![FMODB](./images/FMODB-Logo_20190201-0_300ppi.png)
FMODB ID: 2JYLR
Calculation Name: 4JCS-A-Xray372
Preferred Name:
Target Type:
Ligand Name:
ligand 3-letter code:
PDB ID: 4JCS
Chain ID: A
UniProt ID: Q1LBW6
Base Structure: X-ray
Registration Date: 2023-09-20
Reference: C. Watanabe, N. Tani, K. Kamisaka, T. Honma et al., Interaction energy analysis of Apo structure dataset on FMODB, To be published.
Modeling method
Optimization | MOE:Amber10:EHT |
---|---|
Restraint | OptHSide |
Protonation | MOE:Protonate 3D |
Complement | MOE:Structure Preparation |
Water | No |
Procedure | Auto-FMO protocol ver. 2.20220422 |
FMO calculation
FMO method | FMO2-MP2/6-31G(d) |
---|---|
Fragmentation | Auto |
Number of fragment | 267 |
LigandCharge | |
Software | ABINIT-MP - Open Ver. 1 Rev. 22 / 20200603(SMP) |
Total energy (hartree)
FMO2-HF: Electronic energy | -3396655.848897 |
---|---|
FMO2-HF: Nuclear repulsion | 3293842.487172 |
FMO2-HF: Total energy | -102813.361726 |
FMO2-MP2: Total energy | -103113.134076 |
3D Structure
Ligand structure
![ligand structure](./Kdata/F030293/ligand_interaction/ligand_F030293.png)
Ligand Interaction
![ligand interaction](./Kdata/F030293/ligand_interaction/ligand_interaction_F030293.png)
Ligand binding energy
"IFIE [kcal/mol] | PIEDA [kcal/mol] | Charge transfer value [e] | |||
---|---|---|---|---|---|
IFIE SUMIFIE SUM at MP2 level. | ESElectro static interaction energy. | EXExchange-repulsion energy. | CT+mixCharge transfer and mixing terms energy. | DI(MP2)Dispersion energy. | q(I=>J)Charge transfer value from I to J fragments. |
N/A | N/A | N/A | N/A | N/A | N/A |
Interactive mode: IFIE and PIEDA for fragment #1(A:-2:PHE)
Summations of interaction energy for
fragment #1(A:-2:PHE)
IFIE [kcal/mol] | PIEDA [kcal/mol] | Charge transfer value [e] | |||
---|---|---|---|---|---|
IFIE SUMIFIE SUM at MP2 level. | ESElectro static interaction energy. | EXExchange-repulsion energy. | CT+mixCharge transfer and mixing terms energy. | DI(MP2)Dispersion energy. | q(I=>J)Charge transfer value from I to J fragments. |
-15.429 | -6.36 | 4.472 | -5.518 | -8.023 | -0.025 |
Interaction energy analysis for fragmet #1(A:-2:PHE)
frag_NumFragment number. | ChainChain species. | Res #Residue number. | RES3-letter code of amino acid residue, ligand and solvent molecule. | FCHARGEFormal charge [e]. | q_MullikenFragment charge evaluated by Mulliken charge [e]. | q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. | DISTDistance from Ligand [Å]. | TotalIFIE at MP2 level [kcal/mol]. | ESElectro static interaction energy by PIEDA [kcal/mol]. | EXExchange-repulsion energy by PIEDA [kcal/mol]. | CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. | DI(MP2)Dispersion energy by PIEDA [kcal/mol]. | q(I=>J)Charge transfer value from I to J fragmens [e]. |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3 | A | 0 | SER | 0 | -0.048 | -0.035 | 2.740 | -1.122 | 1.521 | 0.188 | -0.994 | -1.837 | 0.002 |
4 | A | 1 | MET | 0 | -0.054 | -0.025 | 4.564 | -0.411 | -0.275 | 0.000 | -0.026 | -0.109 | 0.000 |
5 | A | 2 | ASP | -1 | -0.888 | -0.935 | 8.394 | -0.165 | -0.165 | 0.000 | 0.000 | 0.000 | 0.000 |
6 | A | 3 | THR | 0 | -0.149 | -0.113 | 11.193 | -0.056 | -0.056 | 0.000 | 0.000 | 0.000 | 0.000 |
7 | A | 4 | LEU | 0 | -0.025 | -0.020 | 8.106 | -0.024 | -0.024 | 0.000 | 0.000 | 0.000 | 0.000 |
8 | A | 5 | ASP | -1 | -0.823 | -0.875 | 3.792 | -1.109 | -0.558 | 0.017 | -0.157 | -0.412 | 0.001 |
9 | A | 6 | PHE | 0 | -0.010 | -0.015 | 4.782 | -0.642 | -0.289 | -0.001 | -0.066 | -0.285 | 0.000 |
10 | A | 7 | GLU | -1 | -0.863 | -0.920 | 2.229 | -7.568 | -3.087 | 4.250 | -3.986 | -4.745 | -0.031 |
11 | A | 8 | VAL | 0 | -0.016 | -0.003 | 3.469 | -0.793 | -0.578 | 0.015 | 0.040 | -0.271 | 0.000 |
