FMO DATABASE

FMODB ID: YY482

Calculation Name: 3KEY-A-Xray372

Preferred Name:

Target Type:

Ligand Name:

ligand 3-letter code:

PDB ID: 3KEY

Chain ID: A

ChEMBL ID:

UniProt ID: P38960

Base Structure: X-ray

Registration Date: 2023-06-19

Reference: C. Watanabe, N. Tani, K. Kamisaka, T. Honma et al., Interaction energy analysis of Apo structure dataset on FMODB, To be published.

DOI:

IFIE MAP

IFIE Diagram

Modeling method

Optimization	MOE:Amber10:EHT
Restraint	OptHSide
Protonation	MOE:Protonate 3D
Complement	MOE:Structure Preparation
Water	No
Procedure	Auto-FMO protocol ver. 2.20220422

FMO calculation

FMO method	FMO2-MP2/6-31G(d)
Fragmentation	Auto
Number of fragment	175
LigandCharge
Software	ABINIT-MP - Open Ver. 1 Rev. 23Q2 / 20200603(SMP)

Total energy (hartree)

FMO2-HF: Electronic energy	-1822343.680161
FMO2-HF: Nuclear repulsion	1752078.158317
FMO2-HF: Total energy	-70265.521844
FMO2-MP2: Total energy	-70471.117705

3D Structure

Snapshot

Ligand structure

Ligand Interaction

Ligand binding energy

IFIE [kcal/mol]	PIEDA [kcal/mol]				Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level.	ESElectro static interaction energy.	EXExchange-repulsion energy.	CT+mixCharge transfer and mixing terms energy.	DI(MP2)Dispersion energy.	q(I=>J)Charge transfer value from I to J fragments.
N/A	N/A	N/A	N/A	N/A	N/A

Interactive mode: IFIE and PIEDA for fragment #1(A:312:ARG)

Summations of interaction energy for fragment #1(A:312:ARG)

IFIE [kcal/mol]	PIEDA [kcal/mol]				Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level.	ESElectro static interaction energy.	EXExchange-repulsion energy.	CT+mixCharge transfer and mixing terms energy.	DI(MP2)Dispersion energy.	q(I=>J)Charge transfer value from I to J fragments.
55.43	59.377	6.356	-4.818	-5.484	-0.047

Interaction energy analysis for fragmet #1(A:312:ARG)

Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE

Single fragment	Multi fragments
	Fragment list

Charge [e] FCHARGE : 1 / q_Mulliken : 0.975 / q_NPA : 0.972

Distance from base fragment(s) [Å]

Dist

Interaction energy by IFIE and PIEDA
[kcal/mol]

| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >

Fragment charge [e]

FCHARGE q_Mulliken
q_NPA q(I=>J)

Residue

Res # RES

Sort

Graph Options

X Axis Label
Y Axis Max Y Axis Min
Display ES EX CT+mix DI(MP2)

