![FMODB](./images/FMODB-Logo_20190201-0_300ppi.png)
FMODB ID: 729MK
Calculation Name: 4JCS-A-Xray372
Preferred Name:
Target Type:
Ligand Name:
ligand 3-letter code:
PDB ID: 4JCS
Chain ID: A
UniProt ID: Q1LBW6
Base Structure: X-ray
Registration Date: 2023-09-20
Reference: C. Watanabe, N. Tani, K. Kamisaka, T. Honma et al., Interaction energy analysis of Apo structure dataset on FMODB, To be published.
Modeling method
Optimization | MOE:Amber10:EHT |
---|---|
Restraint | OptH |
Protonation | MOE:Protonate 3D |
Complement | MOE:Structure Preparation |
Water | No |
Procedure | Auto-FMO protocol ver. 2.20220422 |
FMO calculation
FMO method | FMO2-MP2/6-31G(d) |
---|---|
Fragmentation | Auto |
Number of fragment | 267 |
LigandCharge | |
Software | ABINIT-MP - Open Ver. 1 Rev. 22 / 20200603(SMP) |
Total energy (hartree)
FMO2-HF: Electronic energy | -3395333.027696 |
---|---|
FMO2-HF: Nuclear repulsion | 3292520.342102 |
FMO2-HF: Total energy | -102812.685594 |
FMO2-MP2: Total energy | -103112.452409 |
3D Structure
Ligand structure
![ligand structure](./Kdata/F030294/ligand_interaction/ligand_F030294.png)
Ligand Interaction
![ligand interaction](./Kdata/F030294/ligand_interaction/ligand_interaction_F030294.png)
Ligand binding energy
"IFIE [kcal/mol] | PIEDA [kcal/mol] | Charge transfer value [e] | |||
---|---|---|---|---|---|
IFIE SUMIFIE SUM at MP2 level. | ESElectro static interaction energy. | EXExchange-repulsion energy. | CT+mixCharge transfer and mixing terms energy. | DI(MP2)Dispersion energy. | q(I=>J)Charge transfer value from I to J fragments. |
N/A | N/A | N/A | N/A | N/A | N/A |
Interactive mode: IFIE and PIEDA for fragment #1(A:-2:PHE)
Summations of interaction energy for
fragment #1(A:-2:PHE)
IFIE [kcal/mol] | PIEDA [kcal/mol] | Charge transfer value [e] | |||
---|---|---|---|---|---|
IFIE SUMIFIE SUM at MP2 level. | ESElectro static interaction energy. | EXExchange-repulsion energy. | CT+mixCharge transfer and mixing terms energy. | DI(MP2)Dispersion energy. | q(I=>J)Charge transfer value from I to J fragments. |
-15.695 | -7.022 | 4.139 | -5.14 | -7.669 | -0.017 |
Interaction energy analysis for fragmet #1(A:-2:PHE)
frag_NumFragment number. | ChainChain species. | Res #Residue number. | RES3-letter code of amino acid residue, ligand and solvent molecule. | FCHARGEFormal charge [e]. | q_MullikenFragment charge evaluated by Mulliken charge [e]. | q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. | DISTDistance from Ligand [Å]. | TotalIFIE at MP2 level [kcal/mol]. | ESElectro static interaction energy by PIEDA [kcal/mol]. | EXExchange-repulsion energy by PIEDA [kcal/mol]. | CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. | DI(MP2)Dispersion energy by PIEDA [kcal/mol]. | q(I=>J)Charge transfer value from I to J fragmens [e]. |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3 | A | 0 | SER | 0 | -0.049 | -0.028 | 3.040 | -1.485 | 1.249 | 0.099 | -1.020 | -1.813 | 0.003 |
4 | A | 1 | MET | 0 | -0.045 | -0.022 | 4.861 | -0.422 | -0.294 | 0.000 | -0.023 | -0.104 | 0.000 |
5 | A | 2 | ASP | -1 | -0.871 | -0.925 | 8.579 | -0.186 | -0.186 | 0.000 | 0.000 | 0.000 | 0.000 |
6 | A | 3 | THR | 0 | -0.162 | -0.108 | 11.305 | -0.059 | -0.059 | 0.000 | 0.000 | 0.000 | 0.000 |
7 | A | 4 | LEU | 0 | -0.033 | -0.025 | 8.055 | -0.031 | -0.031 | 0.000 | 0.000 | 0.000 | 0.000 |
8 | A | 5 | ASP | -1 | -0.824 | -0.876 | 3.536 | -1.583 | -1.008 | 0.026 | -0.172 | -0.429 | 0.001 |
9 | A | 6 | PHE | 0 | -0.022 | -0.021 | 4.771 | -0.590 | -0.235 | -0.001 | -0.066 | -0.287 | 0.000 |
10 | A | 7 | GLU | -1 | -0.902 | -0.959 | 2.289 | -5.753 | -1.989 | 3.988 | -3.372 | -4.379 | -0.026 |
11 | A | 8 | VAL | 0 | -0.022 | -0.003 | 3.477 | -0.647 | -0.432 | 0.017 | 0.037 | -0.269 | 0.000 |
