FMO DATABASE

FMODB ID: 6NK2Z

Calculation Name: 6XKI-A-MD433-85ns

Preferred Name:

Target Type:

Ligand Name: (3s,6z,8e,11s,15r)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11-dimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione

ligand 3-letter code: V6D

PDB ID: 6XKI

Chain ID: A

ChEMBL ID:

UniProt ID:

Base Structure: MD

Registration Date: 2023-09-19

Reference: Hironori Saito, Yuma Handa, Mingming Chen, Tilman Schneider-Poetsch, Yuichi Shichino, Mari Takahashi, Daniel Romo, Minoru Yoshida, Alois F�rstner, Takuhiro Ito, Kaori Fukuzawa, Shintaro Iwasaki Pateamine A mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs, To be published.

DOI:

IFIE MAP

IFIE Diagram

Modeling method

Optimization	AMBER14SB
Restraint	OptAll(Heavy atoms were optimized with constraints.)
Protonation	BaseStructure_original
Complement	MOE:Structure Preparation
Water	No
Procedure	Manual calculation

FMO calculation

FMO method	FMO2-MP2/6-31G(d)
Fragmentation	Manual
Number of fragment	400
LigandCharge	V6D=1
Software	ABINIT-MP - Open Ver. 1 Rev. 23Q2 / 20200603(SMP)

Total energy (hartree)

FMO2-HF: Electronic energy	-7645840.858348
FMO2-HF: Nuclear repulsion	7476486.977577
FMO2-HF: Total energy	-169353.880771
FMO2-MP2: Total energy	-169831.969558

3D Structure

Snapshot

Ligand structure

V6D

Ligand Interaction

Ligand binding energy (frag 399-400 : frag 1-398)

IFIE [kcal/mol]	PIEDA [kcal/mol]				Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level.	ESElectro static interaction energy.	EXExchange-repulsion energy.	CT+mixCharge transfer and mixing terms energy.	DI(MP2)Dispersion energy.	q(I=>J)Charge transfer value from I to J fragments.
-286.442491	-236.694583	44.184352	-20.694070	-73.238192	0.065408

Interactive mode: IFIE and PIEDA for fragment #399(:389:V6D)

Summations of interaction energy for fragment #399(:389:V6D)

IFIE [kcal/mol]	PIEDA [kcal/mol]				Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level.	ESElectro static interaction energy.	EXExchange-repulsion energy.	CT+mixCharge transfer and mixing terms energy.	DI(MP2)Dispersion energy.	q(I=>J)Charge transfer value from I to J fragments.
-231.185	-216.563	8.438	-4.672	-18.384	-0.01

Interaction energy analysis for fragmet #399(:389:V6D)

Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE

Single fragment	Multi fragments
	Fragment list

Charge [e] FCHARGE : 1 / q_Mulliken : 1.030 / q_NPA : 1.018

Distance from base fragment(s) [Å]

Dist

Interaction energy by IFIE and PIEDA
[kcal/mol]

| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >

Fragment charge [e]

FCHARGE q_Mulliken
q_NPA q(I=>J)

Residue

Res # RES

Sort

Graph Options

X Axis Label
Y Axis Max Y Axis Min
Display ES EX CT+mix DI(MP2)

