FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-04-23

All entries: 37539

Number of unique PDB entries: 7791

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FMODB ID: 147JZ

Calculation Name: 4FKQ-AB-MD334-md1_22ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: 4-[(2z)-2-(7-oxidanylidene-3,6-dihydropyrrolo[3,2-e]benzotriazol-8-ylidene)hydrazinyl]benzenesulfonamide

ligand 3-letter code: 42K

PDB ID: 4FKQ

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-08-10

Reference: K. Takaba et al., Protein-ligand binding affinity prediction of cyclin-dependent kinase-2 inhibitors by dynamically averaged fragment molecular orbital-based interaction energy, J. Comput. Chem., 43, 1362-1371, 2022.

DOI: 10.1002/jcc.26940

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2699
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -18985580.783664
FMO2-HF: Nuclear repulsion 18684056.12912
FMO2-HF: Total energy -301524.654544
FMO2-MP2: Total energy -302349.954681


3D Structure
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-101.408546-74.49538361.901006-29.308713-59.5054560.060805


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-163.281-156.408126.245-53.736-79.382-0.064
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.065 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.75417.1410.3850.3850.0000.0000.0000.000
2A2GLU-1-0.64218.4440.1100.1100.0000.0000.0000.000
3A3ASN00.03314.6690.2230.2230.0000.0000.0000.000
4A4PHE0-0.00911.317-0.106-0.1060.0000.0000.0000.000
5A5GLN00.05712.6170.1450.1450.0000.0000.0000.000
6A6LYS10.91911.414-1.814-1.8140.0000.0000.0000.000
7A7VAL0-0.0199.530-0.225-0.2250.0000.0000.0000.000
8A8GLU-1-0.6624.8699.4689.659-0.001-0.002-0.1880.000
9A9LYS10.8977.367-4.501-4.5010.0000.0000.0000.000
10A10ILE00.0202.640-2.4301.5572.806-1.250-5.5420.011
11A11GLY00.0583.110-0.6851.1380.237-0.712-1.348-0.005
12A12GLU-1-0.7235.1881.3001.473-0.001-0.006-0.1670.000
13A13GLY00.0235.6171.3401.340-0.001-0.0120.0130.000
14A14THR00.0006.7080.0060.0060.0000.0000.0000.000
15A15TYR0-0.0137.3940.3470.3470.0000.0000.0000.000
16A16GLY00.0499.2530.0100.0100.0000.0000.0000.000
17A17VAL0-0.0358.1490.0100.0100.0000.0000.0000.000
18A18VAL0-0.0033.375-3.360-1.8760.114-0.425-1.1720.004
19A19TYR0-0.0286.7351.7691.7690.0000.0000.0000.000
20A20LYS10.8984.934-2.803-2.8030.0000.0000.0000.000
21A21ALA0-0.0176.7100.2050.2050.0000.0000.0000.000
22A22ARG10.8809.069-0.568-0.5680.0000.0000.0000.000
23A23ASN00.03810.963-0.298-0.2980.0000.0000.0000.000
24A24LYS10.85712.480-0.027-0.0270.0000.0000.0000.000
25A25LEU00.04216.0870.1030.1030.0000.0000.0000.000
26A26THR00.01414.3670.0370.0370.0000.0000.0000.000
27A27GLY00.02815.3110.0700.0700.0000.0000.0000.000
