FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-04-23

All entries: 37539

Number of unique PDB entries: 7791

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FMODB ID: 9G4R2

Calculation Name: 4FKR-AB-MD335-md2_48ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: (8z)-8-{[(2,2-dioxido-1,3-dihydro-2-benzothiophen-5-yl)amino]methylidene}-6,8-dihydro-7h-[1,3]thiazolo[5,4-e]indol-7-one

ligand 3-letter code: 45K

PDB ID: 4FKR

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-08-25

Reference: K. Takaba et al., Protein-ligand binding affinity prediction of cyclin-dependent kinase-2 inhibitors by dynamically averaged fragment molecular orbital-based interaction energy, J. Comput. Chem., 43, 1362-1371, 2022.

DOI: 10.1002/jcc.26940

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2695
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -18946239.870772
FMO2-HF: Nuclear repulsion 18644686.996034
FMO2-HF: Total energy -301552.874738
FMO2-MP2: Total energy -302377.359406


3D Structure
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-119.459473-85.95497267.306627-29.916669-70.8944580.011568


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-166.569-139.093127.618-61.167-93.931-0.006
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.005 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.82412.762-0.357-0.3570.0000.0000.0000.000
2A2GLU-1-0.62915.3860.0860.0860.0000.0000.0000.000
3A3ASN0-0.03714.785-0.057-0.0570.0000.0000.0000.000
4A4PHE00.03911.126-0.067-0.0670.0000.0000.0000.000
5A5GLN00.06612.4470.1310.1310.0000.0000.0000.000
6A6LYS10.82711.118-0.662-0.6620.0000.0000.0000.000
7A7VAL00.0009.0150.0300.0300.0000.0000.0000.000
8A8GLU-1-0.5894.753-5.696-5.501-0.001-0.005-0.1890.000
9A9LYS10.8245.505-3.380-3.3800.0000.0000.0000.000
10A10ILE0-0.0502.732-8.231-1.3205.206-2.472-9.6440.021
11A11GLY00.0682.791-10.463-6.8070.865-1.603-2.918-0.013
12A12GLU-1-0.7434.7392.9733.1390.0000.034-0.2000.000
13A13GLY00.0445.182-1.000-1.0000.0000.0000.0000.000
14A14THR0-0.0166.0320.3290.3290.0000.0000.0000.000
15A15TYR00.0297.626-0.119-0.1190.0000.0000.0000.000
16A16GLY00.0557.6410.0690.0690.0000.0000.0000.000
17A17VAL0-0.0966.556-0.274-0.2740.0000.0000.0000.000
18A18VAL00.0222.710-3.469-0.7443.047-1.052-4.7200.007
19A19TYR00.0066.019-0.762-0.7620.0000.0000.0000.000
20A20LYS10.7784.6465.0535.372-0.001-0.014-0.3050.000
21A21ALA0-0.0277.027-0.097-0.0970.0000.0000.0000.000
22A22ARG10.7788.9380.8770.8770.0000.0000.0000.000
23A23ASN00.06511.5780.1650.1650.0000.0000.0000.000
24A24LYS10.81013.1700.0130.0130.0000.0000.0000.000
25A25LEU0-0.00516.508-0.007-0.0070.0000.0000.0000.000
26A26THR0-0.02614.2650.0020.0020.0000.0000.0000.000
27A27GLY00.14715.158-0.043-0.0430.0000.0000.0000.000
