FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-04-23

All entries: 37539

Number of unique PDB entries: 7791

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FMODB ID: 9G482

Calculation Name: 4FKQ-AB-MD334-md3_48ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: 4-[(2z)-2-(7-oxidanylidene-3,6-dihydropyrrolo[3,2-e]benzotriazol-8-ylidene)hydrazinyl]benzenesulfonamide

ligand 3-letter code: 42K

PDB ID: 4FKQ

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-08-17

Reference: K. Takaba et al., Protein-ligand binding affinity prediction of cyclin-dependent kinase-2 inhibitors by dynamically averaged fragment molecular orbital-based interaction energy, J. Comput. Chem., 43, 1362-1371, 2022.

DOI: 10.1002/jcc.26940

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2634
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -18540516.374304
FMO2-HF: Nuclear repulsion 18243933.386982
FMO2-HF: Total energy -296582.987322
FMO2-MP2: Total energy -297395.637163


3D Structure
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-103.970829-79.94697764.420586-30.022398-58.4220400.140018


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-165.381-137.152110.565-55.084-83.71-0.126
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.126 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.78411.4821.3331.3330.0000.0000.0000.000
2A2GLU-1-0.63415.484-1.048-1.0480.0000.0000.0000.000
3A3ASN00.05514.3750.2570.2570.0000.0000.0000.000
4A4PHE00.04111.274-0.013-0.0130.0000.0000.0000.000
5A5GLN0-0.02813.393-0.018-0.0180.0000.0000.0000.000
6A6LYS10.81411.5561.1091.1090.0000.0000.0000.000
7A7VAL00.01310.9080.0880.0880.0000.0000.0000.000
8A8GLU-1-0.6546.6240.1220.1220.0000.0000.0000.000
9A9LYS10.8386.5300.3420.3420.0000.0000.0000.000
10A10ILE0-0.0212.669-5.074-1.1073.006-1.425-5.5480.011
11A11GLY00.0311.866-15.952-18.16412.174-4.684-5.279-0.057
12A12GLU-1-0.7323.8330.6580.9330.004-0.041-0.2390.000
13A13GLY00.0856.5371.2141.2140.0000.0000.0000.000
14A14THR00.0217.740-0.771-0.7710.0000.0000.0000.000
15A15TYR0-0.0107.758-0.254-0.2540.0000.0000.0000.000
16A16GLY00.0477.059-0.635-0.6350.0000.0000.0000.000
17A17VAL0-0.0377.2301.0041.0040.0000.0000.0000.000
18A18VAL0-0.0162.866-4.292-1.5800.879-0.748-2.8440.009
19A19TYR00.0045.932-0.373-0.3730.0000.0000.0000.000
20A20LYS10.8546.457-0.243-0.2430.0000.0000.0000.000
21A21ALA00.0047.414-0.104-0.1040.0000.0000.0000.000
22A22ARG10.8159.1600.5690.5690.0000.0000.0000.000
23A23ASN00.00311.6380.0500.0500.0000.0000.0000.000
24A24LYS10.82913.7780.9750.9750.0000.0000.0000.000
25A25LEU0-0.00217.2190.1080.1080.0000.0000.0000.000
26A26THR00.02115.7630.0850.0850.0000.0000.0000.000
27A27GLY00.08715.9730.0870.0870.0000.0000.0000.000