frag_NumFragment number.	ChainChain species.	Res #Residue number.	RES3-letter code of amino acid residue, ligand and solvent molecule.	FCHARGEFormal charge [e].	q_MullikenFragment charge evaluated by Mulliken charge [e].	q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e].	DISTDistance from Ligand [Å].	TotalIFIE at MP2 level [kcal/mol].	ESElectro static interaction energy by PIEDA [kcal/mol].	EXExchange-repulsion energy by PIEDA [kcal/mol].	CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol].	DI(MP2)Dispersion energy by PIEDA [kcal/mol].	q(I=>J)Charge transfer value from I to J fragmens [e].
3	A	314	SER	0	0.085	0.053	3.689	-5.661	-3.223	-0.001	-1.204	-1.233	-0.001
4	A	315	ALA	0	0.079	0.037	5.441	-3.858	-3.858	0.000	0.000	0.000	0.000
5	A	316	LYS	1	0.854	0.900	6.465	24.070	24.070	0.000	0.000	0.000	0.000
6	A	317	SER	0	0.037	0.006	7.007	1.754	1.754	0.000	0.000	0.000	0.000
7	A	318	ASN	0	-0.055	-0.027	1.978	-28.100	-26.933	6.354	-3.567	-3.954	-0.046
8	A	319	LEU	0	0.060	0.036	5.172	1.882	1.930	-0.001	-0.002	-0.045	0.000
9	A	320	MET	0	-0.014	-0.002	8.682	2.373	2.373	0.000	0.000	0.000	0.000
10	A	321	LEU	0	-0.049	-0.028	4.975	1.612	1.612	0.000	0.000	0.000	0.000
11	A	322	ILE	0	0.006	0.019	7.141	1.802	1.802	0.000	0.000	0.000	0.000
12	A	323	LEU	0	-0.012	-0.018	9.568	2.194	2.194	0.000	0.000	0.000	0.000
13	A	324	LEU	0	-0.046	-0.016	11.548	1.331	1.331	0.000	0.000	0.000	0.000
14	A	325	GLY	0	0.011	0.010	11.869	1.256	1.256	0.000	0.000	0.000	0.000
15	A	326	LEU	0	0.013	0.025	13.183	1.183	1.183	0.000	0.000	0.000	0.000
16	A	327	GLN	0	-0.016	-0.001	15.700	1.251	1.251	0.000	0.000	0.000	0.000
17	A	328	MET	0	-0.005	-0.003	18.639	0.724	0.724	0.000	0.000	0.000	0.000
18	A	329	LYS	1	0.987	0.990	20.030	10.640	10.640	0.000	0.000	0.000	0.000
19	A	330	GLU	-1	-0.829	-0.897	21.558	-11.592	-11.592	0.000	0.000	0.000	0.000
20	A	331	ILE	0	0.006	0.002	17.322	-0.127	-0.127	0.000	0.000	0.000	0.000
21	A	332	SER	0	0.064	0.028	21.009	-0.183	-0.183	0.000	0.000	0.000	0.000
22	A	333	ASN	0	0.069	0.013	19.970	-1.315	-1.315	0.000	0.000	0.000	0.000
23	A	334	SER	0	-0.008	-0.008	19.754	-0.480	-0.480	0.000	0.000	0.000	0.000
24	A	335	ASP	-1	-0.837	-0.899	20.680	-13.128	-13.128	0.000	0.000	0.000	0.000
25	A	336	LEU	0	-0.008	0.003	13.939	-0.721	-0.721	0.000	0.000	0.000	0.000
26	A	337	TYR	0	-0.014	-0.013	15.605	-1.242	-1.242	0.000	0.000	0.000	0.000
27	A	338	LYS	1	0.854	0.920	16.855	12.626	12.626	0.000	0.000	0.000	0.000
28	A	339	LEU	0	-0.006	0.018	13.784	-0.085	-0.085	0.000	0.000	0.000	0.000
29	A	340	LYS	1	1.016	0.998	12.582	19.423	19.423	0.000	0.000	0.000	0.000
30	A	341	GLU	-1	-0.908	-0.965	8.355	-30.083	-30.083	0.000	0.000	0.000	0.000
