FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-04-23

All entries: 37539

Number of unique PDB entries: 7791

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FMODB ID: 7G21K

Calculation Name: 4FKL-AB-MD339-md4_44ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: 4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine

ligand 3-letter code: CK2

PDB ID: 4FKL

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-09-05

Reference: K. Takaba et al., Protein-ligand binding affinity prediction of cyclin-dependent kinase-2 inhibitors by dynamically averaged fragment molecular orbital-based interaction energy, J. Comput. Chem., 43, 1362-1371, 2022.

DOI: 10.1002/jcc.26940

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2695
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -18835845.821399
FMO2-HF: Nuclear repulsion 18535202.77213
FMO2-HF: Total energy -300643.04927
FMO2-MP2: Total energy -301465.561139


3D Structure
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-53.348760-30.68612029.410959-14.684888-37.3887100.017543


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-73.176-48.00645.731-23.487-47.417-0.031
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.030 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.70213.791-0.006-0.0060.0000.0000.0000.000
2A2GLU-1-0.55818.103-0.048-0.0480.0000.0000.0000.000
3A3ASN0-0.00114.407-0.003-0.0030.0000.0000.0000.000
4A4PHE00.03911.043-0.019-0.0190.0000.0000.0000.000
5A5GLN00.03013.1180.0020.0020.0000.0000.0000.000
6A6LYS10.81611.4880.1460.1460.0000.0000.0000.000
7A7VAL0-0.01610.7850.0040.0040.0000.0000.0000.000
8A8GLU-1-0.6819.110-0.868-0.8680.0000.0000.0000.000
9A9LYS10.8397.2750.8540.8540.0000.0000.0000.000
10A10ILE00.0032.415-2.263-0.1781.481-0.633-2.9340.003
11A11GLY00.0542.392-3.521-2.3100.769-0.831-1.149-0.002
12A12GLU-1-0.7653.4230.5850.3760.0000.299-0.0900.000
13A13GLY00.0516.453-0.169-0.1690.0000.0000.0000.000
14A14THR00.1299.1280.0960.0960.0000.0000.0000.000
15A15TYR00.0266.3180.1850.1850.0000.0000.0000.000
16A16GLY00.0617.9630.2230.2230.0000.0000.0000.000
17A17VAL0-0.0275.676-0.390-0.3900.0000.0000.0000.000
18A18VAL00.0002.439-2.693-1.0364.080-1.230-4.5080.005
19A19TYR0-0.0204.507-1.188-0.961-0.001-0.006-0.2200.000
20A20LYS10.8845.6681.5531.5530.0000.0000.0000.000
21A21ALA00.0177.5920.0360.0360.0000.0000.0000.000
22A22ARG10.8209.7480.2200.2200.0000.0000.0000.000
23A23ASN00.02511.4000.0330.0330.0000.0000.0000.000
24A24LYS10.82912.9350.0970.0970.0000.0000.0000.000
25A25LEU00.03516.2010.0110.0110.0000.0000.0000.000
26A26THR0-0.07213.6140.0050.0050.0000.0000.0000.000
27A27GLY00.07215.3570.0130.0130.0000.0000.0000.000
28A28GLU-1-0.70810.040-0.026-0.0260.0000.0000.0000.000
29A29VAL00.0076.471-0.038-0.0380.0000.0000.0000.000