12 | A | 9 | VAL | 0 | 0.015 | 0.009 | 5.308 | -0.535 | -0.535 | 0.000 | 0.000 | 0.000 | 0.000 |
13 | A | 10 | ASN | 0 | -0.038 | -0.027 | 7.927 | 0.064 | 0.064 | 0.000 | 0.000 | 0.000 | 0.000 |
14 | A | 11 | ASN | 0 | -0.036 | -0.030 | 10.031 | -0.108 | -0.108 | 0.000 | 0.000 | 0.000 | 0.000 |
15 | A | 12 | VAL | 0 | 0.007 | 0.012 | 10.412 | 0.038 | 0.038 | 0.000 | 0.000 | 0.000 | 0.000 |
16 | A | 13 | GLY | 0 | 0.019 | -0.002 | 7.870 | 0.127 | 0.127 | 0.000 | 0.000 | 0.000 | 0.000 |
17 | A | 14 | TRP | 0 | -0.032 | -0.019 | 6.460 | -0.307 | -0.307 | 0.000 | 0.000 | 0.000 | 0.000 |
18 | A | 15 | ILE | 0 | 0.013 | 0.000 | 6.942 | 0.177 | 0.177 | 0.000 | 0.000 | 0.000 | 0.000 |
19 | A | 16 | ARG | 1 | 0.865 | 0.939 | 4.975 | 1.151 | 1.151 | 0.000 | 0.000 | 0.000 | 0.000 |
20 | A | 17 | MET | 0 | -0.021 | -0.010 | 8.032 | -0.013 | -0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
21 | A | 18 | ASN | 0 | -0.003 | -0.009 | 6.638 | 0.021 | 0.021 | 0.000 | 0.000 | 0.000 | 0.000 |
22 | A | 19 | ARG | 1 | 0.862 | 0.926 | 9.855 | 0.017 | 0.017 | 0.000 | 0.000 | 0.000 | 0.000 |
23 | A | 20 | ALA | 0 | 0.059 | 0.021 | 13.034 | 0.045 | 0.045 | 0.000 | 0.000 | 0.000 | 0.000 |
24 | A | 21 | ALA | 0 | 0.010 | 0.007 | 14.988 | 0.031 | 0.031 | 0.000 | 0.000 | 0.000 | 0.000 |
25 | A | 22 | LYS | 1 | 0.916 | 0.954 | 16.842 | 0.161 | 0.161 | 0.000 | 0.000 | 0.000 | 0.000 |
26 | A | 23 | HIS | 0 | 0.028 | 0.018 | 18.073 | 0.023 | 0.023 | 0.000 | 0.000 | 0.000 | 0.000 |
27 | A | 24 | ASN | 0 | -0.023 | -0.008 | 13.854 | 0.008 | 0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
28 | A | 25 | PRO | 0 | 0.010 | 0.023 | 16.688 | 0.026 | 0.026 | 0.000 | 0.000 | 0.000 | 0.000 |
29 | A | 26 | PHE | 0 | 0.062 | 0.008 | 18.758 | 0.011 | 0.011 | 0.000 | 0.000 | 0.000 | 0.000 |
30 | A | 27 | ASP | -1 | -0.811 | -0.912 | 18.661 | 0.032 | 0.032 | 0.000 | 0.000 | 0.000 | 0.000 |
31 | A | 28 | ALA | 0 | -0.063 | -0.052 | 20.141 | 0.023 | 0.023 | 0.000 | 0.000 | 0.000 | 0.000 |
32 | A | 29 | GLU | -1 | -0.854 | -0.928 | 16.443 | 0.077 | 0.077 | 0.000 | 0.000 | 0.000 | 0.000 |
33 | A | 30 | LEU | 0 | 0.034 | 0.025 | 14.398 | 0.034 | 0.034 | 0.000 | 0.000 | 0.000 | 0.000 |
34 | A | 31 | ARG | 1 | 0.865 | 0.934 | 15.774 | -0.077 | -0.077 | 0.000 | 0.000 | 0.000 | 0.000 |
35 | A | 32 | ALA | 0 | 0.017 | 0.011 | 16.952 | 0.045 | 0.045 | 0.000 | 0.000 | 0.000 | 0.000 |
36 | A | 33 | ASP | -1 | -0.740 | -0.845 | 11.801 | 0.334 | 0.334 | 0.000 | 0.000 | 0.000 | 0.000 |
37 | A | 34 | LEU | 0 | -0.029 | -0.025 | 12.005 | 0.150 | 0.150 | 0.000 | 0.000 | 0.000 | 0.000 |
38 | A | 35 | MET | 0 | -0.076 | -0.035 | 13.888 | 0.056 | 0.056 | 0.000 | 0.000 | 0.000 | 0.000 |
39 | A | 36 | THR | 0 | 0.005 | 0.011 | 10.391 | 0.020 | 0.020 | 0.000 | 0.000 | 0.000 | 0.000 |
40 | A | 37 | VAL | 0 | -0.021 | -0.010 | 8.521 | 0.165 | 0.165 | 0.000 | 0.000 | 0.000 | 0.000 |
41 | A | 38 | LEU | 0 | -0.038 | -0.032 | 10.814 | 0.092 | 0.092 | 0.000 | 0.000 | 0.000 | 0.000 |
42 | A | 39 | GLU | -1 | -0.877 | -0.937 | 14.118 | 0.548 | 0.548 | 0.000 | 0.000 | 0.000 | 0.000 |
43 | A | 40 | ARG | 1 | 0.989 | 0.999 | 3.579 | -8.073 | -7.171 | 0.010 | -0.524 | -0.388 | 0.005 |
44 | A | 41 | VAL | 0 | -0.048 | -0.030 | 10.945 | 0.030 | 0.030 | 0.000 | 0.000 | 0.000 | 0.000 |
45 | A | 42 | ARG | 1 | 0.831 | 0.912 | 12.599 | -0.540 | -0.540 | 0.000 | 0.000 | 0.000 | 0.000 |
46 | A | 43 | ASP | -1 | -0.902 | -0.932 | 13.384 | 0.609 | 0.609 | 0.000 | 0.000 | 0.000 | 0.000 |
47 | A | 44 | ASP | -1 | -0.890 | -0.945 | 9.989 | 1.256 | 1.256 | 0.000 | 0.000 | 0.000 | 0.000 |
48 | A | 45 | ALA | 0 | -0.035 | -0.021 | 13.170 | 0.013 | 0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
49 | A | 46 | ASP | -1 | -0.936 | -0.956 | 11.877 | 0.486 | 0.486 | 0.000 | 0.000 | 0.000 | 0.000 |