28A28GLU-1-0.71810.721-0.636-0.6360.0000.0000.0000.000
29A29VAL00.0126.0430.1440.1440.0000.0000.0000.000
30A30VAL0-0.0685.585-0.047-0.0470.0000.0000.0000.000
31A31ALA00.0372.538-1.468-0.0352.684-1.218-2.8980.007
32A32LEU0-0.0314.420-0.449-0.0460.000-0.049-0.3540.000
33A33LYS10.8003.884-8.045-7.1390.003-0.335-0.5740.002
34A34LYS10.7837.178-1.604-1.6040.0000.0000.0000.000
35A35ILE00.0258.3320.2720.2720.0000.0000.0000.000
36A36ARG10.81111.164-0.873-0.8730.0000.0000.0000.000
37A37LEU00.01012.2050.0550.0550.0000.0000.0000.000
38A38ASP-1-0.64114.2600.4230.4230.0000.0000.0000.000
39A39THR00.02316.004-0.040-0.0400.0000.0000.0000.000
40A40GLU-1-0.70317.8740.4160.4160.0000.0000.0000.000
41A41THR00.05419.2130.0350.0350.0000.0000.0000.000
42A42GLU-1-0.59921.1410.3400.3400.0000.0000.0000.000
43A43GLY00.01219.713-0.038-0.0380.0000.0000.0000.000
44A44VAL00.00615.0130.0540.0540.0000.0000.0000.000
45A45PRO00.02415.628-0.059-0.0590.0000.0000.0000.000
46A46SER00.04617.4500.0330.0330.0000.0000.0000.000
47A47THR00.02419.0930.0190.0190.0000.0000.0000.000
48A48ALA00.05713.942-0.018-0.0180.0000.0000.0000.000
49A49ILE0-0.05715.2290.0280.0280.0000.0000.0000.000
50A50ARG10.80517.483-0.431-0.4310.0000.0000.0000.000
51A51GLU-1-0.68013.6300.4540.4540.0000.0000.0000.000
52A52ILE00.00411.7950.0000.0000.0000.0000.0000.000
53A53SER0-0.01113.454-0.073-0.0730.0000.0000.0000.000
54A54LEU00.06514.433-0.060-0.0600.0000.0000.0000.000
55A55LEU00.0347.546-0.073-0.0730.0000.0000.0000.000
56A56LYS10.84311.414-0.238-0.2380.0000.0000.0000.000
57A57GLU-1-0.66413.4560.0230.0230.0000.0000.0000.000
58A58LEU0-0.02111.788-0.044-0.0440.0000.0000.0000.000
59A59ASN0-0.04612.153-0.040-0.0400.0000.0000.0000.000
60A60HIS00.04112.168-0.014-0.0140.0000.0000.0000.000
61A61PRO00.05011.693-0.019-0.0190.0000.0000.0000.000
62A62ASN00.04311.376-0.189-0.1890.0000.0000.0000.000
63A63ILE00.0038.5580.0980.0980.0000.0000.0000.000
64A64VAL00.0022.816-1.581-0.2640.247-0.369-1.1950.003
65A65LYS10.8635.7570.7650.7650.0000.0000.0000.000
66A66LEU0-0.0166.453-0.418-0.4180.0000.0000.0000.000
67A67LEU00.0397.4620.0350.0350.0000.0000.0000.000
68A68ASP-1-0.6899.3270.1830.1830.0000.0000.0000.000
69A69VAL00.01610.0790.1250.1250.0000.0000.0000.000
70A70ILE0-0.02812.410-0.102-0.1020.0000.0000.0000.000
71A71HIS00.07114.4660.1480.1480.0000.0000.0000.000
72A72THR00.06316.499-0.043-0.0430.0000.0000.0000.000
73A73GLU-1-0.67719.0970.3790.3790.0000.0000.0000.000
74A74ASN0-0.02520.1580.0440.0440.0000.0000.0000.000
75A75LYS10.79115.971-0.440-0.4400.0000.0000.0000.000
76A76LEU00.01911.398-0.067-0.0670.0000.0000.0000.000
77A77TYR0-0.02610.6810.1690.1690.0000.0000.0000.000
78A78LEU00.0136.781-0.208-0.2080.0000.0000.0000.000