12 | A | 9 | VAL | 0 | 0.014 | 0.007 | 5.265 | -0.562 | -0.562 | 0.000 | 0.000 | 0.000 | 0.000 |
13 | A | 10 | ASN | 0 | -0.052 | -0.042 | 7.886 | 0.071 | 0.071 | 0.000 | 0.000 | 0.000 | 0.000 |
14 | A | 11 | ASN | 0 | -0.038 | -0.032 | 9.980 | -0.097 | -0.097 | 0.000 | 0.000 | 0.000 | 0.000 |
15 | A | 12 | VAL | 0 | 0.009 | 0.014 | 10.340 | 0.042 | 0.042 | 0.000 | 0.000 | 0.000 | 0.000 |
16 | A | 13 | GLY | 0 | 0.018 | -0.004 | 7.846 | 0.116 | 0.116 | 0.000 | 0.000 | 0.000 | 0.000 |
17 | A | 14 | TRP | 0 | -0.024 | -0.013 | 6.508 | -0.301 | -0.301 | 0.000 | 0.000 | 0.000 | 0.000 |
18 | A | 15 | ILE | 0 | 0.012 | 0.000 | 6.939 | 0.280 | 0.280 | 0.000 | 0.000 | 0.000 | 0.000 |
19 | A | 16 | ARG | 1 | 0.825 | 0.893 | 4.696 | 1.021 | 1.128 | -0.001 | -0.001 | -0.104 | 0.000 |
20 | A | 17 | MET | 0 | -0.020 | -0.011 | 8.384 | 0.012 | 0.012 | 0.000 | 0.000 | 0.000 | 0.000 |
21 | A | 18 | ASN | 0 | -0.011 | -0.009 | 6.620 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
22 | A | 19 | ARG | 1 | 0.831 | 0.895 | 9.788 | -0.023 | -0.023 | 0.000 | 0.000 | 0.000 | 0.000 |
23 | A | 20 | ALA | 0 | 0.076 | 0.027 | 12.937 | 0.040 | 0.040 | 0.000 | 0.000 | 0.000 | 0.000 |
24 | A | 21 | ALA | 0 | -0.007 | 0.000 | 14.857 | 0.028 | 0.028 | 0.000 | 0.000 | 0.000 | 0.000 |
25 | A | 22 | LYS | 1 | 0.914 | 0.950 | 16.901 | 0.147 | 0.147 | 0.000 | 0.000 | 0.000 | 0.000 |
26 | A | 23 | HIS | 0 | 0.026 | 0.018 | 17.958 | 0.025 | 0.025 | 0.000 | 0.000 | 0.000 | 0.000 |
27 | A | 24 | ASN | 0 | -0.037 | -0.015 | 13.855 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
28 | A | 25 | PRO | 0 | 0.014 | 0.024 | 16.632 | 0.026 | 0.026 | 0.000 | 0.000 | 0.000 | 0.000 |
29 | A | 26 | PHE | 0 | 0.063 | 0.010 | 18.780 | 0.012 | 0.012 | 0.000 | 0.000 | 0.000 | 0.000 |
30 | A | 27 | ASP | -1 | -0.804 | -0.884 | 18.642 | 0.043 | 0.043 | 0.000 | 0.000 | 0.000 | 0.000 |
31 | A | 28 | ALA | 0 | -0.060 | -0.055 | 20.239 | 0.024 | 0.024 | 0.000 | 0.000 | 0.000 | 0.000 |
32 | A | 29 | GLU | -1 | -0.839 | -0.923 | 16.546 | 0.092 | 0.092 | 0.000 | 0.000 | 0.000 | 0.000 |
33 | A | 30 | LEU | 0 | 0.047 | 0.028 | 14.290 | 0.036 | 0.036 | 0.000 | 0.000 | 0.000 | 0.000 |
34 | A | 31 | ARG | 1 | 0.865 | 0.941 | 15.769 | -0.084 | -0.084 | 0.000 | 0.000 | 0.000 | 0.000 |
35 | A | 32 | ALA | 0 | 0.013 | 0.012 | 16.941 | 0.046 | 0.046 | 0.000 | 0.000 | 0.000 | 0.000 |
36 | A | 33 | ASP | -1 | -0.725 | -0.833 | 11.876 | 0.346 | 0.346 | 0.000 | 0.000 | 0.000 | 0.000 |
37 | A | 34 | LEU | 0 | -0.031 | -0.024 | 11.991 | 0.152 | 0.152 | 0.000 | 0.000 | 0.000 | 0.000 |
38 | A | 35 | MET | 0 | -0.069 | -0.033 | 13.868 | 0.052 | 0.052 | 0.000 | 0.000 | 0.000 | 0.000 |
39 | A | 36 | THR | 0 | -0.003 | 0.002 | 10.544 | 0.021 | 0.021 | 0.000 | 0.000 | 0.000 | 0.000 |
40 | A | 37 | VAL | 0 | -0.018 | -0.007 | 8.446 | 0.157 | 0.157 | 0.000 | 0.000 | 0.000 | 0.000 |
41 | A | 38 | LEU | 0 | -0.028 | -0.023 | 10.787 | 0.088 | 0.088 | 0.000 | 0.000 | 0.000 | 0.000 |
42 | A | 39 | GLU | -1 | -0.836 | -0.907 | 14.087 | 0.496 | 0.496 | 0.000 | 0.000 | 0.000 | 0.000 |
43 | A | 40 | ARG | 1 | 0.958 | 0.985 | 3.731 | -6.576 | -5.993 | 0.004 | -0.328 | -0.260 | 0.003 |
44 | A | 41 | VAL | 0 | -0.044 | -0.029 | 10.873 | 0.024 | 0.024 | 0.000 | 0.000 | 0.000 | 0.000 |
45 | A | 42 | ARG | 1 | 0.776 | 0.854 | 12.599 | -0.530 | -0.530 | 0.000 | 0.000 | 0.000 | 0.000 |
46 | A | 43 | ASP | -1 | -0.910 | -0.939 | 13.434 | 0.586 | 0.586 | 0.000 | 0.000 | 0.000 | 0.000 |
47 | A | 44 | ASP | -1 | -0.903 | -0.955 | 9.576 | 1.380 | 1.380 | 0.000 | 0.000 | 0.000 | 0.000 |
48 | A | 45 | ALA | 0 | -0.025 | -0.019 | 13.133 | 0.014 | 0.014 | 0.000 | 0.000 | 0.000 | 0.000 |
49 | A | 46 | ASP | -1 | -0.925 | -0.950 | 12.065 | 0.447 | 0.447 | 0.000 | 0.000 | 0.000 | 0.000 |
50 | A | 47 | ILE | 0 | -0.064 | -0.014 | 8.353 | 0.032 | 0.032 | 0.000 | 0.000 | 0.000 | 0.000 |
