FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-12-18

All entries: 87239

Number of unique PDB entries: 32030

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FMODB ID: GN671

Calculation Name: 4FKR-AB-MD335-md4_20ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: (8z)-8-{[(2,2-dioxido-1,3-dihydro-2-benzothiophen-5-yl)amino]methylidene}-6,8-dihydro-7h-[1,3]thiazolo[5,4-e]indol-7-one | acetyl group

Ligand 3-letter code: 45K | ACE

Ligand of Interest (LOI): LIG

Structure Source: PDB

PDB ID: 4FKR

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-08-30

Reference: K. Takaba et al., Protein-ligand binding affinity prediction of cyclin-dependent kinase-2 inhibitors by dynamically averaged fragment molecular orbital-based interaction energy, J. Comput. Chem., 43, 1362-1371, 2022.

DOI: 10.1002/jcc.26940

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
Remarks
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2753
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -19303483.875823
FMO2-HF: Nuclear repulsion 18997522.034306
FMO2-HF: Total energy -305961.841517
FMO2-MP2: Total energy -306797.312545


3D Structure Molmil
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-128.600404-100.13866663.381397-26.990497-64.852638-0.040539


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-157.582-131.343111.13-51.232-86.1340.01
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : 0.012 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.78619.3200.2560.2560.0000.0000.0000.000
2A2GLU-1-0.68616.830-0.284-0.2840.0000.0000.0000.000
3A3ASN00.01913.9320.0620.0620.0000.0000.0000.000
4A4PHE00.03210.998-0.021-0.0210.0000.0000.0000.000
5A5GLN00.04713.2130.0430.0430.0000.0000.0000.000
6A6LYS10.85110.9900.2860.2860.0000.0000.0000.000
7A7VAL00.0159.5540.0560.0560.0000.0000.0000.000
8A8GLU-1-0.6445.426-2.458-2.4580.0000.0000.0000.000
9A9LYS10.8235.8600.5000.5000.0000.0000.0000.000
10A10ILE0-0.0222.559-4.763-0.7086.720-2.203-8.5720.014
11A11GLY00.0772.263-14.874-13.4284.477-1.962-3.961-0.027
12A12GLU-1-0.7114.6791.1151.367-0.001-0.032-0.2200.000
13A13GLY00.0884.125-2.012-1.8720.000-0.046-0.0940.000
14A14THR0-0.0546.181-0.008-0.0080.0000.0000.0000.000
15A15TYR00.0089.2980.0010.0010.0000.0000.0000.000
16A16GLY00.0529.1830.0560.0560.0000.0000.0000.000
17A17VAL0-0.0118.022-0.219-0.2190.0000.0000.0000.000
18A18VAL0-0.0113.194-1.7400.2720.760-0.501-2.2700.001
19A19TYR00.0046.468-1.273-1.049-0.001-0.007-0.2160.000
20A20LYS10.9044.4453.2683.7890.000-0.036-0.4840.000
21A21ALA0-0.0196.502-0.207-0.2070.0000.0000.0000.000
22A22ARG10.8488.8930.6410.6410.0000.0000.0000.000
23A23ASN0-0.01611.6870.0600.0600.0000.0000.0000.000
24A24LYS10.82013.9250.3010.3010.0000.0000.0000.000
