FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-04-23

All entries: 37539

Number of unique PDB entries: 7791

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FMODB ID: 43JQN

Calculation Name: 4FKW-AB-MD341-md5_30ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: 2-methylpropyl (3z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1h-indole-5-carboxylate

ligand 3-letter code: 62K

PDB ID: 4FKW

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-09-12

Reference: K. Takaba et al., Protein-Ligand Binding Affinity Prediction of CDK2 Inhibitors by Dynamically Averaged FMO-based Interaction Energy, To be published.

DOI:

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2639
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -18603916.806059
FMO2-HF: Nuclear repulsion 18306772.37884
FMO2-HF: Total energy -297144.427219
FMO2-MP2: Total energy -297958.390232


3D Structure
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-119.547911-80.42806760.801832-28.641166-71.280511-0.019791


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-165.443-131.921112.653-53.33-92.835-0.024
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.022 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.77013.5560.7070.7070.0000.0000.0000.000
2A2GLU-1-0.64417.221-0.692-0.6920.0000.0000.0000.000
3A3ASN00.05614.6480.0250.0250.0000.0000.0000.000
4A4PHE00.05011.078-0.029-0.0290.0000.0000.0000.000
5A5GLN00.05511.625-0.340-0.3400.0000.0000.0000.000
6A6LYS10.87211.2631.5171.5170.0000.0000.0000.000
7A7VAL0-0.0089.5070.2910.2910.0000.0000.0000.000
8A8GLU-1-0.6714.265-5.437-5.171-0.001-0.050-0.2160.000
9A9LYS10.8536.4833.7623.7620.0000.0000.0000.000
10A10ILE0-0.0372.636-7.443-2.2722.041-1.531-5.6810.014
11A11GLY00.0622.644-4.167-2.6430.803-0.730-1.597-0.001
12A12GLU-1-0.7012.387-3.571-3.9032.651-0.124-2.195-0.002
13A13GLY00.0402.403-2.920-2.1352.411-0.698-2.498-0.011
14A14THR00.0163.3490.7060.5020.0170.384-0.1960.000
15A15TYR0-0.0235.4280.1540.1540.0000.0000.0000.000
16A16GLY00.0325.2970.4150.4150.0000.0000.0000.000
17A17VAL0-0.0663.981-1.575-1.2990.001-0.033-0.2430.000
18A18VAL00.0022.868-1.9241.2011.194-0.806-3.5130.008
19A19TYR00.0175.225-1.523-1.319-0.001-0.006-0.1970.000
20A20LYS10.8424.6382.0272.353-0.001-0.016-0.3100.000
21A21ALA00.0316.8310.4100.4100.0000.0000.0000.000
22A22ARG10.8459.1810.9110.9110.0000.0000.0000.000
23A23ASN00.00311.3470.1110.1110.0000.0000.0000.000
24A24LYS10.84712.7891.0461.0460.0000.0000.0000.000
25A25LEU0-0.01315.9340.1040.1040.0000.0000.0000.000
26A26THR0-0.01614.2540.0610.0610.0000.0000.0000.000
27A27GLY00.12515.6420.1020.1020.0000.0000.0000.000
28A28GLU-1-0.69010.464-1.211-1.2110.0000.0000.0000.000