frag_NumFragment number.	Res #Residue number.	RES3-letter code of amino acid residue, ligand and solvent molecule.	FCHARGEFormal charge [e].	q_MullikenFragment charge evaluated by Mulliken charge [e].	q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e].	DISTDistance from Ligand [Å].	TotalIFIE at MP2 level [kcal/mol].	ESElectro static interaction energy by PIEDA [kcal/mol].	EXExchange-repulsion energy by PIEDA [kcal/mol].	CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol].	DI(MP2)Dispersion energy by PIEDA [kcal/mol].	q(I=>J)Charge transfer value from I to J fragmens [e].
82	82	ARG	1	0.866	0.915	2.577	46.564	47.301	0.676	-0.293	-1.119	0.002
132	132	GLY	0	0.035	0.033	2.687	0.519	0.027	0.184	0.167	0.142	0.000
133	133	ARG	1	0.841	0.877	3.537	31.876	31.976	0.005	0.096	-0.201	0.000
135	135	PHE	0	-0.009	-0.010	5.349	2.214	2.250	-0.001	-0.002	-0.033	0.000
167	167	GLN	0	0.017	0.012	5.076	-1.745	-1.662	-0.001	-0.005	-0.077	0.000
254	254	ARG	1	0.958	0.954	4.208	40.023	40.152	-0.001	-0.005	-0.124	0.000
277	277	ASP	-1	-1.035	-1.003	4.420	-48.055	-47.816	-0.001	-0.018	-0.219	0.000
390	384	G	-1	-0.483	-0.579	4.325	-35.837	-35.498	-0.001	-0.031	-0.307	0.000
391	385	G	0	-0.311	-0.277	2.724	-13.537	-6.095	2.886	-2.383	-7.945	-0.017
392	385	G	-1	-0.475	-0.588	2.222	-43.160	-39.854	3.232	-2.412	-4.126	0.002
393	386	G	0	-0.369	-0.321	2.959	-5.398	-3.366	1.332	-0.794	-2.569	0.005
394	386	G	-1	-0.577	-0.656	3.074	-46.168	-45.965	0.129	1.019	-1.350	-0.002
395	387	G	0	-0.357	-0.305	4.996	-7.048	-6.690	0.000	-0.007	-0.351	0.000
398	388	G	0	0.351	0.301	3.975	0.076	0.186	-0.001	-0.004	-0.105	0.000
1	1	GLU	0	-0.136	-0.087	38.006	0.581	0.581	0.000	0.000	0.000	0.000
2	2	ILE	0	0.018	0.014	37.836	-0.232	-0.232	0.000	0.000	0.000	0.000
3	3	VAL	0	0.062	0.039	38.285	0.146	0.146	0.000	0.000	0.000	0.000
4	4	ASP	-1	-0.924	-0.965	38.409	-7.292	-7.292	0.000	0.000	0.000	0.000
5	5	SER	0	0.004	-0.052	39.927	-0.014	-0.014	0.000	0.000	0.000	0.000
6	6	PHE	0	0.023	-0.008	32.920	-0.058	-0.058	0.000	0.000	0.000	0.000
7	7	ASP	-1	-0.838	-0.891	37.717	-7.132	-7.132	0.000	0.000	0.000	0.000
8	8	ASP	-1	-0.863	-0.919	40.575	-6.756	-6.756	0.000	0.000	0.000	0.000
9	9	MET	0	-0.180	-0.087	35.053	-0.107	-0.107	0.000	0.000	0.000	0.000
10	10	ASN	0	-0.070	-0.037	37.340	-0.022	-0.022	0.000	0.000	0.000	0.000
11	11	LEU	0	-0.036	-0.010	33.267	-0.102	-0.102	0.000	0.000	0.000	0.000
12	12	SER	0	0.061	0.028	34.667	0.215	0.215	0.000	0.000	0.000	0.000
13	13	GLU	-1	-0.867	-0.936	36.451	-7.505	-7.505	0.000	0.000	0.000	0.000
14	14	SER	0	-0.045	-0.035	35.510	0.039	0.039	0.000	0.000	0.000	0.000
15	15	LEU	0	-0.003	0.005	30.268	-0.207	-0.207	0.000	0.000	0.000	0.000
16	16	LEU	0	-0.022	-0.008	33.794	-0.158	-0.158	0.000	0.000	0.000	0.000
17	17	ARG	1	0.930	0.967	36.386	7.368	7.368	0.000	0.000	0.000	0.000
18	18	GLY	0	0.038	0.032	32.838	0.008	0.008	0.000	0.000	0.000	0.000
19	19	ILE	0	-0.010	-0.011	31.865	-0.169	-0.169	0.000	0.000	0.000	0.000
20	20	TYR	0	-0.013	-0.016	33.515	0.026	0.026	0.000	0.000	0.000	0.000
21	21	ALA	0	-0.016	-0.002	34.694	0.039	0.039	0.000	0.000	0.000	0.000
22	22	TYR	0	-0.064	-0.027	26.903	-0.208	-0.208	0.000	0.000	0.000	0.000
23	23	GLY	0	0.015	0.012	32.492	-0.129	-0.129	0.000	0.000	0.000	0.000
24	24	PHE	0	-0.111	-0.053	30.197	0.023	0.023	0.000	0.000	0.000	0.000
25	25	GLU	-1	-0.902	-0.956	35.774	-7.063	-7.063	0.000	0.000	0.000	0.000
26	26	LYS	1	0.943	0.971	37.757	7.272	7.272	0.000	0.000	0.000	0.000
27	27	PRO	0	-0.023	0.012	34.674	-0.191	-0.191	0.000	0.000	0.000	0.000
28	28	SER	0	0.005	-0.022	31.158	0.208	0.208	0.000	0.000	0.000	0.000
29	29	ALA	0	0.025	-0.001	34.361	0.028	0.028	0.000	0.000	0.000	0.000
30	30	ILE	0	-0.011	0.008	28.179	0.080	0.080	0.000	0.000	0.000	0.000
31	31	GLN	0	0.026	0.017	29.476	0.277	0.277	0.000	0.000	0.000	0.000
32	32	GLN	0	-0.016	-0.003	31.860	0.136	0.136	0.000	0.000	0.000	0.000
33	33	ARG	1	0.918	0.949	33.145	8.153	8.153	0.000	0.000	0.000	0.000
34	34	ALA	0	0.000	-0.009	28.131	-0.003	-0.003	0.000	0.000	0.000	0.000
35	35	ILE	0	0.036	0.036	29.242	-0.180	-0.180	0.000	0.000	0.000	0.000
36	36	LEU	0	0.037	0.016	30.666	-0.078	-0.078	0.000	0.000	0.000	0.000
37	37	PRO	0	-0.055	-0.033	30.328	0.044	0.044	0.000	0.000	0.000	0.000
