FMO DATABASE

FMODB ID: JQYM9

Calculation Name: 3G7K-A-Xray372

Preferred Name:

Target Type:

Ligand Name:

ligand 3-letter code:

PDB ID: 3G7K

Chain ID: A

ChEMBL ID:

UniProt ID: Q0QLE6

Base Structure: X-ray

Registration Date: 2023-09-22

Reference: C. Watanabe, N. Tani, K. Kamisaka, T. Honma et al., Interaction energy analysis of Apo structure dataset on FMODB, To be published.

DOI:

IFIE MAP

IFIE Diagram

Modeling method

Optimization	MOE:Amber10:EHT
Restraint	OptHSide
Protonation	MOE:Protonate 3D
Complement	MOE:Structure Preparation
Water	No
Procedure	Auto-FMO protocol ver. 2.20220422

FMO calculation

FMO method	FMO2-MP2/6-31G(d)
Fragmentation	Auto
Number of fragment	379
LigandCharge
Software	ABINIT-MP - Open Ver. 1 Rev. 23Q2 / 20200603(SMP)

Total energy (hartree)

FMO2-HF: Electronic energy	-5993802.311372
FMO2-HF: Nuclear repulsion	5850730.083111
FMO2-HF: Total energy	-143072.228261
FMO2-MP2: Total energy	-143482.331162

3D Structure

Snapshot

Ligand structure

Ligand Interaction

Ligand binding energy

IFIE [kcal/mol]	PIEDA [kcal/mol]				Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level.	ESElectro static interaction energy.	EXExchange-repulsion energy.	CT+mixCharge transfer and mixing terms energy.	DI(MP2)Dispersion energy.	q(I=>J)Charge transfer value from I to J fragments.
N/A	N/A	N/A	N/A	N/A	N/A

Interactive mode: IFIE and PIEDA for fragment #1(A:2:SER)

Summations of interaction energy for fragment #1(A:2:SER)

IFIE [kcal/mol]	PIEDA [kcal/mol]				Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level.	ESElectro static interaction energy.	EXExchange-repulsion energy.	CT+mixCharge transfer and mixing terms energy.	DI(MP2)Dispersion energy.	q(I=>J)Charge transfer value from I to J fragments.
-2.518	0.704	0.535	-1.588	-2.169	0.008

Interaction energy analysis for fragmet #1(A:2:SER)

Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE

Single fragment	Multi fragments
	Fragment list

Charge [e] FCHARGE : 0 / q_Mulliken : 0.003 / q_NPA : -0.009

Distance from base fragment(s) [Å]

Dist

Interaction energy by IFIE and PIEDA
[kcal/mol]

| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >

Fragment charge [e]

FCHARGE q_Mulliken
q_NPA q(I=>J)

Residue

Res # RES

Sort

Graph Options

X Axis Label
Y Axis Max Y Axis Min
Display ES EX CT+mix DI(MP2)

