FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-04-23

All entries: 37539

Number of unique PDB entries: 7791

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FMODB ID: 439ZN

Calculation Name: 4FKL-AB-MD339-md3_30ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: 4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine

ligand 3-letter code: CK2

PDB ID: 4FKL

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-09-02

Reference: K. Takaba et al., Protein-ligand binding affinity prediction of cyclin-dependent kinase-2 inhibitors by dynamically averaged fragment molecular orbital-based interaction energy, J. Comput. Chem., 43, 1362-1371, 2022.

DOI: 10.1002/jcc.26940

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2649
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -18525297.97119
FMO2-HF: Nuclear repulsion 18228152.319476
FMO2-HF: Total energy -297145.651714
FMO2-MP2: Total energy -297958.998801


3D Structure
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-77.217667-60.96325048.975472-19.901700-45.328189-0.000149


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-74.195-53.25954.792-24.662-51.072-0.043
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.042 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.80615.804-0.115-0.1150.0000.0000.0000.000
2A2GLU-1-0.67517.7690.0350.0350.0000.0000.0000.000
3A3ASN00.05016.433-0.033-0.0330.0000.0000.0000.000
4A4PHE00.06011.771-0.045-0.0450.0000.0000.0000.000
5A5GLN00.03313.3580.0390.0390.0000.0000.0000.000
6A6LYS10.82611.0730.1150.1150.0000.0000.0000.000
7A7VAL00.00211.0720.0410.0410.0000.0000.0000.000
8A8GLU-1-0.64110.116-0.793-0.7930.0000.0000.0000.000
9A9LYS10.8467.4541.3661.3660.0000.0000.0000.000
10A10ILE0-0.0392.692-2.272-0.5591.225-0.757-2.1800.009
11A11GLY00.0472.633-6.431-3.9741.580-1.435-2.602-0.005
12A12GLU-1-0.6683.529-1.133-0.3170.183-0.012-0.986-0.001
13A13GLY00.0632.312-6.341-4.7112.804-2.040-2.394-0.021
14A14THR00.0173.2081.3811.0010.0250.582-0.2270.000
15A15TYR0-0.0224.6200.2830.389-0.001-0.005-0.1000.000
16A16GLY00.0105.1790.4620.4620.0000.0000.0000.000
17A17VAL00.0254.010-1.500-1.2560.001-0.043-0.2030.000
18A18VAL0-0.0162.895-3.602-0.1732.248-1.107-4.5710.006
19A19TYR00.0335.715-0.967-0.697-0.001-0.009-0.2600.000
20A20LYS10.8165.8420.2940.2940.0000.0000.0000.000
21A21ALA00.0357.0370.3010.3010.0000.0000.0000.000
22A22ARG10.8729.3810.1590.1590.0000.0000.0000.000
23A23ASN00.00811.9910.0710.0710.0000.0000.0000.000
24A24LYS10.88214.7070.0580.0580.0000.0000.0000.000
25A25LEU0-0.00218.1710.0100.0100.0000.0000.0000.000
26A26THR00.04216.169-0.012-0.0120.0000.0000.0000.000
27A27GLY00.05616.602-0.005-0.0050.0000.0000.0000.000
28A28GLU-1-0.72412.749-0.117-0.1170.0000.0000.0000.000