25A25LEU00.00417.2850.0300.0300.0000.0000.0000.000
26A26THR00.02715.6050.0210.0210.0000.0000.0000.000
27A27GLY00.12715.5510.0010.0010.0000.0000.0000.000
28A28GLU-1-0.69011.757-0.630-0.6300.0000.0000.0000.000
29A29VAL0-0.0096.7180.0330.0330.0000.0000.0000.000
30A30VAL0-0.0105.797-0.042-0.0420.0000.0000.0000.000
31A31ALA0-0.0082.635-1.0830.9261.197-0.968-2.2370.007
32A32LEU0-0.0094.662-1.200-0.873-0.001-0.024-0.3020.000
33A33LYS10.8342.060-19.841-19.4308.002-2.899-5.5140.036
34A34LYS10.8447.043-0.092-0.0920.0000.0000.0000.000
35A35ILE0-0.0238.0600.1040.1040.0000.0000.0000.000
36A36ARG10.80111.6540.0040.0040.0000.0000.0000.000
37A37LEU00.00015.3040.0040.0040.0000.0000.0000.000
38A38ASP-1-0.72818.173-0.068-0.0680.0000.0000.0000.000
39A39THR00.01420.399-0.005-0.0050.0000.0000.0000.000
40A40GLU-1-0.64623.220-0.103-0.1030.0000.0000.0000.000
41A41THR0-0.02924.9870.0000.0000.0000.0000.0000.000
42A42GLU-1-0.69323.571-0.137-0.1370.0000.0000.0000.000
43A43GLY00.02820.617-0.011-0.0110.0000.0000.0000.000
44A44VAL00.05816.5200.0070.0070.0000.0000.0000.000
45A45PRO00.01719.222-0.013-0.0130.0000.0000.0000.000
46A46SER0-0.00920.024-0.006-0.0060.0000.0000.0000.000
47A47THR00.04021.066-0.012-0.0120.0000.0000.0000.000
48A48ALA00.01616.4590.0000.0000.0000.0000.0000.000
49A49ILE00.01016.030-0.009-0.0090.0000.0000.0000.000
50A50ARG10.85916.8540.1590.1590.0000.0000.0000.000
51A51GLU-1-0.64214.069-0.154-0.1540.0000.0000.0000.000
52A52ILE00.01311.427-0.021-0.0210.0000.0000.0000.000
53A53SER0-0.03713.081-0.081-0.0810.0000.0000.0000.000
54A54LEU00.00815.664-0.036-0.0360.0000.0000.0000.000
55A55LEU0-0.0137.5730.0030.0030.0000.0000.0000.000
56A56LYS10.79611.3330.4090.4090.0000.0000.0000.000
57A57GLU-1-0.61212.749-0.433-0.4330.0000.0000.0000.000
58A58LEU0-0.05610.9380.0260.0260.0000.0000.0000.000
59A59ASN00.00911.889-0.188-0.1880.0000.0000.0000.000
60A60HIS00.04511.8650.0410.0410.0000.0000.0000.000
61A61PRO00.06211.482-0.143-0.1430.0000.0000.0000.000
62A62ASN0-0.06411.809-0.016-0.0160.0000.0000.0000.000
63A63ILE00.0018.1100.1070.1070.0000.0000.0000.000
64A64VAL00.0032.217-1.379-0.5161.296-0.565-1.5950.002
65A65LYS10.8825.6411.2071.2070.0000.0000.0000.000
66A66LEU0-0.0165.745-0.965-0.9650.0000.0000.0000.000
67A67LEU00.0317.2100.2910.2910.0000.0000.0000.000
68A68ASP-1-0.7168.953-0.278-0.2780.0000.0000.0000.000
69A69VAL00.0079.844-0.049-0.0490.0000.0000.0000.000
70A70ILE0-0.00112.3590.0220.0220.0000.0000.0000.000
71A71HIS00.03414.3670.0200.0200.0000.0000.0000.000
72A72THR00.06416.7560.0150.0150.0000.0000.0000.000
73A73GLU-1-0.71919.526-0.196-0.1960.0000.0000.0000.000
74A74ASN00.05520.8900.0040.0040.0000.0000.0000.000
75A75LYS10.80515.9640.1960.1960.0000.0000.0000.000
76A76LEU00.02512.081-0.017-0.0170.0000.0000.0000.000