frag_NumFragment number.	ChainChain species.	Res #Residue number.	RES3-letter code of amino acid residue, ligand and solvent molecule.	FCHARGEFormal charge [e].	q_MullikenFragment charge evaluated by Mulliken charge [e].	q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e].	DISTDistance from Ligand [Å].	TotalIFIE at MP2 level [kcal/mol].	ESElectro static interaction energy by PIEDA [kcal/mol].	EXExchange-repulsion energy by PIEDA [kcal/mol].	CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol].	DI(MP2)Dispersion energy by PIEDA [kcal/mol].	q(I=>J)Charge transfer value from I to J fragmens [e].
3	A	4	GLN	0	-0.037	-0.025	3.214	-4.149	-1.777	0.055	-1.170	-1.257	0.005
4	A	5	MET	0	-0.066	-0.027	4.365	1.947	2.185	0.000	-0.034	-0.204	0.000
5	A	6	ARG	1	0.905	0.947	6.748	-2.377	-2.377	0.000	0.000	0.000	0.000
6	A	7	ILE	0	0.021	0.010	9.459	-0.177	-0.177	0.000	0.000	0.000	0.000
7	A	8	PRO	0	0.003	0.015	13.004	0.031	0.031	0.000	0.000	0.000	0.000
8	A	9	CYS	0	-0.034	-0.011	16.008	-0.064	-0.064	0.000	0.000	0.000	0.000
9	A	10	VAL	0	0.052	0.031	18.366	0.013	0.013	0.000	0.000	0.000	0.000
10	A	11	ILE	0	-0.005	0.011	20.113	-0.025	-0.025	0.000	0.000	0.000	0.000
11	A	12	MET	0	-0.006	0.000	23.656	-0.008	-0.008	0.000	0.000	0.000	0.000
12	A	13	ARG	1	0.824	0.920	27.442	-0.183	-0.183	0.000	0.000	0.000	0.000
13	A	14	ALA	0	0.029	0.028	30.552	-0.004	-0.004	0.000	0.000	0.000	0.000
14	A	15	GLY	0	0.083	0.038	32.699	-0.006	-0.006	0.000	0.000	0.000	0.000
15	A	16	THR	0	0.018	0.006	35.716	0.002	0.002	0.000	0.000	0.000	0.000
16	A	17	SER	0	-0.045	-0.012	31.925	-0.006	-0.006	0.000	0.000	0.000	0.000
17	A	18	LYS	1	0.951	0.975	25.919	-0.282	-0.282	0.000	0.000	0.000	0.000
18	A	19	GLY	0	0.029	0.011	26.768	-0.009	-0.009	0.000	0.000	0.000	0.000
19	A	20	ILE	0	-0.010	-0.001	20.139	0.019	0.019	0.000	0.000	0.000	0.000
20	A	21	PHE	0	0.006	-0.013	23.210	-0.028	-0.028	0.000	0.000	0.000	0.000
21	A	22	LEU	0	-0.020	-0.009	18.502	0.041	0.041	0.000	0.000	0.000	0.000
22	A	23	LYS	1	0.949	0.967	20.943	-0.390	-0.390	0.000	0.000	0.000	0.000
23	A	24	GLY	0	0.026	-0.002	21.045	0.018	0.018	0.000	0.000	0.000	0.000
24	A	25	ASN	0	-0.078	-0.053	20.346	-0.013	-0.013	0.000	0.000	0.000	0.000
25	A	26	ASP	-1	-0.891	-0.937	16.918	0.461	0.461	0.000	0.000	0.000	0.000
26	A	27	LEU	0	-0.024	-0.007	16.055	0.061	0.061	0.000	0.000	0.000	0.000
27	A	28	PRO	0	-0.002	-0.004	15.383	-0.036	-0.036	0.000	0.000	0.000	0.000
28	A	29	ALA	0	0.012	0.003	18.005	-0.003	-0.003	0.000	0.000	0.000	0.000
29	A	30	ASP	-1	-0.853	-0.928	20.040	0.028	0.028	0.000	0.000	0.000	0.000
30	A	31	GLN	0	0.000	-0.005	21.034	0.019	0.019	0.000	0.000	0.000	0.000
31	A	32	GLU	-1	-0.839	-0.902	21.814	0.006	0.006	0.000	0.000	0.000	0.000
32	A	33	LEU	0	-0.033	-0.020	14.823	0.014	0.014	0.000	0.000	0.000	0.000
33	A	34	ARG	1	0.840	0.909	17.816	-0.152	-0.152	0.000	0.000	0.000	0.000
34	A	35	ASP	-1	-0.722	-0.849	19.360	0.191	0.191	0.000	0.000	0.000	0.000
35	A	36	LYS	1	0.859	0.929	17.262	0.017	0.017	0.000	0.000	0.000	0.000