29A29VAL00.0186.257-0.157-0.1570.0000.0000.0000.000
30A30VAL00.0065.9590.1040.1040.0000.0000.0000.000
31A31ALA00.0013.009-0.9190.0730.205-0.309-0.8870.001
32A32LEU0-0.0384.9210.1470.337-0.001-0.006-0.1830.000
33A33LYS10.8261.774-23.871-27.74610.428-3.207-3.3470.037
34A34LYS10.8017.0800.4870.4870.0000.0000.0000.000
35A35ILE00.0496.9710.1250.1250.0000.0000.0000.000
36A36ARG10.8809.2850.2490.2490.0000.0000.0000.000
37A37LEU0-0.01211.8610.1150.1150.0000.0000.0000.000
38A38ASP-1-0.63815.217-0.241-0.2410.0000.0000.0000.000
39A39THR00.03618.5640.0020.0020.0000.0000.0000.000
40A40GLU-1-0.61815.336-0.544-0.5440.0000.0000.0000.000
41A41THR0-0.03618.5140.0010.0010.0000.0000.0000.000
42A42GLU-1-0.62220.956-0.247-0.2470.0000.0000.0000.000
43A43GLY00.04221.6200.0100.0100.0000.0000.0000.000
44A44VAL0-0.04317.3450.0050.0050.0000.0000.0000.000
45A45PRO00.07820.012-0.013-0.0130.0000.0000.0000.000
46A46SER00.08219.7410.0140.0140.0000.0000.0000.000
47A47THR00.01419.3470.0090.0090.0000.0000.0000.000
48A48ALA0-0.02516.5450.0370.0370.0000.0000.0000.000
49A49ILE0-0.00614.8390.0630.0630.0000.0000.0000.000
50A50ARG10.76215.2280.0010.0010.0000.0000.0000.000
51A51GLU-1-0.67012.0320.2710.2710.0000.0000.0000.000
52A52ILE00.0289.5560.0450.0450.0000.0000.0000.000
53A53SER0-0.00611.787-0.173-0.1730.0000.0000.0000.000
54A54LEU00.03214.674-0.070-0.0700.0000.0000.0000.000
55A55LEU00.0177.592-0.047-0.0470.0000.0000.0000.000
56A56LYS10.87411.9180.4690.4690.0000.0000.0000.000
57A57GLU-1-0.64613.467-0.310-0.3100.0000.0000.0000.000
58A58LEU0-0.05211.1760.0180.0180.0000.0000.0000.000
59A59ASN00.08312.014-0.154-0.1540.0000.0000.0000.000
60A60HIS00.02811.8340.0810.0810.0000.0000.0000.000
61A61PRO00.04011.414-0.150-0.1500.0000.0000.0000.000
62A62ASN00.00111.533-0.066-0.0660.0000.0000.0000.000
63A63ILE0-0.0257.6740.1720.1720.0000.0000.0000.000
64A64VAL00.0282.557-2.132-0.6981.341-0.631-2.1450.005
65A65LYS10.7765.6202.2922.2920.0000.0000.0000.000
66A66LEU00.0445.364-1.388-1.3880.0000.0000.0000.000
67A67LEU0-0.0067.0290.3320.3320.0000.0000.0000.000
68A68ASP-1-0.7029.074-0.501-0.5010.0000.0000.0000.000
69A69VAL00.00910.080-0.027-0.0270.0000.0000.0000.000
70A70ILE0-0.05512.6270.0060.0060.0000.0000.0000.000
71A71HIS00.10115.3670.0390.0390.0000.0000.0000.000
72A72THR00.01718.2560.0260.0260.0000.0000.0000.000
73A73GLU-1-0.67820.393-0.499-0.4990.0000.0000.0000.000
74A74ASN00.05021.6870.0070.0070.0000.0000.0000.000
75A75LYS10.85217.6930.5520.5520.0000.0000.0000.000
76A76LEU00.05313.060-0.044-0.0440.0000.0000.0000.000
77A77TYR0-0.02811.4210.0170.0170.0000.0000.0000.000
78A78LEU0-0.0176.842-0.010-0.0100.0000.0000.0000.000
79A79VAL00.0086.891-0.083-0.0830.0000.0000.0000.000
80A80PHE00.0402.472-2.003-0.0681.078-0.738-2.275-0.004