50 | A | 47 | ILE | 0 | -0.060 | -0.020 | 8.536 | 0.045 | 0.045 | 0.000 | 0.000 | 0.000 | 0.000 |
51 | A | 48 | ARG | 1 | 0.882 | 0.945 | 11.595 | -0.428 | -0.428 | 0.000 | 0.000 | 0.000 | 0.000 |
52 | A | 49 | VAL | 0 | -0.011 | 0.006 | 13.585 | -0.070 | -0.070 | 0.000 | 0.000 | 0.000 | 0.000 |
53 | A | 50 | LEU | 0 | -0.002 | 0.009 | 10.985 | 0.127 | 0.127 | 0.000 | 0.000 | 0.000 | 0.000 |
54 | A | 51 | VAL | 0 | 0.010 | 0.013 | 11.524 | -0.098 | -0.098 | 0.000 | 0.000 | 0.000 | 0.000 |
55 | A | 52 | LEU | 0 | -0.011 | -0.002 | 11.724 | 0.039 | 0.039 | 0.000 | 0.000 | 0.000 | 0.000 |
56 | A | 53 | THR | 0 | 0.000 | -0.023 | 10.434 | -0.067 | -0.067 | 0.000 | 0.000 | 0.000 | 0.000 |
57 | A | 54 | SER | 0 | -0.012 | 0.002 | 11.365 | 0.036 | 0.036 | 0.000 | 0.000 | 0.000 | 0.000 |
58 | A | 55 | HIS | 0 | 0.018 | 0.022 | 10.669 | -0.103 | -0.103 | 0.000 | 0.000 | 0.000 | 0.000 |
59 | A | 56 | PRO | 0 | 0.027 | -0.005 | 11.600 | 0.075 | 0.075 | 0.000 | 0.000 | 0.000 | 0.000 |
60 | A | 57 | GLY | 0 | -0.047 | -0.011 | 14.768 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
61 | A | 58 | SER | 0 | -0.053 | -0.035 | 15.899 | 0.027 | 0.027 | 0.000 | 0.000 | 0.000 | 0.000 |
62 | A | 59 | PHE | 0 | -0.027 | -0.011 | 16.032 | -0.010 | -0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
63 | A | 60 | CYS | 0 | -0.042 | 0.000 | 16.459 | 0.010 | 0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
64 | A | 61 | ALA | 0 | 0.065 | 0.025 | 19.052 | 0.011 | 0.011 | 0.000 | 0.000 | 0.000 | 0.000 |
65 | A | 62 | GLY | 0 | -0.026 | -0.001 | 22.272 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
66 | A | 63 | GLY | 0 | 0.049 | 0.006 | 23.718 | -0.012 | -0.012 | 0.000 | 0.000 | 0.000 | 0.000 |
67 | A | 64 | ASN | 0 | -0.027 | -0.017 | 23.748 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
68 | A | 65 | LEU | 0 | 0.059 | 0.022 | 25.431 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
69 | A | 66 | HIS | 0 | 0.006 | 0.012 | 27.309 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
70 | A | 67 | VAL | 0 | 0.056 | 0.040 | 25.877 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
71 | A | 68 | LEU | 0 | 0.000 | -0.005 | 29.127 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
72 | A | 69 | ARG | 1 | 0.944 | 0.974 | 31.627 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
73 | A | 70 | ASP | -1 | -0.916 | -0.968 | 31.374 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
74 | A | 71 | ASN | 0 | -0.077 | -0.042 | 31.529 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
75 | A | 72 | LEU | 0 | -0.019 | -0.004 | 34.916 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
76 | A | 73 | ASP | -1 | -0.900 | -0.936 | 37.445 | 0.017 | 0.017 | 0.000 | 0.000 | 0.000 | 0.000 |
77 | A | 74 | SER | 0 | -0.055 | -0.031 | 35.668 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
78 | A | 75 | GLY | 0 | 0.018 | 0.020 | 38.714 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
79 | A | 76 | PRO | 0 | 0.021 | -0.015 | 38.906 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
80 | A | 77 | ALA | 0 | 0.013 | 0.011 | 38.699 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
81 | A | 78 | TYR | 0 | 0.040 | 0.026 | 31.860 | 0.008 | 0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
82 | A | 79 | TRP | 0 | 0.054 | 0.009 | 31.690 | 0.010 | 0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
83 | A | 80 | GLN | 0 | -0.006 | 0.004 | 34.118 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
84 | A | 81 | GLN | 0 | -0.003 | -0.010 | 31.642 | 0.016 | 0.016 | 0.000 | 0.000 | 0.000 | 0.000 |
85 | A | 82 | ARG | 1 | 0.933 | 0.972 | 26.875 | -0.049 | -0.049 | 0.000 | 0.000 | 0.000 | 0.000 |
86 | A | 83 | ILE | 0 | 0.037 | 0.015 | 29.079 | 0.008 | 0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
87 | A | 84 | LYS | 1 | 0.939 | 0.971 | 29.419 | -0.081 | -0.081 | 0.000 | 0.000 | 0.000 | 0.000 |