36	A	37	VAL	0	-0.032	-0.021	13.948	0.047	0.047	0.000	0.000	0.000	0.000
37	A	38	ILE	0	0.004	0.012	16.306	0.071	0.071	0.000	0.000	0.000	0.000
38	A	39	LEU	0	0.018	0.011	19.272	0.030	0.030	0.000	0.000	0.000	0.000
39	A	40	ARG	1	0.787	0.874	13.260	-0.422	-0.422	0.000	0.000	0.000	0.000
40	A	41	ILE	0	-0.016	0.001	15.345	0.063	0.063	0.000	0.000	0.000	0.000
41	A	42	PHE	0	0.025	-0.007	16.757	0.020	0.020	0.000	0.000	0.000	0.000
42	A	43	GLY	0	0.004	0.030	18.731	-0.006	-0.006	0.000	0.000	0.000	0.000
43	A	44	SER	0	-0.052	-0.020	19.638	-0.027	-0.027	0.000	0.000	0.000	0.000
44	A	45	PRO	0	-0.038	-0.014	20.883	0.009	0.009	0.000	0.000	0.000	0.000
45	A	46	ASP	-1	-0.793	-0.930	22.898	0.205	0.205	0.000	0.000	0.000	0.000
46	A	47	VAL	0	-0.042	-0.018	24.896	0.011	0.011	0.000	0.000	0.000	0.000
47	A	48	ARG	1	0.887	0.930	23.911	-0.175	-0.175	0.000	0.000	0.000	0.000
48	A	49	GLN	0	-0.010	-0.001	22.392	0.013	0.013	0.000	0.000	0.000	0.000
49	A	50	ILE	0	-0.035	-0.015	19.856	0.024	0.024	0.000	0.000	0.000	0.000
50	A	51	ASP	-1	-0.891	-0.933	14.968	0.528	0.528	0.000	0.000	0.000	0.000
51	A	52	GLY	0	0.037	0.012	16.365	0.041	0.041	0.000	0.000	0.000	0.000
52	A	53	LEU	0	-0.071	-0.044	16.984	-0.004	-0.004	0.000	0.000	0.000	0.000
53	A	54	ALA	0	-0.072	-0.019	19.441	-0.024	-0.024	0.000	0.000	0.000	0.000
54	A	55	GLY	0	-0.023	-0.022	22.997	0.006	0.006	0.000	0.000	0.000	0.000
55	A	56	ALA	0	-0.007	0.013	25.884	-0.018	-0.018	0.000	0.000	0.000	0.000
56	A	57	ASP	-1	-0.786	-0.882	27.503	0.137	0.137	0.000	0.000	0.000	0.000
57	A	58	PRO	0	0.084	0.045	29.838	0.015	0.015	0.000	0.000	0.000	0.000
58	A	59	LEU	0	-0.061	-0.042	30.918	0.008	0.008	0.000	0.000	0.000	0.000
59	A	60	THR	0	-0.099	-0.065	27.477	0.013	0.013	0.000	0.000	0.000	0.000
60	A	61	SER	0	0.039	0.016	25.725	0.035	0.035	0.000	0.000	0.000	0.000
61	A	62	LYS	1	0.808	0.920	26.673	-0.184	-0.184	0.000	0.000	0.000	0.000
62	A	63	LEU	0	-0.001	-0.002	22.474	0.028	0.028	0.000	0.000	0.000	0.000
63	A	64	ALA	0	0.017	0.019	25.714	-0.027	-0.027	0.000	0.000	0.000	0.000
64	A	65	ILE	0	-0.024	-0.014	23.290	0.029	0.029	0.000	0.000	0.000	0.000
65	A	66	ILE	0	0.008	0.003	25.125	-0.021	-0.021	0.000	0.000	0.000	0.000
66	A	67	GLY	0	0.006	0.000	25.554	0.022	0.022	0.000	0.000	0.000	0.000
67	A	68	PRO	0	0.009	-0.006	27.233	-0.004	-0.004	0.000	0.000	0.000	0.000
68	A	69	SER	0	0.005	0.007	30.500	-0.002	-0.002	0.000	0.000	0.000	0.000
69	A	70	THR	0	-0.049	-0.015	33.127	-0.007	-0.007	0.000	0.000	0.000	0.000
70	A	71	HIS	0	-0.004	-0.002	35.060	-0.006	-0.006	0.000	0.000	0.000	0.000
71	A	72	PRO	0	-0.039	-0.024	38.580	0.003	0.003	0.000	0.000	0.000	0.000
72	A	73	ASP	-1	-0.889	-0.943	41.210	0.073	0.073	0.000	0.000	0.000	0.000
73	A	74	ALA	0	-0.036	-0.012	37.499	0.002	0.002	0.000	0.000	0.000	0.000
74	A	75	ASP	-1	-0.839	-0.901	36.311	0.115	0.115	0.000	0.000	0.000	0.000
75	A	76	VAL	0	-0.093	-0.053	31.012	0.009	0.009	0.000	0.000	0.000	0.000
76	A	77	ASP	-1	-0.768	-0.877	30.804	0.113	0.113	0.000	0.000	0.000	0.000
77	A	78	TYR	0	-0.033	-0.037	30.092	0.021	0.021	0.000	0.000	0.000	0.000