29A29VAL0-0.0308.894-0.009-0.0090.0000.0000.0000.000
30A30VAL00.0126.9660.0620.0620.0000.0000.0000.000
31A31ALA0-0.0112.707-1.283-0.3800.589-0.432-1.0600.002
32A32LEU0-0.0064.5550.6220.764-0.001-0.012-0.1290.000
33A33LYS10.7841.855-26.599-32.07316.942-4.900-6.5680.057
34A34LYS10.8586.234-0.399-0.3990.0000.0000.0000.000
35A35ILE00.0525.6530.0970.0970.0000.0000.0000.000
36A36ARG10.7559.246-0.138-0.1380.0000.0000.0000.000
37A37LEU00.0429.1580.0470.0470.0000.0000.0000.000
38A38ASP-1-0.66711.0450.0290.0290.0000.0000.0000.000
39A39THR00.02212.713-0.006-0.0060.0000.0000.0000.000
40A40GLU-1-0.65814.416-0.089-0.0890.0000.0000.0000.000
41A41THR0-0.00416.665-0.004-0.0040.0000.0000.0000.000
42A42GLU-1-0.70613.0390.1480.1480.0000.0000.0000.000
43A43GLY00.06514.6700.0680.0680.0000.0000.0000.000
44A44VAL00.00012.8580.0080.0080.0000.0000.0000.000
45A45PRO00.03715.119-0.035-0.0350.0000.0000.0000.000
46A46SER00.06916.5950.0620.0620.0000.0000.0000.000
47A47THR0-0.00917.3930.0530.0530.0000.0000.0000.000
48A48ALA00.01312.3430.0510.0510.0000.0000.0000.000
49A49ILE00.02312.8700.1470.1470.0000.0000.0000.000
50A50ARG10.83514.081-0.331-0.3310.0000.0000.0000.000
51A51GLU-1-0.72211.9350.8600.8600.0000.0000.0000.000
52A52ILE00.0367.7640.0980.0980.0000.0000.0000.000
53A53SER00.00310.813-0.028-0.0280.0000.0000.0000.000
54A54LEU0-0.05113.519-0.058-0.0580.0000.0000.0000.000
55A55LEU00.0047.442-0.047-0.0470.0000.0000.0000.000
56A56LYS10.81411.174-0.495-0.4950.0000.0000.0000.000
57A57GLU-1-0.73812.2930.3690.3690.0000.0000.0000.000
58A58LEU00.03412.703-0.055-0.0550.0000.0000.0000.000
59A59ASN00.04410.1550.2730.2730.0000.0000.0000.000
60A60HIS00.00711.461-0.048-0.0480.0000.0000.0000.000
61A61PRO00.03311.6070.1120.1120.0000.0000.0000.000
62A62ASN0-0.02011.778-0.034-0.0340.0000.0000.0000.000
63A63ILE0-0.0067.5100.1480.1480.0000.0000.0000.000
64A64VAL0-0.0252.851-1.174-0.2520.135-0.193-0.8640.001
65A65LYS10.8195.937-0.345-0.3450.0000.0000.0000.000
66A66LEU00.0006.159-0.180-0.1800.0000.0000.0000.000
67A67LEU00.0257.735-0.132-0.1320.0000.0000.0000.000
68A68ASP-1-0.6999.7650.2490.2490.0000.0000.0000.000
69A69VAL00.0179.8100.1570.1570.0000.0000.0000.000
70A70ILE0-0.00511.684-0.106-0.1060.0000.0000.0000.000
71A71HIS00.06313.8700.0440.0440.0000.0000.0000.000
72A72THR00.04816.096-0.046-0.0460.0000.0000.0000.000
73A73GLU-1-0.59819.0490.1220.1220.0000.0000.0000.000
74A74ASN0-0.02919.9250.0120.0120.0000.0000.0000.000
75A75LYS10.79914.936-0.146-0.1460.0000.0000.0000.000
76A76LEU00.05211.513-0.028-0.0280.0000.0000.0000.000
77A77TYR0-0.03810.0810.0510.0510.0000.0000.0000.000
78A78LEU0-0.0095.6320.0060.0060.0000.0000.0000.000
79A79VAL00.0146.825-0.080-0.0800.0000.0000.0000.000
80A80PHE00.0173.336-1.3920.3330.332-0.535-1.522-0.006