77A77TYR0-0.02810.4360.0530.0530.0000.0000.0000.000
78A78LEU0-0.0176.451-0.075-0.0750.0000.0000.0000.000
79A79VAL0-0.0206.7740.1620.1620.0000.0000.0000.000
80A80PHE00.0742.534-3.123-0.6931.046-0.877-2.600-0.005
81A81GLU-1-0.6744.068-1.788-1.1710.000-0.242-0.375-0.001
82A82PHE0-0.0531.994-20.716-16.06810.471-5.725-9.393-0.029
83A83LEU00.0341.773-9.235-14.47913.920-4.079-4.5970.034
84A84HIS00.0192.302-8.700-5.7493.628-2.250-4.329-0.014
85A85GLN00.0302.895-2.842-1.4943.037-0.499-3.886-0.010
86A86ASP-1-0.6473.457-4.897-3.7800.017-0.313-0.820-0.002
87A87LEU00.0596.4341.2431.2430.0000.0000.0000.000
88A88LYS10.8446.004-2.354-2.3540.0000.0000.0000.000
89A89LYS10.9282.373-23.116-21.8603.165-1.228-3.1930.018
90A90PHE00.0366.043-0.018-0.0180.0000.0000.0000.000
91A91MET0-0.0059.098-0.079-0.0790.0000.0000.0000.000
92A92ASP-1-0.6318.9802.4352.4350.0000.0000.0000.000
93A93ALA0-0.0169.472-0.097-0.0970.0000.0000.0000.000
94A94SER00.01811.324-0.286-0.2860.0000.0000.0000.000
95A95ALA00.02014.036-0.136-0.1360.0000.0000.0000.000
96A96LEU00.00215.746-0.088-0.0880.0000.0000.0000.000
97A97THR0-0.03018.340-0.079-0.0790.0000.0000.0000.000
98A98GLY00.06118.726-0.063-0.0630.0000.0000.0000.000
99A99ILE00.00815.1250.0210.0210.0000.0000.0000.000
100A100PRO00.08318.963-0.019-0.0190.0000.0000.0000.000
101A101LEU00.00721.291-0.021-0.0210.0000.0000.0000.000
102A102PRO00.05823.448-0.022-0.0220.0000.0000.0000.000
103A103LEU0-0.02715.882-0.034-0.0340.0000.0000.0000.000
104A104ILE0-0.02419.093-0.047-0.0470.0000.0000.0000.000
105A105LYS10.81920.1080.0310.0310.0000.0000.0000.000
106A106SER00.03519.276-0.007-0.0070.0000.0000.0000.000
107A107TYR0-0.01713.136-0.114-0.1140.0000.0000.0000.000
108A108LEU0-0.01716.916-0.050-0.0500.0000.0000.0000.000
109A109PHE00.02218.501-0.019-0.0190.0000.0000.0000.000
110A110GLN00.01714.655-0.082-0.0820.0000.0000.0000.000
111A111LEU00.00112.337-0.018-0.0180.0000.0000.0000.000
112A112LEU0-0.00514.9780.0150.0150.0000.0000.0000.000
113A113GLN00.06417.2540.0460.0460.0000.0000.0000.000
114A114GLY00.06413.556-0.004-0.0040.0000.0000.0000.000
115A115LEU0-0.02313.9050.0160.0160.0000.0000.0000.000
116A116ALA00.00615.1950.0230.0230.0000.0000.0000.000
117A117PHE00.02014.8610.0220.0220.0000.0000.0000.000
118A118CYS0-0.04712.7940.0120.0120.0000.0000.0000.000
119A119HIS00.01015.3840.0140.0140.0000.0000.0000.000
120A120SER0-0.03318.5490.0250.0250.0000.0000.0000.000
121A121HIS00.08317.0910.0300.0300.0000.0000.0000.000
122A122ARG10.79318.5140.1290.1290.0000.0000.0000.000
123A123VAL00.00413.6310.0120.0120.0000.0000.0000.000
124A124LEU0-0.00814.777-0.019-0.0190.0000.0000.0000.000
125A125HIS00.0537.588-0.063-0.0630.0000.0000.0000.000
126A126ARG10.83512.0830.1490.1490.0000.0000.0000.000
127A127ASP-1-0.6787.957-0.464-0.4640.0000.0000.0000.000