88 | A | 85 | THR | 0 | -0.049 | -0.018 | 24.945 | 0.014 | 0.014 | 0.000 | 0.000 | 0.000 | 0.000 |
89 | A | 86 | GLY | 0 | 0.002 | 0.006 | 24.880 | 0.016 | 0.016 | 0.000 | 0.000 | 0.000 | 0.000 |
90 | A | 87 | LEU | 0 | -0.006 | -0.024 | 24.899 | 0.011 | 0.011 | 0.000 | 0.000 | 0.000 | 0.000 |
91 | A | 88 | ARG | 1 | 0.946 | 0.984 | 24.451 | -0.149 | -0.149 | 0.000 | 0.000 | 0.000 | 0.000 |
92 | A | 89 | PHE | 0 | 0.075 | 0.041 | 17.288 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
93 | A | 90 | ILE | 0 | -0.005 | 0.001 | 21.613 | 0.017 | 0.017 | 0.000 | 0.000 | 0.000 | 0.000 |
94 | A | 91 | HIS | 0 | -0.030 | -0.018 | 23.801 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
95 | A | 92 | ASP | -1 | -0.864 | -0.948 | 20.089 | 0.294 | 0.294 | 0.000 | 0.000 | 0.000 | 0.000 |
96 | A | 93 | MET | 0 | -0.046 | -0.018 | 17.268 | 0.046 | 0.046 | 0.000 | 0.000 | 0.000 | 0.000 |
97 | A | 94 | LEU | 0 | -0.035 | -0.020 | 20.588 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
98 | A | 95 | ASN | 0 | -0.018 | -0.012 | 23.238 | -0.010 | -0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
99 | A | 96 | LEU | 0 | -0.026 | 0.016 | 15.679 | 0.017 | 0.017 | 0.000 | 0.000 | 0.000 | 0.000 |
100 | A | 97 | GLY | 0 | 0.013 | -0.004 | 20.206 | -0.021 | -0.021 | 0.000 | 0.000 | 0.000 | 0.000 |
101 | A | 98 | ARG | 1 | 0.812 | 0.890 | 14.380 | -0.647 | -0.647 | 0.000 | 0.000 | 0.000 | 0.000 |
102 | A | 99 | PRO | 0 | 0.005 | 0.005 | 18.091 | -0.016 | -0.016 | 0.000 | 0.000 | 0.000 | 0.000 |
103 | A | 100 | VAL | 0 | 0.001 | 0.002 | 16.253 | 0.048 | 0.048 | 0.000 | 0.000 | 0.000 | 0.000 |
104 | A | 101 | ILE | 0 | 0.000 | -0.002 | 16.223 | -0.042 | -0.042 | 0.000 | 0.000 | 0.000 | 0.000 |
105 | A | 102 | ALA | 0 | 0.013 | 0.010 | 16.058 | 0.008 | 0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
106 | A | 103 | ALA | 0 | -0.006 | 0.001 | 14.655 | -0.013 | -0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
107 | A | 104 | VAL | 0 | -0.016 | -0.018 | 15.943 | -0.025 | -0.025 | 0.000 | 0.000 | 0.000 | 0.000 |
108 | A | 105 | ASP | -1 | -0.686 | -0.799 | 16.674 | -0.166 | -0.166 | 0.000 | 0.000 | 0.000 | 0.000 |
109 | A | 106 | GLY | 0 | 0.032 | 0.013 | 18.649 | -0.021 | -0.021 | 0.000 | 0.000 | 0.000 | 0.000 |
110 | A | 107 | PRO | 0 | 0.009 | -0.002 | 20.435 | 0.015 | 0.015 | 0.000 | 0.000 | 0.000 | 0.000 |
111 | A | 108 | ALA | 0 | 0.032 | 0.027 | 21.081 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
112 | A | 109 | PHE | 0 | -0.017 | -0.024 | 22.675 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
113 | A | 110 | GLY | 0 | -0.015 | -0.012 | 24.662 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
114 | A | 111 | ALA | 0 | 0.053 | 0.016 | 23.249 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
115 | A | 112 | GLY | 0 | 0.044 | 0.026 | 21.081 | 0.016 | 0.016 | 0.000 | 0.000 | 0.000 | 0.000 |
116 | A | 113 | PHE | 0 | -0.009 | -0.008 | 21.981 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
117 | A | 114 | ALA | 0 | 0.018 | 0.007 | 24.756 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
118 | A | 115 | LEU | 0 | 0.011 | 0.004 | 17.375 | 0.012 | 0.012 | 0.000 | 0.000 | 0.000 | 0.000 |
119 | A | 116 | SER | 0 | -0.073 | -0.042 | 20.999 | 0.012 | 0.012 | 0.000 | 0.000 | 0.000 | 0.000 |
120 | A | 117 | LEU | 0 | -0.025 | -0.026 | 21.935 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
121 | A | 118 | THR | 0 | -0.065 | -0.029 | 21.290 | 0.014 | 0.014 | 0.000 | 0.000 | 0.000 | 0.000 |
122 | A | 119 | ALA | 0 | -0.050 | -0.007 | 20.128 | 0.023 | 0.023 | 0.000 | 0.000 | 0.000 | 0.000 |
123 | A | 120 | ASP | -1 | -0.758 | -0.861 | 20.909 | 0.200 | 0.200 | 0.000 | 0.000 | 0.000 | 0.000 |
124 | A | 121 | ILE | 0 | -0.028 | -0.012 | 20.984 | -0.020 | -0.020 | 0.000 | 0.000 | 0.000 | 0.000 |