78	A	79	THR	0	0.003	0.009	27.951	-0.012	-0.012	0.000	0.000	0.000	0.000
79	A	80	PHE	0	-0.040	-0.031	28.516	0.021	0.021	0.000	0.000	0.000	0.000
80	A	81	ALA	0	0.044	0.021	26.482	-0.012	-0.012	0.000	0.000	0.000	0.000
81	A	82	GLN	0	0.032	0.029	28.082	0.016	0.016	0.000	0.000	0.000	0.000
82	A	83	VAL	0	-0.011	-0.001	23.283	-0.011	-0.011	0.000	0.000	0.000	0.000
83	A	84	SER	0	0.027	0.033	26.612	0.003	0.003	0.000	0.000	0.000	0.000
84	A	85	ILE	0	0.012	0.030	26.247	0.013	0.013	0.000	0.000	0.000	0.000
85	A	86	THR	0	0.017	-0.009	26.662	0.006	0.006	0.000	0.000	0.000	0.000
86	A	87	ASP	-1	-0.889	-0.950	27.880	0.070	0.070	0.000	0.000	0.000	0.000
87	A	88	ALA	0	-0.049	-0.019	24.137	0.020	0.020	0.000	0.000	0.000	0.000
88	A	89	VAL	0	-0.013	-0.008	25.462	-0.010	-0.010	0.000	0.000	0.000	0.000
89	A	90	VAL	0	-0.023	-0.015	23.322	0.018	0.018	0.000	0.000	0.000	0.000
90	A	91	ASP	-1	-0.810	-0.901	26.770	0.093	0.093	0.000	0.000	0.000	0.000
91	A	92	TYR	0	-0.041	-0.068	24.463	0.015	0.015	0.000	0.000	0.000	0.000
92	A	93	ASN	0	-0.024	-0.009	31.190	-0.007	-0.007	0.000	0.000	0.000	0.000
93	A	94	GLY	0	0.055	0.022	34.171	-0.007	-0.007	0.000	0.000	0.000	0.000
94	A	95	ASN	0	0.043	0.029	34.276	0.017	0.017	0.000	0.000	0.000	0.000
95	A	96	CYS	0	-0.044	-0.011	33.333	0.001	0.001	0.000	0.000	0.000	0.000
96	A	97	GLY	0	0.085	0.036	35.348	0.004	0.004	0.000	0.000	0.000	0.000
97	A	98	ASN	0	0.005	0.016	35.076	-0.005	-0.005	0.000	0.000	0.000	0.000
98	A	99	ILE	0	0.038	0.019	29.700	0.004	0.004	0.000	0.000	0.000	0.000
99	A	100	SER	0	0.003	-0.014	32.529	0.006	0.006	0.000	0.000	0.000	0.000
100	A	101	ALA	0	0.031	0.000	34.629	-0.001	-0.001	0.000	0.000	0.000	0.000
101	A	102	GLY	0	-0.010	-0.002	31.345	0.003	0.003	0.000	0.000	0.000	0.000
102	A	103	VAL	0	-0.039	-0.009	30.899	0.013	0.013	0.000	0.000	0.000	0.000
103	A	104	GLY	0	0.072	0.040	32.076	0.004	0.004	0.000	0.000	0.000	0.000
104	A	105	PRO	0	0.017	-0.006	32.220	0.005	0.005	0.000	0.000	0.000	0.000
105	A	106	PHE	0	-0.002	-0.002	24.021	0.012	0.012	0.000	0.000	0.000	0.000
106	A	107	ALA	0	0.015	-0.002	29.120	0.010	0.010	0.000	0.000	0.000	0.000
107	A	108	ILE	0	0.003	0.006	31.089	-0.002	-0.002	0.000	0.000	0.000	0.000
108	A	109	ASP	-1	-0.869	-0.940	28.619	0.231	0.231	0.000	0.000	0.000	0.000
109	A	110	GLU	-1	-0.852	-0.910	24.338	0.350	0.350	0.000	0.000	0.000	0.000
110	A	111	SER	0	-0.085	-0.034	27.851	-0.002	-0.002	0.000	0.000	0.000	0.000
111	A	112	PHE	0	-0.056	-0.028	25.383	-0.004	-0.004	0.000	0.000	0.000	0.000
112	A	113	VAL	0	0.040	0.027	31.322	-0.012	-0.012	0.000	0.000	0.000	0.000
113	A	114	LYS	1	0.886	0.944	34.642	-0.113	-0.113	0.000	0.000	0.000	0.000
114	A	115	ALA	0	0.041	0.032	35.770	-0.005	-0.005	0.000	0.000	0.000	0.000
115	A	116	VAL	0	-0.068	-0.050	37.625	-0.006	-0.006	0.000	0.000	0.000	0.000
116	A	117	GLU	-1	-0.798	-0.923	40.955	0.124	0.124	0.000	0.000	0.000	0.000
117	A	118	PRO	0	-0.056	-0.026	42.924	-0.005	-0.005	0.000	0.000	0.000	0.000
118	A	119	MET	0	0.018	0.027	42.741	0.003	0.003	0.000	0.000	0.000	0.000
