ASN	0	-0.096	-0.065	13.756	-2.115	-2.115	0.000	0.000	0.000	0.000
155	A	466	TRP	0	0.023	0.024	8.596	0.265	0.265	0.000	0.000	0.000	0.000
156	A	467	TRP	0	0.001	0.001	12.843	-0.800	-0.800	0.000	0.000	0.000	0.000
157	A	468	ILE	0	-0.057	-0.036	12.658	0.200	0.200	0.000	0.000	0.000	0.000
158	A	469	ASP	-1	-0.804	-0.871	15.005	-14.882	-14.882	0.000	0.000	0.000	0.000
159	A	470	LEU	0	-0.047	-0.045	17.073	-0.245	-0.245	0.000	0.000	0.000	0.000
160	A	471	ASP	-1	-0.847	-0.909	20.103	-11.180	-11.180	0.000	0.000	0.000	0.000
161	A	480	ASN	0	-0.004	-0.020	22.638	-0.516	-0.516	0.000	0.000	0.000	0.000
162	A	481	SER	0	0.049	0.027	23.720	-0.081	-0.081	0.000	0.000	0.000	0.000
163	A	482	GLY	0	0.023	0.002	23.095	0.206	0.206	0.000	0.000	0.000	0.000
164	A	483	ILE	0	-0.073	-0.014	16.896	-0.275	-0.275	0.000	0.000	0.000	0.000
165	A	484	LEU	0	0.022	0.024	19.482	0.351	0.351	0.000	0.000	0.000	0.000
166	A	485	LEU	0	-0.032	-0.013	16.654	-0.768	-0.768	0.000	0.000	0.000	0.000
167	A	486	HIS	0	0.038	0.016	17.298	0.973	0.973	0.000	0.000	0.000	0.000
168	A	487	LEU	0	-0.050	-0.039	16.935	-1.136	-1.136	0.000	0.000	0.000	0.000
169	A	488	GLU	-1	-0.768	-0.862	17.939	-13.115	-13.115	0.000	0.000	0.000	0.000
170	A	489	TYR	0	0.014	-0.017	18.868	-0.694	-0.694	0.000	0.000	0.000	0.000
171	A	490	ALA	0	-0.050	-0.020	19.810	0.077	0.077	0.000	0.000	0.000	0.000
172	A	491	ALA	0	0.026	-0.003	21.778	0.336	0.336	0.000	0.000	0.000	0.000
173	A	492	ALA	0	-0.018	0.003	24.228	0.382	0.382	0.000	0.000	0.000	0.000
174	A	493	TYR	0	-0.003	-0.001	24.492	0.347	0.347	0.000	0.000	0.000	0.000
175	A	494	SER	0	-0.064	-0.022	26.301	0.226	0.226	0.000	0.000	0.000	0.000

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Interactive mode: IFIE and PIEDA for fragment #1(A:312:ARG)