FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-04-23

All entries: 37539

Number of unique PDB entries: 7791

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FMODB ID: J3QQ9

Calculation Name: 4FKW-AB-MD341-md4_14ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: 2-methylpropyl (3z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1h-indole-5-carboxylate

ligand 3-letter code: 62K

PDB ID: 4FKW

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-09-12

Reference: K. Takaba et al., Protein-Ligand Binding Affinity Prediction of CDK2 Inhibitors by Dynamically Averaged FMO-based Interaction Energy, To be published.

DOI:

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2651
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -18637314.306966
FMO2-HF: Nuclear repulsion 18339257.886248
FMO2-HF: Total energy -298056.420717
FMO2-MP2: Total energy -298872.667849


3D Structure
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-141.553913-129.651917111.462466-40.953984-82.4104790.108384


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-161.046-158.481172.042-69.966-104.635-0.083
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.084 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.73912.098-0.379-0.3790.0000.0000.0000.000
2A2GLU-1-0.58616.4680.1760.1760.0000.0000.0000.000
3A3ASN00.00714.417-0.006-0.0060.0000.0000.0000.000
4A4PHE00.08110.383-0.074-0.0740.0000.0000.0000.000
5A5GLN00.01811.8110.0800.0800.0000.0000.0000.000
6A6LYS10.90410.653-0.870-0.8700.0000.0000.0000.000
7A7VAL0-0.02210.097-0.037-0.0370.0000.0000.0000.000
8A8GLU-1-0.6756.6852.4522.4520.0000.0000.0000.000
9A9LYS10.8147.620-0.998-0.9980.0000.0000.0000.000
10A10ILE00.0022.793-3.0541.1631.214-1.190-4.2410.008
11A11GLY00.0783.055-6.427-4.6330.439-0.685-1.548-0.003
12A12GLU-1-0.6733.0040.8661.5570.057-0.163-0.584-0.001
13A13GLY00.0802.869-2.722-1.6990.164-0.485-0.703-0.001
14A14THR0-0.0713.6730.8701.0360.0030.027-0.1970.000
15A15TYR00.0135.362-0.007-0.0070.0000.0000.0000.000
16A16GLY00.0356.0930.3160.3160.0000.0000.0000.000
17A17VAL0-0.0725.581-0.857-0.8570.0000.0000.0000.000
18A18VAL00.0012.386-3.714-0.5113.291-1.537-4.9570.012
19A19TYR00.0345.753-0.830-0.8300.0000.0000.0000.000
20A20LYS10.8905.332-0.135-0.1350.0000.0000.0000.000
21A21ALA0-0.0366.740-0.062-0.0620.0000.0000.0000.000
22A22ARG10.8858.807-0.261-0.2610.0000.0000.0000.000
23A23ASN00.00911.0670.1270.1270.0000.0000.0000.000
24A24LYS10.89912.624-0.215-0.2150.0000.0000.0000.000
25A25LEU0-0.01016.2040.0060.0060.0000.0000.0000.000
26A26THR0-0.02514.1650.0000.0000.0000.0000.0000.000
27A27GLY00.08115.1060.0070.0070.0000.0000.0000.000
28A28GLU-1-0.70311.450-0.359-0.3590.0000.0000.0000.000