28A28GLU-1-0.72511.702-1.045-1.0450.0000.0000.0000.000
29A29VAL00.0556.277-0.149-0.1490.0000.0000.0000.000
30A30VAL0-0.0215.826-0.295-0.2950.0000.0000.0000.000
31A31ALA00.0272.697-0.5620.3423.129-1.116-2.9180.006
32A32LEU0-0.0024.550-1.498-1.1360.000-0.036-0.3260.000
33A33LYS10.8332.7847.2639.0780.125-0.656-1.2830.000
34A34LYS10.8296.6270.6310.6310.0000.0000.0000.000
35A35ILE0-0.0067.4320.1220.1220.0000.0000.0000.000
36A36ARG10.7979.902-0.108-0.1080.0000.0000.0000.000
37A37LEU00.00111.6850.1670.1670.0000.0000.0000.000
38A38ASP-1-0.66013.731-0.208-0.2080.0000.0000.0000.000
39A39THR00.00416.594-0.126-0.1260.0000.0000.0000.000
40A40GLU-1-0.61418.591-0.363-0.3630.0000.0000.0000.000
41A41THR0-0.02418.687-0.002-0.0020.0000.0000.0000.000
42A42GLU-1-0.60420.144-0.471-0.4710.0000.0000.0000.000
43A43GLY00.00516.5130.0100.0100.0000.0000.0000.000
44A44VAL0-0.02712.522-0.045-0.0450.0000.0000.0000.000
45A45PRO00.13115.1320.0290.0290.0000.0000.0000.000
46A46SER00.04517.183-0.119-0.1190.0000.0000.0000.000
47A47THR0-0.07516.0670.0440.0440.0000.0000.0000.000
48A48ALA0-0.00314.141-0.151-0.1510.0000.0000.0000.000
49A49ILE00.06313.072-0.339-0.3390.0000.0000.0000.000
50A50ARG10.80514.7881.0621.0620.0000.0000.0000.000
51A51GLU-1-0.60414.877-1.192-1.1920.0000.0000.0000.000
52A52ILE00.0109.268-0.202-0.2020.0000.0000.0000.000
53A53SER00.00711.896-0.251-0.2510.0000.0000.0000.000
54A54LEU0-0.01914.0610.1450.1450.0000.0000.0000.000
55A55LEU00.0176.9830.1490.1490.0000.0000.0000.000
56A56LYS10.76110.3901.6771.6770.0000.0000.0000.000
57A57GLU-1-0.68211.721-1.391-1.3910.0000.0000.0000.000
58A58LEU00.03310.6890.2540.2540.0000.0000.0000.000
59A59ASN0-0.09211.050-0.690-0.6900.0000.0000.0000.000
60A60HIS00.05411.3270.2080.2080.0000.0000.0000.000
61A61PRO00.05910.948-0.393-0.3930.0000.0000.0000.000
62A62ASN0-0.05110.9950.0370.0370.0000.0000.0000.000
63A63ILE0-0.0076.7070.3320.3320.0000.0000.0000.000
64A64VAL0-0.0062.576-1.4050.2671.749-0.679-2.7420.002
65A65LYS10.8804.7361.8512.059-0.001-0.008-0.1990.000
66A66LEU0-0.0094.941-2.231-2.130-0.001-0.008-0.0920.000
67A67LEU0-0.0326.6091.1051.1050.0000.0000.0000.000
68A68ASP-1-0.6378.573-1.338-1.3380.0000.0000.0000.000
69A69VAL00.0029.245-0.633-0.6330.0000.0000.0000.000
70A70ILE0-0.04211.2280.3520.3520.0000.0000.0000.000
71A71HIS00.13113.939-0.136-0.1360.0000.0000.0000.000
72A72THR00.01516.3600.0520.0520.0000.0000.0000.000
73A73GLU-1-0.71619.922-0.576-0.5760.0000.0000.0000.000
74A74ASN00.01719.268-0.053-0.0530.0000.0000.0000.000
75A75LYS10.88015.5570.8420.8420.0000.0000.0000.000
76A76LEU00.0009.912-0.046-0.0460.0000.0000.0000.000
77A77TYR00.02110.443-0.082-0.0820.0000.0000.0000.000
78A78LEU00.0126.232-0.014-0.0140.0000.0000.0000.000