30A30VAL0-0.0205.5700.0230.0230.0000.0000.0000.000
31A31ALA00.0312.928-1.6590.2680.404-0.577-1.7540.003
32A32LEU0-0.0154.888-0.472-0.217-0.001-0.010-0.2440.000
33A33LYS10.8194.331-4.059-3.7430.000-0.028-0.2880.000
34A34LYS10.8816.963-0.369-0.3690.0000.0000.0000.000
35A35ILE00.0069.0080.1210.1210.0000.0000.0000.000
36A36ARG10.83111.902-0.160-0.1600.0000.0000.0000.000
37A37LEU00.0418.4590.0540.0540.0000.0000.0000.000
38A38ASP-1-0.70212.6550.1150.1150.0000.0000.0000.000
39A39THR00.08816.413-0.008-0.0080.0000.0000.0000.000
40A40GLU-1-0.65618.1750.0110.0110.0000.0000.0000.000
41A41THR0-0.02616.9200.0140.0140.0000.0000.0000.000
42A42GLU-1-0.67416.4920.0770.0770.0000.0000.0000.000
43A43GLY00.04516.253-0.003-0.0030.0000.0000.0000.000
44A44VAL00.05514.4880.0280.0280.0000.0000.0000.000
45A45PRO00.05917.398-0.010-0.0100.0000.0000.0000.000
46A46SER00.07819.2770.0320.0320.0000.0000.0000.000
47A47THR0-0.08220.7290.0150.0150.0000.0000.0000.000
48A48ALA0-0.01716.2390.0160.0160.0000.0000.0000.000
49A49ILE00.01115.2390.0610.0610.0000.0000.0000.000
50A50ARG10.85515.530-0.229-0.2290.0000.0000.0000.000
51A51GLU-1-0.70812.9450.4550.4550.0000.0000.0000.000
52A52ILE00.06410.9750.0640.0640.0000.0000.0000.000
53A53SER0-0.07612.488-0.027-0.0270.0000.0000.0000.000
54A54LEU00.00614.631-0.026-0.0260.0000.0000.0000.000
55A55LEU0-0.0197.185-0.006-0.0060.0000.0000.0000.000
56A56LYS10.85511.344-0.189-0.1890.0000.0000.0000.000
57A57GLU-1-0.60413.3790.2370.2370.0000.0000.0000.000
58A58LEU0-0.05310.806-0.007-0.0070.0000.0000.0000.000
59A59ASN00.01811.1580.0720.0720.0000.0000.0000.000
60A60HIS00.05610.9130.0330.0330.0000.0000.0000.000
61A61PRO00.05810.6350.1020.1020.0000.0000.0000.000
62A62ASN00.01210.607-0.010-0.0100.0000.0000.0000.000
63A63ILE0-0.0187.5320.1750.1750.0000.0000.0000.000
64A64VAL0-0.0122.507-2.415-0.6160.837-0.653-1.9820.007
65A65LYS10.8824.916-0.793-0.698-0.001-0.002-0.0920.000
66A66LEU0-0.0115.601-0.854-0.8540.0000.0000.0000.000
67A67LEU00.0217.1540.1960.1960.0000.0000.0000.000
68A68ASP-1-0.6549.0910.1700.1700.0000.0000.0000.000
69A69VAL00.00710.3420.0000.0000.0000.0000.0000.000
70A70ILE0-0.04412.364-0.019-0.0190.0000.0000.0000.000
71A71HIS00.04514.8960.0220.0220.0000.0000.0000.000
72A72THR00.02516.9540.0000.0000.0000.0000.0000.000
73A73GLU-1-0.70920.0580.0040.0040.0000.0000.0000.000
74A74ASN00.00319.816-0.014-0.0140.0000.0000.0000.000
75A75LYS10.80716.316-0.044-0.0440.0000.0000.0000.000
76A76LEU00.03111.893-0.020-0.0200.0000.0000.0000.000
77A77TYR0-0.01211.0930.0590.0590.0000.0000.0000.000
78A78LEU0-0.0306.111-0.048-0.0480.0000.0000.0000.000
79A79VAL00.0236.5840.1440.1440.0000.0000.0000.000
80A80PHE00.0142.970-2.069-0.0190.342-0.656-1.736-0.004
81A81GLU-1-0.6852.8920.5461.6760.082-0.490-0.721-0.002