128A128LEU0-0.0378.890-0.145-0.1450.0000.0000.0000.000
129A129LYS10.8807.7501.0341.0340.0000.0000.0000.000
130A130PRO00.0228.253-0.309-0.3090.0000.0000.0000.000
131A131GLN00.0204.5980.6940.921-0.001-0.010-0.2160.000
132A132ASN0-0.0984.301-2.442-1.9370.008-0.106-0.4080.000
133A133LEU0-0.0105.1690.9041.039-0.001-0.005-0.1290.000
134A134LEU00.0052.789-4.038-1.5104.669-1.088-6.1100.005
135A135ILE0-0.0206.7630.4860.4860.0000.0000.0000.000
136A136ASN00.0386.459-0.489-0.4890.0000.0000.0000.000
137A137THR00.0517.8130.1930.1930.0000.0000.0000.000
138A138GLU-1-0.63010.169-0.561-0.5610.0000.0000.0000.000
139A139GLY00.03012.7210.0970.0970.0000.0000.0000.000
140A140ALA0-0.05311.6470.0610.0610.0000.0000.0000.000
141A141ILE0-0.04610.457-0.116-0.1160.0000.0000.0000.000
142A142LYS10.7987.2371.6621.6620.0000.0000.0000.000
143A143LEU0-0.0178.5400.0180.0180.0000.0000.0000.000
144A144ALA00.0303.042-1.441-0.3530.322-0.370-1.0400.004
145A145ASP-1-0.7212.846-2.713-0.4180.642-0.853-2.0840.007
146A146PHE00.0344.434-1.749-1.4470.007-0.102-0.2080.000
147A147GLY00.0797.349-0.167-0.1670.0000.0000.0000.000
148A148LEU00.0199.299-0.118-0.1180.0000.0000.0000.000
149A149ALA00.06611.848-0.018-0.0180.0000.0000.0000.000
150A150ARG10.79213.8370.1000.1000.0000.0000.0000.000
151A151ALA0-0.02614.807-0.014-0.0140.0000.0000.0000.000
152A152PHE00.06912.342-0.008-0.0080.0000.0000.0000.000
153A153GLY00.09713.6450.0110.0110.0000.0000.0000.000
154A154VAL0-0.02611.6210.0480.0480.0000.0000.0000.000
155A155PRO00.02812.550-0.014-0.0140.0000.0000.0000.000
156A156VAL0-0.00512.856-0.061-0.0610.0000.0000.0000.000
157A157ARG10.83513.2120.1120.1120.0000.0000.0000.000
158A158THR0-0.0317.5900.0820.0820.0000.0000.0000.000
159A159TYR0-0.0109.8170.1060.1060.0000.0000.0000.000
160A160THR00.01511.9050.0680.0680.0000.0000.0000.000
161A161HIS00.05014.1940.0710.0710.0000.0000.0000.000
162A162GLU-1-0.69613.4460.1280.1280.0000.0000.0000.000
163A163VAL00.03913.130-0.130-0.1300.0000.0000.0000.000
164A164VAL0-0.03110.192-0.043-0.0430.0000.0000.0000.000
165A165THR00.00512.6850.0320.0320.0000.0000.0000.000
166A166LEU00.03713.806-0.067-0.0670.0000.0000.0000.000
167A167TRP00.01014.648-0.019-0.0190.0000.0000.0000.000
168A168TYR0-0.00713.0740.0040.0040.0000.0000.0000.000
169A169ARG10.81714.8420.1540.1540.0000.0000.0000.000
170A170ALA00.02317.4110.0220.0220.0000.0000.0000.000
171A171PRO00.01920.5800.0010.0010.0000.0000.0000.000
172A172GLU-1-0.68223.307-0.068-0.0680.0000.0000.0000.000
173A173ILE0-0.00618.2070.0030.0030.0000.0000.0000.000
174A174LEU00.03220.1050.0010.0010.0000.0000.0000.000
175A175LEU0-0.03523.0850.0080.0080.0000.0000.0000.000
176A176GLY00.05124.9690.0040.0040.0000.0000.0000.000
177A177CYS0-0.03025.876-0.001-0.0010.0000.0000.0000.000