29A29VAL00.0026.4860.0610.0610.0000.0000.0000.000
30A30VAL00.0145.472-0.259-0.2590.0000.0000.0000.000
31A31ALA0-0.0112.589-0.7150.3321.974-0.820-2.2010.003
32A32LEU0-0.0294.334-0.827-0.5030.000-0.031-0.2920.000
33A33LYS10.8042.885-15.215-12.6570.476-0.970-2.0630.010
34A34LYS10.8255.922-1.205-1.2050.0000.0000.0000.000
35A35ILE0-0.0077.0530.5710.5710.0000.0000.0000.000
36A36ARG10.7719.833-0.851-0.8510.0000.0000.0000.000
37A37LEU00.01012.1510.0180.0180.0000.0000.0000.000
38A38ASP-1-0.69015.8570.3540.3540.0000.0000.0000.000
39A39THR00.01618.339-0.038-0.0380.0000.0000.0000.000
40A40GLU-1-0.68521.7520.2270.2270.0000.0000.0000.000
41A41THR00.01218.939-0.006-0.0060.0000.0000.0000.000
42A42GLU-1-0.64520.6710.2810.2810.0000.0000.0000.000
43A43GLY00.07919.300-0.001-0.0010.0000.0000.0000.000
44A44VAL0-0.01115.2070.0220.0220.0000.0000.0000.000
45A45PRO00.06218.286-0.027-0.0270.0000.0000.0000.000
46A46SER00.01818.8620.0570.0570.0000.0000.0000.000
47A47THR00.02619.3820.0360.0360.0000.0000.0000.000
48A48ALA00.01214.9020.0370.0370.0000.0000.0000.000
49A49ILE00.01814.6560.1170.1170.0000.0000.0000.000
50A50ARG10.81215.876-0.230-0.2300.0000.0000.0000.000
51A51GLU-1-0.71613.2530.4820.4820.0000.0000.0000.000
52A52ILE00.05710.4550.0390.0390.0000.0000.0000.000
53A53SER00.00612.589-0.041-0.0410.0000.0000.0000.000
54A54LEU0-0.05415.456-0.092-0.0920.0000.0000.0000.000
55A55LEU00.0457.626-0.088-0.0880.0000.0000.0000.000
56A56LYS10.83712.229-0.349-0.3490.0000.0000.0000.000
57A57GLU-1-0.61913.4150.0200.0200.0000.0000.0000.000
58A58LEU0-0.05911.983-0.090-0.0900.0000.0000.0000.000
59A59ASN00.06812.7440.0050.0050.0000.0000.0000.000
60A60HIS00.02412.825-0.039-0.0390.0000.0000.0000.000
61A61PRO00.06412.477-0.038-0.0380.0000.0000.0000.000
62A62ASN0-0.04612.180-0.055-0.0550.0000.0000.0000.000
63A63ILE0-0.0259.3630.0870.0870.0000.0000.0000.000
64A64VAL00.0053.529-1.137-0.2390.065-0.230-0.7320.002
65A65LYS10.8416.8091.4061.4060.0000.0000.0000.000
66A66LEU0-0.0285.767-0.843-0.8430.0000.0000.0000.000
67A67LEU00.0287.1530.0660.0660.0000.0000.0000.000
68A68ASP-1-0.6598.7640.2980.2980.0000.0000.0000.000
69A69VAL00.0119.5130.1280.1280.0000.0000.0000.000
70A70ILE0-0.04511.364-0.108-0.1080.0000.0000.0000.000
71A71HIS00.06913.6920.1640.1640.0000.0000.0000.000
72A72THR00.05716.105-0.042-0.0420.0000.0000.0000.000
73A73GLU-1-0.65318.0540.4270.4270.0000.0000.0000.000
74A74ASN0-0.01420.2280.0000.0000.0000.0000.0000.000
75A75LYS10.79015.326-0.499-0.4990.0000.0000.0000.000
76A76LEU00.03011.662-0.042-0.0420.0000.0000.0000.000
77A77TYR0-0.0019.8570.1420.1420.0000.0000.0000.000
78A78LEU0-0.0106.194-0.097-0.0970.0000.0000.0000.000
79A79VAL00.0145.8520.2210.2210.0000.0000.0000.000
80A80PHE00.0202.081-1.490-0.2342.522-1.124-2.655-0.006