79A79VAL00.0316.4090.3440.3440.0000.0000.0000.000
80A80PHE0-0.0132.519-6.079-2.5582.036-1.323-4.234-0.011
81A81GLU-1-0.6374.249-2.840-1.9820.000-0.401-0.456-0.001
82A82PHE0-0.0321.894-21.982-19.42811.246-6.763-7.038-0.032
83A83LEU00.0902.191-5.387-6.3142.1470.730-1.9490.013
84A84HIS00.0152.733-5.595-1.8151.085-1.850-3.015-0.020
85A85GLN00.0332.394-5.128-2.6033.850-2.201-4.173-0.020
86A86ASP-1-0.7113.4219.0569.1150.0060.576-0.6410.000
87A87LEU00.0426.4610.3170.3170.0000.0000.0000.000
88A88LYS10.7548.085-4.282-4.2820.0000.0000.0000.000
89A89LYS10.9213.721-11.552-10.8170.014-0.199-0.5500.001
90A90PHE00.0267.143-0.869-0.8690.0000.0000.0000.000
91A91MET00.0089.994-0.612-0.6120.0000.0000.0000.000
92A92ASP-1-0.63510.0132.7502.7500.0000.0000.0000.000
93A93ALA0-0.00910.905-0.203-0.2030.0000.0000.0000.000
94A94SER00.03212.718-0.349-0.3490.0000.0000.0000.000
95A95ALA00.05515.735-0.163-0.1630.0000.0000.0000.000
96A96LEU00.02117.218-0.095-0.0950.0000.0000.0000.000
97A97THR0-0.03518.471-0.089-0.0890.0000.0000.0000.000
98A98GLY00.06619.034-0.125-0.1250.0000.0000.0000.000
99A99ILE0-0.03515.5230.0890.0890.0000.0000.0000.000
100A100PRO00.05718.921-0.005-0.0050.0000.0000.0000.000
101A101LEU00.02221.7680.0280.0280.0000.0000.0000.000
102A102PRO00.04623.4360.0020.0020.0000.0000.0000.000
103A103LEU00.02417.612-0.053-0.0530.0000.0000.0000.000
104A104ILE0-0.00418.3360.0300.0300.0000.0000.0000.000
105A105LYS10.80719.816-0.416-0.4160.0000.0000.0000.000
106A106SER00.00920.192-0.100-0.1000.0000.0000.0000.000
107A107TYR0-0.02213.929-0.045-0.0450.0000.0000.0000.000
108A108LEU0-0.02816.525-0.065-0.0650.0000.0000.0000.000
109A109PHE00.03918.722-0.118-0.1180.0000.0000.0000.000
110A110GLN0-0.00314.867-0.236-0.2360.0000.0000.0000.000
111A111LEU0-0.01512.496-0.209-0.2090.0000.0000.0000.000
112A112LEU00.03815.250-0.220-0.2200.0000.0000.0000.000
113A113GLN00.03117.387-0.141-0.1410.0000.0000.0000.000
114A114GLY00.03013.265-0.141-0.1410.0000.0000.0000.000
115A115LEU0-0.03314.011-0.206-0.2060.0000.0000.0000.000
116A116ALA00.05814.962-0.141-0.1410.0000.0000.0000.000
117A117PHE0-0.02714.346-0.023-0.0230.0000.0000.0000.000
118A118CYS00.02212.270-0.162-0.1620.0000.0000.0000.000
119A119HIS0-0.03714.5310.1010.1010.0000.0000.0000.000
120A120SER00.02317.5880.1080.1080.0000.0000.0000.000
121A121HIS0-0.03916.1260.0540.0540.0000.0000.0000.000
122A122ARG10.83316.1191.2941.2940.0000.0000.0000.000
123A123VAL00.01211.059-0.061-0.0610.0000.0000.0000.000
124A124LEU00.01813.4330.1930.1930.0000.0000.0000.000
125A125HIS0-0.0236.291-0.181-0.1810.0000.0000.0000.000
126A126ARG10.82810.3011.0711.0710.0000.0000.0000.000
127A127ASP-1-0.6608.6780.3430.3430.0000.0000.0000.000
128A128LEU0-0.0139.1070.2880.2880.0000.0000.0000.000