82A82PHE00.0111.851-15.658-15.60114.385-6.326-8.116-0.037
83A83LEU0-0.0032.490-4.560-3.7941.4880.199-2.4530.011
84A84HIS00.0582.816-4.732-3.0670.305-0.857-1.113-0.010
85A85GLN0-0.0115.102-0.565-0.495-0.001-0.003-0.0660.000
86A86ASP-1-0.6366.500-0.217-0.2170.0000.0000.0000.000
87A87LEU00.0318.229-0.120-0.1200.0000.0000.0000.000
88A88LYS10.76811.3300.1670.1670.0000.0000.0000.000
89A89LYS10.86011.2720.4530.4530.0000.0000.0000.000
90A90PHE00.00412.4710.0390.0390.0000.0000.0000.000
91A91MET00.02314.2060.0080.0080.0000.0000.0000.000
92A92ASP-1-0.66416.564-0.210-0.2100.0000.0000.0000.000
93A93ALA00.02016.329-0.001-0.0010.0000.0000.0000.000
94A94SER00.00517.8760.0180.0180.0000.0000.0000.000
95A95ALA00.02720.2730.0140.0140.0000.0000.0000.000
96A96LEU0-0.02922.4960.0060.0060.0000.0000.0000.000
97A97THR00.04123.543-0.002-0.0020.0000.0000.0000.000
98A98GLY00.02624.0510.0100.0100.0000.0000.0000.000
99A99ILE0-0.01018.8920.0040.0040.0000.0000.0000.000
100A100PRO00.00622.151-0.001-0.0010.0000.0000.0000.000
101A101LEU00.03123.5900.0230.0230.0000.0000.0000.000
102A102PRO00.03424.5750.0180.0180.0000.0000.0000.000
103A103LEU00.02417.8170.0270.0270.0000.0000.0000.000
104A104ILE0-0.00319.8210.0430.0430.0000.0000.0000.000
105A105LYS10.80320.698-0.115-0.1150.0000.0000.0000.000
106A106SER00.00218.7230.0420.0420.0000.0000.0000.000
107A107TYR0-0.01514.4890.0290.0290.0000.0000.0000.000
108A108LEU00.03216.3080.0730.0730.0000.0000.0000.000
109A109PHE00.01318.4490.0300.0300.0000.0000.0000.000
110A110GLN0-0.03214.2200.1100.1100.0000.0000.0000.000
111A111LEU00.00512.6390.0630.0630.0000.0000.0000.000
112A112LEU00.00315.0660.0310.0310.0000.0000.0000.000
113A113GLN00.07216.678-0.030-0.0300.0000.0000.0000.000
114A114GLY00.04213.147-0.021-0.0210.0000.0000.0000.000
115A115LEU0-0.00913.9960.0030.0030.0000.0000.0000.000
116A116ALA0-0.01515.375-0.037-0.0370.0000.0000.0000.000
117A117PHE0-0.06913.766-0.027-0.0270.0000.0000.0000.000
118A118CYS0-0.01411.604-0.016-0.0160.0000.0000.0000.000
119A119HIS0-0.00215.232-0.063-0.0630.0000.0000.0000.000
120A120SER0-0.00418.185-0.034-0.0340.0000.0000.0000.000
121A121HIS0-0.01216.380-0.055-0.0550.0000.0000.0000.000
122A122ARG10.79918.592-0.261-0.2610.0000.0000.0000.000
123A123VAL00.01412.144-0.007-0.0070.0000.0000.0000.000
124A124LEU00.02714.7350.0240.0240.0000.0000.0000.000
125A125HIS0-0.0297.715-0.142-0.1420.0000.0000.0000.000
126A126ARG10.83011.552-0.167-0.1670.0000.0000.0000.000
127A127ASP-1-0.6619.037-0.210-0.2100.0000.0000.0000.000
128A128LEU0-0.03310.228-0.041-0.0410.0000.0000.0000.000
129A129LYS10.8886.3910.2670.2670.0000.0000.0000.000
130A130PRO00.02310.0700.1650.1650.0000.0000.0000.000
131A131GLN00.0136.0820.3430.3430.0000.0000.0000.000
132A132ASN0-0.0745.690-0.608-0.6080.0000.0000.0000.000