51 | A | 48 | ARG | 1 | 0.869 | 0.940 | 11.529 | -0.403 | -0.403 | 0.000 | 0.000 | 0.000 | 0.000 |
52 | A | 49 | VAL | 0 | -0.014 | 0.000 | 13.511 | -0.068 | -0.068 | 0.000 | 0.000 | 0.000 | 0.000 |
53 | A | 50 | LEU | 0 | 0.001 | 0.015 | 10.895 | 0.128 | 0.128 | 0.000 | 0.000 | 0.000 | 0.000 |
54 | A | 51 | VAL | 0 | 0.006 | 0.007 | 11.622 | -0.103 | -0.103 | 0.000 | 0.000 | 0.000 | 0.000 |
55 | A | 52 | LEU | 0 | -0.014 | -0.002 | 11.797 | 0.058 | 0.058 | 0.000 | 0.000 | 0.000 | 0.000 |
56 | A | 53 | THR | 0 | -0.008 | -0.034 | 10.576 | -0.080 | -0.080 | 0.000 | 0.000 | 0.000 | 0.000 |
57 | A | 54 | SER | 0 | -0.003 | 0.003 | 11.592 | 0.049 | 0.049 | 0.000 | 0.000 | 0.000 | 0.000 |
58 | A | 55 | HIS | 0 | 0.005 | 0.018 | 10.398 | -0.118 | -0.118 | 0.000 | 0.000 | 0.000 | 0.000 |
59 | A | 56 | PRO | 0 | 0.010 | -0.007 | 11.675 | 0.071 | 0.071 | 0.000 | 0.000 | 0.000 | 0.000 |
60 | A | 57 | GLY | 0 | -0.030 | -0.007 | 14.771 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
61 | A | 58 | SER | 0 | -0.045 | -0.030 | 15.914 | 0.020 | 0.020 | 0.000 | 0.000 | 0.000 | 0.000 |
62 | A | 59 | PHE | 0 | -0.025 | -0.014 | 16.097 | -0.007 | -0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
63 | A | 60 | CYS | 0 | -0.043 | 0.003 | 16.736 | 0.014 | 0.014 | 0.000 | 0.000 | 0.000 | 0.000 |
64 | A | 61 | ALA | 0 | 0.065 | 0.020 | 19.353 | 0.008 | 0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
65 | A | 62 | GLY | 0 | -0.019 | 0.006 | 22.206 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
66 | A | 63 | GLY | 0 | 0.048 | 0.007 | 23.274 | -0.011 | -0.011 | 0.000 | 0.000 | 0.000 | 0.000 |
67 | A | 64 | ASN | 0 | -0.023 | -0.018 | 23.766 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
68 | A | 65 | LEU | 0 | 0.061 | 0.024 | 25.493 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
69 | A | 66 | HIS | 0 | 0.017 | 0.017 | 27.140 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
70 | A | 67 | VAL | 0 | 0.048 | 0.031 | 26.045 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
71 | A | 68 | LEU | 0 | -0.002 | -0.001 | 29.001 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
72 | A | 69 | ARG | 1 | 0.907 | 0.944 | 31.716 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
73 | A | 70 | ASP | -1 | -0.882 | -0.941 | 31.644 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
74 | A | 71 | ASN | 0 | -0.056 | -0.028 | 31.764 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
75 | A | 72 | LEU | 0 | -0.001 | 0.014 | 35.054 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
76 | A | 73 | ASP | -1 | -0.908 | -0.944 | 37.550 | 0.019 | 0.019 | 0.000 | 0.000 | 0.000 | 0.000 |
77 | A | 74 | SER | 0 | -0.047 | -0.020 | 35.707 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
78 | A | 75 | GLY | 0 | 0.022 | 0.021 | 38.812 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
79 | A | 76 | PRO | 0 | 0.022 | -0.015 | 38.899 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
80 | A | 77 | ALA | 0 | 0.003 | 0.005 | 38.688 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
81 | A | 78 | TYR | 0 | 0.019 | 0.005 | 31.969 | 0.009 | 0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
82 | A | 79 | TRP | 0 | 0.047 | 0.003 | 31.799 | 0.010 | 0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
83 | A | 80 | GLN | 0 | 0.001 | 0.014 | 34.108 | 0.010 | 0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
84 | A | 81 | GLN | 0 | 0.012 | 0.000 | 31.708 | 0.014 | 0.014 | 0.000 | 0.000 | 0.000 | 0.000 |
85 | A | 82 | ARG | 1 | 0.929 | 0.969 | 27.558 | -0.049 | -0.049 | 0.000 | 0.000 | 0.000 | 0.000 |
86 | A | 83 | ILE | 0 | 0.045 | 0.017 | 29.068 | 0.009 | 0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
87 | A | 84 | LYS | 1 | 0.922 | 0.955 | 29.405 | -0.081 | -0.081 | 0.000 | 0.000 | 0.000 | 0.000 |