119	A	120	THR	0	-0.005	0.016	38.266	-0.002	-0.002	0.000	0.000	0.000	0.000
120	A	121	ARG	1	0.869	0.928	40.964	-0.088	-0.088	0.000	0.000	0.000	0.000
121	A	122	VAL	0	-0.023	-0.012	35.602	0.003	0.003	0.000	0.000	0.000	0.000
122	A	123	CYS	0	-0.056	-0.013	39.052	-0.001	-0.001	0.000	0.000	0.000	0.000
123	A	124	ILE	0	-0.016	-0.023	34.529	0.006	0.006	0.000	0.000	0.000	0.000
124	A	125	HIS	0	0.039	-0.001	34.858	-0.012	-0.012	0.000	0.000	0.000	0.000
125	A	126	ASN	0	-0.084	-0.049	33.674	0.002	0.002	0.000	0.000	0.000	0.000
126	A	127	THR	0	0.049	0.003	31.024	-0.003	-0.003	0.000	0.000	0.000	0.000
127	A	128	ASN	0	-0.100	-0.052	31.257	-0.001	-0.001	0.000	0.000	0.000	0.000
128	A	129	THR	0	-0.030	-0.016	34.674	-0.007	-0.007	0.000	0.000	0.000	0.000
129	A	130	GLY	0	0.001	0.017	37.480	-0.007	-0.007	0.000	0.000	0.000	0.000
130	A	131	LYS	1	0.767	0.888	39.178	-0.074	-0.074	0.000	0.000	0.000	0.000
131	A	132	LEU	0	0.031	0.022	39.168	0.007	0.007	0.000	0.000	0.000	0.000
132	A	133	LEU	0	-0.048	-0.027	37.371	-0.003	-0.003	0.000	0.000	0.000	0.000
133	A	134	TYR	0	-0.020	-0.009	40.212	0.003	0.003	0.000	0.000	0.000	0.000
134	A	135	ALA	0	0.027	0.013	38.757	0.000	0.000	0.000	0.000	0.000	0.000
135	A	136	GLU	-1	-0.914	-0.943	40.757	0.092	0.092	0.000	0.000	0.000	0.000
136	A	137	VAL	0	0.004	-0.011	36.653	0.002	0.002	0.000	0.000	0.000	0.000
137	A	138	GLU	-1	-0.845	-0.926	40.101	0.117	0.117	0.000	0.000	0.000	0.000
138	A	139	VAL	0	-0.067	-0.026	37.240	0.010	0.010	0.000	0.000	0.000	0.000
139	A	140	GLU	-1	-0.823	-0.902	37.943	0.129	0.129	0.000	0.000	0.000	0.000
140	A	141	ASP	-1	-0.909	-0.950	36.488	0.152	0.152	0.000	0.000	0.000	0.000
141	A	142	GLY	0	-0.101	-0.059	35.063	0.010	0.010	0.000	0.000	0.000	0.000
142	A	143	LYS	1	0.853	0.929	28.469	-0.231	-0.231	0.000	0.000	0.000	0.000
143	A	144	ALA	0	0.019	0.016	33.554	-0.012	-0.012	0.000	0.000	0.000	0.000
144	A	145	LYS	1	0.785	0.884	34.741	-0.128	-0.128	0.000	0.000	0.000	0.000
145	A	146	VAL	0	0.011	-0.002	32.852	0.004	0.004	0.000	0.000	0.000	0.000
146	A	147	SER	0	-0.049	-0.047	36.233	-0.001	-0.001	0.000	0.000	0.000	0.000
147	A	148	GLY	0	0.048	0.014	39.247	-0.003	-0.003	0.000	0.000	0.000	0.000
148	A	149	ASP	-1	-0.940	-0.960	42.632	0.111	0.111	0.000	0.000	0.000	0.000
149	A	150	CYS	0	-0.015	0.007	43.064	-0.007	-0.007	0.000	0.000	0.000	0.000
150	A	151	LYS	1	0.852	0.934	42.154	-0.114	-0.114	0.000	0.000	0.000	0.000
151	A	152	ILE	0	0.001	-0.005	38.365	-0.003	-0.003	0.000	0.000	0.000	0.000
152	A	153	ASP	-1	-0.798	-0.891	41.591	0.108	0.108	0.000	0.000	0.000	0.000
153	A	154	GLY	0	0.029	-0.001	39.844	0.001	0.001	0.000	0.000	0.000	0.000
154	A	155	VAL	0	-0.086	-0.036	36.154	0.011	0.011	0.000	0.000	0.000	0.000
155	A	156	PRO	0	-0.027	-0.019	36.761	-0.007	-0.007	0.000	0.000	0.000	0.000
156	A	157	GLY	0	-0.005	0.002	39.004	0.005	0.005	0.000	0.000	0.000	0.000
157	A	158	THR	0	-0.009	0.012	41.149	-0.002	-0.002	0.000	0.000	0.000	0.000
158	A	159	ASN	0	-0.033	-0.043	37.039	0.015	0.015	0.000	0.000	0.000	0.000