133A133LEU0-0.0097.3830.6700.6700.0000.0000.0000.000
134A134LEU0-0.0032.899-2.460-0.7221.945-0.560-3.1240.004
135A135ILE00.0397.0240.0340.0340.0000.0000.0000.000
136A136ASN00.0267.7570.1670.1670.0000.0000.0000.000
137A137THR00.05510.382-0.083-0.0830.0000.0000.0000.000
138A138GLU-1-0.64613.5830.2190.2190.0000.0000.0000.000
139A139GLY00.02314.573-0.053-0.0530.0000.0000.0000.000
140A140ALA0-0.00911.420-0.023-0.0230.0000.0000.0000.000
141A141ILE00.00210.2450.0400.0400.0000.0000.0000.000
142A142LYS10.7526.053-1.575-1.5750.0000.0000.0000.000
143A143LEU00.0417.7680.3110.3110.0000.0000.0000.000
144A144ALA00.0462.762-1.746-0.0680.318-0.488-1.5070.004
145A145ASP-1-0.7052.417-2.3561.3872.933-1.878-4.7970.000
146A146PHE0-0.0013.667-1.935-1.5320.0440.045-0.4930.001
147A147GLY00.1006.678-0.062-0.0620.0000.0000.0000.000
148A148LEU00.0157.723-0.166-0.1660.0000.0000.0000.000
149A149ALA00.03710.742-0.111-0.1110.0000.0000.0000.000
150A150ARG10.82312.194-0.491-0.4910.0000.0000.0000.000
151A151ALA00.01414.368-0.069-0.0690.0000.0000.0000.000
152A152PHE00.02610.955-0.036-0.0360.0000.0000.0000.000
153A153GLY00.04411.5920.0000.0000.0000.0000.0000.000
154A154VAL00.0029.1310.1840.1840.0000.0000.0000.000
155A155PRO0-0.0035.830-0.026-0.0260.0000.0000.0000.000
156A156VAL00.0369.076-0.015-0.0150.0000.0000.0000.000
157A157ARG10.80211.5890.1810.1810.0000.0000.0000.000
158A158THR00.0449.785-0.076-0.0760.0000.0000.0000.000
159A159TYR00.0099.0450.0480.0480.0000.0000.0000.000
160A160THR00.01611.4900.0640.0640.0000.0000.0000.000
161A161HIS00.03414.1710.0360.0360.0000.0000.0000.000
162A162GLU-1-0.66215.522-0.298-0.2980.0000.0000.0000.000
163A163VAL0-0.00514.111-0.066-0.0660.0000.0000.0000.000
164A164VAL00.02010.262-0.043-0.0430.0000.0000.0000.000
165A165THR00.03713.2210.0620.0620.0000.0000.0000.000
166A166LEU00.01814.3050.0090.0090.0000.0000.0000.000
167A167TRP0-0.01214.9110.0360.0360.0000.0000.0000.000
168A168TYR00.02612.6170.0570.0570.0000.0000.0000.000
169A169ARG10.81014.3350.0640.0640.0000.0000.0000.000
170A170ALA00.03517.529-0.004-0.0040.0000.0000.0000.000
171A171PRO00.01020.276-0.012-0.0120.0000.0000.0000.000
172A172GLU-1-0.70921.9260.1340.1340.0000.0000.0000.000
173A173ILE00.00417.588-0.007-0.0070.0000.0000.0000.000
174A174LEU00.00520.136-0.017-0.0170.0000.0000.0000.000
175A175LEU00.00522.767-0.012-0.0120.0000.0000.0000.000
176A176GLY00.00723.929-0.001-0.0010.0000.0000.0000.000
177A177CYS0-0.07824.0390.0090.0090.0000.0000.0000.000
178A178LYS10.93422.393-0.065-0.0650.0000.0000.0000.000
179A179TYR0-0.05222.8030.0200.0200.0000.0000.0000.000
180A180TYR00.03018.0940.0170.0170.0000.0000.0000.000
181A181SER0-0.03722.0650.0130.0130.0000.0000.0000.000
182A182THR00.04818.510-0.015-0.0150.0000.0000.0000.000