28A28GLU-1-0.68211.759-0.765-0.7650.0000.0000.0000.000
29A29VAL00.0156.655-0.069-0.0690.0000.0000.0000.000
30A30VAL0-0.0385.738-0.597-0.5970.0000.0000.0000.000
31A31ALA0-0.0132.8590.0371.5421.223-0.660-2.0670.004
32A32LEU0-0.0144.751-2.295-1.985-0.001-0.015-0.2950.000
33A33LYS10.8522.7859.51511.2170.240-0.519-1.4220.001
34A34LYS10.8486.822-0.439-0.4390.0000.0000.0000.000
35A35ILE0-0.0355.888-0.337-0.3370.0000.0000.0000.000
36A36ARG10.7249.7190.6000.6000.0000.0000.0000.000
37A37LEU00.06412.872-0.133-0.1330.0000.0000.0000.000
38A38ASP-1-0.66115.531-0.329-0.3290.0000.0000.0000.000
39A39THR00.03719.0790.0890.0890.0000.0000.0000.000
40A40GLU-1-0.70117.367-0.263-0.2630.0000.0000.0000.000
41A41THR00.02720.3280.0330.0330.0000.0000.0000.000
42A42GLU-1-0.63523.712-0.258-0.2580.0000.0000.0000.000
43A43GLY00.07523.4390.0220.0220.0000.0000.0000.000
44A44VAL0-0.04820.2980.0040.0040.0000.0000.0000.000
45A45PRO00.02415.3210.0120.0120.0000.0000.0000.000
46A46SER00.05917.245-0.164-0.1640.0000.0000.0000.000
47A47THR0-0.06518.5920.0050.0050.0000.0000.0000.000
48A48ALA00.04113.794-0.044-0.0440.0000.0000.0000.000
49A49ILE00.00314.517-0.259-0.2590.0000.0000.0000.000
50A50ARG10.85215.7750.9350.9350.0000.0000.0000.000
51A51GLU-1-0.66313.590-1.404-1.4040.0000.0000.0000.000
52A52ILE00.0069.909-0.305-0.3050.0000.0000.0000.000
53A53SER0-0.03011.423-0.245-0.2450.0000.0000.0000.000
54A54LEU00.02214.091-0.072-0.0720.0000.0000.0000.000
55A55LEU0-0.0198.3190.0120.0120.0000.0000.0000.000
56A56LYS10.8779.7601.6731.6730.0000.0000.0000.000
57A57GLU-1-0.67711.180-1.485-1.4850.0000.0000.0000.000
58A58LEU0-0.0179.9130.2150.2150.0000.0000.0000.000
59A59ASN00.05110.411-0.654-0.6540.0000.0000.0000.000
60A60HIS00.05211.0770.2330.2330.0000.0000.0000.000
61A61PRO00.08610.967-0.349-0.3490.0000.0000.0000.000
62A62ASN0-0.02010.825-0.031-0.0310.0000.0000.0000.000
63A63ILE00.0267.0600.1830.1830.0000.0000.0000.000
64A64VAL0-0.0232.714-1.704-0.3140.228-0.400-1.2180.001
65A65LYS10.8233.974-0.822-0.4020.001-0.064-0.3570.000
66A66LEU00.0034.850-2.193-2.078-0.001-0.013-0.1010.000
67A67LEU0-0.0215.9341.2041.2040.0000.0000.0000.000
68A68ASP-1-0.7038.251-1.147-1.1470.0000.0000.0000.000
69A69VAL00.0259.161-0.619-0.6190.0000.0000.0000.000
70A70ILE0-0.03211.6110.3440.3440.0000.0000.0000.000
71A71HIS00.07613.821-0.176-0.1760.0000.0000.0000.000
72A72THR00.03516.4870.1180.1180.0000.0000.0000.000
73A73GLU-1-0.72418.728-0.047-0.0470.0000.0000.0000.000
74A74ASN00.02619.9460.0030.0030.0000.0000.0000.000
75A75LYS10.84815.6320.0600.0600.0000.0000.0000.000
76A76LEU00.02611.492-0.026-0.0260.0000.0000.0000.000
77A77TYR0-0.02310.0010.0600.0600.0000.0000.0000.000
78A78LEU0-0.0226.1140.0360.0360.0000.0000.0000.000