79A79VAL00.0036.5480.2640.2640.0000.0000.0000.000
80A80PHE00.0352.179-2.659-0.6792.338-1.261-3.058-0.004
81A81GLU-1-0.6194.143-1.522-0.8160.000-0.248-0.457-0.001
82A82PHE00.0032.015-19.126-14.58211.123-6.470-9.196-0.028
83A83LEU0-0.0161.697-5.700-16.15519.331-4.414-4.4620.029
84A84HIS0-0.0102.232-11.982-8.7792.975-2.220-3.959-0.026
85A85GLN00.0063.045-6.001-2.5641.739-1.454-3.7230.001
86A86ASP-1-0.6952.325-20.393-17.3185.205-2.349-5.932-0.037
87A87LEU00.0384.1040.9531.2420.003-0.026-0.2660.000
88A88LYS10.7976.0611.2101.2100.0000.0000.0000.000
89A89LYS10.8512.522-8.400-6.4312.875-1.148-3.6950.014
90A90PHE00.0014.6970.8760.991-0.001-0.010-0.1050.000
91A91MET0-0.0167.4030.4700.4700.0000.0000.0000.000
92A92ASP-1-0.6517.0392.2512.2510.0000.0000.0000.000
93A93ALA00.0067.2350.1340.1340.0000.0000.0000.000
94A94SER00.0899.174-0.226-0.2260.0000.0000.0000.000
95A95ALA00.02612.477-0.041-0.0410.0000.0000.0000.000
96A96LEU00.03113.930-0.045-0.0450.0000.0000.0000.000
97A97THR0-0.01516.6030.0040.0040.0000.0000.0000.000
98A98GLY00.06816.259-0.015-0.0150.0000.0000.0000.000
99A99ILE0-0.01914.846-0.044-0.0440.0000.0000.0000.000
100A100PRO00.03318.0200.0360.0360.0000.0000.0000.000
101A101LEU00.04120.221-0.044-0.0440.0000.0000.0000.000
102A102PRO00.01522.064-0.013-0.0130.0000.0000.0000.000
103A103LEU0-0.01816.388-0.005-0.0050.0000.0000.0000.000
104A104ILE00.00417.108-0.042-0.0420.0000.0000.0000.000
105A105LYS10.79318.6920.2940.2940.0000.0000.0000.000
106A106SER00.01419.0370.0360.0360.0000.0000.0000.000
107A107TYR0-0.00813.116-0.027-0.0270.0000.0000.0000.000
108A108LEU0-0.01116.4970.0390.0390.0000.0000.0000.000
109A109PHE00.00418.2940.0540.0540.0000.0000.0000.000
110A110GLN0-0.00613.993-0.066-0.0660.0000.0000.0000.000
111A111LEU00.00411.4680.0560.0560.0000.0000.0000.000
112A112LEU0-0.00214.9450.1150.1150.0000.0000.0000.000
113A113GLN00.03317.5060.0610.0610.0000.0000.0000.000
114A114GLY00.03413.5040.0310.0310.0000.0000.0000.000
115A115LEU0-0.01313.0030.0920.0920.0000.0000.0000.000
116A116ALA00.07214.8960.0560.0560.0000.0000.0000.000
117A117PHE0-0.02914.5460.0210.0210.0000.0000.0000.000
118A118CYS0-0.03811.3090.0110.0110.0000.0000.0000.000
119A119HIS00.02214.922-0.020-0.0200.0000.0000.0000.000
120A120SER00.05018.076-0.003-0.0030.0000.0000.0000.000
121A121HIS00.05116.9960.0150.0150.0000.0000.0000.000
122A122ARG10.74218.695-0.179-0.1790.0000.0000.0000.000
123A123VAL00.02412.1680.0400.0400.0000.0000.0000.000
124A124LEU00.00914.895-0.030-0.0300.0000.0000.0000.000
125A125HIS00.0277.0790.0350.0350.0000.0000.0000.000
126A126ARG10.75411.679-0.408-0.4080.0000.0000.0000.000
127A127ASP-1-0.7668.4020.1980.1980.0000.0000.0000.000
128A128LEU00.0248.350-0.077-0.0770.0000.0000.0000.000
129A129LYS10.8236.9640.2240.2240.0000.0000.0000.000