125 | A | 122 | VAL | 0 | 0.023 | 0.019 | 20.767 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
126 | A | 123 | LEU | 0 | -0.013 | -0.001 | 18.310 | -0.008 | -0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
127 | A | 124 | ALA | 0 | 0.010 | 0.004 | 20.110 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
128 | A | 125 | SER | 0 | 0.041 | -0.001 | 20.371 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
129 | A | 126 | PRO | 0 | 0.008 | -0.011 | 22.316 | 0.009 | 0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
130 | A | 127 | ARG | 1 | 0.838 | 0.901 | 18.143 | 0.171 | 0.171 | 0.000 | 0.000 | 0.000 | 0.000 |
131 | A | 128 | ALA | 0 | -0.067 | -0.005 | 22.224 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
132 | A | 129 | ARG | 1 | 0.882 | 0.946 | 23.378 | 0.052 | 0.052 | 0.000 | 0.000 | 0.000 | 0.000 |
133 | A | 130 | PHE | 0 | 0.038 | 0.025 | 23.316 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
134 | A | 131 | SER | 0 | 0.003 | 0.017 | 27.035 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
135 | A | 132 | MET | 0 | 0.006 | 0.003 | 28.471 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
136 | A | 133 | ALA | 0 | 0.033 | 0.002 | 30.630 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
137 | A | 134 | TYR | 0 | -0.021 | -0.029 | 28.177 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
138 | A | 135 | LEU | 0 | 0.053 | 0.037 | 33.433 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
139 | A | 136 | ARG | 1 | 0.860 | 0.926 | 32.388 | 0.008 | 0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
140 | A | 137 | LEU | 0 | -0.049 | -0.024 | 31.262 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
141 | A | 138 | GLY | 0 | 0.004 | 0.017 | 36.012 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
142 | A | 139 | LEU | 0 | -0.051 | -0.017 | 33.680 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
143 | A | 140 | VAL | 0 | -0.013 | -0.010 | 35.633 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
144 | A | 141 | PRO | 0 | -0.006 | -0.027 | 32.466 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
145 | A | 142 | ASP | -1 | -0.842 | -0.901 | 28.983 | 0.065 | 0.065 | 0.000 | 0.000 | 0.000 | 0.000 |
146 | A | 143 | LEU | 0 | -0.005 | -0.013 | 24.455 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
147 | A | 144 | GLY | 0 | 0.068 | 0.034 | 27.318 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
148 | A | 145 | ALA | 0 | 0.045 | 0.029 | 29.659 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
149 | A | 146 | LEU | 0 | -0.035 | -0.031 | 30.845 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
150 | A | 147 | TYR | 0 | -0.101 | -0.068 | 30.011 | -0.004 | -0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
151 | A | 148 | LEU | 0 | 0.054 | 0.017 | 26.821 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
152 | A | 149 | LEU | 0 | 0.030 | 0.023 | 30.760 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
153 | A | 150 | PRO | 0 | -0.049 | -0.035 | 32.392 | -0.004 | -0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
154 | A | 151 | ARG | 1 | 0.810 | 0.900 | 32.653 | -0.082 | -0.082 | 0.000 | 0.000 | 0.000 | 0.000 |
155 | A | 152 | ALA | 0 | 0.018 | 0.041 | 30.616 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
156 | A | 153 | VAL | 0 | -0.021 | -0.012 | 32.600 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
157 | A | 154 | GLY | 0 | 0.031 | 0.021 | 35.248 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
158 | A | 155 | LEU | 0 | 0.000 | -0.018 | 38.036 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
159 | A | 156 | GLN | 0 | 0.028 | -0.011 | 40.148 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
160 | A | 157 | ARG | 1 | 1.027 | 1.017 | 36.738 | -0.020 | -0.020 | 0.000 | 0.000 | 0.000 | 0.000 |