81A81GLU-1-0.6545.0260.3260.3260.0000.0000.0000.000
82A82PHE0-0.0143.529-1.971-1.4020.021-0.204-0.386-0.001
83A83LEU00.0082.555-0.4360.2572.429-0.768-2.3540.008
84A84HIS0-0.0131.813-10.935-13.27511.948-4.809-4.800-0.042
85A85GLN00.0783.560-2.675-2.1450.0400.180-0.750-0.001
86A86ASP-1-0.6833.682-4.581-3.6370.021-0.258-0.707-0.001
87A87LEU00.0685.1140.1080.134-0.001-0.005-0.0210.000
88A88LYS10.7907.8810.9740.9740.0000.0000.0000.000
89A89LYS10.9087.3311.0841.0840.0000.0000.0000.000
90A90PHE0-0.0049.1970.1580.1580.0000.0000.0000.000
91A91MET00.00011.1330.1350.1350.0000.0000.0000.000
92A92ASP-1-0.68412.055-0.628-0.6280.0000.0000.0000.000
93A93ALA00.01412.6760.0640.0640.0000.0000.0000.000
94A94SER00.01014.4790.0690.0690.0000.0000.0000.000
95A95ALA0-0.00517.1400.0380.0380.0000.0000.0000.000
96A96LEU0-0.03819.4050.0210.0210.0000.0000.0000.000
97A97THR00.01619.7740.0100.0100.0000.0000.0000.000
98A98GLY00.08320.7470.0250.0250.0000.0000.0000.000
99A99ILE0-0.01115.768-0.010-0.0100.0000.0000.0000.000
100A100PRO00.05519.7750.0130.0130.0000.0000.0000.000
101A101LEU00.05621.2010.0120.0120.0000.0000.0000.000
102A102PRO0-0.00922.5500.0160.0160.0000.0000.0000.000
103A103LEU0-0.00216.6750.0240.0240.0000.0000.0000.000
104A104ILE0-0.00517.9200.0280.0280.0000.0000.0000.000
105A105LYS10.81718.683-0.033-0.0330.0000.0000.0000.000
106A106SER00.01618.4550.0460.0460.0000.0000.0000.000
107A107TYR00.01611.6520.0700.0700.0000.0000.0000.000
108A108LEU0-0.00415.7210.0630.0630.0000.0000.0000.000
109A109PHE0-0.00517.8810.0380.0380.0000.0000.0000.000
110A110GLN0-0.01714.6610.0730.0730.0000.0000.0000.000
111A111LEU00.01911.4910.1160.1160.0000.0000.0000.000
112A112LEU0-0.00214.3830.0730.0730.0000.0000.0000.000
113A113GLN00.01616.4730.0570.0570.0000.0000.0000.000
114A114GLY00.02912.4980.0140.0140.0000.0000.0000.000
115A115LEU00.00012.1590.0640.0640.0000.0000.0000.000
116A116ALA00.02114.401-0.019-0.0190.0000.0000.0000.000
117A117PHE00.02813.600-0.036-0.0360.0000.0000.0000.000
118A118CYS00.00512.4230.0250.0250.0000.0000.0000.000
119A119HIS00.05714.935-0.081-0.0810.0000.0000.0000.000
120A120SER00.00818.286-0.067-0.0670.0000.0000.0000.000
121A121HIS00.05916.806-0.076-0.0760.0000.0000.0000.000
122A122ARG10.87619.066-0.256-0.2560.0000.0000.0000.000
123A123VAL00.01012.9680.0000.0000.0000.0000.0000.000
124A124LEU00.01414.274-0.007-0.0070.0000.0000.0000.000
125A125HIS0-0.0626.1090.2590.2590.0000.0000.0000.000
126A126ARG10.85810.918-0.172-0.1720.0000.0000.0000.000
127A127ASP-1-0.6836.674-0.513-0.5130.0000.0000.0000.000
128A128LEU00.0137.659-0.140-0.1400.0000.0000.0000.000
129A129LYS10.8245.2051.1121.1120.0000.0000.0000.000
130A130PRO00.0397.7270.0730.0730.0000.0000.0000.000
131A131GLN00.0325.0890.3610.3610.0000.0000.0000.000