88 | A | 85 | THR | 0 | -0.052 | -0.023 | 24.992 | 0.014 | 0.014 | 0.000 | 0.000 | 0.000 | 0.000 |
89 | A | 86 | GLY | 0 | 0.011 | 0.011 | 24.869 | 0.017 | 0.017 | 0.000 | 0.000 | 0.000 | 0.000 |
90 | A | 87 | LEU | 0 | -0.006 | -0.024 | 24.884 | 0.012 | 0.012 | 0.000 | 0.000 | 0.000 | 0.000 |
91 | A | 88 | ARG | 1 | 0.923 | 0.974 | 24.672 | -0.145 | -0.145 | 0.000 | 0.000 | 0.000 | 0.000 |
92 | A | 89 | PHE | 0 | 0.064 | 0.035 | 17.121 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
93 | A | 90 | ILE | 0 | -0.005 | 0.000 | 21.592 | 0.017 | 0.017 | 0.000 | 0.000 | 0.000 | 0.000 |
94 | A | 91 | HIS | 0 | -0.039 | -0.021 | 23.783 | -0.009 | -0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
95 | A | 92 | ASP | -1 | -0.800 | -0.889 | 20.111 | 0.300 | 0.300 | 0.000 | 0.000 | 0.000 | 0.000 |
96 | A | 93 | MET | 0 | -0.032 | -0.009 | 17.271 | 0.046 | 0.046 | 0.000 | 0.000 | 0.000 | 0.000 |
97 | A | 94 | LEU | 0 | -0.032 | -0.017 | 20.563 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
98 | A | 95 | ASN | 0 | -0.040 | -0.027 | 23.203 | -0.013 | -0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
99 | A | 96 | LEU | 0 | -0.025 | 0.014 | 15.678 | 0.017 | 0.017 | 0.000 | 0.000 | 0.000 | 0.000 |
100 | A | 97 | GLY | 0 | 0.013 | -0.003 | 20.175 | -0.021 | -0.021 | 0.000 | 0.000 | 0.000 | 0.000 |
101 | A | 98 | ARG | 1 | 0.796 | 0.880 | 14.152 | -0.658 | -0.658 | 0.000 | 0.000 | 0.000 | 0.000 |
102 | A | 99 | PRO | 0 | 0.006 | 0.004 | 18.053 | -0.014 | -0.014 | 0.000 | 0.000 | 0.000 | 0.000 |
103 | A | 100 | VAL | 0 | -0.004 | -0.006 | 16.069 | 0.049 | 0.049 | 0.000 | 0.000 | 0.000 | 0.000 |
104 | A | 101 | ILE | 0 | -0.002 | -0.004 | 16.342 | -0.044 | -0.044 | 0.000 | 0.000 | 0.000 | 0.000 |
105 | A | 102 | ALA | 0 | 0.012 | 0.013 | 16.100 | 0.013 | 0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
106 | A | 103 | ALA | 0 | -0.003 | 0.000 | 14.648 | -0.018 | -0.018 | 0.000 | 0.000 | 0.000 | 0.000 |
107 | A | 104 | VAL | 0 | -0.015 | -0.012 | 15.992 | -0.021 | -0.021 | 0.000 | 0.000 | 0.000 | 0.000 |
108 | A | 105 | ASP | -1 | -0.700 | -0.795 | 16.645 | -0.167 | -0.167 | 0.000 | 0.000 | 0.000 | 0.000 |
109 | A | 106 | GLY | 0 | 0.046 | 0.020 | 18.669 | -0.021 | -0.021 | 0.000 | 0.000 | 0.000 | 0.000 |
110 | A | 107 | PRO | 0 | 0.005 | -0.004 | 20.544 | 0.015 | 0.015 | 0.000 | 0.000 | 0.000 | 0.000 |
111 | A | 108 | ALA | 0 | 0.027 | 0.024 | 21.301 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
112 | A | 109 | PHE | 0 | -0.025 | -0.030 | 22.893 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
113 | A | 110 | GLY | 0 | -0.013 | -0.008 | 24.978 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
114 | A | 111 | ALA | 0 | 0.048 | 0.015 | 23.606 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
115 | A | 112 | GLY | 0 | 0.047 | 0.028 | 21.384 | 0.017 | 0.017 | 0.000 | 0.000 | 0.000 | 0.000 |
116 | A | 113 | PHE | 0 | -0.007 | -0.007 | 22.233 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
117 | A | 114 | ALA | 0 | 0.010 | 0.002 | 25.002 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
118 | A | 115 | LEU | 0 | 0.009 | 0.004 | 17.671 | 0.011 | 0.011 | 0.000 | 0.000 | 0.000 | 0.000 |
119 | A | 116 | SER | 0 | -0.066 | -0.038 | 21.181 | 0.012 | 0.012 | 0.000 | 0.000 | 0.000 | 0.000 |
120 | A | 117 | LEU | 0 | -0.024 | -0.025 | 22.128 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
121 | A | 118 | THR | 0 | -0.063 | -0.032 | 21.360 | 0.013 | 0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
122 | A | 119 | ALA | 0 | -0.053 | -0.008 | 20.121 | 0.023 | 0.023 | 0.000 | 0.000 | 0.000 | 0.000 |
123 | A | 120 | ASP | -1 | -0.755 | -0.856 | 20.894 | 0.204 | 0.204 | 0.000 | 0.000 | 0.000 | 0.000 |
124 | A | 121 | ILE | 0 | -0.025 | -0.014 | 21.096 | -0.022 | -0.022 | 0.000 | 0.000 | 0.000 | 0.000 |