130A130PRO00.0497.605-0.259-0.2590.0000.0000.0000.000
131A131GLN00.0015.313-0.759-0.7590.0000.0000.0000.000
132A132ASN0-0.0623.575-4.536-3.1560.103-0.445-1.037-0.002
133A133LEU0-0.0064.5911.3821.6590.000-0.015-0.2620.000
134A134LEU00.0152.692-5.642-3.7527.851-1.554-8.1880.006
135A135ILE00.0246.1800.9660.9660.0000.0000.0000.000
136A136ASN0-0.0016.789-0.581-0.5810.0000.0000.0000.000
137A137THR00.0489.6180.3040.3040.0000.0000.0000.000
138A138GLU-1-0.66712.302-1.069-1.0690.0000.0000.0000.000
139A139GLY00.04913.5470.1730.1730.0000.0000.0000.000
140A140ALA0-0.06412.0080.1460.1460.0000.0000.0000.000
141A141ILE00.03810.347-0.297-0.2970.0000.0000.0000.000
142A142LYS10.7447.2521.2161.2160.0000.0000.0000.000
143A143LEU00.0258.008-0.145-0.1450.0000.0000.0000.000
144A144ALA00.0682.762-1.566-0.2261.647-0.726-2.2620.006
145A145ASP-1-0.6973.2820.8852.3240.064-0.435-1.0670.002
146A146PHE00.0544.628-1.912-1.6250.002-0.057-0.2320.000
147A147GLY00.0576.8750.3670.3670.0000.0000.0000.000
148A148LEU0-0.0408.825-0.306-0.3060.0000.0000.0000.000
149A149ALA00.02911.229-0.105-0.1050.0000.0000.0000.000
150A150ARG10.83212.754-0.512-0.5120.0000.0000.0000.000
151A151ALA00.01314.795-0.086-0.0860.0000.0000.0000.000
152A152PHE0-0.0139.568-0.037-0.0370.0000.0000.0000.000
153A153GLY00.09215.136-0.014-0.0140.0000.0000.0000.000
154A154VAL0-0.02715.6150.0530.0530.0000.0000.0000.000
155A155PRO00.01913.737-0.050-0.0500.0000.0000.0000.000
156A156VAL00.03115.422-0.011-0.0110.0000.0000.0000.000
157A157ARG10.79814.663-0.453-0.4530.0000.0000.0000.000
158A158THR00.01010.9020.0040.0040.0000.0000.0000.000
159A159TYR00.01211.728-0.014-0.0140.0000.0000.0000.000
160A160THR00.03714.340-0.043-0.0430.0000.0000.0000.000
161A161HIS00.09116.2550.0160.0160.0000.0000.0000.000
162A162GLU-1-0.67713.3261.0221.0220.0000.0000.0000.000
163A163VAL00.00114.095-0.019-0.0190.0000.0000.0000.000
164A164VAL00.00011.0350.0050.0050.0000.0000.0000.000
165A165THR0-0.00313.105-0.016-0.0160.0000.0000.0000.000
166A166LEU00.00213.542-0.070-0.0700.0000.0000.0000.000
167A167TRP0-0.06913.933-0.020-0.0200.0000.0000.0000.000
168A168TYR00.04112.242-0.063-0.0630.0000.0000.0000.000
169A169ARG10.79611.834-0.299-0.2990.0000.0000.0000.000
170A170ALA00.08216.777-0.014-0.0140.0000.0000.0000.000
171A171PRO00.11319.9480.0240.0240.0000.0000.0000.000
172A172GLU-1-0.71521.7950.1170.1170.0000.0000.0000.000
173A173ILE00.01416.6520.0170.0170.0000.0000.0000.000
174A174LEU00.00119.7000.0200.0200.0000.0000.0000.000
175A175LEU0-0.05821.6530.0130.0130.0000.0000.0000.000
176A176GLY00.08223.196-0.002-0.0020.0000.0000.0000.000
177A177CYS0-0.01824.157-0.004-0.0040.0000.0000.0000.000
178A178LYS10.84825.541-0.121-0.1210.0000.0000.0000.000