161 | A | 158 | ALA | 0 | 0.070 | 0.046 | 35.780 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
162 | A | 159 | LYS | 1 | 0.926 | 0.956 | 36.795 | -0.028 | -0.028 | 0.000 | 0.000 | 0.000 | 0.000 |
163 | A | 160 | GLU | -1 | -0.843 | -0.888 | 38.132 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
164 | A | 161 | LEU | 0 | 0.048 | 0.037 | 32.830 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
165 | A | 162 | MET | 0 | -0.058 | -0.029 | 33.244 | -0.002 | -0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
166 | A | 163 | PHE | 0 | -0.048 | -0.024 | 36.224 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
167 | A | 164 | SER | 0 | -0.007 | -0.009 | 37.491 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
168 | A | 165 | THR | 0 | -0.063 | -0.018 | 34.339 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
169 | A | 166 | ARG | 1 | 0.746 | 0.838 | 33.800 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
170 | A | 167 | GLU | -1 | -0.944 | -0.985 | 29.448 | -0.030 | -0.030 | 0.000 | 0.000 | 0.000 | 0.000 |
171 | A | 168 | LEU | 0 | -0.039 | -0.012 | 29.820 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
172 | A | 169 | ASP | -1 | -0.827 | -0.917 | 28.692 | -0.026 | -0.026 | 0.000 | 0.000 | 0.000 | 0.000 |
173 | A | 170 | ALA | 0 | 0.037 | 0.007 | 25.833 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
174 | A | 171 | GLU | -1 | -0.929 | -0.958 | 27.480 | -0.016 | -0.016 | 0.000 | 0.000 | 0.000 | 0.000 |
175 | A | 172 | GLU | -1 | -0.818 | -0.907 | 30.661 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
176 | A | 173 | ALA | 0 | 0.002 | -0.011 | 27.896 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
177 | A | 174 | HIS | 0 | -0.078 | -0.029 | 28.431 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
178 | A | 175 | ARG | 1 | 0.943 | 0.971 | 29.821 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
179 | A | 176 | LEU | 0 | -0.145 | -0.076 | 32.368 | 0.003 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
180 | A | 177 | GLY | 0 | 0.025 | 0.027 | 30.881 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
181 | A | 178 | LEU | 0 | -0.045 | -0.012 | 27.503 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
182 | A | 179 | VAL | 0 | -0.016 | 0.000 | 24.376 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
183 | A | 180 | MET | 0 | 0.003 | 0.008 | 24.633 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
184 | A | 181 | GLU | -1 | -0.807 | -0.884 | 23.979 | -0.007 | -0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
185 | A | 182 | VAL | 0 | 0.023 | 0.012 | 24.075 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
186 | A | 183 | HIS | 0 | -0.090 | -0.072 | 21.309 | -0.007 | -0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
187 | A | 184 | GLU | -1 | -0.854 | -0.935 | 22.507 | -0.090 | -0.090 | 0.000 | 0.000 | 0.000 | 0.000 |
188 | A | 185 | SER | 0 | -0.001 | -0.030 | 18.899 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
189 | A | 186 | GLU | -1 | -0.941 | -0.970 | 17.733 | -0.175 | -0.175 | 0.000 | 0.000 | 0.000 | 0.000 |
190 | A | 187 | ALA | 0 | -0.040 | -0.021 | 18.058 | -0.013 | -0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
191 | A | 188 | LEU | 0 | -0.030 | -0.006 | 16.794 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
192 | A | 189 | GLU | -1 | -0.824 | -0.917 | 9.911 | -0.561 | -0.561 | 0.000 | 0.000 | 0.000 | 0.000 |
193 | A | 190 | GLN | 0 | 0.015 | 0.002 | 14.375 | -0.020 | -0.020 | 0.000 | 0.000 | 0.000 | 0.000 |
194 | A | 191 | ARG | 1 | 0.797 | 0.883 | 16.064 | 0.039 | 0.039 | 0.000 | 0.000 | 0.000 | 0.000 |
195 | A | 192 | ALA | 0 | 0.027 | -0.003 | 14.630 | 0.029 | 0.029 | 0.000 | 0.000 | 0.000 | 0.000 |