79A79VAL0-0.0116.5430.1660.1660.0000.0000.0000.000
80A80PHE00.0212.326-5.899-2.8593.319-1.644-4.714-0.012
81A81GLU-1-0.6314.149-0.741-0.173-0.001-0.230-0.338-0.001
82A82PHE00.0561.974-21.964-17.73110.381-6.292-8.322-0.035
83A83LEU00.0141.860-3.820-10.1989.822-0.303-3.1410.019
84A84HIS0-0.0102.490-9.213-5.5011.931-2.106-3.537-0.025
85A85GLN00.0602.482-4.660-1.6303.152-1.892-4.290-0.011
86A86ASP-1-0.7542.8562.0117.1221.437-1.934-4.615-0.002
87A87LEU00.0224.777-1.653-1.3360.003-0.048-0.2720.000
88A88LYS10.8466.978-2.000-2.0000.0000.0000.0000.000
89A89LYS10.8071.965-21.700-22.9357.118-2.177-3.7060.026
90A90PHE00.0486.168-0.044-0.0440.0000.0000.0000.000
91A91MET0-0.0077.7270.1980.1980.0000.0000.0000.000
92A92ASP-1-0.6919.5601.3671.3670.0000.0000.0000.000
93A93ALA00.0599.2100.0270.0270.0000.0000.0000.000
94A94SER0-0.00311.042-0.035-0.0350.0000.0000.0000.000
95A95ALA00.00413.602-0.019-0.0190.0000.0000.0000.000
96A96LEU0-0.04015.747-0.002-0.0020.0000.0000.0000.000
97A97THR00.01016.745-0.017-0.0170.0000.0000.0000.000
98A98GLY00.05216.938-0.009-0.0090.0000.0000.0000.000
99A99ILE0-0.04413.420-0.038-0.0380.0000.0000.0000.000
100A100PRO00.06516.6860.0270.0270.0000.0000.0000.000
101A101LEU00.01619.331-0.036-0.0360.0000.0000.0000.000
102A102PRO0-0.01121.766-0.025-0.0250.0000.0000.0000.000
103A103LEU00.06613.848-0.035-0.0350.0000.0000.0000.000
104A104ILE0-0.02817.630-0.039-0.0390.0000.0000.0000.000
105A105LYS10.79218.7680.1940.1940.0000.0000.0000.000
106A106SER0-0.00418.464-0.057-0.0570.0000.0000.0000.000
107A107TYR00.03511.443-0.025-0.0250.0000.0000.0000.000
108A108LEU00.03816.319-0.052-0.0520.0000.0000.0000.000
109A109PHE0-0.00718.713-0.069-0.0690.0000.0000.0000.000
110A110GLN00.01414.826-0.141-0.1410.0000.0000.0000.000
111A111LEU00.01512.170-0.140-0.1400.0000.0000.0000.000
112A112LEU0-0.01715.371-0.122-0.1220.0000.0000.0000.000
113A113GLN00.06617.202-0.118-0.1180.0000.0000.0000.000
114A114GLY00.06713.570-0.059-0.0590.0000.0000.0000.000
115A115LEU0-0.01313.953-0.161-0.1610.0000.0000.0000.000
116A116ALA00.01515.551-0.042-0.0420.0000.0000.0000.000
117A117PHE00.02814.686-0.006-0.0060.0000.0000.0000.000
118A118CYS0-0.06412.141-0.130-0.1300.0000.0000.0000.000
119A119HIS00.02714.4670.0760.0760.0000.0000.0000.000
120A120SER00.04617.4200.1260.1260.0000.0000.0000.000
121A121HIS0-0.06914.2550.2210.2210.0000.0000.0000.000
122A122ARG10.80417.3590.7650.7650.0000.0000.0000.000
123A123VAL00.00912.591-0.015-0.0150.0000.0000.0000.000
124A124LEU00.00414.2130.0950.0950.0000.0000.0000.000
125A125HIS00.0036.319-0.337-0.3370.0000.0000.0000.000
126A126ARG10.80210.5961.1221.1220.0000.0000.0000.000
127A127ASP-1-0.6607.659-0.280-0.2800.0000.0000.0000.000
128A128LEU0-0.0018.7560.1070.1070.0000.0000.0000.000