81A81GLU-1-0.6484.007-2.589-1.6590.000-0.343-0.587-0.001
82A82PHE00.0201.903-19.440-16.95810.189-6.085-6.586-0.036
83A83LEU0-0.0191.734-6.559-13.61017.795-5.419-5.3240.033
84A84HIS00.0521.920-19.049-17.4386.472-3.548-4.535-0.042
85A85GLN00.0291.728-7.284-7.48614.271-5.830-8.239-0.012
86A86ASP-1-0.6941.653-37.908-47.86524.071-4.015-10.098-0.064
87A87LEU00.0013.801-1.887-1.2440.009-0.208-0.444-0.001
88A88LYS10.8743.9386.0136.3520.000-0.018-0.3210.000
89A89LYS10.9212.574-8.419-7.8473.787-1.227-3.1320.000
90A90PHE00.0414.3862.3112.4580.001-0.027-0.1210.000
91A91MET00.0226.5171.0411.0410.0000.0000.0000.000
92A92ASP-1-0.7397.7090.1360.1360.0000.0000.0000.000
93A93ALA0-0.0387.5630.5660.5660.0000.0000.0000.000
94A94SER00.0129.4320.3620.3620.0000.0000.0000.000
95A95ALA0-0.03312.0010.1420.1420.0000.0000.0000.000
96A96LEU0-0.00913.8910.0930.0930.0000.0000.0000.000
97A97THR00.00415.4030.0240.0240.0000.0000.0000.000
98A98GLY00.10316.0530.0700.0700.0000.0000.0000.000
99A99ILE0-0.03612.194-0.148-0.1480.0000.0000.0000.000
100A100PRO00.03915.9390.1010.1010.0000.0000.0000.000
101A101LEU00.06918.338-0.115-0.1150.0000.0000.0000.000
102A102PRO00.05320.656-0.051-0.0510.0000.0000.0000.000
103A103LEU0-0.04913.141-0.049-0.0490.0000.0000.0000.000
104A104ILE0-0.03216.362-0.109-0.1090.0000.0000.0000.000
105A105LYS10.85117.6990.5810.5810.0000.0000.0000.000
106A106SER00.03117.9570.0490.0490.0000.0000.0000.000
107A107TYR0-0.00510.9090.1330.1330.0000.0000.0000.000
108A108LEU00.02616.1980.0140.0140.0000.0000.0000.000
109A109PHE0-0.01218.2000.0660.0660.0000.0000.0000.000
110A110GLN00.01015.2170.0180.0180.0000.0000.0000.000
111A111LEU0-0.00111.3090.0940.0940.0000.0000.0000.000
112A112LEU0-0.02114.8740.1570.1570.0000.0000.0000.000
113A113GLN0-0.00317.9530.1570.1570.0000.0000.0000.000
114A114GLY00.04214.8340.0750.0750.0000.0000.0000.000
115A115LEU00.02113.2700.1480.1480.0000.0000.0000.000
116A116ALA00.00615.5440.0960.0960.0000.0000.0000.000
117A117PHE00.05115.2260.0380.0380.0000.0000.0000.000
118A118CYS0-0.01814.2920.0900.0900.0000.0000.0000.000
119A119HIS00.05914.8160.0100.0100.0000.0000.0000.000
120A120SER0-0.02218.880-0.018-0.0180.0000.0000.0000.000
121A121HIS00.02918.126-0.029-0.0290.0000.0000.0000.000
122A122ARG10.75819.653-0.031-0.0310.0000.0000.0000.000
123A123VAL0-0.00213.5070.0500.0500.0000.0000.0000.000
124A124LEU0-0.01613.642-0.096-0.0960.0000.0000.0000.000
125A125HIS00.0245.0260.1460.1460.0000.0000.0000.000
126A126ARG10.8559.057-0.012-0.0120.0000.0000.0000.000
127A127ASP-1-0.6685.488-0.717-0.7170.0000.0000.0000.000
128A128LEU00.0006.420-0.213-0.2130.0000.0000.0000.000
129A129LYS10.8384.8571.4721.4720.0000.0000.0000.000