129A129LYS10.7858.801-1.246-1.2460.0000.0000.0000.000
130A130PRO00.0589.4630.0070.0070.0000.0000.0000.000
131A131GLN00.0325.5540.1320.1320.0000.0000.0000.000
132A132ASN0-0.0334.4471.0101.288-0.001-0.039-0.2380.000
133A133LEU0-0.0146.510-1.442-1.4420.0000.0000.0000.000
134A134LEU00.0432.572-3.854-1.9677.063-1.774-7.1760.010
135A135ILE00.0026.088-0.735-0.7350.0000.0000.0000.000
136A136ASN00.0186.9130.1370.1370.0000.0000.0000.000
137A137THR00.0479.4580.1080.1080.0000.0000.0000.000
138A138GLU-1-0.74112.3650.5180.5180.0000.0000.0000.000
139A139GLY00.06013.971-0.077-0.0770.0000.0000.0000.000
140A140ALA0-0.00511.720-0.084-0.0840.0000.0000.0000.000
141A141ILE0-0.06410.0320.2770.2770.0000.0000.0000.000
142A142LYS10.7456.3921.7891.7890.0000.0000.0000.000
143A143LEU0-0.0127.7400.5740.5740.0000.0000.0000.000
144A144ALA00.0503.117-2.701-1.1340.725-0.601-1.6900.007
145A145ASP-1-0.6981.710-32.418-35.49915.160-6.723-5.356-0.057
146A146PHE00.0693.5881.2901.6040.025-0.029-0.3110.000
147A147GLY00.0857.164-0.255-0.2550.0000.0000.0000.000
148A148LEU0-0.0194.0390.3970.5480.000-0.026-0.1240.000
149A149ALA00.0267.6310.6800.6800.0000.0000.0000.000
150A150ARG10.8209.5191.8571.8570.0000.0000.0000.000
151A151ALA00.01311.1760.3100.3100.0000.0000.0000.000
152A152PHE0-0.0048.1960.2020.2020.0000.0000.0000.000
153A153GLY00.01813.0250.2510.2510.0000.0000.0000.000
154A154VAL00.01111.770-0.179-0.1790.0000.0000.0000.000
155A155PRO0-0.00812.9720.1660.1660.0000.0000.0000.000
156A156VAL00.02714.7590.0730.0730.0000.0000.0000.000
157A157ARG10.82117.398-0.034-0.0340.0000.0000.0000.000
158A158THR0-0.01214.508-0.055-0.0550.0000.0000.0000.000
159A159TYR00.03714.494-0.028-0.0280.0000.0000.0000.000
160A160THR00.02617.057-0.057-0.0570.0000.0000.0000.000
161A161HIS00.07919.3280.1260.1260.0000.0000.0000.000
162A162GLU-1-0.63718.4990.7110.7110.0000.0000.0000.000
163A163VAL00.00718.701-0.054-0.0540.0000.0000.0000.000
164A164VAL00.02613.7770.1490.1490.0000.0000.0000.000
165A165THR0-0.00814.455-0.152-0.1520.0000.0000.0000.000
166A166LEU00.02915.180-0.059-0.0590.0000.0000.0000.000
167A167TRP0-0.01213.892-0.025-0.0250.0000.0000.0000.000
168A168TYR0-0.01213.9550.0140.0140.0000.0000.0000.000
169A169ARG10.87114.350-0.169-0.1690.0000.0000.0000.000
170A170ALA00.01316.9560.0530.0530.0000.0000.0000.000
171A171PRO00.02319.634-0.031-0.0310.0000.0000.0000.000
172A172GLU-1-0.73121.359-0.119-0.1190.0000.0000.0000.000
173A173ILE0-0.01916.992-0.009-0.0090.0000.0000.0000.000
174A174LEU0-0.01419.9400.0050.0050.0000.0000.0000.000
175A175LEU00.00822.9130.0060.0060.0000.0000.0000.000
176A176GLY00.07424.079-0.019-0.0190.0000.0000.0000.000
177A177CYS0-0.06723.379-0.065-0.0650.0000.0000.0000.000