38	38	CYS	0	-0.014	0.013	25.718	-0.151	-0.151	0.000	0.000	0.000	0.000
39	39	ILE	0	0.084	0.043	28.565	-0.071	-0.071	0.000	0.000	0.000	0.000
40	40	LYS	1	0.871	0.932	30.999	7.841	7.841	0.000	0.000	0.000	0.000
41	41	GLY	0	0.045	0.039	28.565	0.136	0.136	0.000	0.000	0.000	0.000
42	42	TYR	0	-0.046	-0.024	28.101	-0.036	-0.036	0.000	0.000	0.000	0.000
43	43	ASP	-1	-0.685	-0.814	24.210	-10.884	-10.884	0.000	0.000	0.000	0.000
44	44	VAL	0	-0.035	-0.023	24.690	0.366	0.366	0.000	0.000	0.000	0.000
45	45	ILE	0	0.009	0.007	23.344	-0.470	-0.470	0.000	0.000	0.000	0.000
46	46	ALA	0	-0.011	-0.022	24.261	0.440	0.440	0.000	0.000	0.000	0.000
47	47	GLN	0	-0.012	0.003	24.928	-0.173	-0.173	0.000	0.000	0.000	0.000
48	48	ALA	0	-0.029	-0.034	25.571	0.434	0.434	0.000	0.000	0.000	0.000
49	49	GLN	0	0.074	0.042	26.109	-0.654	-0.654	0.000	0.000	0.000	0.000
50	50	SER	0	0.006	0.009	24.900	-0.213	-0.213	0.000	0.000	0.000	0.000
51	51	GLY	0	0.020	0.007	26.398	0.283	0.283	0.000	0.000	0.000	0.000
52	52	THR	0	-0.058	-0.033	28.181	0.168	0.168	0.000	0.000	0.000	0.000
53	53	GLY	0	0.073	0.049	27.395	0.216	0.216	0.000	0.000	0.000	0.000
54	54	LYS	1	0.828	0.895	20.287	13.432	13.432	0.000	0.000	0.000	0.000
55	55	THR	0	0.024	0.004	21.177	-0.201	-0.201	0.000	0.000	0.000	0.000
56	56	ALA	0	0.062	0.028	23.300	-0.020	-0.020	0.000	0.000	0.000	0.000
57	57	THR	0	-0.031	-0.019	25.961	0.302	0.302	0.000	0.000	0.000	0.000
58	58	PHE	0	0.051	0.026	19.323	0.247	0.247	0.000	0.000	0.000	0.000
59	59	ALA	0	0.007	0.012	23.534	0.051	0.051	0.000	0.000	0.000	0.000
60	60	ILE	0	0.025	0.009	24.495	0.143	0.143	0.000	0.000	0.000	0.000
61	61	SER	0	-0.020	-0.031	25.995	0.319	0.319	0.000	0.000	0.000	0.000
62	62	ILE	0	-0.014	0.000	21.040	0.080	0.080	0.000	0.000	0.000	0.000
63	63	LEU	0	-0.007	-0.012	25.433	0.181	0.181	0.000	0.000	0.000	0.000
64	64	GLN	0	0.038	0.029	27.895	0.163	0.163	0.000	0.000	0.000	0.000
65	65	GLN	0	-0.095	-0.060	27.382	0.314	0.314	0.000	0.000	0.000	0.000
66	66	ILE	0	-0.063	-0.025	23.621	-0.018	-0.018	0.000	0.000	0.000	0.000
67	67	GLU	-1	-0.877	-0.927	27.740	-8.488	-8.488	0.000	0.000	0.000	0.000
68	68	LEU	0	0.051	0.007	28.625	-0.328	-0.328	0.000	0.000	0.000	0.000
69	69	ASP	-1	-0.908	-0.945	30.315	-8.544	-8.544	0.000	0.000	0.000	0.000
70	70	LEU	0	-0.137	-0.056	25.998	0.023	0.023	0.000	0.000	0.000	0.000
71	71	LYS	1	0.957	0.971	26.940	9.198	9.198	0.000	0.000	0.000	0.000
72	72	ALA	0	0.024	-0.001	22.981	-0.154	-0.154	0.000	0.000	0.000	0.000
73	73	THR	0	-0.007	0.001	17.675	0.009	0.009	0.000	0.000	0.000	0.000
74	74	GLN	0	-0.051	-0.031	20.739	0.082	0.082	0.000	0.000	0.000	0.000
75	75	ALA	0	0.000	0.010	20.355	0.070	0.070	0.000	0.000	0.000	0.000
76	76	LEU	0	-0.005	0.000	12.805	-0.395	-0.395	0.000	0.000	0.000	0.000
77	77	VAL	0	0.000	-0.001	15.794	0.237	0.237	0.000	0.000	0.000	0.000
78	78	LEU	0	-0.025	-0.016	9.684	-0.985	-0.985	0.000	0.000	0.000	0.000
79	79	ALA	0	0.036	0.016	11.461	1.163	1.163	0.000	0.000	0.000	0.000
80	80	PRO	0	0.054	0.016	9.910	-1.415	-1.415	0.000	0.000	0.000	0.000
81	81	THR	0	-0.032	-0.014	7.927	-1.884	-1.884	0.000	0.000	0.000	0.000
83	83	GLU	-1	-0.727	-0.846	9.572	-23.363	-23.363	0.000	0.000	0.000	0.000
84	84	LEU	0	-0.018	-0.002	12.352	1.493	1.493	0.000	0.000	0.000	0.000
85	85	ALA	0	0.015	0.004	12.180	1.165	1.165	0.000	0.000	0.000	0.000
86	86	GLN	0	-0.048	-0.026	13.852	0.484	0.484	0.000	0.000	0.000	0.000
87	87	GLN	0	0.003	0.018	15.606	0.793	0.793	0.000	0.000	0.000	0.000
88	88	ILE	0	0.010	-0.003	16.201	0.842	0.842	0.000	0.000	0.000	0.000
89	89	GLN	0	0.045	0.016	17.820	0.570	0.570	0.000	0.000	0.000	0.000
90	90	LYS	1	0.905	0.954	19.588	12.768	12.768	0.000	0.000	0.000	0.000
91	91	VAL	0	-0.013	0.002	22.289	0.538	0.538	0.000	0.000	0.000	0.000
92	92	VAL	0	0.019	-0.001	20.831	0.469	0.469	0.000	0.000	0.000	0.000
93	93	MET	0	-0.026	0.001	22.728	0.338	0.338	0.000	0.000	0.000	0.000
94	94	ALA	0	-0.013	0.007	25.301	0.350	0.350	0.000	0.000	0.000	0.000
95	95	LEU	0	-0.023	-0.003	26.174	0.352	0.352	0.000	0.000	0.000	0.000
96	96	GLY	0	0.028	-0.002	27.733	0.339	0.339	0.000	0.000	0.000	0.000
97	97	ASP	-1	-0.959	-0.974	29.136	-9.256	-9.256	0.000	0.000	0.000	0.000