179A179TYR0-0.00926.3530.0020.0020.0000.0000.0000.000
180A180TYR00.04720.1330.0040.0040.0000.0000.0000.000
181A181SER0-0.00222.180-0.005-0.0050.0000.0000.0000.000
182A182THR00.10517.4740.0040.0040.0000.0000.0000.000
183A183ALA00.00818.589-0.007-0.0070.0000.0000.0000.000
184A184VAL00.02316.369-0.027-0.0270.0000.0000.0000.000
185A185ASP-1-0.68414.5590.3410.3410.0000.0000.0000.000
186A186ILE0-0.04715.769-0.049-0.0490.0000.0000.0000.000
187A187TRP00.04318.116-0.038-0.0380.0000.0000.0000.000
188A188SER00.00613.3100.0000.0000.0000.0000.0000.000
189A189LEU00.01314.135-0.075-0.0750.0000.0000.0000.000
190A190GLY00.03715.717-0.055-0.0550.0000.0000.0000.000
191A191CYS0-0.05716.170-0.018-0.0180.0000.0000.0000.000
192A192ILE00.00011.381-0.029-0.0290.0000.0000.0000.000
193A193PHE00.02315.629-0.085-0.0850.0000.0000.0000.000
194A194ALA0-0.00118.650-0.010-0.0100.0000.0000.0000.000
195A195GLU-1-0.67113.298-0.333-0.3330.0000.0000.0000.000
196A196MET0-0.01713.7690.0050.0050.0000.0000.0000.000
197A197VAL00.00615.600-0.014-0.0140.0000.0000.0000.000
198A198THR0-0.00117.6500.0100.0100.0000.0000.0000.000
199A199ARG10.74013.2600.3480.3480.0000.0000.0000.000
200A200ARG10.87114.4940.1400.1400.0000.0000.0000.000
201A201ALA00.01315.807-0.061-0.0610.0000.0000.0000.000
202A202LEU00.02817.0310.0390.0390.0000.0000.0000.000
203A203PHE00.00919.4290.0280.0280.0000.0000.0000.000
204A204PRO00.06218.9910.0160.0160.0000.0000.0000.000
205A205GLY00.03920.3230.0280.0280.0000.0000.0000.000
206A206ASP-1-0.62420.7260.3090.3090.0000.0000.0000.000
207A207SER00.03422.4290.0250.0250.0000.0000.0000.000
208A208GLU-1-0.64521.4200.2250.2250.0000.0000.0000.000
209A209ILE00.01022.528-0.013-0.0130.0000.0000.0000.000
210A210ASP-1-0.74624.8070.1430.1430.0000.0000.0000.000
211A211GLN00.05619.8140.0080.0080.0000.0000.0000.000
212A212LEU0-0.01123.182-0.017-0.0170.0000.0000.0000.000
213A213PHE00.03425.851-0.012-0.0120.0000.0000.0000.000
214A214ARG10.82523.600-0.156-0.1560.0000.0000.0000.000
215A215ILE00.01022.052-0.016-0.0160.0000.0000.0000.000
216A216PHE00.00625.951-0.011-0.0110.0000.0000.0000.000
217A217ARG10.77529.500-0.098-0.0980.0000.0000.0000.000
218A218THR0-0.00427.8010.0010.0010.0000.0000.0000.000
219A219LEU00.02225.557-0.010-0.0100.0000.0000.0000.000
220A220GLY00.03129.272-0.005-0.0050.0000.0000.0000.000
221A221THR0-0.00431.0070.0020.0020.0000.0000.0000.000
222A222PRO00.03629.940-0.007-0.0070.0000.0000.0000.000
223A223ASP-1-0.63832.5720.0470.0470.0000.0000.0000.000
224A224GLU-1-0.58334.7080.0530.0530.0000.0000.0000.000
225A225VAL0-0.00636.402-0.001-0.0010.0000.0000.0000.000
226A226VAL00.00232.508-0.005-0.0050.0000.0000.0000.000
227A227TRP00.00327.842-0.001-0.0010.0000.0000.0000.000
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