125 | A | 122 | VAL | 0 | 0.022 | 0.020 | 20.787 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
126 | A | 123 | LEU | 0 | -0.006 | 0.004 | 18.229 | -0.010 | -0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
127 | A | 124 | ALA | 0 | 0.009 | 0.002 | 20.090 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
128 | A | 125 | SER | 0 | 0.045 | 0.000 | 20.266 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
129 | A | 126 | PRO | 0 | 0.013 | -0.007 | 22.236 | 0.010 | 0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
130 | A | 127 | ARG | 1 | 0.840 | 0.913 | 18.044 | 0.169 | 0.169 | 0.000 | 0.000 | 0.000 | 0.000 |
131 | A | 128 | ALA | 0 | -0.064 | -0.003 | 22.256 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
132 | A | 129 | ARG | 1 | 0.863 | 0.927 | 23.434 | 0.047 | 0.047 | 0.000 | 0.000 | 0.000 | 0.000 |
133 | A | 130 | PHE | 0 | 0.042 | 0.025 | 23.353 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
134 | A | 131 | SER | 0 | 0.002 | 0.011 | 27.202 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
135 | A | 132 | MET | 0 | 0.002 | 0.004 | 28.730 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
136 | A | 133 | ALA | 0 | 0.031 | 0.000 | 30.926 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
137 | A | 134 | TYR | 0 | -0.014 | -0.019 | 28.613 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
138 | A | 135 | LEU | 0 | 0.055 | 0.036 | 33.646 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
139 | A | 136 | ARG | 1 | 0.852 | 0.909 | 32.487 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
140 | A | 137 | LEU | 0 | -0.047 | -0.021 | 31.237 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
141 | A | 138 | GLY | 0 | 0.001 | 0.015 | 35.979 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
142 | A | 139 | LEU | 0 | -0.053 | -0.017 | 33.598 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
143 | A | 140 | VAL | 0 | -0.004 | -0.008 | 35.771 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
144 | A | 141 | PRO | 0 | -0.010 | -0.029 | 32.709 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
145 | A | 142 | ASP | -1 | -0.845 | -0.915 | 29.106 | 0.074 | 0.074 | 0.000 | 0.000 | 0.000 | 0.000 |
146 | A | 143 | LEU | 0 | -0.012 | -0.010 | 24.585 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
147 | A | 144 | GLY | 0 | 0.067 | 0.034 | 27.307 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
148 | A | 145 | ALA | 0 | 0.039 | 0.027 | 29.809 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
149 | A | 146 | LEU | 0 | -0.032 | -0.031 | 30.874 | -0.004 | -0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
150 | A | 147 | TYR | 0 | -0.087 | -0.060 | 29.982 | -0.004 | -0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
151 | A | 148 | LEU | 0 | 0.057 | 0.025 | 26.672 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
152 | A | 149 | LEU | 0 | 0.027 | 0.022 | 30.886 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
153 | A | 150 | PRO | 0 | -0.048 | -0.036 | 32.602 | -0.004 | -0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
154 | A | 151 | ARG | 1 | 0.786 | 0.877 | 32.617 | -0.084 | -0.084 | 0.000 | 0.000 | 0.000 | 0.000 |
155 | A | 152 | ALA | 0 | 0.020 | 0.040 | 30.773 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
156 | A | 153 | VAL | 0 | -0.016 | -0.011 | 32.728 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
157 | A | 154 | GLY | 0 | 0.041 | 0.026 | 35.369 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
158 | A | 155 | LEU | 0 | -0.002 | -0.020 | 38.205 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
159 | A | 156 | GLN | 0 | 0.019 | -0.011 | 40.345 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
160 | A | 157 | ARG | 1 | 1.019 | 1.014 | 37.012 | -0.021 | -0.021 | 0.000 | 0.000 | 0.000 | 0.000 |