98	98	TYR	0	-0.001	-0.017	31.191	0.320	0.320	0.000	0.000	0.000	0.000
99	99	MET	0	-0.066	-0.022	30.286	0.192	0.192	0.000	0.000	0.000	0.000
100	100	GLY	0	0.010	0.018	30.322	0.042	0.042	0.000	0.000	0.000	0.000
101	101	ALA	0	-0.034	-0.018	26.758	-0.168	-0.168	0.000	0.000	0.000	0.000
102	102	SER	0	-0.044	-0.040	24.345	-0.462	-0.462	0.000	0.000	0.000	0.000
103	103	CYS	0	-0.027	-0.030	19.451	-0.313	-0.313	0.000	0.000	0.000	0.000
104	104	HIS	0	-0.019	-0.040	15.213	0.903	0.903	0.000	0.000	0.000	0.000
105	105	ALA	0	0.010	0.008	14.364	-0.150	-0.150	0.000	0.000	0.000	0.000
106	106	CYS	0	-0.048	0.000	10.810	-0.448	-0.448	0.000	0.000	0.000	0.000
107	107	ILE	0	-0.011	-0.007	9.251	-0.999	-0.999	0.000	0.000	0.000	0.000
108	108	GLY	0	0.023	0.010	5.420	0.097	0.097	0.000	0.000	0.000	0.000
109	109	GLY	0	0.014	0.006	5.241	1.618	1.618	0.000	0.000	0.000	0.000
110	110	THR	0	-0.013	0.002	6.106	1.441	1.441	0.000	0.000	0.000	0.000
111	111	ASN	0	0.041	0.015	9.414	0.015	0.015	0.000	0.000	0.000	0.000
112	112	VAL	0	0.066	0.038	10.459	1.511	1.511	0.000	0.000	0.000	0.000
113	113	ARG	1	0.915	0.963	12.214	16.436	16.436	0.000	0.000	0.000	0.000
114	114	ALA	0	0.024	-0.004	14.960	1.064	1.064	0.000	0.000	0.000	0.000
115	115	GLU	-1	-0.783	-0.862	11.768	-21.039	-21.039	0.000	0.000	0.000	0.000
116	116	VAL	0	0.003	-0.014	14.874	0.961	0.961	0.000	0.000	0.000	0.000
117	117	GLN	0	-0.044	-0.015	17.094	0.498	0.498	0.000	0.000	0.000	0.000
118	118	LYS	1	0.964	0.987	17.990	16.148	16.148	0.000	0.000	0.000	0.000
119	119	LEU	0	-0.003	-0.004	14.735	0.530	0.530	0.000	0.000	0.000	0.000
120	120	GLN	0	-0.008	-0.013	19.361	0.877	0.877	0.000	0.000	0.000	0.000
121	121	MET	0	-0.116	-0.051	22.357	0.397	0.397	0.000	0.000	0.000	0.000
122	122	GLU	-1	-0.864	-0.893	22.439	-11.066	-11.066	0.000	0.000	0.000	0.000
123	123	ALA	0	-0.041	-0.010	22.432	0.406	0.406	0.000	0.000	0.000	0.000
124	124	PRO	0	-0.018	0.014	19.488	0.270	0.270	0.000	0.000	0.000	0.000
125	125	HIS	0	0.064	0.043	21.370	-0.645	-0.645	0.000	0.000	0.000	0.000
126	126	ILE	0	-0.025	-0.013	19.449	-0.076	-0.076	0.000	0.000	0.000	0.000
127	127	ILE	0	-0.007	-0.008	13.899	-0.320	-0.320	0.000	0.000	0.000	0.000
128	128	VAL	0	0.006	0.014	14.554	0.151	0.151	0.000	0.000	0.000	0.000
129	129	GLY	0	0.020	-0.001	11.181	-0.248	-0.248	0.000	0.000	0.000	0.000
130	130	THR	0	-0.005	-0.026	6.232	1.251	1.251	0.000	0.000	0.000	0.000
131	131	PRO	0	0.034	0.006	5.475	0.047	0.047	0.000	0.000	0.000	0.000
134	134	VAL	0	0.021	0.007	6.707	2.410	2.410	0.000	0.000	0.000	0.000
136	136	ASP	-1	-0.785	-0.874	6.736	-25.216	-25.216	0.000	0.000	0.000	0.000
137	137	MET	0	-0.036	-0.018	8.215	2.412	2.412	0.000	0.000	0.000	0.000
138	138	LEU	0	-0.015	0.000	10.417	1.573	1.573	0.000	0.000	0.000	0.000
139	139	ASN	0	-0.053	-0.016	10.551	2.139	2.139	0.000	0.000	0.000	0.000
140	140	ARG	1	0.768	0.866	10.138	25.154	25.154	0.000	0.000	0.000	0.000
141	141	ARG	1	0.906	0.952	14.294	14.548	14.548	0.000	0.000	0.000	0.000
142	142	TYR	0	0.002	-0.003	16.520	0.688	0.688	0.000	0.000	0.000	0.000
143	143	LEU	0	0.015	0.021	13.328	0.633	0.633	0.000	0.000	0.000	0.000
144	144	SER	0	0.001	-0.010	16.946	0.064	0.064	0.000	0.000	0.000	0.000
145	145	PRO	0	0.032	-0.001	17.906	0.197	0.197	0.000	0.000	0.000	0.000
146	146	LYS	1	0.891	0.954	19.769	10.392	10.392	0.000	0.000	0.000	0.000
147	147	TYR	0	0.014	-0.003	21.745	0.370	0.370	0.000	0.000	0.000	0.000
148	148	ILE	0	-0.010	0.011	16.314	0.153	0.153	0.000	0.000	0.000	0.000
149	149	LYS	1	0.976	0.990	20.524	10.102	10.102	0.000	0.000	0.000	0.000
150	150	MET	0	-0.024	0.003	21.113	0.226	0.226	0.000	0.000	0.000	0.000
151	151	PHE	0	0.022	0.004	12.572	-0.494	-0.494	0.000	0.000	0.000	0.000
152	152	VAL	0	0.002	-0.003	17.078	0.442	0.442	0.000	0.000	0.000	0.000
153	153	LEU	0	0.005	0.002	13.062	-0.767	-0.767	0.000	0.000	0.000	0.000
154	154	ASP	-1	-0.795	-0.893	15.515	-13.404	-13.404	0.000	0.000	0.000	0.000
155	155	GLU	-1	-0.845	-0.940	15.141	-15.472	-15.472	0.000	0.000	0.000	0.000
156	156	ALA	0	0.003	-0.005	15.880	-0.545	-0.545	0.000	0.000	0.000	0.000
157	157	ASP	-1	-0.755	-0.831	16.271	-14.448	-14.448	0.000	0.000	0.000	0.000
158	158	GLU	-1	-0.858	-0.924	12.780	-17.887	-17.887	0.000	0.000	0.000	0.000