81A81GLU-1-0.6803.523-2.765-1.9310.003-0.241-0.596-0.001
82A82PHE00.0032.148-19.046-13.0916.447-4.830-7.571-0.028
83A83LEU00.0141.781-6.491-11.07013.345-3.744-5.0210.025
84A84HIS0-0.0152.520-5.955-3.8241.593-1.101-2.623-0.011
85A85GLN00.0623.086-1.6132.2682.011-1.656-4.235-0.001
86A86ASP-1-0.6692.746-15.518-11.1221.260-1.511-4.144-0.017
87A87LEU00.0434.1911.8742.1800.003-0.029-0.2800.000
88A88LYS10.8316.1660.4650.4650.0000.0000.0000.000
89A89LYS10.8382.525-18.237-16.3103.460-1.178-4.2090.018
90A90PHE00.0364.885-0.433-0.318-0.001-0.005-0.1100.000
91A91MET00.0077.962-0.319-0.3190.0000.0000.0000.000
92A92ASP-1-0.6657.0383.5743.5740.0000.0000.0000.000
93A93ALA0-0.0827.445-0.125-0.1250.0000.0000.0000.000
94A94SER00.0079.211-0.484-0.4840.0000.0000.0000.000
95A95ALA00.01312.315-0.368-0.3680.0000.0000.0000.000
96A96LEU00.02014.224-0.251-0.2510.0000.0000.0000.000
97A97THR00.00715.047-0.142-0.1420.0000.0000.0000.000
98A98GLY00.06116.039-0.187-0.1870.0000.0000.0000.000
99A99ILE0-0.01013.0350.1390.1390.0000.0000.0000.000
100A100PRO00.02517.427-0.110-0.1100.0000.0000.0000.000
101A101LEU00.05020.166-0.010-0.0100.0000.0000.0000.000
102A102PRO00.00421.943-0.023-0.0230.0000.0000.0000.000
103A103LEU00.02915.084-0.048-0.0480.0000.0000.0000.000
104A104ILE00.02217.382-0.066-0.0660.0000.0000.0000.000
105A105LYS10.82818.477-0.297-0.2970.0000.0000.0000.000
106A106SER0-0.00418.517-0.082-0.0820.0000.0000.0000.000
107A107TYR0-0.01112.297-0.152-0.1520.0000.0000.0000.000
108A108LEU00.00016.310-0.087-0.0870.0000.0000.0000.000
109A109PHE00.01417.898-0.043-0.0430.0000.0000.0000.000
110A110GLN0-0.00915.624-0.117-0.1170.0000.0000.0000.000
111A111LEU0-0.00311.505-0.060-0.0600.0000.0000.0000.000
112A112LEU0-0.03615.119-0.013-0.0130.0000.0000.0000.000
113A113GLN00.06717.919-0.042-0.0420.0000.0000.0000.000
114A114GLY00.02614.014-0.033-0.0330.0000.0000.0000.000
115A115LEU0-0.03512.5830.0210.0210.0000.0000.0000.000
116A116ALA00.03915.1510.0160.0160.0000.0000.0000.000
117A117PHE00.02215.1030.0100.0100.0000.0000.0000.000
118A118CYS0-0.00312.0440.0000.0000.0000.0000.0000.000
119A119HIS00.02414.5260.0040.0040.0000.0000.0000.000
120A120SER00.04017.7880.0020.0020.0000.0000.0000.000
121A121HIS0-0.02416.9550.0030.0030.0000.0000.0000.000
122A122ARG10.82318.8080.0280.0280.0000.0000.0000.000
123A123VAL00.06412.5680.0170.0170.0000.0000.0000.000
124A124LEU0-0.04413.816-0.009-0.0090.0000.0000.0000.000
125A125HIS00.0055.418-0.004-0.0040.0000.0000.0000.000
126A126ARG10.83110.6470.0360.0360.0000.0000.0000.000
127A127ASP-1-0.6525.870-0.658-0.6580.0000.0000.0000.000
128A128LEU0-0.0215.890-0.125-0.1250.0000.0000.0000.000
129A129LYS10.8333.6990.9171.2320.005-0.037-0.2840.000
130A130PRO00.0435.535-0.225-0.2250.0000.0000.0000.000