132A132ASN0-0.0453.575-2.341-0.9200.120-0.392-1.149-0.001
133A133LEU00.0084.5901.0001.087-0.001-0.009-0.0770.000
134A134LEU00.0072.592-4.384-1.9585.796-1.295-6.9280.009
135A135ILE00.0175.9430.0680.118-0.001-0.003-0.0470.000
136A136ASN00.0706.8460.1870.1870.0000.0000.0000.000
137A137THR00.0249.559-0.045-0.0450.0000.0000.0000.000
138A138GLU-1-0.60212.3320.2500.2500.0000.0000.0000.000
139A139GLY00.00913.819-0.030-0.0300.0000.0000.0000.000
140A140ALA0-0.02612.6670.0050.0050.0000.0000.0000.000
141A141ILE00.0139.3930.0060.0060.0000.0000.0000.000
142A142LYS10.8317.426-1.075-1.0750.0000.0000.0000.000
143A143LEU0-0.0217.6370.1460.1460.0000.0000.0000.000
144A144ALA00.0512.661-0.7450.0560.382-0.204-0.9790.000
145A145ASP-1-0.6982.544-0.9021.3052.157-1.178-3.186-0.012
146A146PHE00.0384.405-1.729-1.3950.003-0.059-0.2780.000
147A147GLY00.0547.7180.1140.1140.0000.0000.0000.000
148A148LEU00.0027.995-0.012-0.0120.0000.0000.0000.000
149A149ALA0-0.01510.315-0.153-0.1530.0000.0000.0000.000
150A150ARG10.84411.996-0.781-0.7810.0000.0000.0000.000
151A151ALA00.00713.874-0.057-0.0570.0000.0000.0000.000
152A152PHE00.02311.336-0.048-0.0480.0000.0000.0000.000
153A153GLY00.02815.515-0.058-0.0580.0000.0000.0000.000
154A154VAL00.01814.2950.0530.0530.0000.0000.0000.000
155A155PRO0-0.01610.019-0.022-0.0220.0000.0000.0000.000
156A156VAL00.02912.880-0.024-0.0240.0000.0000.0000.000
157A157ARG10.84113.1740.0490.0490.0000.0000.0000.000
158A158THR00.0217.676-0.026-0.0260.0000.0000.0000.000
159A159TYR00.0438.813-0.004-0.0040.0000.0000.0000.000
160A160THR0-0.0128.8990.0670.0670.0000.0000.0000.000
161A161HIS00.00412.036-0.012-0.0120.0000.0000.0000.000
162A162GLU-1-0.66010.020-1.032-1.0320.0000.0000.0000.000
163A163VAL00.04813.0100.0660.0660.0000.0000.0000.000
164A164VAL0-0.02710.378-0.145-0.1450.0000.0000.0000.000
165A165THR0-0.0139.5560.0410.0410.0000.0000.0000.000
166A166LEU0-0.04411.8760.0800.0800.0000.0000.0000.000
167A167TRP0-0.01015.0490.0190.0190.0000.0000.0000.000
168A168TYR0-0.04312.275-0.010-0.0100.0000.0000.0000.000
169A169ARG10.79314.5830.1630.1630.0000.0000.0000.000
170A170ALA00.02616.316-0.008-0.0080.0000.0000.0000.000
171A171PRO00.02319.090-0.004-0.0040.0000.0000.0000.000
172A172GLU-1-0.71521.5390.1000.1000.0000.0000.0000.000
173A173ILE00.00216.785-0.001-0.0010.0000.0000.0000.000
174A174LEU0-0.02219.295-0.011-0.0110.0000.0000.0000.000
175A175LEU0-0.01621.997-0.005-0.0050.0000.0000.0000.000
176A176GLY00.07824.183-0.001-0.0010.0000.0000.0000.000
177A177CYS0-0.03423.6020.0100.0100.0000.0000.0000.000
178A178LYS10.83423.426-0.108-0.1080.0000.0000.0000.000
179A179TYR0-0.01424.1360.0160.0160.0000.0000.0000.000
180A180TYR00.03517.757-0.008-0.0080.0000.0000.0000.000
181A181SER00.01220.8210.0150.0150.0000.0000.0000.000