159	A	160	ALA	0	0.067	0.049	38.890	-0.008	-0.008	0.000	0.000	0.000	0.000
160	A	161	PRO	0	-0.055	-0.020	39.974	0.005	0.005	0.000	0.000	0.000	0.000
161	A	162	GLU	-1	-0.835	-0.937	37.453	0.152	0.152	0.000	0.000	0.000	0.000
162	A	163	LEU	0	-0.028	-0.001	41.337	-0.002	-0.002	0.000	0.000	0.000	0.000
163	A	164	MET	0	-0.024	-0.001	37.933	0.003	0.003	0.000	0.000	0.000	0.000
164	A	165	ASP	-1	-0.821	-0.900	42.575	0.079	0.079	0.000	0.000	0.000	0.000
165	A	166	PHE	0	-0.026	-0.032	39.543	0.003	0.003	0.000	0.000	0.000	0.000
166	A	167	SER	0	0.020	-0.010	44.600	-0.004	-0.004	0.000	0.000	0.000	0.000
167	A	168	ASP	-1	-0.905	-0.935	44.108	0.073	0.073	0.000	0.000	0.000	0.000
168	A	169	THR	0	-0.006	-0.036	42.364	0.000	0.000	0.000	0.000	0.000	0.000
169	A	170	ALA	0	0.005	0.005	44.853	0.000	0.000	0.000	0.000	0.000	0.000
170	A	171	GLY	0	-0.016	-0.006	46.878	-0.001	-0.001	0.000	0.000	0.000	0.000
171	A	172	ALA	0	-0.027	0.002	41.530	-0.001	-0.001	0.000	0.000	0.000	0.000
172	A	173	ALA	0	0.029	0.008	41.481	0.002	0.002	0.000	0.000	0.000	0.000
173	A	174	THR	0	-0.047	-0.047	42.678	-0.004	-0.004	0.000	0.000	0.000	0.000
174	A	175	GLY	0	0.001	0.019	46.091	-0.004	-0.004	0.000	0.000	0.000	0.000
175	A	176	LYS	1	0.827	0.911	47.898	-0.043	-0.043	0.000	0.000	0.000	0.000
176	A	177	VAL	0	0.080	0.033	49.643	0.002	0.002	0.000	0.000	0.000	0.000
177	A	178	LEU	0	0.032	0.018	51.231	0.002	0.002	0.000	0.000	0.000	0.000
178	A	179	PRO	0	-0.024	-0.011	48.650	-0.003	-0.003	0.000	0.000	0.000	0.000
179	A	180	THR	0	-0.015	-0.035	51.213	-0.002	-0.002	0.000	0.000	0.000	0.000
180	A	181	GLY	0	-0.067	-0.014	54.060	-0.002	-0.002	0.000	0.000	0.000	0.000
181	A	182	ASN	0	-0.066	-0.040	56.593	-0.002	-0.002	0.000	0.000	0.000	0.000
182	A	183	VAL	0	0.011	0.009	56.215	0.002	0.002	0.000	0.000	0.000	0.000
183	A	184	VAL	0	-0.004	0.006	56.691	0.002	0.002	0.000	0.000	0.000	0.000
184	A	185	ASP	-1	-0.811	-0.862	55.193	0.036	0.036	0.000	0.000	0.000	0.000
185	A	186	VAL	0	0.030	0.020	56.772	0.001	0.001	0.000	0.000	0.000	0.000
186	A	187	LEU	0	-0.068	-0.042	50.856	-0.001	-0.001	0.000	0.000	0.000	0.000
187	A	188	SER	0	0.027	0.016	55.436	-0.001	-0.001	0.000	0.000	0.000	0.000
188	A	189	THR	0	-0.021	-0.035	52.740	0.003	0.003	0.000	0.000	0.000	0.000
189	A	190	SER	0	-0.079	-0.058	51.448	-0.002	-0.002	0.000	0.000	0.000	0.000
190	A	191	LYS	1	0.827	0.910	51.089	-0.041	-0.041	0.000	0.000	0.000	0.000
191	A	192	GLY	0	-0.030	-0.006	56.049	0.000	0.000	0.000	0.000	0.000	0.000
192	A	193	ASP	-1	-0.931	-0.977	56.855	0.030	0.030	0.000	0.000	0.000	0.000
193	A	194	ILE	0	-0.022	-0.002	53.385	0.001	0.001	0.000	0.000	0.000	0.000
194	A	195	ASP	-1	-0.853	-0.909	56.702	0.037	0.037	0.000	0.000	0.000	0.000
195	A	196	VAL	0	-0.034	-0.029	51.932	0.003	0.003	0.000	0.000	0.000	0.000
196	A	197	SER	0	0.000	-0.007	53.280	-0.002	-0.002	0.000	0.000	0.000	0.000
197	A	198	ILE	0	-0.029	-0.014	48.245	0.003	0.003	0.000	0.000	0.000	0.000
198	A	199	VAL	0	0.017	0.008	49.247	-0.002	-0.002	0.000	0.000	0.000	0.000