31	A	342	VAL	0	0.015	0.006	9.038	-2.839	-2.839	0.000	0.000	0.000	0.000
32	A	343	ARG	1	0.882	0.929	11.067	17.053	17.053	0.000	0.000	0.000	0.000
33	A	344	SER	0	-0.026	0.001	8.466	0.218	0.218	0.000	0.000	0.000	0.000
34	A	345	VAL	0	-0.028	-0.014	5.669	-1.318	-1.318	0.000	0.000	0.000	0.000
35	A	346	VAL	0	-0.018	-0.010	7.963	0.509	0.509	0.000	0.000	0.000	0.000
36	A	347	THR	0	0.009	-0.009	11.563	0.787	0.787	0.000	0.000	0.000	0.000
37	A	348	SER	0	-0.045	-0.010	8.014	-0.082	-0.082	0.000	0.000	0.000	0.000
38	A	349	LEU	0	-0.014	-0.007	9.956	0.841	0.841	0.000	0.000	0.000	0.000
39	A	350	ALA	0	0.052	0.025	11.180	1.347	1.347	0.000	0.000	0.000	0.000
40	A	351	SER	0	-0.061	-0.032	12.314	1.219	1.219	0.000	0.000	0.000	0.000
41	A	352	PHE	0	-0.004	-0.001	12.394	0.664	0.664	0.000	0.000	0.000	0.000
42	A	353	LEU	0	-0.002	-0.015	14.388	0.999	0.999	0.000	0.000	0.000	0.000
43	A	354	PHE	0	-0.010	-0.010	17.141	0.976	0.976	0.000	0.000	0.000	0.000
44	A	355	GLN	0	-0.024	-0.022	15.967	0.835	0.835	0.000	0.000	0.000	0.000
45	A	356	GLN	0	-0.040	-0.009	17.407	0.154	0.154	0.000	0.000	0.000	0.000
46	A	357	GLN	0	-0.008	0.029	20.185	0.790	0.790	0.000	0.000	0.000	0.000
47	A	358	ASN	0	0.016	0.011	23.237	0.114	0.114	0.000	0.000	0.000	0.000
48	A	359	VAL	0	0.089	0.032	26.412	0.032	0.032	0.000	0.000	0.000	0.000
49	A	360	GLY	0	-0.018	-0.006	29.147	0.199	0.199	0.000	0.000	0.000	0.000
50	A	361	VAL	0	-0.077	-0.034	26.021	0.161	0.161	0.000	0.000	0.000	0.000
51	A	362	MET	0	0.002	-0.008	25.825	-0.506	-0.506	0.000	0.000	0.000	0.000
52	A	363	LYS	1	0.847	0.930	23.004	13.164	13.164	0.000	0.000	0.000	0.000
53	A	364	SER	0	0.036	0.009	24.114	-0.400	-0.400	0.000	0.000	0.000	0.000
54	A	365	PHE	0	0.072	0.018	15.274	-0.181	-0.181	0.000	0.000	0.000	0.000
55	A	366	ASP	-1	-0.799	-0.880	19.497	-13.668	-13.668	0.000	0.000	0.000	0.000
56	A	367	SER	0	-0.014	-0.003	20.635	-0.197	-0.197	0.000	0.000	0.000	0.000
57	A	368	LEU	0	0.010	0.000	18.366	-0.298	-0.298	0.000	0.000	0.000	0.000
58	A	369	GLU	-1	-0.802	-0.882	15.528	-18.700	-18.700	0.000	0.000	0.000	0.000
59	A	370	LYS	1	0.817	0.893	16.551	12.341	12.341	0.000	0.000	0.000	0.000
60	A	371	GLU	-1	-0.823	-0.882	18.948	-13.759	-13.759	0.000	0.000	0.000	0.000
61	A	372	ALA	0	0.020	0.005	13.507	-0.327	-0.327	0.000	0.000	0.000	0.000
62	A	373	PHE	0	-0.010	-0.014	14.126	-1.072	-1.072	0.000	0.000	0.000	0.000
63	A	374	ARG	1	0.900	0.933	15.329	14.150	14.150	0.000	0.000	0.000	0.000
64	A	375	ASP	-1	-0.810	-0.887	15.450	-16.552	-16.552	0.000	0.000	0.000	0.000
65	A	376	LEU	0	-0.079	-0.038	9.833	-0.577	-0.577	0.000	0.000	0.000	0.000
66	A	377	VAL	0	0.015	0.009	13.626	-0.298	-0.298	0.000	0.000	0.000	0.000
67	A	378	ASN	0	0.037	0.013	16.095	0.501	0.501	0.000	0.000	0.000	0.000