131A131GLN00.0542.474-0.7591.0521.336-0.734-2.414-0.004
132A132ASN0-0.0682.176-5.107-2.9054.478-2.169-4.511-0.023
133A133LEU00.0133.8050.2930.7740.023-0.052-0.4520.000
134A134LEU0-0.0052.710-4.491-1.0153.150-1.146-5.4800.011
135A135ILE00.0236.2840.3900.3900.0000.0000.0000.000
136A136ASN00.0296.4500.0300.0300.0000.0000.0000.000
137A137THR0-0.0048.5730.1760.1760.0000.0000.0000.000
138A138GLU-1-0.64510.806-0.151-0.1510.0000.0000.0000.000
139A139GLY00.08013.070-0.012-0.0120.0000.0000.0000.000
140A140ALA00.00212.2720.0050.0050.0000.0000.0000.000
141A141ILE0-0.01810.2790.0070.0070.0000.0000.0000.000
142A142LYS10.7926.9451.6831.6830.0000.0000.0000.000
143A143LEU00.0207.763-0.020-0.0200.0000.0000.0000.000
144A144ALA00.0553.365-1.264-0.2740.108-0.376-0.7210.002
145A145ASP-1-0.7202.2611.6743.9861.395-1.141-2.5670.000
146A146PHE00.0434.373-1.319-1.1270.001-0.063-0.1310.000
147A147GLY00.0517.8530.3810.3810.0000.0000.0000.000
148A148LEU0-0.0029.915-0.203-0.2030.0000.0000.0000.000
149A149ALA00.0629.170-0.134-0.1340.0000.0000.0000.000
150A150ARG10.81011.290-0.318-0.3180.0000.0000.0000.000
151A151ALA00.03013.914-0.043-0.0430.0000.0000.0000.000
152A152PHE00.04113.683-0.036-0.0360.0000.0000.0000.000
153A153GLY00.09114.192-0.036-0.0360.0000.0000.0000.000
154A154VAL0-0.02412.2800.0180.0180.0000.0000.0000.000
155A155PRO00.06310.360-0.023-0.0230.0000.0000.0000.000
156A156VAL0-0.00611.217-0.069-0.0690.0000.0000.0000.000
157A157ARG10.76910.9680.5380.5380.0000.0000.0000.000
158A158THR00.0315.9300.1960.1960.0000.0000.0000.000
159A159TYR0-0.0247.0760.1770.1770.0000.0000.0000.000
160A160THR0-0.0437.802-0.023-0.0230.0000.0000.0000.000
161A161HIS00.0689.9090.0000.0000.0000.0000.0000.000
162A162GLU-1-0.7228.762-1.881-1.8810.0000.0000.0000.000
163A163VAL0-0.03210.4610.0060.0060.0000.0000.0000.000
164A164VAL00.0087.212-0.194-0.1940.0000.0000.0000.000
165A165THR0-0.0159.5320.1330.1330.0000.0000.0000.000
166A166LEU0-0.02011.038-0.015-0.0150.0000.0000.0000.000
167A167TRP0-0.02012.0250.0460.0460.0000.0000.0000.000
168A168TYR00.0159.0290.1240.1240.0000.0000.0000.000
169A169ARG10.82311.5410.2690.2690.0000.0000.0000.000
170A170ALA00.02714.3980.0190.0190.0000.0000.0000.000
171A171PRO00.09517.414-0.008-0.0080.0000.0000.0000.000
172A172GLU-1-0.74320.192-0.017-0.0170.0000.0000.0000.000
173A173ILE0-0.01815.4370.0000.0000.0000.0000.0000.000
174A174LEU0-0.03617.248-0.018-0.0180.0000.0000.0000.000
175A175LEU0-0.00920.7040.0010.0010.0000.0000.0000.000
176A176GLY00.09822.5060.0030.0030.0000.0000.0000.000
177A177CYS0-0.02123.0490.0000.0000.0000.0000.0000.000
178A178LYS10.89622.6940.0410.0410.0000.0000.0000.000
179A179TYR0-0.00723.5450.0030.0030.0000.0000.0000.000