129A129LYS10.8567.302-0.755-0.7550.0000.0000.0000.000
130A130PRO00.0098.7680.1930.1930.0000.0000.0000.000
131A131GLN00.0605.981-0.526-0.5260.0000.0000.0000.000
132A132ASN0-0.0764.3502.7673.2470.001-0.080-0.4010.000
133A133LEU0-0.0025.435-1.744-1.565-0.001-0.005-0.1730.000
134A134LEU0-0.0152.900-3.986-0.0972.150-1.199-4.8390.010
135A135ILE0-0.0146.220-0.055-0.0550.0000.0000.0000.000
136A136ASN00.0606.991-0.392-0.3920.0000.0000.0000.000
137A137THR00.0709.4380.1240.1240.0000.0000.0000.000
138A138GLU-1-0.66411.845-0.504-0.5040.0000.0000.0000.000
139A139GLY00.01713.5600.0680.0680.0000.0000.0000.000
140A140ALA0-0.03412.3940.0390.0390.0000.0000.0000.000
141A141ILE00.00510.209-0.060-0.0600.0000.0000.0000.000
142A142LYS10.8107.3861.4111.4110.0000.0000.0000.000
143A143LEU00.0248.7880.3890.3890.0000.0000.0000.000
144A144ALA00.0793.340-1.939-0.6150.279-0.473-1.1290.005
145A145ASP-1-0.7461.707-32.568-37.33917.446-6.777-5.899-0.050
146A146PHE00.0803.7901.8902.2040.019-0.068-0.2650.000
147A147GLY00.0387.097-0.439-0.4390.0000.0000.0000.000
148A148LEU0-0.0036.3810.5970.5970.0000.0000.0000.000
149A149ALA00.0699.0030.4230.4230.0000.0000.0000.000
150A150ARG10.82710.3371.7331.7330.0000.0000.0000.000
151A151ALA0-0.00513.3070.2590.2590.0000.0000.0000.000
152A152PHE00.04512.5370.1770.1770.0000.0000.0000.000
153A153GLY00.02814.0110.1830.1830.0000.0000.0000.000
154A154VAL00.01615.245-0.010-0.0100.0000.0000.0000.000
155A155PRO0-0.03412.4800.1480.1480.0000.0000.0000.000
156A156VAL00.03815.6700.0570.0570.0000.0000.0000.000
157A157ARG10.73716.277-0.301-0.3010.0000.0000.0000.000
158A158THR00.05112.044-0.269-0.2690.0000.0000.0000.000
159A159TYR0-0.00413.004-0.065-0.0650.0000.0000.0000.000
160A160THR0-0.03614.260-0.084-0.0840.0000.0000.0000.000
161A161HIS00.01116.3850.0710.0710.0000.0000.0000.000
162A162GLU-1-0.62514.5511.8381.8380.0000.0000.0000.000
163A163VAL00.03116.083-0.119-0.1190.0000.0000.0000.000
164A164VAL0-0.02812.2020.2160.2160.0000.0000.0000.000
165A165THR00.05014.269-0.165-0.1650.0000.0000.0000.000
166A166LEU0-0.00114.706-0.090-0.0900.0000.0000.0000.000
167A167TRP00.02314.249-0.078-0.0780.0000.0000.0000.000
168A168TYR00.01912.749-0.137-0.1370.0000.0000.0000.000
169A169ARG10.81212.9160.1120.1120.0000.0000.0000.000
170A170ALA00.04316.9900.0590.0590.0000.0000.0000.000
171A171PRO00.04119.880-0.001-0.0010.0000.0000.0000.000
172A172GLU-1-0.73821.862-0.368-0.3680.0000.0000.0000.000
173A173ILE00.01416.701-0.001-0.0010.0000.0000.0000.000
174A174LEU0-0.01720.0530.0230.0230.0000.0000.0000.000
175A175LEU0-0.02122.4640.0360.0360.0000.0000.0000.000
176A176GLY00.07823.4640.0180.0180.0000.0000.0000.000
177A177CYS0-0.06424.5230.0090.0090.0000.0000.0000.000
178A178LYS10.83824.0580.3660.3660.0000.0000.0000.000