130A130PRO00.0626.123-0.238-0.2380.0000.0000.0000.000
131A131GLN00.0492.635-5.164-3.3391.072-0.773-2.124-0.008
132A132ASN0-0.0832.245-5.377-3.2963.723-1.890-3.914-0.013
133A133LEU00.0013.3331.6891.8100.0300.241-0.3930.000
134A134LEU00.0412.458-4.193-6.27013.620-2.223-9.3190.012
135A135ILE0-0.0085.3601.4191.4190.0000.0000.0000.000
136A136ASN00.0226.352-0.855-0.8550.0000.0000.0000.000
137A137THR00.0589.1630.1540.1540.0000.0000.0000.000
138A138GLU-1-0.62511.439-0.712-0.7120.0000.0000.0000.000
139A139GLY00.00313.2200.2140.2140.0000.0000.0000.000
140A140ALA0-0.06612.2990.2520.2520.0000.0000.0000.000
141A141ILE00.03310.101-0.498-0.4980.0000.0000.0000.000
142A142LYS10.7578.0481.9601.9600.0000.0000.0000.000
143A143LEU00.0268.599-0.373-0.3730.0000.0000.0000.000
144A144ALA00.0543.816-0.5680.1550.037-0.208-0.5530.002
145A145ASP-1-0.6692.170-1.3131.2416.128-2.574-6.108-0.004
146A146PHE0-0.0633.326-1.250-1.2660.0530.402-0.4380.002
147A147GLY00.0256.8850.2430.2430.0000.0000.0000.000
148A148LEU0-0.0249.311-0.037-0.0370.0000.0000.0000.000
149A149ALA00.0199.248-0.248-0.2480.0000.0000.0000.000
150A150ARG10.82911.124-0.465-0.4650.0000.0000.0000.000
151A151ALA0-0.01714.235-0.084-0.0840.0000.0000.0000.000
152A152PHE00.03113.572-0.036-0.0360.0000.0000.0000.000
153A153GLY00.03014.280-0.066-0.0660.0000.0000.0000.000
154A154VAL0-0.01210.4350.1280.1280.0000.0000.0000.000
155A155PRO00.0109.639-0.111-0.1110.0000.0000.0000.000
156A156VAL00.00610.349-0.094-0.0940.0000.0000.0000.000
157A157ARG10.77210.491-0.008-0.0080.0000.0000.0000.000
158A158THR0-0.0016.4140.0770.0770.0000.0000.0000.000
159A159TYR0-0.0327.5380.1730.1730.0000.0000.0000.000
160A160THR0-0.0189.5290.0010.0010.0000.0000.0000.000
161A161HIS00.08711.326-0.050-0.0500.0000.0000.0000.000
162A162GLU-1-0.72410.5050.1140.1140.0000.0000.0000.000
163A163VAL00.01310.724-0.101-0.1010.0000.0000.0000.000
164A164VAL0-0.0217.089-0.166-0.1660.0000.0000.0000.000
165A165THR00.0129.7320.0690.0690.0000.0000.0000.000
166A166LEU00.00210.504-0.133-0.1330.0000.0000.0000.000
167A167TRP0-0.05012.328-0.016-0.0160.0000.0000.0000.000
168A168TYR00.0269.636-0.042-0.0420.0000.0000.0000.000
169A169ARG10.83711.3860.3570.3570.0000.0000.0000.000
170A170ALA00.03614.450-0.010-0.0100.0000.0000.0000.000
171A171PRO00.00217.7070.0340.0340.0000.0000.0000.000
172A172GLU-1-0.66919.345-0.252-0.2520.0000.0000.0000.000
173A173ILE0-0.01814.8000.0270.0270.0000.0000.0000.000
174A174LEU0-0.01717.4650.0180.0180.0000.0000.0000.000
175A175LEU0-0.02420.4380.0280.0280.0000.0000.0000.000
176A176GLY00.06322.4790.0160.0160.0000.0000.0000.000
177A177CYS0-0.07121.2030.0300.0300.0000.0000.0000.000
178A178LYS10.82620.4870.0320.0320.0000.0000.0000.000
179A179TYR0-0.00120.5340.0200.0200.0000.0000.0000.000