178A178LYS10.88521.7020.3290.3290.0000.0000.0000.000
179A179TYR00.02621.667-0.092-0.0920.0000.0000.0000.000
180A180TYR0-0.02716.8900.0260.0260.0000.0000.0000.000
181A181SER0-0.01020.832-0.056-0.0560.0000.0000.0000.000
182A182THR00.02817.8250.0250.0250.0000.0000.0000.000
183A183ALA0-0.03318.4530.0320.0320.0000.0000.0000.000
184A184VAL00.02815.6170.0940.0940.0000.0000.0000.000
185A185ASP-1-0.71713.650-0.746-0.7460.0000.0000.0000.000
186A186ILE0-0.00315.9260.1440.1440.0000.0000.0000.000
187A187TRP00.04418.8670.0790.0790.0000.0000.0000.000
188A188SER00.01614.1480.0510.0510.0000.0000.0000.000
189A189LEU0-0.01814.7760.2230.2230.0000.0000.0000.000
190A190GLY00.02616.6370.1250.1250.0000.0000.0000.000
191A191CYS0-0.05017.3530.0680.0680.0000.0000.0000.000
192A192ILE0-0.00712.1910.1360.1360.0000.0000.0000.000
193A193PHE00.01416.3520.1640.1640.0000.0000.0000.000
194A194ALA00.05619.3950.0490.0490.0000.0000.0000.000
195A195GLU-1-0.67812.9592.9832.9830.0000.0000.0000.000
196A196MET00.00115.5170.0410.0410.0000.0000.0000.000
197A197VAL00.04717.349-0.012-0.0120.0000.0000.0000.000
198A198THR00.01219.277-0.061-0.0610.0000.0000.0000.000
199A199ARG10.81515.789-1.776-1.7760.0000.0000.0000.000
200A200ARG10.87615.896-0.861-0.8610.0000.0000.0000.000
201A201ALA00.00616.286-0.043-0.0430.0000.0000.0000.000
202A202LEU00.01417.649-0.113-0.1130.0000.0000.0000.000
203A203PHE00.00820.660-0.111-0.1110.0000.0000.0000.000
204A204PRO00.05119.938-0.003-0.0030.0000.0000.0000.000
205A205GLY00.01820.974-0.039-0.0390.0000.0000.0000.000
206A206ASP-1-0.69621.2230.6600.6600.0000.0000.0000.000
207A207SER00.03823.095-0.032-0.0320.0000.0000.0000.000
208A208GLU-1-0.65821.5390.0480.0480.0000.0000.0000.000
209A209ILE00.00423.587-0.005-0.0050.0000.0000.0000.000
210A210ASP-1-0.67825.6150.5480.5480.0000.0000.0000.000
211A211GLN0-0.01120.7040.0810.0810.0000.0000.0000.000
212A212LEU00.00123.8490.0170.0170.0000.0000.0000.000
213A213PHE00.02726.0560.0070.0070.0000.0000.0000.000
214A214ARG10.82124.407-0.654-0.6540.0000.0000.0000.000
215A215ILE00.00722.7430.0190.0190.0000.0000.0000.000
216A216PHE0-0.01326.622-0.012-0.0120.0000.0000.0000.000
217A217ARG10.80928.304-0.508-0.5080.0000.0000.0000.000
218A218THR0-0.01226.8210.0300.0300.0000.0000.0000.000
219A219LEU0-0.03226.642-0.006-0.0060.0000.0000.0000.000
220A220GLY00.05130.656-0.034-0.0340.0000.0000.0000.000
221A221THR0-0.05332.0680.0080.0080.0000.0000.0000.000
222A222PRO0-0.01030.335-0.016-0.0160.0000.0000.0000.000
223A223ASP-1-0.61033.0660.0600.0600.0000.0000.0000.000
224A224GLU-1-0.61935.466-0.011-0.0110.0000.0000.0000.000
225A225VAL00.04237.210-0.013-0.0130.0000.0000.0000.000
226A226VAL0-0.00533.155-0.001-0.0010.0000.0000.0000.000
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