183A183ALA00.04319.3060.0250.0250.0000.0000.0000.000
184A184VAL0-0.02717.230-0.012-0.0120.0000.0000.0000.000
185A185ASP-1-0.71115.3390.4800.4800.0000.0000.0000.000
186A186ILE0-0.01917.3340.0160.0160.0000.0000.0000.000
187A187TRP00.08020.002-0.006-0.0060.0000.0000.0000.000
188A188SER0-0.00615.590-0.004-0.0040.0000.0000.0000.000
189A189LEU0-0.03416.0400.0050.0050.0000.0000.0000.000
190A190GLY00.04718.005-0.013-0.0130.0000.0000.0000.000
191A191CYS0-0.07818.195-0.023-0.0230.0000.0000.0000.000
192A192ILE0-0.01413.854-0.024-0.0240.0000.0000.0000.000
193A193PHE0-0.02717.839-0.005-0.0050.0000.0000.0000.000
194A194ALA00.05020.981-0.014-0.0140.0000.0000.0000.000
195A195GLU-1-0.71217.308-0.079-0.0790.0000.0000.0000.000
196A196MET00.01017.378-0.007-0.0070.0000.0000.0000.000
197A197VAL0-0.01520.967-0.005-0.0050.0000.0000.0000.000
198A198THR0-0.03123.598-0.019-0.0190.0000.0000.0000.000
199A199ARG10.86920.368-0.050-0.0500.0000.0000.0000.000
200A200ARG10.82621.767-0.028-0.0280.0000.0000.0000.000
201A201ALA00.03119.7830.0240.0240.0000.0000.0000.000
202A202LEU0-0.02621.1170.0020.0020.0000.0000.0000.000
203A203PHE00.06121.6260.0050.0050.0000.0000.0000.000
204A204PRO00.04120.958-0.010-0.0100.0000.0000.0000.000
205A205GLY00.04721.2270.0180.0180.0000.0000.0000.000
206A206ASP-1-0.64321.150-0.153-0.1530.0000.0000.0000.000
207A207SER00.04522.226-0.013-0.0130.0000.0000.0000.000
208A208GLU-1-0.64120.960-0.013-0.0130.0000.0000.0000.000
209A209ILE0-0.00222.6950.0150.0150.0000.0000.0000.000
210A210ASP-1-0.70525.285-0.059-0.0590.0000.0000.0000.000
211A211GLN0-0.01020.653-0.015-0.0150.0000.0000.0000.000
212A212LEU0-0.00623.8740.0110.0110.0000.0000.0000.000
213A213PHE00.03326.0870.0100.0100.0000.0000.0000.000
214A214ARG10.84725.3810.0460.0460.0000.0000.0000.000
215A215ILE00.00123.1910.0080.0080.0000.0000.0000.000
216A216PHE0-0.03027.1520.0050.0050.0000.0000.0000.000
217A217ARG10.80929.2560.0310.0310.0000.0000.0000.000
218A218THR0-0.01828.050-0.004-0.0040.0000.0000.0000.000
219A219LEU0-0.00628.0740.0060.0060.0000.0000.0000.000
220A220GLY00.07231.7780.0030.0030.0000.0000.0000.000
221A221THR0-0.02833.2090.0060.0060.0000.0000.0000.000
222A222PRO00.04130.9400.0030.0030.0000.0000.0000.000
223A223ASP-1-0.61033.9330.0330.0330.0000.0000.0000.000
224A224GLU-1-0.68835.9970.0650.0650.0000.0000.0000.000
225A225VAL00.04237.7240.0030.0030.0000.0000.0000.000
226A226VAL0-0.04333.4870.0020.0020.0000.0000.0000.000
227A227TRP00.01126.7670.0070.0070.0000.0000.0000.000
228A228PRO00.01933.793-0.003-0.0030.0000.0000.0000.000
229A229GLY00.04632.8660.0090.0090.0000.0000.0000.000
230A230VAL0-0.01130.706-0.001-0.0010.0000.0000.0000.000
231A231THR0-0.00632.282-0.005-0.0050.0000.0000.0000.000
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