161 | A | 158 | ALA | 0 | 0.064 | 0.043 | 35.986 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
162 | A | 159 | LYS | 1 | 0.930 | 0.959 | 36.996 | -0.031 | -0.031 | 0.000 | 0.000 | 0.000 | 0.000 |
163 | A | 160 | GLU | -1 | -0.822 | -0.872 | 38.137 | 0.011 | 0.011 | 0.000 | 0.000 | 0.000 | 0.000 |
164 | A | 161 | LEU | 0 | 0.042 | 0.046 | 33.103 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
165 | A | 162 | MET | 0 | -0.059 | -0.030 | 33.553 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
166 | A | 163 | PHE | 0 | -0.045 | -0.023 | 36.478 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
167 | A | 164 | SER | 0 | -0.012 | -0.021 | 37.743 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
168 | A | 165 | THR | 0 | -0.073 | -0.017 | 34.606 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
169 | A | 166 | ARG | 1 | 0.750 | 0.831 | 34.035 | -0.008 | -0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
170 | A | 167 | GLU | -1 | -0.929 | -0.972 | 29.480 | -0.025 | -0.025 | 0.000 | 0.000 | 0.000 | 0.000 |
171 | A | 168 | LEU | 0 | -0.036 | -0.010 | 29.996 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
172 | A | 169 | ASP | -1 | -0.835 | -0.923 | 28.754 | -0.024 | -0.024 | 0.000 | 0.000 | 0.000 | 0.000 |
173 | A | 170 | ALA | 0 | 0.040 | 0.006 | 25.831 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
174 | A | 171 | GLU | -1 | -0.867 | -0.918 | 27.480 | -0.010 | -0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
175 | A | 172 | GLU | -1 | -0.787 | -0.887 | 30.621 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
176 | A | 173 | ALA | 0 | -0.006 | -0.011 | 27.946 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
177 | A | 174 | HIS | 0 | -0.087 | -0.041 | 28.353 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
178 | A | 175 | ARG | 1 | 0.863 | 0.926 | 29.793 | 0.008 | 0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
179 | A | 176 | LEU | 0 | -0.103 | -0.056 | 32.479 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
180 | A | 177 | GLY | 0 | 0.010 | 0.018 | 30.874 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
181 | A | 178 | LEU | 0 | -0.039 | -0.008 | 27.613 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
182 | A | 179 | VAL | 0 | -0.024 | -0.005 | 24.356 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
183 | A | 180 | MET | 0 | 0.006 | 0.013 | 24.569 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
184 | A | 181 | GLU | -1 | -0.780 | -0.867 | 23.511 | -0.014 | -0.014 | 0.000 | 0.000 | 0.000 | 0.000 |
185 | A | 182 | VAL | 0 | 0.016 | 0.010 | 23.972 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
186 | A | 183 | HIS | 0 | -0.063 | -0.054 | 21.133 | -0.009 | -0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
187 | A | 184 | GLU | -1 | -0.845 | -0.930 | 22.351 | -0.087 | -0.087 | 0.000 | 0.000 | 0.000 | 0.000 |
188 | A | 185 | SER | 0 | -0.002 | -0.040 | 18.852 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
189 | A | 186 | GLU | -1 | -0.940 | -0.974 | 17.539 | -0.190 | -0.190 | 0.000 | 0.000 | 0.000 | 0.000 |
190 | A | 187 | ALA | 0 | -0.039 | -0.019 | 17.747 | -0.016 | -0.016 | 0.000 | 0.000 | 0.000 | 0.000 |
191 | A | 188 | LEU | 0 | -0.027 | -0.005 | 16.765 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
192 | A | 189 | GLU | -1 | -0.792 | -0.881 | 9.234 | -0.598 | -0.598 | 0.000 | 0.000 | 0.000 | 0.000 |
193 | A | 190 | GLN | 0 | 0.019 | 0.002 | 14.136 | -0.023 | -0.023 | 0.000 | 0.000 | 0.000 | 0.000 |
194 | A | 191 | ARG | 1 | 0.776 | 0.866 | 15.721 | 0.045 | 0.045 | 0.000 | 0.000 | 0.000 | 0.000 |
195 | A | 192 | ALA | 0 | 0.022 | -0.004 | 14.476 | 0.029 | 0.029 | 0.000 | 0.000 | 0.000 | 0.000 |
196 | A | 193 | ARG | 1 | 0.849 | 0.917 | 9.620 | 0.432 | 0.432 | 0.000 | 0.000 | 0.000 | 0.000 |