68	A	379	ARG	1	0.835	0.907	12.658	20.736	20.736	0.000	0.000	0.000	0.000
69	A	380	LEU	0	-0.014	-0.007	12.026	0.057	0.057	0.000	0.000	0.000	0.000
70	A	381	VAL	0	0.013	0.006	16.067	0.510	0.510	0.000	0.000	0.000	0.000
71	A	382	SER	0	-0.023	-0.005	19.301	0.679	0.679	0.000	0.000	0.000	0.000
72	A	383	GLN	0	-0.035	0.005	15.092	-0.776	-0.776	0.000	0.000	0.000	0.000
73	A	384	GLY	0	0.079	0.028	19.448	0.106	0.106	0.000	0.000	0.000	0.000
74	A	385	LEU	0	-0.089	-0.036	13.967	0.004	0.004	0.000	0.000	0.000	0.000
75	A	386	ILE	0	-0.004	-0.002	15.831	-0.201	-0.201	0.000	0.000	0.000	0.000
76	A	387	GLY	0	0.053	0.031	18.972	0.265	0.265	0.000	0.000	0.000	0.000
77	A	388	LEU	0	-0.036	0.000	22.148	-0.301	-0.301	0.000	0.000	0.000	0.000
78	A	389	LYS	1	0.845	0.909	24.148	11.929	11.929	0.000	0.000	0.000	0.000
79	A	390	ASP	-1	-0.775	-0.862	26.392	-9.745	-9.745	0.000	0.000	0.000	0.000
80	A	391	LYS	1	0.805	0.891	26.281	11.200	11.200	0.000	0.000	0.000	0.000
81	A	392	THR	0	-0.006	-0.002	28.656	-0.031	-0.031	0.000	0.000	0.000	0.000
82	A	393	SER	0	-0.061	-0.046	28.410	-0.125	-0.125	0.000	0.000	0.000	0.000
83	A	394	GLU	-1	-0.826	-0.897	24.148	-12.416	-12.416	0.000	0.000	0.000	0.000
84	A	395	THR	0	-0.018	-0.017	23.589	-0.738	-0.738	0.000	0.000	0.000	0.000
85	A	396	PHE	0	-0.034	-0.031	19.554	0.129	0.129	0.000	0.000	0.000	0.000
86	A	397	ASP	-1	-0.828	-0.941	21.713	-12.580	-12.580	0.000	0.000	0.000	0.000
87	A	398	LEU	0	-0.019	-0.030	16.688	-0.634	-0.634	0.000	0.000	0.000	0.000
88	A	399	LEU	0	-0.006	-0.008	19.000	-0.581	-0.581	0.000	0.000	0.000	0.000
89	A	400	PRO	0	0.000	0.011	20.421	-0.120	-0.120	0.000	0.000	0.000	0.000
90	A	401	LEU	0	0.023	0.020	13.151	-0.238	-0.238	0.000	0.000	0.000	0.000
91	A	402	LYS	1	0.856	0.894	17.054	15.764	15.764	0.000	0.000	0.000	0.000
92	A	403	ASN	0	0.014	0.012	18.379	-0.030	-0.030	0.000	0.000	0.000	0.000
93	A	404	LEU	0	-0.013	-0.004	18.278	0.194	0.194	0.000	0.000	0.000	0.000
94	A	405	PHE	0	-0.003	-0.020	11.511	-0.602	-0.602	0.000	0.000	0.000	0.000
95	A	406	GLU	-1	-0.834	-0.890	17.413	-13.070	-13.070	0.000	0.000	0.000	0.000
96	A	407	TYR	0	-0.065	-0.031	20.443	0.598	0.598	0.000	0.000	0.000	0.000
97	A	408	ALA	0	0.010	-0.005	16.943	0.384	0.384	0.000	0.000	0.000	0.000
98	A	409	GLU	-1	-0.882	-0.951	15.662	-18.032	-18.032	0.000	0.000	0.000	0.000
99	A	410	LYS	1	0.844	0.911	18.911	13.122	13.122	0.000	0.000	0.000	0.000
100	A	411	ARG	1	0.915	0.973	21.046	12.570	12.570	0.000	0.000	0.000	0.000
101	A	412	ILE	0	0.043	0.007	15.696	0.387	0.387	0.000	0.000	0.000	0.000
102	A	413	SER	0	0.014	0.013	20.000	0.610	0.610	0.000	0.000	0.000	0.000
103	A	414	VAL	0	-0.033	-0.025	22.119	0.365	0.365	0.000	0.000	0.000	0.000
104	A	415	LEU	0	0.011	0.000	21.453	0.348	0.348	0.000	0.000	0.000	0.000