196 | A | 193 | ARG | 1 | 0.884 | 0.946 | 9.718 | 0.400 | 0.400 | 0.000 | 0.000 | 0.000 | 0.000 |
197 | A | 194 | GLU | -1 | -0.898 | -0.955 | 14.624 | -0.019 | -0.019 | 0.000 | 0.000 | 0.000 | 0.000 |
198 | A | 195 | ILE | 0 | -0.025 | -0.012 | 18.102 | 0.024 | 0.024 | 0.000 | 0.000 | 0.000 | 0.000 |
199 | A | 196 | ALA | 0 | 0.040 | 0.029 | 14.571 | 0.026 | 0.026 | 0.000 | 0.000 | 0.000 | 0.000 |
200 | A | 197 | GLU | -1 | -0.851 | -0.939 | 12.982 | 0.009 | 0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
201 | A | 198 | SER | 0 | -0.102 | -0.057 | 16.538 | 0.013 | 0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
202 | A | 199 | LEU | 0 | 0.012 | -0.008 | 18.964 | 0.006 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
203 | A | 200 | VAL | 0 | 0.013 | 0.034 | 14.669 | 0.023 | 0.023 | 0.000 | 0.000 | 0.000 | 0.000 |
204 | A | 201 | GLN | 0 | -0.042 | -0.025 | 17.705 | 0.010 | 0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
205 | A | 202 | ALA | 0 | -0.057 | -0.013 | 21.034 | -0.013 | -0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
206 | A | 203 | ALA | 0 | 0.011 | -0.006 | 21.587 | 0.022 | 0.022 | 0.000 | 0.000 | 0.000 | 0.000 |
207 | A | 204 | PRO | 0 | 0.038 | 0.019 | 19.706 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
208 | A | 205 | THR | 0 | 0.022 | 0.017 | 21.853 | 0.009 | 0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
209 | A | 206 | ALA | 0 | 0.035 | 0.016 | 25.222 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
210 | A | 207 | LEU | 0 | -0.013 | 0.000 | 20.628 | -0.010 | -0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
211 | A | 208 | ALA | 0 | 0.018 | 0.019 | 22.766 | -0.007 | -0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
212 | A | 209 | LEU | 0 | -0.021 | -0.017 | 24.307 | -0.008 | -0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
213 | A | 210 | THR | 0 | -0.031 | -0.016 | 27.376 | -0.016 | -0.016 | 0.000 | 0.000 | 0.000 | 0.000 |
214 | A | 211 | LYS | 1 | 0.844 | 0.929 | 20.323 | -0.268 | -0.268 | 0.000 | 0.000 | 0.000 | 0.000 |
215 | A | 212 | ALA | 0 | -0.001 | 0.001 | 26.358 | -0.009 | -0.009 | 0.000 | 0.000 | 0.000 | 0.000 |
216 | A | 213 | ALA | 0 | 0.010 | 0.000 | 27.979 | -0.010 | -0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
217 | A | 214 | LEU | 0 | -0.017 | -0.022 | 28.768 | -0.011 | -0.011 | 0.000 | 0.000 | 0.000 | 0.000 |
218 | A | 215 | ASN | 0 | -0.044 | -0.025 | 25.211 | -0.022 | -0.022 | 0.000 | 0.000 | 0.000 | 0.000 |
219 | A | 216 | VAL | 0 | -0.002 | 0.008 | 29.585 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
220 | A | 217 | SER | 0 | 0.001 | -0.001 | 32.899 | -0.010 | -0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
221 | A | 218 | LEU | 0 | -0.029 | -0.030 | 34.658 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
222 | A | 219 | ASP | -1 | -0.829 | -0.875 | 34.089 | 0.090 | 0.090 | 0.000 | 0.000 | 0.000 | 0.000 |
223 | A | 220 | SER | 0 | -0.026 | -0.003 | 37.287 | -0.003 | -0.003 | 0.000 | 0.000 | 0.000 | 0.000 |
224 | A | 221 | ASP | -1 | -0.849 | -0.914 | 39.217 | 0.065 | 0.065 | 0.000 | 0.000 | 0.000 | 0.000 |
225 | A | 222 | GLU | -1 | -0.926 | -0.967 | 41.510 | 0.057 | 0.057 | 0.000 | 0.000 | 0.000 | 0.000 |
226 | A | 223 | GLN | 0 | 0.017 | 0.008 | 42.715 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
227 | A | 224 | THR | 0 | -0.026 | -0.028 | 38.715 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
228 | A | 225 | MET | 0 | -0.037 | -0.005 | 34.622 | 0.007 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
229 | A | 226 | PHE | 0 | 0.017 | 0.005 | 38.472 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
230 | A | 227 | SER | 0 | -0.016 | -0.005 | 40.517 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
231 | A | 228 | LEU | 0 | -0.024 | -0.007 | 33.056 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