197 | A | 194 | GLU | -1 | -0.861 | -0.926 | 14.533 | -0.029 | -0.029 | 0.000 | 0.000 | 0.000 | 0.000 |
198 | A | 195 | ILE | 0 | -0.036 | -0.017 | 17.981 | 0.025 | 0.025 | 0.000 | 0.000 | 0.000 | 0.000 |
199 | A | 196 | ALA | 0 | 0.040 | 0.033 | 14.542 | 0.026 | 0.026 | 0.000 | 0.000 | 0.000 | 0.000 |
200 | A | 197 | GLU | -1 | -0.826 | -0.920 | 12.798 | -0.028 | -0.028 | 0.000 | 0.000 | 0.000 | 0.000 |
201 | A | 198 | SER | 0 | -0.104 | -0.062 | 16.430 | 0.013 | 0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
202 | A | 199 | LEU | 0 | 0.012 | -0.007 | 18.935 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
203 | A | 200 | VAL | 0 | 0.012 | 0.033 | 14.710 | 0.024 | 0.024 | 0.000 | 0.000 | 0.000 | 0.000 |
204 | A | 201 | GLN | 0 | -0.036 | -0.019 | 17.646 | 0.014 | 0.014 | 0.000 | 0.000 | 0.000 | 0.000 |
205 | A | 202 | ALA | 0 | -0.056 | -0.017 | 20.980 | -0.012 | -0.012 | 0.000 | 0.000 | 0.000 | 0.000 |
206 | A | 203 | ALA | 0 | 0.015 | -0.002 | 21.526 | 0.022 | 0.022 | 0.000 | 0.000 | 0.000 | 0.000 |
207 | A | 204 | PRO | 0 | 0.050 | 0.020 | 19.607 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
208 | A | 205 | THR | 0 | 0.018 | 0.014 | 21.788 | 0.009 | 0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
209 | A | 206 | ALA | 0 | 0.037 | 0.017 | 25.156 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
210 | A | 207 | LEU | 0 | -0.013 | 0.008 | 20.594 | -0.010 | -0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
211 | A | 208 | ALA | 0 | 0.021 | 0.019 | 22.705 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
212 | A | 209 | LEU | 0 | -0.016 | -0.015 | 24.244 | -0.008 | -0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
213 | A | 210 | THR | 0 | -0.033 | -0.025 | 27.293 | -0.016 | -0.016 | 0.000 | 0.000 | 0.000 | 0.000 |
214 | A | 211 | LYS | 1 | 0.843 | 0.929 | 20.323 | -0.273 | -0.273 | 0.000 | 0.000 | 0.000 | 0.000 |
215 | A | 212 | ALA | 0 | -0.003 | 0.001 | 26.331 | -0.009 | -0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
216 | A | 213 | ALA | 0 | 0.012 | 0.002 | 27.949 | -0.010 | -0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
217 | A | 214 | LEU | 0 | -0.013 | -0.019 | 28.503 | -0.010 | -0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
218 | A | 215 | ASN | 0 | -0.058 | -0.032 | 25.064 | -0.019 | -0.019 | 0.000 | 0.000 | 0.000 | 0.000 |
219 | A | 216 | VAL | 0 | 0.007 | 0.012 | 29.561 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
220 | A | 217 | SER | 0 | 0.034 | 0.011 | 32.873 | -0.009 | -0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
221 | A | 218 | LEU | 0 | -0.072 | -0.047 | 34.430 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
222 | A | 219 | ASP | -1 | -0.824 | -0.866 | 33.982 | 0.090 | 0.090 | 0.000 | 0.000 | 0.000 | 0.000 |
223 | A | 220 | SER | 0 | -0.028 | -0.005 | 37.263 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
224 | A | 221 | ASP | -1 | -0.837 | -0.897 | 39.191 | 0.065 | 0.065 | 0.000 | 0.000 | 0.000 | 0.000 |
225 | A | 222 | GLU | -1 | -0.929 | -0.965 | 41.482 | 0.057 | 0.057 | 0.000 | 0.000 | 0.000 | 0.000 |
226 | A | 223 | GLN | 0 | 0.025 | 0.013 | 42.686 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
227 | A | 224 | THR | 0 | -0.043 | -0.044 | 38.676 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
228 | A | 225 | MET | 0 | -0.006 | 0.009 | 34.618 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
229 | A | 226 | PHE | 0 | 0.010 | 0.003 | 38.442 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
230 | A | 227 | SER | 0 | -0.031 | -0.020 | 40.484 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
231 | A | 228 | LEU | 0 | -0.019 | -0.005 | 33.039 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