105	A	416	MET	0	0.021	0.017	18.931	-0.026	-0.026	0.000	0.000	0.000	0.000
106	A	417	LYS	1	0.888	0.956	23.209	12.200	12.200	0.000	0.000	0.000	0.000
107	A	418	LEU	0	-0.033	-0.002	26.530	0.390	0.390	0.000	0.000	0.000	0.000
108	A	419	GLN	0	-0.034	-0.007	25.339	0.343	0.343	0.000	0.000	0.000	0.000
109	A	420	CYS	0	-0.009	0.007	24.735	0.325	0.325	0.000	0.000	0.000	0.000
110	A	421	TYR	0	0.048	0.034	22.974	-0.585	-0.585	0.000	0.000	0.000	0.000
111	A	422	THR	0	0.021	0.007	21.953	-0.412	-0.412	0.000	0.000	0.000	0.000
112	A	423	GLY	0	-0.004	0.006	22.536	0.538	0.538	0.000	0.000	0.000	0.000
113	A	424	THR	0	0.002	0.018	22.556	-0.417	-0.417	0.000	0.000	0.000	0.000
114	A	425	VAL	0	-0.089	-0.040	21.021	0.227	0.227	0.000	0.000	0.000	0.000
115	A	426	GLN	0	0.017	0.007	23.255	-0.130	-0.130	0.000	0.000	0.000	0.000
116	A	427	LEU	0	-0.001	-0.013	22.973	-0.146	-0.146	0.000	0.000	0.000	0.000
117	A	428	SER	0	0.050	0.020	25.016	-0.086	-0.086	0.000	0.000	0.000	0.000
118	A	429	HIS	0	0.010	0.005	27.382	0.042	0.042	0.000	0.000	0.000	0.000
119	A	430	VAL	0	-0.034	-0.013	22.156	0.009	0.009	0.000	0.000	0.000	0.000
120	A	431	GLN	0	-0.039	-0.023	25.541	0.285	0.285	0.000	0.000	0.000	0.000
121	A	432	GLU	-1	-0.897	-0.941	27.318	-9.383	-9.383	0.000	0.000	0.000	0.000
122	A	433	LYS	1	0.890	0.949	27.361	10.500	10.500	0.000	0.000	0.000	0.000
123	A	434	LEU	0	-0.055	-0.042	23.081	-0.001	-0.001	0.000	0.000	0.000	0.000
124	A	435	HIS	0	0.030	0.033	27.129	-0.071	-0.071	0.000	0.000	0.000	0.000
125	A	436	LEU	0	-0.040	-0.016	22.417	-0.205	-0.205	0.000	0.000	0.000	0.000
126	A	437	PRO	0	0.044	-0.001	26.095	-0.327	-0.327	0.000	0.000	0.000	0.000
127	A	438	TYR	0	-0.012	-0.008	24.571	-0.052	-0.052	0.000	0.000	0.000	0.000
128	A	439	ILE	0	-0.030	0.019	19.579	-0.534	-0.534	0.000	0.000	0.000	0.000
129	A	440	THR	0	0.040	0.021	19.972	0.184	0.184	0.000	0.000	0.000	0.000
130	A	441	THR	0	0.076	0.024	19.705	-0.605	-0.605	0.000	0.000	0.000	0.000
131	A	442	ASN	0	0.010	-0.003	15.828	-0.702	-0.702	0.000	0.000	0.000	0.000
132	A	443	GLY	0	0.004	0.011	15.132	-1.331	-1.331	0.000	0.000	0.000	0.000
133	A	444	ILE	0	0.038	0.013	15.664	-0.959	-0.959	0.000	0.000	0.000	0.000
134	A	445	VAL	0	0.014	0.009	12.525	-0.639	-0.639	0.000	0.000	0.000	0.000
135	A	446	ASP	-1	-0.823	-0.902	10.963	-26.515	-26.515	0.000	0.000	0.000	0.000
136	A	447	VAL	0	0.003	0.011	11.194	-1.706	-1.706	0.000	0.000	0.000	0.000
137	A	448	PHE	0	0.076	0.024	12.993	-0.376	-0.376	0.000	0.000	0.000	0.000
138	A	449	LYS	1	0.876	0.949	8.362	24.685	24.685	0.000	0.000	0.000	0.000
139	A	450	GLU	-1	-0.817	-0.907	6.602	-39.016	-39.016	0.000	0.000	0.000	0.000
140	A	451	CYS	0	-0.009	0.008	9.487	-0.079	-0.079	0.000	0.000	0.000	0.000