232 | A | 229 | GLU | -1 | -0.941 | -0.960 | 35.634 | 0.087 | 0.087 | 0.000 | 0.000 | 0.000 | 0.000 |
233 | A | 230 | ALA | 0 | 0.001 | 0.002 | 36.517 | 0.004 | 0.004 | 0.000 | 0.000 | 0.000 | 0.000 |
234 | A | 231 | ALA | 0 | -0.022 | -0.015 | 35.830 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
235 | A | 232 | SER | 0 | -0.020 | -0.020 | 32.051 | 0.010 | 0.010 | 0.000 | 0.000 | 0.000 | 0.000 |
236 | A | 233 | GLN | 0 | 0.033 | 0.009 | 32.595 | 0.013 | 0.013 | 0.000 | 0.000 | 0.000 | 0.000 |
237 | A | 234 | ALA | 0 | -0.025 | -0.007 | 34.586 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
238 | A | 235 | ALA | 0 | -0.010 | -0.003 | 30.748 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
239 | A | 236 | ALA | 0 | 0.020 | 0.004 | 29.961 | 0.008 | 0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
240 | A | 237 | PHE | 0 | -0.046 | -0.018 | 30.898 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
241 | A | 238 | SER | 0 | -0.057 | -0.004 | 32.273 | -0.007 | -0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
242 | A | 239 | THR | 0 | -0.044 | -0.033 | 27.215 | 0.012 | 0.012 | 0.000 | 0.000 | 0.000 | 0.000 |
243 | A | 240 | LYS | 1 | 0.971 | 0.972 | 22.453 | -0.204 | -0.204 | 0.000 | 0.000 | 0.000 | 0.000 |
244 | A | 241 | GLU | -1 | -0.882 | -0.966 | 23.838 | 0.187 | 0.187 | 0.000 | 0.000 | 0.000 | 0.000 |
245 | A | 242 | PRO | 0 | 0.033 | 0.030 | 27.926 | -0.011 | -0.011 | 0.000 | 0.000 | 0.000 | 0.000 |
246 | A | 243 | ARG | 1 | 0.947 | 0.982 | 31.475 | -0.093 | -0.093 | 0.000 | 0.000 | 0.000 | 0.000 |
247 | A | 244 | ALA | 0 | 0.011 | 0.007 | 28.474 | -0.007 | -0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
248 | A | 245 | ALA | 0 | -0.006 | -0.009 | 29.673 | -0.007 | -0.007 | 0.000 | 0.000 | 0.000 | 0.000 |
249 | A | 246 | ILE | 0 | -0.008 | -0.007 | 31.106 | -0.008 | -0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
250 | A | 247 | GLU | -1 | -0.867 | -0.942 | 33.754 | 0.066 | 0.066 | 0.000 | 0.000 | 0.000 | 0.000 |
251 | A | 248 | ALA | 0 | -0.017 | 0.001 | 31.565 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
252 | A | 249 | LEU | 0 | 0.018 | 0.003 | 33.588 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
253 | A | 250 | LEU | 0 | -0.028 | -0.008 | 35.847 | -0.006 | -0.006 | 0.000 | 0.000 | 0.000 | 0.000 |
254 | A | 251 | SER | 0 | -0.060 | -0.013 | 36.215 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
255 | A | 252 | LYS | 1 | 0.881 | 0.927 | 38.099 | -0.031 | -0.031 | 0.000 | 0.000 | 0.000 | 0.000 |
256 | A | 253 | GLN | 0 | -0.043 | -0.009 | 32.984 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
257 | A | 254 | PRO | 0 | -0.019 | -0.019 | 30.144 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
258 | A | 255 | PRO | 0 | 0.031 | 0.024 | 29.450 | 0.002 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 |
259 | A | 256 | PRO | 0 | 0.008 | -0.012 | 24.554 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
260 | A | 257 | PHE | 0 | 0.021 | 0.021 | 23.326 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
261 | A | 258 | ARG | 1 | 0.913 | 0.950 | 25.743 | -0.055 | -0.055 | 0.000 | 0.000 | 0.000 | 0.000 |
262 | A | 259 | GLY | 0 | 0.034 | 0.033 | 26.517 | -0.008 | -0.008 | 0.000 | 0.000 | 0.000 | 0.000 |
263 | A | 260 | PHE | 0 | 0.005 | -0.003 | 23.014 | 0.001 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 |
264 | A | 261 | PRO | 0 | 0.026 | 0.016 | 21.380 | -0.005 | -0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
265 | A | 262 | ARG | 1 | 0.944 | 0.977 | 24.693 | 0.005 | 0.005 | 0.000 | 0.000 | 0.000 | 0.000 |
266 | A | 263 | ARG | 1 | 0.976 | 0.993 | 25.455 | 0.024 | 0.024 | 0.000 | 0.000 | 0.000 | 0.000 |
267 | A | 264 | SER | 0 | 0.006 | 0.012 | 24.562 | -0.001 | -0.001 | 0.000 | 0.000 | 0.000 | 0.000 |