199	A	200	ASP	-1	-0.760	-0.866	44.783	0.072	0.072	0.000	0.000	0.000	0.000
200	A	201	VAL	0	0.022	0.003	46.572	-0.002	-0.002	0.000	0.000	0.000	0.000
201	A	202	ALA	0	-0.003	0.018	41.874	0.004	0.004	0.000	0.000	0.000	0.000
202	A	203	ASN	0	-0.068	-0.086	37.779	0.003	0.003	0.000	0.000	0.000	0.000
203	A	204	PRO	0	0.042	0.029	41.368	-0.002	-0.002	0.000	0.000	0.000	0.000
204	A	205	CYS	0	-0.095	-0.042	43.470	0.006	0.006	0.000	0.000	0.000	0.000
205	A	206	ILE	0	0.032	0.016	45.458	-0.004	-0.004	0.000	0.000	0.000	0.000
206	A	207	PHE	0	-0.007	-0.013	47.778	0.003	0.003	0.000	0.000	0.000	0.000
207	A	208	VAL	0	0.070	0.026	50.813	-0.003	-0.003	0.000	0.000	0.000	0.000
208	A	209	HIS	0	0.047	0.025	52.788	0.004	0.004	0.000	0.000	0.000	0.000
209	A	210	ALA	0	0.015	0.005	53.127	-0.001	-0.001	0.000	0.000	0.000	0.000
210	A	211	LYS	1	0.974	0.971	54.138	-0.044	-0.044	0.000	0.000	0.000	0.000
211	A	212	ASP	-1	-0.870	-0.921	55.916	0.041	0.041	0.000	0.000	0.000	0.000
212	A	213	VAL	0	-0.053	-0.033	50.900	-0.001	-0.001	0.000	0.000	0.000	0.000
213	A	214	ASN	0	-0.116	-0.063	53.016	0.000	0.000	0.000	0.000	0.000	0.000
214	A	215	MET	0	-0.048	0.009	49.034	0.000	0.000	0.000	0.000	0.000	0.000
215	A	216	THR	0	-0.054	-0.079	53.773	-0.001	-0.001	0.000	0.000	0.000	0.000
216	A	217	GLY	0	-0.011	-0.011	51.805	-0.001	-0.001	0.000	0.000	0.000	0.000
217	A	218	THR	0	-0.019	-0.005	50.994	0.004	0.004	0.000	0.000	0.000	0.000
218	A	219	GLU	-1	-0.759	-0.849	48.885	0.062	0.062	0.000	0.000	0.000	0.000
219	A	220	THR	0	0.013	0.004	44.987	0.004	0.004	0.000	0.000	0.000	0.000
220	A	221	PRO	0	0.035	0.009	40.747	-0.002	-0.002	0.000	0.000	0.000	0.000
221	A	222	ASP	-1	-0.904	-0.945	41.635	0.095	0.095	0.000	0.000	0.000	0.000
222	A	223	VAL	0	-0.035	-0.023	43.351	-0.003	-0.003	0.000	0.000	0.000	0.000
223	A	224	ILE	0	-0.008	-0.005	44.011	-0.003	-0.003	0.000	0.000	0.000	0.000
224	A	225	ASN	0	-0.010	-0.031	39.528	-0.003	-0.003	0.000	0.000	0.000	0.000
225	A	226	GLY	0	0.016	0.029	41.842	0.000	0.000	0.000	0.000	0.000	0.000
226	A	227	ASN	0	-0.033	-0.024	44.099	-0.002	-0.002	0.000	0.000	0.000	0.000
227	A	228	ALA	0	0.056	0.015	43.921	0.000	0.000	0.000	0.000	0.000	0.000
228	A	229	ASP	-1	-0.874	-0.930	44.950	0.042	0.042	0.000	0.000	0.000	0.000
229	A	230	LEU	0	0.011	0.014	46.911	-0.001	-0.001	0.000	0.000	0.000	0.000
230	A	231	LEU	0	-0.004	0.004	40.840	0.001	0.001	0.000	0.000	0.000	0.000
231	A	232	ALA	0	-0.002	-0.012	43.977	0.001	0.001	0.000	0.000	0.000	0.000
232	A	233	TYR	0	-0.016	-0.014	44.932	-0.002	-0.002	0.000	0.000	0.000	0.000
233	A	234	LEU	0	0.034	0.010	45.177	-0.001	-0.001	0.000	0.000	0.000	0.000
234	A	235	GLU	-1	-0.742	-0.838	40.667	0.071	0.071	0.000	0.000	0.000	0.000
235	A	236	GLU	-1	-0.784	-0.834	43.776	0.035	0.035	0.000	0.000	0.000	0.000
236	A	237	ILE	0	0.026	0.009	46.541	-0.001	-0.001	0.000	0.000	0.000	0.000
237	A	238	ARG	1	0.755	0.858	38.915	-0.076	-0.076	0.000	0.000	0.000	0.000
238	A	239	ALA	0	0.022	-0.003	42.780	0.000	0.000	0.000	0.000	0.000	0.000
239	A	240	LYS	1	0.788	0.880	43.926	-0.037	-0.037	0.000	0.000	0.000	0.000