178A178LYS10.87724.5770.0370.0370.0000.0000.0000.000
179A179TYR00.02425.410-0.004-0.0040.0000.0000.0000.000
180A180TYR00.05819.199-0.002-0.0020.0000.0000.0000.000
181A181SER00.02723.139-0.003-0.0030.0000.0000.0000.000
182A182THR00.04518.6960.0000.0000.0000.0000.0000.000
183A183ALA0-0.02520.167-0.009-0.0090.0000.0000.0000.000
184A184VAL0-0.00617.2930.0010.0010.0000.0000.0000.000
185A185ASP-1-0.67115.065-0.143-0.1430.0000.0000.0000.000
186A186ILE0-0.05916.810-0.017-0.0170.0000.0000.0000.000
187A187TRP00.07219.4740.0030.0030.0000.0000.0000.000
188A188SER00.02614.3760.0140.0140.0000.0000.0000.000
189A189LEU00.00515.241-0.008-0.0080.0000.0000.0000.000
190A190GLY00.03616.7500.0110.0110.0000.0000.0000.000
191A191CYS0-0.01917.5990.0380.0380.0000.0000.0000.000
192A192ILE0-0.00912.1860.0360.0360.0000.0000.0000.000
193A193PHE0-0.03316.3700.0450.0450.0000.0000.0000.000
194A194ALA00.02419.4430.0310.0310.0000.0000.0000.000
195A195GLU-1-0.66814.2760.2180.2180.0000.0000.0000.000
196A196MET0-0.02316.0600.0730.0730.0000.0000.0000.000
197A197VAL0-0.02117.8160.0270.0270.0000.0000.0000.000
198A198THR00.02319.8900.0310.0310.0000.0000.0000.000
199A199ARG10.80217.109-0.371-0.3710.0000.0000.0000.000
200A200ARG10.85417.004-0.173-0.1730.0000.0000.0000.000
201A201ALA0-0.00516.459-0.065-0.0650.0000.0000.0000.000
202A202LEU00.06518.2950.0160.0160.0000.0000.0000.000
203A203PHE00.00820.5240.0070.0070.0000.0000.0000.000
204A204PRO00.04919.319-0.043-0.0430.0000.0000.0000.000
205A205GLY00.05520.3850.0240.0240.0000.0000.0000.000
206A206ASP-1-0.73619.9090.0740.0740.0000.0000.0000.000
207A207SER00.09121.447-0.020-0.0200.0000.0000.0000.000
208A208GLU-1-0.62321.453-0.057-0.0570.0000.0000.0000.000
209A209ILE00.05623.345-0.002-0.0020.0000.0000.0000.000
210A210ASP-1-0.77124.4730.0920.0920.0000.0000.0000.000
211A211GLN0-0.02519.9930.0160.0160.0000.0000.0000.000
212A212LEU0-0.00323.215-0.002-0.0020.0000.0000.0000.000
213A213PHE00.01825.5070.0040.0040.0000.0000.0000.000
214A214ARG10.79923.590-0.123-0.1230.0000.0000.0000.000
215A215ILE00.04322.3300.0070.0070.0000.0000.0000.000
216A216PHE00.01126.2450.0030.0030.0000.0000.0000.000
217A217ARG10.81428.573-0.096-0.0960.0000.0000.0000.000
218A218THR00.01128.1980.0100.0100.0000.0000.0000.000
219A219LEU00.01325.992-0.001-0.0010.0000.0000.0000.000
220A220GLY00.05630.581-0.008-0.0080.0000.0000.0000.000
221A221THR0-0.01932.438-0.006-0.0060.0000.0000.0000.000
222A222PRO00.03730.712-0.001-0.0010.0000.0000.0000.000
223A223ASP-1-0.66133.9560.0030.0030.0000.0000.0000.000
224A224GLU-1-0.59236.593-0.018-0.0180.0000.0000.0000.000
225A225VAL0-0.01238.341-0.003-0.0030.0000.0000.0000.000
226A226VAL0-0.01034.197-0.002-0.0020.0000.0000.0000.000
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