232 | A | 229 | GLU | -1 | -0.942 | -0.958 | 35.563 | 0.087 | 0.087 | 0.000 | 0.000 | 0.000 | 0.000 |
233 | A | 230 | ALA | 0 | 0.003 | 0.001 | 36.448 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
234 | A | 231 | ALA | 0 | -0.022 | -0.014 | 35.779 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
235 | A | 232 | SER | 0 | -0.018 | -0.022 | 32.030 | 0.010 | 0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
236 | A | 233 | GLN | 0 | 0.013 | -0.001 | 32.528 | 0.011 | 0.011 | 0.000 | 0.000 | 0.000 | 0.000 |
237 | A | 234 | ALA | 0 | -0.014 | -0.001 | 34.522 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
238 | A | 235 | ALA | 0 | 0.000 | 0.001 | 30.717 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
239 | A | 236 | ALA | 0 | 0.014 | 0.001 | 29.898 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
240 | A | 237 | PHE | 0 | -0.040 | -0.022 | 30.838 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
241 | A | 238 | SER | 0 | -0.069 | -0.008 | 31.902 | -0.007 | -0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
242 | A | 239 | THR | 0 | -0.048 | -0.032 | 27.157 | 0.012 | 0.012 | 0.000 | 0.000 | 0.000 | 0.000 |
243 | A | 240 | LYS | 1 | 0.954 | 0.974 | 22.217 | -0.205 | -0.205 | 0.000 | 0.000 | 0.000 | 0.000 |
244 | A | 241 | GLU | -1 | -0.876 | -0.968 | 23.703 | 0.180 | 0.180 | 0.000 | 0.000 | 0.000 | 0.000 |
245 | A | 242 | PRO | 0 | 0.032 | 0.029 | 27.873 | -0.011 | -0.011 | 0.000 | 0.000 | 0.000 | 0.000 |
246 | A | 243 | ARG | 1 | 0.915 | 0.949 | 31.419 | -0.088 | -0.088 | 0.000 | 0.000 | 0.000 | 0.000 |
247 | A | 244 | ALA | 0 | 0.007 | 0.006 | 28.442 | -0.008 | -0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
248 | A | 245 | ALA | 0 | -0.007 | -0.011 | 29.581 | -0.008 | -0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
249 | A | 246 | ILE | 0 | 0.005 | -0.002 | 31.055 | -0.008 | -0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
250 | A | 247 | GLU | -1 | -0.836 | -0.911 | 33.739 | 0.062 | 0.062 | 0.000 | 0.000 | 0.000 | 0.000 |
251 | A | 248 | ALA | 0 | -0.012 | 0.012 | 31.526 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
252 | A | 249 | LEU | 0 | 0.020 | 0.007 | 33.631 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
253 | A | 250 | LEU | 0 | -0.030 | -0.009 | 35.800 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
254 | A | 251 | SER | 0 | -0.064 | -0.025 | 36.164 | -0.004 | -0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
255 | A | 252 | LYS | 1 | 0.878 | 0.933 | 38.061 | -0.029 | -0.029 | 0.000 | 0.000 | 0.000 | 0.000 |
256 | A | 253 | GLN | 0 | -0.038 | -0.013 | 32.939 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
257 | A | 254 | PRO | 0 | -0.015 | -0.020 | 30.154 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
258 | A | 255 | PRO | 0 | 0.030 | 0.028 | 29.430 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
259 | A | 256 | PRO | 0 | 0.013 | -0.009 | 24.512 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
260 | A | 257 | PHE | 0 | 0.022 | 0.019 | 23.281 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
261 | A | 258 | ARG | 1 | 0.896 | 0.942 | 25.689 | -0.051 | -0.051 | 0.000 | 0.000 | 0.000 | 0.000 |
262 | A | 259 | GLY | 0 | 0.034 | 0.035 | 26.447 | -0.008 | -0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
263 | A | 260 | PHE | 0 | 0.011 | -0.003 | 23.169 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
264 | A | 261 | PRO | 0 | 0.032 | 0.019 | 21.246 | -0.004 | -0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
265 | A | 262 | ARG | 1 | 0.945 | 0.977 | 24.564 | 0.013 | 0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
266 | A | 263 | ARG | 1 | 0.917 | 0.960 | 24.937 | 0.027 | 0.027 | 0.000 | 0.000 | 0.000 | 0.000 |
267 | A | 264 | SER | 0 | 0.003 | 0.009 | 24.187 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |