FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-04-23

All entries: 37539

Number of unique PDB entries: 7791

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FMODB ID: 4395N

Calculation Name: 4FKL-AB-MD339-md1_30ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: 4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine

ligand 3-letter code: CK2

PDB ID: 4FKL

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-09-01

Reference: K. Takaba et al., Protein-ligand binding affinity prediction of cyclin-dependent kinase-2 inhibitors by dynamically averaged fragment molecular orbital-based interaction energy, J. Comput. Chem., 43, 1362-1371, 2022.

DOI: 10.1002/jcc.26940

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2700
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -18864863.042366
FMO2-HF: Nuclear repulsion 18563840.609411
FMO2-HF: Total energy -301022.432955
FMO2-MP2: Total energy -301846.101569


3D Structure
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-49.442411-28.14537530.863661-14.836229-37.3244670.019015


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-76.705-49.68251.068-27.267-50.824-0.034
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.034 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.75318.089-0.121-0.1210.0000.0000.0000.000
2A2GLU-1-0.66318.5570.0510.0510.0000.0000.0000.000
3A3ASN00.05613.699-0.016-0.0160.0000.0000.0000.000
4A4PHE0-0.04610.942-0.010-0.0100.0000.0000.0000.000
5A5GLN00.02312.724-0.002-0.0020.0000.0000.0000.000
6A6LYS10.86910.752-0.024-0.0240.0000.0000.0000.000
7A7VAL0-0.0239.651-0.039-0.0390.0000.0000.0000.000
8A8GLU-1-0.6888.534-1.081-1.0810.0000.0000.0000.000
9A9LYS10.8307.0330.8880.8880.0000.0000.0000.000
10A10ILE0-0.0542.763-1.854-0.7562.139-0.622-2.6150.005
11A11GLY00.0752.682-2.547-1.7170.227-0.306-0.750-0.001
12A12GLU-1-0.6942.896-0.9190.0570.125-0.222-0.879-0.003
13A13GLY00.0412.746-3.158-2.3131.200-0.830-1.215-0.011
14A14THR0-0.0404.256-0.484-0.3300.001-0.023-0.1310.000
15A15TYR00.0026.639-0.319-0.3190.0000.0000.0000.000
16A16GLY0-0.0096.955-0.064-0.0640.0000.0000.0000.000
17A17VAL00.0105.8680.0850.0850.0000.0000.0000.000
18A18VAL00.0012.695-3.192-0.9263.877-1.227-4.9150.006
19A19TYR00.0325.632-1.197-1.1970.0000.0000.0000.000
20A20LYS10.8335.3561.6521.6520.0000.0000.0000.000
21A21ALA0-0.0316.170-0.111-0.1110.0000.0000.0000.000
22A22ARG10.8349.2150.0530.0530.0000.0000.0000.000
23A23ASN0-0.00811.330-0.005-0.0050.0000.0000.0000.000
24A24LYS10.86212.603-0.062-0.0620.0000.0000.0000.000
25A25LEU0-0.00316.062-0.013-0.0130.0000.0000.0000.000
26A26THR00.10514.010-0.010-0.0100.0000.0000.0000.000
27A27GLY00.03115.550-0.009-0.0090.0000.0000.0000.000
28A28GLU-1-0.70411.0520.1620.1620.0000.0000.0000.000
29A29VAL00.0666.876-0.011-0.0110.0000.0000.0000.000
30A30VAL0-0.0445.7690.0590.0590.0000.0000.0000.000
31A31ALA0-0.0062.642-1.3860.1690.770-0.743-1.5820.007
32A32LEU0-0.0154.587-0.759-0.634-0.001-0.010-0.1150.000
33A33LYS10.7982.328-6.804-6.0170.826-0.381-1.2320.005
34A34LYS10.8107.077-0.601-0.6010.0000.0000.0000.000
35A35ILE00.0099.9650.1490.1490.0000.0000.0000.000
36A36ARG10.73312.145-0.173-0.1730.0000.0000.0000.000
37A37LEU00.07210.8820.0110.0110.0000.0000.0000.000
38A38ASP-1-0.70313.6050.1370.1370.0000.0000.0000.000
39A39THR00.02217.008-0.014-0.0140.0000.0000.0000.000
40A40GLU-1-0.68419.8670.0410.0410.0000.0000.0000.000
41A41THR00.02819.937-0.012-0.0120.0000.0000.0000.000
42A42GLU-1-0.70116.5710.2220.2220.0000.0000.0000.000
43A43GLY00.08018.1320.0410.0410.0000.0000.0000.000
44A44VAL00.00216.1460.0280.0280.0000.0000.0000.000
45A45PRO00.01819.337-0.030-0.0300.0000.0000.0000.000
46A46SER0-0.00820.4850.0270.0270.0000.0000.0000.000
47A47THR00.00221.2700.0020.0020.0000.0000.0000.000
48A48ALA00.00616.3550.0170.0170.0000.0000.0000.000
49A49ILE0-0.01316.6550.0280.0280.0000.0000.0000.000
50A50ARG10.85118.019-0.210-0.2100.0000.0000.0000.000
51A51GLU-1-0.66216.2510.3490.3490.0000.0000.0000.000
52A52ILE00.00611.2950.0300.0300.0000.0000.0000.000
53A53SER00.03713.647-0.015-0.0150.0000.0000.0000.000
54A54LEU0-0.05415.894-0.003-0.0030.0000.0000.0000.000
55A55LEU0-0.00310.388-0.014-0.0140.0000.0000.0000.000
56A56LYS10.88512.074-0.193-0.1930.0000.0000.0000.000
57A57GLU-1-0.64513.5680.2340.2340.0000.0000.0000.000
58A58LEU0-0.02112.858-0.018-0.0180.0000.0000.0000.000
59A59ASN00.03212.0070.0340.0340.0000.0000.0000.000
60A60HIS00.04212.3980.0090.0090.0000.0000.0000.000
61A61PRO00.05712.1760.0790.0790.0000.0000.0000.000
62A62ASN00.01011.931-0.004-0.0040.0000.0000.0000.000
63A63ILE0-0.0178.9840.0770.0770.0000.0000.0000.000
64A64VAL0-0.0143.098-0.867-0.0760.067-0.230-0.6290.001
65A65LYS10.8566.437-0.402-0.4020.0000.0000.0000.000
66A66LEU0-0.0106.686-0.324-0.3240.0000.0000.0000.000
67A67LEU00.0207.5210.0700.0700.0000.0000.0000.000
68A68ASP-1-0.7639.3230.2470.2470.0000.0000.0000.000
69A69VAL00.04510.4950.0510.0510.0000.0000.0000.000
70A70ILE0-0.02612.047-0.041-0.0410.0000.0000.0000.000
71A71HIS00.01315.2740.0220.0220.0000.0000.0000.000
72A72THR00.03818.659-0.012-0.0120.0000.0000.0000.000
73A73GLU-1-0.72322.2000.1290.1290.0000.0000.0000.000
74A74ASN00.02922.1950.0080.0080.0000.0000.0000.000
75A75LYS10.86217.689-0.128-0.1280.0000.0000.0000.000
76A76LEU00.03213.284-0.017-0.0170.0000.0000.0000.000
77A77TYR0-0.01511.3580.0690.0690.0000.0000.0000.000
78A78LEU00.0098.155-0.071-0.0710.0000.0000.0000.000
79A79VAL00.0037.0690.1110.1110.0000.0000.0000.000
80A80PHE00.0163.223-0.751-0.0280.071-0.174-0.6210.000
81A81GLU-1-0.6594.3290.4890.846-0.001-0.185-0.1710.000
82A82PHE00.0151.923-12.193-11.45810.384-4.574-6.545-0.020
83A83LEU00.0052.615-5.109-3.6760.908-0.342-1.9990.014
84A84HIS00.0562.430-5.415-4.4842.187-1.140-1.977-0.016
85A85GLN00.0284.666-0.419-0.318-0.001-0.004-0.0960.000
86A86ASP-1-0.6485.021-2.547-2.5470.0000.0000.0000.000
87A87LEU00.0346.947-0.062-0.0620.0000.0000.0000.000
88A88LYS10.7666.6560.8630.8630.0000.0000.0000.000
89A89LYS10.8245.8363.5373.5370.0000.0000.0000.000
90A90PHE00.03110.1570.1640.1640.0000.0000.0000.000
91A91MET00.03412.4180.1150.1150.0000.0000.0000.000
92A92ASP-1-0.65612.617-0.637-0.6370.0000.0000.0000.000
93A93ALA00.04414.1820.0430.0430.0000.0000.0000.000
94A94SER00.00216.1900.0790.0790.0000.0000.0000.000
95A95ALA00.03717.6760.0460.0460.0000.0000.0000.000
96A96LEU00.01119.3600.0270.0270.0000.0000.0000.000
97A97THR00.01022.2980.0200.0200.0000.0000.0000.000
98A98GLY00.04920.6900.0180.0180.0000.0000.0000.000
99A99ILE0-0.03617.656-0.002-0.0020.0000.0000.0000.000
100A100PRO00.05921.8640.0150.0150.0000.0000.0000.000
101A101LEU00.03423.0850.0130.0130.0000.0000.0000.000
102A102PRO00.01523.7980.0160.0160.0000.0000.0000.000
103A103LEU00.04118.9710.0200.0200.0000.0000.0000.000
104A104ILE00.00519.2350.0310.0310.0000.0000.0000.000
105A105LYS10.77519.294-0.037-0.0370.0000.0000.0000.000
106A106SER00.02319.3290.0400.0400.0000.0000.0000.000
107A107TYR00.00615.1510.0570.0570.0000.0000.0000.000
108A108LEU00.02115.8600.0600.0600.0000.0000.0000.000
109A109PHE00.05317.4910.0380.0380.0000.0000.0000.000
110A110GLN00.01014.9040.0860.0860.0000.0000.0000.000
111A111LEU0-0.03611.0230.0580.0580.0000.0000.0000.000
112A112LEU0-0.01214.3070.0460.0460.0000.0000.0000.000
113A113GLN00.05517.2720.0030.0030.0000.0000.0000.000
114A114GLY00.09613.399-0.006-0.0060.0000.0000.0000.000
115A115LEU0-0.03113.4970.0160.0160.0000.0000.0000.000
116A116ALA00.01315.172-0.014-0.0140.0000.0000.0000.000
117A117PHE00.03015.977-0.017-0.0170.0000.0000.0000.000
118A118CYS0-0.01813.2300.0010.0010.0000.0000.0000.000
119A119HIS00.02215.420-0.055-0.0550.0000.0000.0000.000
120A120SER0-0.01118.242-0.037-0.0370.0000.0000.0000.000
121A121HIS00.03417.310-0.026-0.0260.0000.0000.0000.000
122A122ARG10.68419.268-0.243-0.2430.0000.0000.0000.000
123A123VAL0-0.00512.9910.0100.0100.0000.0000.0000.000
124A124LEU0-0.03114.127-0.022-0.0220.0000.0000.0000.000
125A125HIS00.0225.926-0.241-0.2410.0000.0000.0000.000
126A126ARG10.92510.274-0.348-0.3480.0000.0000.0000.000
127A127ASP-1-0.6727.6820.7540.7540.0000.0000.0000.000
128A128LEU0-0.0088.3370.2260.2260.0000.0000.0000.000
129A129LYS10.7926.330-0.666-0.6660.0000.0000.0000.000
130A130PRO00.0077.4790.3230.3230.0000.0000.0000.000
131A131GLN00.0542.504-0.0200.5490.309-0.170-0.7080.000