179A179TYR0-0.01624.168-0.059-0.0590.0000.0000.0000.000
180A180TYR00.01217.8280.0020.0020.0000.0000.0000.000
181A181SER00.02621.583-0.081-0.0810.0000.0000.0000.000
182A182THR00.00618.0050.0010.0010.0000.0000.0000.000
183A183ALA00.03518.992-0.013-0.0130.0000.0000.0000.000
184A184VAL0-0.00516.0860.0670.0670.0000.0000.0000.000
185A185ASP-1-0.70413.644-1.243-1.2430.0000.0000.0000.000
186A186ILE0-0.05415.9630.0640.0640.0000.0000.0000.000
187A187TRP00.00519.0450.0390.0390.0000.0000.0000.000
188A188SER00.01714.2460.0240.0240.0000.0000.0000.000
189A189LEU00.00414.9930.1140.1140.0000.0000.0000.000
190A190GLY00.04116.4510.0620.0620.0000.0000.0000.000
191A191CYS0-0.05416.7870.0630.0630.0000.0000.0000.000
192A192ILE00.00812.1220.0860.0860.0000.0000.0000.000
193A193PHE0-0.01816.2100.0160.0160.0000.0000.0000.000
194A194ALA00.05119.4700.0150.0150.0000.0000.0000.000
195A195GLU-1-0.67714.8140.7880.7880.0000.0000.0000.000
196A196MET0-0.01014.196-0.007-0.0070.0000.0000.0000.000
197A197VAL0-0.02017.446-0.024-0.0240.0000.0000.0000.000
198A198THR0-0.00920.1350.0240.0240.0000.0000.0000.000
199A199ARG10.79417.067-0.142-0.1420.0000.0000.0000.000
200A200ARG10.82117.636-0.313-0.3130.0000.0000.0000.000
201A201ALA00.04217.433-0.097-0.0970.0000.0000.0000.000
202A202LEU00.02818.950-0.010-0.0100.0000.0000.0000.000
203A203PHE00.02321.057-0.024-0.0240.0000.0000.0000.000
204A204PRO00.05921.0490.0260.0260.0000.0000.0000.000
205A205GLY00.05921.904-0.074-0.0740.0000.0000.0000.000
206A206ASP-1-0.72221.2780.6550.6550.0000.0000.0000.000
207A207SER00.06022.2600.0080.0080.0000.0000.0000.000
208A208GLU-1-0.66321.573-0.131-0.1310.0000.0000.0000.000
209A209ILE00.06122.800-0.008-0.0080.0000.0000.0000.000
210A210ASP-1-0.69225.2840.2760.2760.0000.0000.0000.000
211A211GLN00.00920.4900.0650.0650.0000.0000.0000.000
212A212LEU00.03023.717-0.017-0.0170.0000.0000.0000.000
213A213PHE00.00325.641-0.010-0.0100.0000.0000.0000.000
214A214ARG10.87825.233-0.292-0.2920.0000.0000.0000.000
215A215ILE00.00223.0750.0010.0010.0000.0000.0000.000
216A216PHE00.00426.903-0.009-0.0090.0000.0000.0000.000
217A217ARG10.84129.753-0.200-0.2000.0000.0000.0000.000
218A218THR0-0.01226.6650.0270.0270.0000.0000.0000.000
219A219LEU0-0.02027.839-0.005-0.0050.0000.0000.0000.000
220A220GLY00.08030.869-0.015-0.0150.0000.0000.0000.000
221A221THR0-0.00332.543-0.009-0.0090.0000.0000.0000.000
222A222PRO00.05330.533-0.005-0.0050.0000.0000.0000.000
223A223ASP-1-0.62033.323-0.089-0.0890.0000.0000.0000.000
224A224GLU-1-0.68235.883-0.179-0.1790.0000.0000.0000.000
225A225VAL00.02437.251-0.014-0.0140.0000.0000.0000.000
226A226VAL0-0.03232.858-0.007-0.0070.0000.0000.0000.000
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