180A180TYR00.03915.400-0.007-0.0070.0000.0000.0000.000
181A181SER0-0.01119.7300.0270.0270.0000.0000.0000.000
182A182THR00.04017.6480.0080.0080.0000.0000.0000.000
183A183ALA0-0.02817.221-0.036-0.0360.0000.0000.0000.000
184A184VAL00.01814.017-0.062-0.0620.0000.0000.0000.000
185A185ASP-1-0.69312.326-0.206-0.2060.0000.0000.0000.000
186A186ILE0-0.01914.101-0.130-0.1300.0000.0000.0000.000
187A187TRP00.05215.586-0.035-0.0350.0000.0000.0000.000
188A188SER0-0.01411.507-0.029-0.0290.0000.0000.0000.000
189A189LEU0-0.02613.328-0.176-0.1760.0000.0000.0000.000
190A190GLY00.04114.661-0.086-0.0860.0000.0000.0000.000
191A191CYS0-0.04514.032-0.002-0.0020.0000.0000.0000.000
192A192ILE0-0.02110.266-0.083-0.0830.0000.0000.0000.000
193A193PHE00.00514.569-0.065-0.0650.0000.0000.0000.000
194A194ALA00.07018.1710.0120.0120.0000.0000.0000.000
195A195GLU-1-0.67712.869-1.856-1.8560.0000.0000.0000.000
196A196MET0-0.01912.4110.0900.0900.0000.0000.0000.000
197A197VAL0-0.00216.1830.0510.0510.0000.0000.0000.000
198A198THR0-0.00918.6840.0930.0930.0000.0000.0000.000
199A199ARG10.83416.1980.7070.7070.0000.0000.0000.000
200A200ARG10.78416.4280.5810.5810.0000.0000.0000.000
201A201ALA00.06214.987-0.075-0.0750.0000.0000.0000.000
202A202LEU00.04116.7060.1270.1270.0000.0000.0000.000
203A203PHE00.02117.4120.1140.1140.0000.0000.0000.000
204A204PRO00.02716.523-0.013-0.0130.0000.0000.0000.000
205A205GLY00.07816.5990.0850.0850.0000.0000.0000.000
206A206ASP-1-0.68116.602-0.265-0.2650.0000.0000.0000.000
207A207SER00.03718.2320.0080.0080.0000.0000.0000.000
208A208GLU-1-0.64018.914-0.164-0.1640.0000.0000.0000.000
209A209ILE00.00219.8050.0000.0000.0000.0000.0000.000
210A210ASP-1-0.67421.182-0.294-0.2940.0000.0000.0000.000
211A211GLN0-0.00916.647-0.026-0.0260.0000.0000.0000.000
212A212LEU00.02519.797-0.022-0.0220.0000.0000.0000.000
213A213PHE0-0.03122.391-0.005-0.0050.0000.0000.0000.000
214A214ARG10.85620.0850.3560.3560.0000.0000.0000.000
215A215ILE00.01618.636-0.020-0.0200.0000.0000.0000.000
216A216PHE0-0.00522.7510.0050.0050.0000.0000.0000.000
217A217ARG10.82125.2850.2670.2670.0000.0000.0000.000
218A218THR00.00623.1070.0020.0020.0000.0000.0000.000
219A219LEU0-0.02223.521-0.011-0.0110.0000.0000.0000.000
220A220GLY00.04027.1110.0170.0170.0000.0000.0000.000
221A221THR00.04027.943-0.025-0.0250.0000.0000.0000.000
222A222PRO0-0.02127.9660.0070.0070.0000.0000.0000.000
223A223ASP-1-0.60930.471-0.137-0.1370.0000.0000.0000.000
224A224GLU-1-0.64733.558-0.130-0.1300.0000.0000.0000.000
225A225VAL00.02634.827-0.003-0.0030.0000.0000.0000.000
226A226VAL00.00230.312-0.009-0.0090.0000.0000.0000.000
227A227TRP00.02324.443-0.016-0.0160.0000.0000.0000.000
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