159	159	MET	0	-0.048	0.000	9.744	-1.254	-1.254	0.000	0.000	0.000	0.000
160	160	LEU	0	-0.025	-0.021	12.338	-0.393	-0.393	0.000	0.000	0.000	0.000
161	161	SER	0	0.037	0.012	12.881	0.425	0.425	0.000	0.000	0.000	0.000
162	162	ARG	1	0.779	0.860	13.046	17.007	17.007	0.000	0.000	0.000	0.000
163	163	GLY	0	0.103	0.076	10.309	-0.572	-0.572	0.000	0.000	0.000	0.000
164	164	PHE	0	-0.051	-0.027	6.573	-2.465	-2.465	0.000	0.000	0.000	0.000
165	165	LYS	1	0.936	0.973	9.617	15.442	15.442	0.000	0.000	0.000	0.000
166	166	ASP	-1	-0.892	-0.945	9.941	-17.407	-17.407	0.000	0.000	0.000	0.000
168	168	ILE	0	-0.006	-0.009	7.373	0.313	0.313	0.000	0.000	0.000	0.000
169	169	TYR	0	-0.029	-0.014	10.086	1.387	1.387	0.000	0.000	0.000	0.000
170	170	ASP	-1	-0.865	-0.929	8.684	-19.034	-19.034	0.000	0.000	0.000	0.000
171	171	ILE	0	-0.082	-0.046	6.747	0.577	0.577	0.000	0.000	0.000	0.000
172	172	PHE	0	-0.030	-0.018	10.411	1.040	1.040	0.000	0.000	0.000	0.000
173	173	GLN	0	-0.014	-0.007	13.754	0.383	0.383	0.000	0.000	0.000	0.000
174	174	LYS	1	0.908	0.970	11.605	17.791	17.791	0.000	0.000	0.000	0.000
175	175	LEU	0	-0.024	-0.002	14.325	0.423	0.423	0.000	0.000	0.000	0.000
176	176	ASN	0	0.018	0.012	16.620	0.410	0.410	0.000	0.000	0.000	0.000
177	177	SER	0	0.053	0.035	20.436	0.078	0.078	0.000	0.000	0.000	0.000
178	178	ASN	0	-0.082	-0.034	21.797	0.004	0.004	0.000	0.000	0.000	0.000
179	179	THR	0	0.006	-0.007	18.746	0.102	0.102	0.000	0.000	0.000	0.000
180	180	GLN	0	-0.051	-0.026	22.003	-0.158	-0.158	0.000	0.000	0.000	0.000
181	181	VAL	0	-0.001	-0.001	18.822	-0.497	-0.497	0.000	0.000	0.000	0.000
182	182	VAL	0	-0.019	-0.016	20.308	0.516	0.516	0.000	0.000	0.000	0.000
183	183	LEU	0	-0.001	0.006	17.874	-0.637	-0.637	0.000	0.000	0.000	0.000
184	184	LEU	0	0.011	0.005	19.619	0.641	0.641	0.000	0.000	0.000	0.000
185	185	SER	0	-0.026	-0.038	19.529	-0.668	-0.668	0.000	0.000	0.000	0.000
186	186	ALA	0	0.040	0.034	21.435	0.515	0.515	0.000	0.000	0.000	0.000
187	187	THR	0	-0.043	-0.026	21.141	0.462	0.462	0.000	0.000	0.000	0.000
188	188	MET	0	0.004	-0.011	21.867	-0.530	-0.530	0.000	0.000	0.000	0.000
189	189	PRO	0	0.037	0.027	21.577	0.505	0.505	0.000	0.000	0.000	0.000
190	190	SER	0	-0.017	-0.019	24.310	-0.168	-0.168	0.000	0.000	0.000	0.000
191	191	ASP	-1	-0.830	-0.906	22.783	-10.964	-10.964	0.000	0.000	0.000	0.000
192	192	VAL	0	-0.030	-0.018	19.065	-0.308	-0.308	0.000	0.000	0.000	0.000
193	193	LEU	0	-0.034	-0.028	21.253	-0.052	-0.052	0.000	0.000	0.000	0.000
194	194	GLU	-1	-0.844	-0.896	23.546	-9.900	-9.900	0.000	0.000	0.000	0.000
195	195	VAL	0	-0.040	-0.026	16.992	-0.013	-0.013	0.000	0.000	0.000	0.000
196	196	THR	0	0.049	0.012	19.762	-0.169	-0.169	0.000	0.000	0.000	0.000
197	197	LYS	1	0.820	0.909	21.066	9.967	9.967	0.000	0.000	0.000	0.000
198	198	LYS	1	0.918	0.969	17.977	13.513	13.513	0.000	0.000	0.000	0.000
199	199	PHE	0	-0.016	-0.002	13.991	-0.209	-0.209	0.000	0.000	0.000	0.000
200	200	MET	0	-0.075	-0.026	19.824	0.139	0.139	0.000	0.000	0.000	0.000
201	201	ARG	1	0.749	0.837	23.164	10.994	10.994	0.000	0.000	0.000	0.000
202	202	ASP	-1	-0.914	-0.949	26.716	-8.548	-8.548	0.000	0.000	0.000	0.000
203	203	PRO	0	-0.007	0.014	25.233	0.121	0.121	0.000	0.000	0.000	0.000
204	204	ILE	0	0.025	0.005	27.645	0.286	0.286	0.000	0.000	0.000	0.000
205	205	ARG	1	0.844	0.911	28.264	9.033	9.033	0.000	0.000	0.000	0.000
206	206	ILE	0	-0.007	-0.002	28.729	0.325	0.325	0.000	0.000	0.000	0.000
207	207	LEU	0	-0.013	-0.004	27.240	-0.304	-0.304	0.000	0.000	0.000	0.000
208	208	VAL	0	-0.007	-0.009	29.245	0.333	0.333	0.000	0.000	0.000	0.000
209	209	LYS	1	0.948	0.978	29.911	7.797	7.797	0.000	0.000	0.000	0.000
210	210	LYS	1	0.841	0.907	29.109	9.047	9.047	0.000	0.000	0.000	0.000
211	211	GLU	-1	-0.803	-0.906	30.349	-8.870	-8.870	0.000	0.000	0.000	0.000
212	212	GLU	-1	-0.964	-0.973	32.460	-8.183	-8.183	0.000	0.000	0.000	0.000
213	213	LEU	0	-0.055	-0.028	26.462	-0.051	-0.051	0.000	0.000	0.000	0.000
214	214	THR	0	0.033	0.026	29.204	-0.256	-0.256	0.000	0.000	0.000	0.000
215	215	LEU	0	-0.024	-0.013	26.241	0.121	0.121	0.000	0.000	0.000	0.000
216	216	GLU	-1	-0.904	-0.946	30.903	-8.016	-8.016	0.000	0.000	0.000	0.000
217	217	GLY	0	-0.044	-0.016	33.351	0.168	0.168	0.000	0.000	0.000	0.000