141	A	452	LEU	0	0.047	0.035	12.057	0.513	0.513	0.000	0.000	0.000	0.000
142	A	453	LYS	1	0.814	0.905	3.664	46.540	46.834	0.004	-0.045	-0.252	0.000
143	A	454	ARG	1	0.857	0.924	9.191	26.223	26.223	0.000	0.000	0.000	0.000
144	A	455	THR	0	0.019	-0.009	11.323	1.187	1.187	0.000	0.000	0.000	0.000
145	A	456	LYS	1	0.911	0.945	10.989	20.483	20.483	0.000	0.000	0.000	0.000
146	A	457	LYS	1	0.890	0.942	7.046	32.239	32.239	0.000	0.000	0.000	0.000
147	A	458	GLN	0	-0.031	-0.015	12.666	0.900	0.900	0.000	0.000	0.000	0.000
148	A	459	TYR	0	0.003	0.014	15.968	1.134	1.134	0.000	0.000	0.000	0.000
149	A	460	PRO	0	0.009	0.021	15.750	0.161	0.161	0.000	0.000	0.000	0.000
150	A	461	GLU	-1	-0.894	-0.952	17.233	-13.740	-13.740	0.000	0.000	0.000	0.000
151	A	462	VAL	0	-0.023	-0.021	19.759	0.589	0.589	0.000	0.000	0.000	0.000
152	A	463	LEU	0	-0.018	-0.009	14.852	0.174	0.174	0.000	0.000	0.000	0.000
153	A	464	LYS	1	0.856	0.926	16.228	12.737	12.737	0.000	0.000	0.000	0.000
154	A	465	ASN	0	-0.110	-0.068	13.781	-2.184	-2.184	0.000	0.000	0.000	0.000
155	A	466	TRP	0	0.022	0.016	8.847	0.283	0.283	0.000	0.000	0.000	0.000
156	A	467	TRP	0	0.001	0.001	12.965	-0.880	-0.880	0.000	0.000	0.000	0.000
157	A	468	ILE	0	-0.063	-0.031	12.972	0.329	0.329	0.000	0.000	0.000	0.000
158	A	469	ASP	-1	-0.811	-0.882	15.036	-14.908	-14.908	0.000	0.000	0.000	0.000
159	A	470	LEU	0	-0.062	-0.043	17.047	-0.107	-0.107	0.000	0.000	0.000	0.000
160	A	471	ASP	-1	-0.869	-0.941	19.702	-11.536	-11.536	0.000	0.000	0.000	0.000
161	A	480	ASN	0	-0.004	-0.018	22.840	-0.441	-0.441	0.000	0.000	0.000	0.000
162	A	481	SER	0	0.057	0.025	24.080	0.003	0.003	0.000	0.000	0.000	0.000
163	A	482	GLY	0	0.006	-0.010	23.070	0.186	0.186	0.000	0.000	0.000	0.000
164	A	483	ILE	0	-0.060	-0.005	17.366	-0.318	-0.318	0.000	0.000	0.000	0.000
165	A	484	LEU	0	0.034	0.022	19.606	0.443	0.443	0.000	0.000	0.000	0.000
166	A	485	LEU	0	-0.060	-0.031	17.006	-0.827	-0.827	0.000	0.000	0.000	0.000
167	A	486	HIS	0	0.030	0.009	17.608	0.875	0.875	0.000	0.000	0.000	0.000
168	A	487	LEU	0	-0.049	-0.039	17.247	-1.111	-1.111	0.000	0.000	0.000	0.000
169	A	488	GLU	-1	-0.747	-0.860	18.191	-13.253	-13.253	0.000	0.000	0.000	0.000
170	A	489	TYR	0	-0.015	-0.043	18.854	-0.741	-0.741	0.000	0.000	0.000	0.000
171	A	490	ALA	0	-0.059	-0.020	19.556	0.166	0.166	0.000	0.000	0.000	0.000
172	A	491	ALA	0	0.041	0.002	21.377	0.345	0.345	0.000	0.000	0.000	0.000
173	A	492	ALA	0	-0.028	-0.007	24.022	0.327	0.327	0.000	0.000	0.000	0.000
174	A	493	TYR	0	-0.027	-0.021	23.949	0.356	0.356	0.000	0.000	0.000	0.000
175	A	494	SER	0	-0.035	0.002	25.724	0.295	0.295	0.000	0.000	0.000	0.000

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Interactive mode: IFIE and PIEDA for fragment #1(A:312:ARG)