132A132ASN0-0.0513.375-3.298-1.0300.172-0.791-1.649-0.002
133A133LEU00.0224.226-0.445-0.1130.001-0.019-0.3140.000
134A134LEU0-0.0192.518-4.531-1.4003.859-1.337-5.6530.010
135A135ILE00.0186.4790.1240.1240.0000.0000.0000.000
136A136ASN00.0458.445-0.193-0.1930.0000.0000.0000.000
137A137THR00.02310.8640.0360.0360.0000.0000.0000.000
138A138GLU-1-0.66913.9510.2170.2170.0000.0000.0000.000
139A139GLY00.00315.073-0.005-0.0050.0000.0000.0000.000
140A140ALA0-0.00113.053-0.007-0.0070.0000.0000.0000.000
141A141ILE00.02210.0020.0060.0060.0000.0000.0000.000
142A142LYS10.8207.776-0.951-0.9510.0000.0000.0000.000
143A143LEU00.0127.0460.1870.1870.0000.0000.0000.000
144A144ALA00.0402.444-0.281-0.3921.848-0.494-1.2430.000
145A145ASP-1-0.7032.6375.6906.9951.897-0.999-2.203-0.014
146A146PHE00.0354.678-0.305-0.2090.000-0.013-0.0830.000
147A147GLY00.0628.297-0.114-0.1140.0000.0000.0000.000
148A148LEU0-0.0355.902-0.114-0.1140.0000.0000.0000.000
149A149ALA00.01110.167-0.109-0.1090.0000.0000.0000.000
150A150ARG10.80712.310-0.491-0.4910.0000.0000.0000.000
151A151ALA0-0.00113.611-0.080-0.0800.0000.0000.0000.000
152A152PHE0-0.02511.088-0.045-0.0450.0000.0000.0000.000
153A153GLY00.07413.8720.0090.0090.0000.0000.0000.000
154A154VAL0-0.02812.1090.1230.1230.0000.0000.0000.000
155A155PRO0-0.01311.837-0.082-0.0820.0000.0000.0000.000
156A156VAL00.04311.9870.0440.0440.0000.0000.0000.000
157A157ARG10.72712.4370.0440.0440.0000.0000.0000.000
158A158THR00.0439.4800.0730.0730.0000.0000.0000.000
159A159TYR00.05012.776-0.053-0.0530.0000.0000.0000.000
160A160THR0-0.03011.1550.0090.0090.0000.0000.0000.000
161A161HIS00.03414.323-0.069-0.0690.0000.0000.0000.000
162A162GLU-1-0.6628.914-0.762-0.7620.0000.0000.0000.000
163A163VAL00.02111.5410.0990.0990.0000.0000.0000.000
164A164VAL0-0.0316.959-0.245-0.2450.0000.0000.0000.000
165A165THR00.0168.9380.0850.0850.0000.0000.0000.000
166A166LEU00.06210.4300.1240.1240.0000.0000.0000.000
167A167TRP0-0.00411.4960.0260.0260.0000.0000.0000.000
168A168TYR0-0.02111.6850.0010.0010.0000.0000.0000.000
169A169ARG10.83712.230-0.215-0.2150.0000.0000.0000.000
170A170ALA00.05515.796-0.044-0.0440.0000.0000.0000.000
171A171PRO00.06719.2230.0000.0000.0000.0000.0000.000
172A172GLU-1-0.70821.5010.1870.1870.0000.0000.0000.000
173A173ILE0-0.03316.416-0.004-0.0040.0000.0000.0000.000
174A174LEU0-0.01518.032-0.006-0.0060.0000.0000.0000.000
175A175LEU00.00721.205-0.020-0.0200.0000.0000.0000.000
176A176GLY00.03922.507-0.003-0.0030.0000.0000.0000.000
177A177CYS00.01823.5020.0040.0040.0000.0000.0000.000
178A178LYS10.87223.105-0.109-0.1090.0000.0000.0000.000
179A179TYR0-0.02724.0530.0120.0120.0000.0000.0000.000
180A180TYR00.01718.493-0.001-0.0010.0000.0000.0000.000
181A181SER00.04620.217-0.001-0.0010.0000.0000.0000.000