218	218	ILE	0	-0.063	-0.039	27.943	0.026	0.026	0.000	0.000	0.000	0.000
219	219	ARG	1	0.835	0.910	32.068	8.549	8.549	0.000	0.000	0.000	0.000
220	220	GLN	0	0.003	0.010	30.550	-0.553	-0.553	0.000	0.000	0.000	0.000
221	221	PHE	0	0.046	0.012	32.094	0.302	0.302	0.000	0.000	0.000	0.000
222	222	TYR	0	-0.034	-0.019	31.732	-0.411	-0.411	0.000	0.000	0.000	0.000
223	223	ILE	0	0.044	0.023	31.758	0.264	0.264	0.000	0.000	0.000	0.000
224	224	ASN	0	0.015	0.000	32.996	-0.426	-0.426	0.000	0.000	0.000	0.000
225	225	VAL	0	0.021	0.015	30.687	0.159	0.159	0.000	0.000	0.000	0.000
226	226	GLU	-1	-0.909	-0.932	33.583	-7.984	-7.984	0.000	0.000	0.000	0.000
227	227	ARG	1	0.900	0.930	31.501	8.689	8.689	0.000	0.000	0.000	0.000
228	228	GLU	-1	-0.752	-0.860	24.254	-12.186	-12.186	0.000	0.000	0.000	0.000
229	229	GLU	-1	-0.977	-0.997	27.121	-10.307	-10.307	0.000	0.000	0.000	0.000
230	230	TRP	0	0.013	0.007	28.166	-0.067	-0.067	0.000	0.000	0.000	0.000
231	231	LYS	1	0.820	0.899	23.770	12.215	12.215	0.000	0.000	0.000	0.000
232	232	LEU	0	-0.017	-0.005	25.258	-0.122	-0.122	0.000	0.000	0.000	0.000
233	233	ASP	-1	-0.895	-0.953	27.864	-9.517	-9.517	0.000	0.000	0.000	0.000
234	234	THR	0	0.049	0.014	31.214	0.213	0.213	0.000	0.000	0.000	0.000
235	235	LEU	0	-0.048	-0.021	24.908	0.034	0.034	0.000	0.000	0.000	0.000
236	236	CYS	0	-0.097	-0.059	29.322	-0.099	-0.099	0.000	0.000	0.000	0.000
237	237	ASP	-1	-0.876	-0.916	31.247	-8.491	-8.491	0.000	0.000	0.000	0.000
238	238	LEU	0	0.013	-0.007	29.098	0.058	0.058	0.000	0.000	0.000	0.000
239	239	TYR	0	-0.003	-0.018	27.136	0.003	0.003	0.000	0.000	0.000	0.000
240	240	GLU	-1	-0.938	-0.956	31.368	-8.326	-8.326	0.000	0.000	0.000	0.000
241	241	THR	0	-0.051	-0.038	31.641	0.019	0.019	0.000	0.000	0.000	0.000
242	242	LEU	0	-0.049	-0.028	26.868	-0.094	-0.094	0.000	0.000	0.000	0.000
243	243	THR	0	0.009	0.013	29.996	-0.153	-0.153	0.000	0.000	0.000	0.000
244	244	ILE	0	-0.041	-0.028	32.844	0.085	0.085	0.000	0.000	0.000	0.000
245	245	THR	0	-0.052	-0.025	29.864	0.058	0.058	0.000	0.000	0.000	0.000
246	246	GLN	0	-0.061	-0.010	23.584	0.257	0.257	0.000	0.000	0.000	0.000
247	247	ALA	0	0.013	-0.004	25.664	0.137	0.137	0.000	0.000	0.000	0.000
248	248	VAL	0	-0.029	-0.013	19.320	-0.395	-0.395	0.000	0.000	0.000	0.000
249	249	ILE	0	0.018	0.011	21.063	0.425	0.425	0.000	0.000	0.000	0.000
250	250	PHE	0	0.015	0.005	16.618	-0.717	-0.717	0.000	0.000	0.000	0.000
251	251	ILE	0	-0.027	-0.020	16.191	0.695	0.695	0.000	0.000	0.000	0.000
252	252	ASN	0	0.021	-0.001	16.479	-0.898	-0.898	0.000	0.000	0.000	0.000
253	253	THR	0	-0.026	0.010	13.743	-0.667	-0.667	0.000	0.000	0.000	0.000
255	255	ARG	1	0.878	0.935	11.983	21.240	21.240	0.000	0.000	0.000	0.000
256	256	LYS	1	0.835	0.905	14.208	14.506	14.506	0.000	0.000	0.000	0.000
257	257	VAL	0	0.070	0.035	14.159	0.808	0.808	0.000	0.000	0.000	0.000
258	258	ASP	-1	-0.816	-0.878	12.761	-21.266	-21.266	0.000	0.000	0.000	0.000
259	259	TRP	0	-0.041	-0.025	16.079	0.865	0.865	0.000	0.000	0.000	0.000
260	260	LEU	0	-0.009	0.002	19.171	0.739	0.739	0.000	0.000	0.000	0.000
261	261	THR	0	-0.016	-0.031	17.824	0.530	0.530	0.000	0.000	0.000	0.000
262	262	GLU	-1	-0.971	-0.982	19.999	-12.251	-12.251	0.000	0.000	0.000	0.000
263	263	LYS	1	0.939	0.978	21.576	12.836	12.836	0.000	0.000	0.000	0.000
264	264	MET	0	-0.020	-0.022	23.626	0.591	0.591	0.000	0.000	0.000	0.000
265	265	HIS	0	-0.011	0.005	22.763	0.272	0.272	0.000	0.000	0.000	0.000
266	266	ALA	0	-0.016	-0.005	24.839	0.378	0.378	0.000	0.000	0.000	0.000
267	267	ARG	1	0.860	0.935	27.323	10.624	10.624	0.000	0.000	0.000	0.000
268	268	ASP	-1	-0.896	-0.944	29.639	-9.214	-9.214	0.000	0.000	0.000	0.000
269	269	PHE	0	-0.044	-0.012	27.463	0.058	0.058	0.000	0.000	0.000	0.000
270	270	THR	0	-0.013	-0.002	25.991	-0.385	-0.385	0.000	0.000	0.000	0.000
271	271	VAL	0	-0.001	-0.005	21.456	0.065	0.065	0.000	0.000	0.000	0.000
272	272	SER	0	-0.008	0.001	18.500	-0.531	-0.531	0.000	0.000	0.000	0.000
273	273	ALA	0	0.025	0.004	15.588	0.338	0.338	0.000	0.000	0.000	0.000
274	274	MET	0	-0.033	-0.018	11.691	-1.298	-1.298	0.000	0.000	0.000	0.000
275	275	HIS	0	-0.008	-0.035	9.618	-1.258	-1.258	0.000	0.000	0.000	0.000
276	276	GLY	0	0.012	-0.023	5.918	-0.567	-0.567	0.000	0.000	0.000	0.000