182A182THR00.04717.106-0.015-0.0150.0000.0000.0000.000
183A183ALA0-0.01017.6520.0020.0020.0000.0000.0000.000
184A184VAL0-0.01715.523-0.021-0.0210.0000.0000.0000.000
185A185ASP-1-0.75512.6500.3780.3780.0000.0000.0000.000
186A186ILE0-0.05514.8150.0010.0010.0000.0000.0000.000
187A187TRP00.04317.560-0.007-0.0070.0000.0000.0000.000
188A188SER00.02512.849-0.011-0.0110.0000.0000.0000.000
189A189LEU00.01414.153-0.047-0.0470.0000.0000.0000.000
190A190GLY00.06315.422-0.024-0.0240.0000.0000.0000.000
191A191CYS0-0.07016.191-0.027-0.0270.0000.0000.0000.000
192A192ILE0-0.00911.331-0.046-0.0460.0000.0000.0000.000
193A193PHE0-0.04015.370-0.029-0.0290.0000.0000.0000.000
194A194ALA00.07718.584-0.016-0.0160.0000.0000.0000.000
195A195GLU-1-0.72215.275-0.407-0.4070.0000.0000.0000.000
196A196MET00.02515.163-0.031-0.0310.0000.0000.0000.000
197A197VAL00.00917.6980.0010.0010.0000.0000.0000.000
198A198THR00.00820.383-0.007-0.0070.0000.0000.0000.000
199A199ARG10.76117.0830.1620.1620.0000.0000.0000.000
200A200ARG10.83218.4810.1710.1710.0000.0000.0000.000
201A201ALA00.01617.8460.0340.0340.0000.0000.0000.000
202A202LEU00.01518.7810.0200.0200.0000.0000.0000.000
203A203PHE0-0.01519.7910.0220.0220.0000.0000.0000.000
204A204PRO00.07119.743-0.009-0.0090.0000.0000.0000.000
205A205GLY00.03720.5110.0090.0090.0000.0000.0000.000
206A206ASP-1-0.65920.733-0.186-0.1860.0000.0000.0000.000
207A207SER0-0.03521.371-0.010-0.0100.0000.0000.0000.000
208A208GLU-1-0.63919.069-0.079-0.0790.0000.0000.0000.000
209A209ILE0-0.00921.4880.0160.0160.0000.0000.0000.000
210A210ASP-1-0.71324.100-0.105-0.1050.0000.0000.0000.000
211A211GLN00.02419.408-0.012-0.0120.0000.0000.0000.000
212A212LEU00.05222.6050.0030.0030.0000.0000.0000.000
213A213PHE00.02024.9000.0060.0060.0000.0000.0000.000
214A214ARG10.74923.1790.1170.1170.0000.0000.0000.000
215A215ILE00.00422.027-0.001-0.0010.0000.0000.0000.000
216A216PHE00.01425.3680.0030.0030.0000.0000.0000.000
217A217ARG10.84727.5750.0880.0880.0000.0000.0000.000
218A218THR00.00726.6450.0040.0040.0000.0000.0000.000
219A219LEU00.01925.5850.0060.0060.0000.0000.0000.000
220A220GLY00.05528.9230.0100.0100.0000.0000.0000.000
221A221THR00.00930.6420.0010.0010.0000.0000.0000.000
222A222PRO0-0.01829.2760.0050.0050.0000.0000.0000.000
223A223ASP-1-0.63832.4040.0070.0070.0000.0000.0000.000
224A224GLU-1-0.70034.2740.0380.0380.0000.0000.0000.000
225A225VAL0-0.02536.0830.0050.0050.0000.0000.0000.000
226A226VAL0-0.01931.9250.0040.0040.0000.0000.0000.000
227A227TRP0-0.02226.6040.0030.0030.0000.0000.0000.000
228A228PRO00.08031.954-0.004-0.0040.0000.0000.0000.000
229A229GLY00.02030.816-0.002-0.0020.0000.0000.0000.000
230A230VAL00.02029.7700.0000.0000.0000.0000.0000.000
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