182A182THR00.05618.0360.0170.0170.0000.0000.0000.000
183A183ALA00.01918.3540.0180.0180.0000.0000.0000.000
184A184VAL0-0.02615.422-0.011-0.0110.0000.0000.0000.000
185A185ASP-1-0.70913.2830.6330.6330.0000.0000.0000.000
186A186ILE0-0.03815.2030.0030.0030.0000.0000.0000.000
187A187TRP00.02317.341-0.026-0.0260.0000.0000.0000.000
188A188SER00.01313.112-0.002-0.0020.0000.0000.0000.000
189A189LEU0-0.03413.692-0.036-0.0360.0000.0000.0000.000
190A190GLY00.02215.449-0.037-0.0370.0000.0000.0000.000
191A191CYS0-0.04115.045-0.039-0.0390.0000.0000.0000.000
192A192ILE0-0.00211.095-0.056-0.0560.0000.0000.0000.000
193A193PHE00.00514.485-0.051-0.0510.0000.0000.0000.000
194A194ALA00.02417.801-0.027-0.0270.0000.0000.0000.000
195A195GLU-1-0.66112.681-0.359-0.3590.0000.0000.0000.000
196A196MET0-0.01015.439-0.035-0.0350.0000.0000.0000.000
197A197VAL00.03017.673-0.021-0.0210.0000.0000.0000.000
198A198THR0-0.02920.116-0.004-0.0040.0000.0000.0000.000
199A199ARG10.84318.3210.1630.1630.0000.0000.0000.000
200A200ARG10.87316.0670.2020.2020.0000.0000.0000.000
201A201ALA00.00914.3580.0550.0550.0000.0000.0000.000
202A202LEU00.04216.3370.0000.0000.0000.0000.0000.000
203A203PHE00.03618.8830.0030.0030.0000.0000.0000.000
204A204PRO00.05116.1490.0340.0340.0000.0000.0000.000
205A205GLY00.09917.7740.0010.0010.0000.0000.0000.000
206A206ASP-1-0.73018.056-0.168-0.1680.0000.0000.0000.000
207A207SER00.00618.766-0.016-0.0160.0000.0000.0000.000
208A208GLU-1-0.65619.3090.1100.1100.0000.0000.0000.000
209A209ILE00.03420.1840.0030.0030.0000.0000.0000.000
210A210ASP-1-0.73022.103-0.079-0.0790.0000.0000.0000.000
211A211GLN00.04117.975-0.023-0.0230.0000.0000.0000.000
212A212LEU00.00521.0570.0080.0080.0000.0000.0000.000
213A213PHE00.03923.6740.0020.0020.0000.0000.0000.000
214A214ARG10.84222.1720.0740.0740.0000.0000.0000.000
215A215ILE0-0.02120.3020.0000.0000.0000.0000.0000.000
216A216PHE00.00424.4500.0030.0030.0000.0000.0000.000
217A217ARG10.79527.5660.0290.0290.0000.0000.0000.000
218A218THR0-0.01524.453-0.006-0.0060.0000.0000.0000.000
219A219LEU0-0.01025.2560.0010.0010.0000.0000.0000.000
220A220GLY00.03128.8870.0020.0020.0000.0000.0000.000
221A221THR00.03630.4250.0040.0040.0000.0000.0000.000
222A222PRO00.01829.5470.0020.0020.0000.0000.0000.000
223A223ASP-1-0.61031.7190.0370.0370.0000.0000.0000.000
224A224GLU-1-0.59634.9480.0540.0540.0000.0000.0000.000
225A225VAL0-0.00436.6270.0050.0050.0000.0000.0000.000
226A226VAL00.01032.0310.0030.0030.0000.0000.0000.000
227A227TRP0-0.02625.6970.0070.0070.0000.0000.0000.000
228A228PRO00.05932.477-0.002-0.0020.0000.0000.0000.000
229A229GLY00.04931.787-0.003-0.0030.0000.0000.0000.000
230A230VAL0-0.02528.6430.0060.0060.0000.0000.0000.000
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