278	278	MET	0	-0.017	0.025	5.802	-0.385	-0.385	0.000	0.000	0.000	0.000
279	279	ASP	-1	-0.852	-0.930	6.187	-40.403	-40.403	0.000	0.000	0.000	0.000
280	280	GLN	0	-0.029	-0.036	7.214	-0.120	-0.120	0.000	0.000	0.000	0.000
281	281	LYS	1	0.868	0.928	8.794	24.944	24.944	0.000	0.000	0.000	0.000
282	282	GLU	-1	-0.872	-0.923	11.009	-19.361	-19.361	0.000	0.000	0.000	0.000
283	283	ARG	1	0.782	0.840	5.339	35.131	35.131	0.000	0.000	0.000	0.000
284	284	ASP	-1	-0.774	-0.870	11.863	-16.405	-16.405	0.000	0.000	0.000	0.000
285	285	VAL	0	0.000	-0.003	14.177	1.347	1.347	0.000	0.000	0.000	0.000
286	286	ILE	0	0.008	0.010	13.168	1.088	1.088	0.000	0.000	0.000	0.000
287	287	MET	0	-0.010	0.002	15.519	1.369	1.369	0.000	0.000	0.000	0.000
288	288	ARG	1	0.785	0.867	17.272	16.685	16.685	0.000	0.000	0.000	0.000
289	289	GLU	-1	-0.798	-0.899	19.875	-11.999	-11.999	0.000	0.000	0.000	0.000
290	290	PHE	0	-0.004	0.018	19.992	0.606	0.606	0.000	0.000	0.000	0.000
291	291	ARG	1	0.827	0.891	17.857	15.240	15.240	0.000	0.000	0.000	0.000
292	292	SER	0	-0.039	-0.014	23.055	0.319	0.319	0.000	0.000	0.000	0.000
293	293	GLY	0	-0.027	-0.001	25.216	0.460	0.460	0.000	0.000	0.000	0.000
294	294	SER	0	-0.052	-0.026	24.810	0.469	0.469	0.000	0.000	0.000	0.000
295	295	SER	0	-0.025	-0.003	21.149	0.191	0.191	0.000	0.000	0.000	0.000
296	296	ARG	1	0.923	0.947	24.157	9.916	9.916	0.000	0.000	0.000	0.000
297	297	VAL	0	0.054	0.025	24.105	0.102	0.102	0.000	0.000	0.000	0.000
298	298	LEU	0	-0.020	0.009	16.569	-0.259	-0.259	0.000	0.000	0.000	0.000
299	299	ILE	0	0.027	0.009	17.373	0.280	0.280	0.000	0.000	0.000	0.000
300	300	THR	0	-0.033	-0.038	14.624	-1.183	-1.183	0.000	0.000	0.000	0.000
301	301	THR	0	0.037	0.010	10.696	1.126	1.126	0.000	0.000	0.000	0.000
302	302	ASP	-1	-0.785	-0.889	13.174	-16.615	-16.615	0.000	0.000	0.000	0.000
303	303	LEU	0	-0.006	0.022	8.211	0.225	0.225	0.000	0.000	0.000	0.000
304	304	LEU	0	-0.019	-0.018	11.207	0.388	0.388	0.000	0.000	0.000	0.000
305	305	ALA	0	0.019	0.012	14.452	1.196	1.196	0.000	0.000	0.000	0.000
306	306	ARG	1	0.812	0.895	14.863	16.311	16.311	0.000	0.000	0.000	0.000
307	307	GLY	0	0.043	0.027	16.341	-0.474	-0.474	0.000	0.000	0.000	0.000
308	308	ILE	0	-0.075	-0.045	15.122	0.628	0.628	0.000	0.000	0.000	0.000
309	309	ASP	-1	-0.934	-0.967	18.710	-11.156	-11.156	0.000	0.000	0.000	0.000
310	310	VAL	0	0.001	-0.001	20.746	-0.151	-0.151	0.000	0.000	0.000	0.000
311	311	GLN	0	0.073	0.033	23.435	0.432	0.432	0.000	0.000	0.000	0.000
312	312	GLN	0	0.001	-0.031	25.472	0.390	0.390	0.000	0.000	0.000	0.000
313	313	VAL	0	-0.004	0.018	23.378	0.158	0.158	0.000	0.000	0.000	0.000
314	314	SER	0	-0.005	0.001	26.819	0.093	0.093	0.000	0.000	0.000	0.000
315	315	LEU	0	0.026	0.013	28.116	0.027	0.027	0.000	0.000	0.000	0.000
316	316	VAL	0	-0.008	-0.006	23.294	-0.452	-0.452	0.000	0.000	0.000	0.000
317	317	ILE	0	0.032	0.020	24.461	0.422	0.422	0.000	0.000	0.000	0.000
318	318	ASN	0	-0.017	-0.007	22.546	-1.202	-1.202	0.000	0.000	0.000	0.000
319	319	TYR	0	0.060	0.024	22.142	0.501	0.501	0.000	0.000	0.000	0.000
320	320	ASP	-1	-0.761	-0.865	19.876	-13.858	-13.858	0.000	0.000	0.000	0.000
321	321	LEU	0	0.026	0.011	22.402	-0.188	-0.188	0.000	0.000	0.000	0.000
322	322	PRO	0	-0.018	0.020	19.785	-0.253	-0.253	0.000	0.000	0.000	0.000
323	323	THR	0	0.017	-0.015	20.537	0.422	0.422	0.000	0.000	0.000	0.000
324	324	ASN	0	-0.034	-0.025	17.677	0.454	0.454	0.000	0.000	0.000	0.000
325	325	ARG	1	0.986	0.992	20.889	11.422	11.422	0.000	0.000	0.000	0.000
326	326	GLU	-1	-0.873	-0.931	20.900	-12.455	-12.455	0.000	0.000	0.000	0.000
327	327	ASN	0	-0.049	-0.040	16.782	0.533	0.533	0.000	0.000	0.000	0.000
328	328	TYR	0	0.018	0.001	20.012	-0.238	-0.238	0.000	0.000	0.000	0.000
329	329	ILE	0	0.016	0.008	23.101	0.043	0.043	0.000	0.000	0.000	0.000
330	330	HIS	0	-0.069	-0.039	19.142	0.015	0.015	0.000	0.000	0.000	0.000
331	331	ARG	1	0.817	0.883	17.397	15.043	15.043	0.000	0.000	0.000	0.000
332	332	ILE	0	0.032	0.008	20.837	0.057	0.057	0.000	0.000	0.000	0.000
333	333	GLY	0	0.024	0.025	23.501	0.330	0.330	0.000	0.000	0.000	0.000
334	334	ARG	1	0.752	0.870	18.680	13.870	13.870	0.000	0.000	0.000	0.000
335	335	GLY	0	0.009	0.011	22.761	0.078	0.078	0.000	0.000	0.000	0.000