180A180TYR00.00317.370-0.006-0.0060.0000.0000.0000.000
181A181SER00.07920.4770.0040.0040.0000.0000.0000.000
182A182THR00.01916.9600.0010.0010.0000.0000.0000.000
183A183ALA0-0.05017.2430.0010.0010.0000.0000.0000.000
184A184VAL0-0.01314.547-0.002-0.0020.0000.0000.0000.000
185A185ASP-1-0.67312.7750.0750.0750.0000.0000.0000.000
186A186ILE0-0.07214.123-0.012-0.0120.0000.0000.0000.000
187A187TRP00.07115.8230.0160.0160.0000.0000.0000.000
188A188SER0-0.00711.4590.0120.0120.0000.0000.0000.000
189A189LEU0-0.03213.123-0.013-0.0130.0000.0000.0000.000
190A190GLY00.03414.1720.0310.0310.0000.0000.0000.000
191A191CYS0-0.04513.9930.0310.0310.0000.0000.0000.000
192A192ILE0-0.0119.4390.0370.0370.0000.0000.0000.000
193A193PHE0-0.01213.3610.0890.0890.0000.0000.0000.000
194A194ALA00.05916.7390.0570.0570.0000.0000.0000.000
195A195GLU-1-0.67412.3840.3480.3480.0000.0000.0000.000
196A196MET0-0.01214.1200.1560.1560.0000.0000.0000.000
197A197VAL0-0.02616.2630.0990.0990.0000.0000.0000.000
198A198THR0-0.00618.353-0.011-0.0110.0000.0000.0000.000
199A199ARG10.79513.214-1.162-1.1620.0000.0000.0000.000
200A200ARG10.82015.896-0.453-0.4530.0000.0000.0000.000
201A201ALA00.03314.635-0.029-0.0290.0000.0000.0000.000
202A202LEU00.03516.3000.0120.0120.0000.0000.0000.000
203A203PHE00.02717.5530.0070.0070.0000.0000.0000.000
204A204PRO00.06016.827-0.050-0.0500.0000.0000.0000.000
205A205GLY00.05917.8980.0040.0040.0000.0000.0000.000
206A206ASP-1-0.72217.323-0.213-0.2130.0000.0000.0000.000
207A207SER00.04318.534-0.030-0.0300.0000.0000.0000.000
208A208GLU-1-0.66119.151-0.099-0.0990.0000.0000.0000.000
209A209ILE0-0.00120.1410.0150.0150.0000.0000.0000.000
210A210ASP-1-0.64921.816-0.025-0.0250.0000.0000.0000.000
211A211GLN0-0.00316.2870.0400.0400.0000.0000.0000.000
212A212LEU0-0.02420.4740.0150.0150.0000.0000.0000.000
213A213PHE00.02122.8490.0140.0140.0000.0000.0000.000
214A214ARG10.80220.739-0.039-0.0390.0000.0000.0000.000
215A215ILE00.02119.5820.0210.0210.0000.0000.0000.000
216A216PHE00.05223.2320.0140.0140.0000.0000.0000.000
217A217ARG10.81725.219-0.029-0.0290.0000.0000.0000.000
218A218THR0-0.01023.5250.0200.0200.0000.0000.0000.000
219A219LEU0-0.03023.5950.0150.0150.0000.0000.0000.000
220A220GLY00.06527.0870.0000.0000.0000.0000.0000.000
221A221THR0-0.07428.480-0.004-0.0040.0000.0000.0000.000
222A222PRO00.03127.4770.0050.0050.0000.0000.0000.000
223A223ASP-1-0.62730.1240.0180.0180.0000.0000.0000.000
224A224GLU-1-0.70132.8170.0090.0090.0000.0000.0000.000
225A225VAL0-0.07635.1110.0000.0000.0000.0000.0000.000
226A226VAL00.04130.8120.0030.0030.0000.0000.0000.000
227A227TRP0-0.02525.017-0.001-0.0010.0000.0000.0000.000
228A228PRO00.01730.893-0.003-0.0030.0000.0000.0000.000
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