336	336	GLY	0	-0.007	-0.014	26.464	0.067	0.067	0.000	0.000	0.000	0.000
337	337	ARG	1	0.815	0.939	23.771	11.687	11.687	0.000	0.000	0.000	0.000
338	338	PHE	0	-0.015	-0.023	28.655	0.271	0.271	0.000	0.000	0.000	0.000
339	339	GLY	0	0.024	0.016	31.184	0.184	0.184	0.000	0.000	0.000	0.000
340	340	ARG	1	0.813	0.918	31.117	9.760	9.760	0.000	0.000	0.000	0.000
341	341	LYS	1	0.980	0.990	32.802	7.579	7.579	0.000	0.000	0.000	0.000
342	342	GLY	0	0.098	0.051	30.567	0.028	0.028	0.000	0.000	0.000	0.000
343	343	VAL	0	-0.047	-0.002	30.432	0.291	0.291	0.000	0.000	0.000	0.000
344	344	ALA	0	0.022	0.009	27.867	-0.397	-0.397	0.000	0.000	0.000	0.000
345	345	ILE	0	0.018	0.016	28.505	0.291	0.291	0.000	0.000	0.000	0.000
346	346	ASN	0	-0.008	-0.013	27.302	-0.877	-0.877	0.000	0.000	0.000	0.000
347	347	MET	0	-0.007	0.000	27.183	0.261	0.261	0.000	0.000	0.000	0.000
348	348	VAL	0	-0.022	0.001	28.265	-0.266	-0.266	0.000	0.000	0.000	0.000
349	349	THR	0	-0.034	-0.037	28.482	0.311	0.311	0.000	0.000	0.000	0.000
350	350	GLU	-1	-0.823	-0.932	31.126	-8.328	-8.328	0.000	0.000	0.000	0.000
351	351	GLU	-1	-0.938	-0.965	29.424	-9.298	-9.298	0.000	0.000	0.000	0.000
352	352	ASP	-1	-0.867	-0.903	27.016	-11.111	-11.111	0.000	0.000	0.000	0.000
353	353	LYS	1	0.843	0.917	29.556	8.377	8.377	0.000	0.000	0.000	0.000
354	354	ARG	1	0.846	0.920	31.519	9.211	9.211	0.000	0.000	0.000	0.000
355	355	THR	0	0.045	0.020	25.542	0.097	0.097	0.000	0.000	0.000	0.000
356	356	LEU	0	0.026	0.018	28.909	-0.134	-0.134	0.000	0.000	0.000	0.000
357	357	ARG	1	0.887	0.938	30.594	8.341	8.341	0.000	0.000	0.000	0.000
358	358	ASP	-1	-0.856	-0.915	29.080	-9.725	-9.725	0.000	0.000	0.000	0.000
359	359	ILE	0	-0.018	-0.012	25.475	-0.036	-0.036	0.000	0.000	0.000	0.000
360	360	GLU	-1	-0.819	-0.902	29.389	-8.452	-8.452	0.000	0.000	0.000	0.000
361	361	THR	0	-0.109	-0.074	32.958	0.178	0.178	0.000	0.000	0.000	0.000
362	362	PHE	0	-0.047	-0.010	26.227	0.109	0.109	0.000	0.000	0.000	0.000
363	363	TYR	0	-0.001	-0.049	24.711	0.002	0.002	0.000	0.000	0.000	0.000
364	364	ASN	0	-0.045	-0.009	31.463	0.229	0.229	0.000	0.000	0.000	0.000
365	365	THR	0	-0.020	0.003	31.585	0.063	0.063	0.000	0.000	0.000	0.000
366	366	SER	0	-0.060	-0.056	35.007	0.087	0.087	0.000	0.000	0.000	0.000
367	367	ILE	0	-0.025	-0.007	30.847	-0.191	-0.191	0.000	0.000	0.000	0.000
368	368	GLU	-1	-0.827	-0.876	35.086	-7.776	-7.776	0.000	0.000	0.000	0.000
369	369	GLU	-1	-0.947	-0.982	36.294	-8.045	-8.045	0.000	0.000	0.000	0.000
370	370	MET	0	-0.069	-0.028	34.600	0.008	0.008	0.000	0.000	0.000	0.000
371	371	PRO	0	-0.017	0.001	37.292	0.141	0.141	0.000	0.000	0.000	0.000
372	372	LEU	0	0.038	-0.005	38.859	-0.137	-0.137	0.000	0.000	0.000	0.000
373	373	ASN	0	-0.057	-0.029	39.701	-0.152	-0.152	0.000	0.000	0.000	0.000
374	374	VAL	0	0.017	-0.001	35.287	0.046	0.046	0.000	0.000	0.000	0.000
375	375	ALA	0	0.041	0.014	36.882	-0.080	-0.080	0.000	0.000	0.000	0.000
376	376	ASP	-1	-0.879	-0.929	37.908	-7.254	-7.254	0.000	0.000	0.000	0.000
377	377	LEU	0	-0.116	-0.050	38.269	0.131	0.131	0.000	0.000	0.000	0.000
378	378	ILE	-1	-0.966	-0.968	33.117	-8.429	-8.429	0.000	0.000	0.000	0.000
379	379	A	0	-0.358	-0.297	21.007	-0.046	-0.046	0.000	0.000	0.000	0.000
380	379	A	-1	-0.550	-0.635	16.550	-15.148	-15.148	0.000	0.000	0.000	0.000
381	380	G	0	-0.365	-0.313	18.317	-0.319	-0.319	0.000	0.000	0.000	0.000
382	380	G	-1	-0.517	-0.622	14.456	-17.847	-17.847	0.000	0.000	0.000	0.000
383	381	A	0	-0.338	-0.278	15.966	0.034	0.034	0.000	0.000	0.000	0.000
384	381	A	-1	-0.601	-0.671	12.746	-20.477	-20.477	0.000	0.000	0.000	0.000
385	382	G	0	-0.358	-0.306	13.287	-0.897	-0.897	0.000	0.000	0.000	0.000
386	382	G	-1	-0.567	-0.697	10.869	-22.811	-22.811	0.000	0.000	0.000	0.000
387	383	A	0	-0.328	-0.288	9.033	-0.385	-0.385	0.000	0.000	0.000	0.000
388	383	A	-1	-0.466	-0.589	6.322	-29.047	-29.047	0.000	0.000	0.000	0.000
389	384	G	0	-0.377	-0.324	6.263	-3.272	-3.272	0.000	0.000	0.000	0.000
396	387	G	-1	-0.568	-0.686	7.321	-23.464	-23.464	0.000	0.000	0.000	0.000
397	388	G	0	-0.390	-0.316	6.923	3.616	3.616	0.000	0.000	0.000	0.000

Top

Graph

Overview

Highlights

Manual

Support

Interactive mode: IFIE and PIEDA for fragment #399(:389:V6D)