240	A	241	CYS	0	-0.046	-0.029	46.949	-0.002	-0.002	0.000	0.000	0.000	0.000
241	A	242	CYS	0	-0.021	-0.002	40.669	0.000	0.000	0.000	0.000	0.000	0.000
242	A	243	VAL	0	0.006	0.006	44.304	-0.001	-0.001	0.000	0.000	0.000	0.000
243	A	244	LYS	1	0.774	0.892	45.694	-0.039	-0.039	0.000	0.000	0.000	0.000
244	A	245	ILE	0	-0.038	-0.029	45.054	-0.001	-0.001	0.000	0.000	0.000	0.000
245	A	246	GLY	0	-0.018	0.005	45.191	0.001	0.001	0.000	0.000	0.000	0.000
246	A	247	MET	0	-0.027	-0.005	39.456	0.000	0.000	0.000	0.000	0.000	0.000
247	A	248	ALA	0	-0.003	-0.002	39.854	0.003	0.003	0.000	0.000	0.000	0.000
248	A	249	ALA	0	-0.002	0.012	41.373	-0.003	-0.003	0.000	0.000	0.000	0.000
249	A	250	THR	0	-0.067	-0.035	41.981	-0.003	-0.003	0.000	0.000	0.000	0.000
250	A	251	GLU	-1	-0.760	-0.887	42.510	0.039	0.039	0.000	0.000	0.000	0.000
251	A	252	LYS	1	0.900	0.951	37.853	-0.021	-0.021	0.000	0.000	0.000	0.000
252	A	253	GLU	-1	-0.874	-0.948	37.252	0.041	0.041	0.000	0.000	0.000	0.000
253	A	254	ALA	0	0.039	0.029	37.468	0.005	0.005	0.000	0.000	0.000	0.000
254	A	255	SER	0	-0.007	-0.010	38.136	0.005	0.005	0.000	0.000	0.000	0.000
255	A	256	GLU	-1	-0.875	-0.931	34.453	0.041	0.041	0.000	0.000	0.000	0.000
256	A	257	LYS	1	0.840	0.894	32.777	-0.036	-0.036	0.000	0.000	0.000	0.000
257	A	258	SER	0	-0.025	0.011	33.588	0.006	0.006	0.000	0.000	0.000	0.000
258	A	259	PRO	0	-0.005	0.009	33.048	-0.002	-0.002	0.000	0.000	0.000	0.000
259	A	260	ALA	0	0.010	0.003	33.854	0.001	0.001	0.000	0.000	0.000	0.000
260	A	261	PHE	0	-0.044	0.007	34.087	0.000	0.000	0.000	0.000	0.000	0.000
261	A	262	PRO	0	0.084	0.018	38.812	-0.002	-0.002	0.000	0.000	0.000	0.000
262	A	263	MET	0	-0.032	-0.013	39.770	0.004	0.004	0.000	0.000	0.000	0.000
263	A	264	ILE	0	0.023	0.011	42.180	-0.004	-0.004	0.000	0.000	0.000	0.000
264	A	265	ALA	0	-0.003	-0.008	44.650	0.004	0.004	0.000	0.000	0.000	0.000
265	A	266	PHE	0	-0.003	0.004	46.869	-0.004	-0.004	0.000	0.000	0.000	0.000
266	A	267	VAL	0	0.006	0.000	50.167	0.003	0.003	0.000	0.000	0.000	0.000
267	A	268	THR	0	-0.005	-0.012	52.596	-0.003	-0.003	0.000	0.000	0.000	0.000
268	A	269	LYS	1	0.921	0.967	55.563	-0.049	-0.049	0.000	0.000	0.000	0.000
269	A	270	PRO	0	-0.014	-0.009	56.480	0.001	0.001	0.000	0.000	0.000	0.000
270	A	271	GLU	-1	-0.953	-0.971	56.290	0.050	0.050	0.000	0.000	0.000	0.000
271	A	272	ASP	-1	-0.816	-0.901	55.670	0.062	0.062	0.000	0.000	0.000	0.000
272	A	273	TYR	0	-0.072	-0.046	48.327	-0.002	-0.002	0.000	0.000	0.000	0.000
273	A	274	VAL	0	0.001	0.006	48.486	0.001	0.001	0.000	0.000	0.000	0.000
274	A	275	ASP	-1	-0.736	-0.821	44.734	0.105	0.105	0.000	0.000	0.000	0.000
275	A	276	PHE	0	-0.026	-0.023	39.252	0.004	0.004	0.000	0.000	0.000	0.000
276	A	277	SER	0	-0.117	-0.059	40.799	0.003	0.003	0.000	0.000	0.000	0.000
277	A	278	THR	0	-0.061	-0.071	42.401	0.002	0.002	0.000	0.000	0.000	0.000
278	A	279	GLY	0	-0.031	-0.011	45.111	-0.002	-0.002	0.000	0.000	0.000	0.000
279	A	280	ASN	0	-0.049	-0.030	47.938	-0.007	-0.007	0.000	0.000	0.000	0.000
280	A	281	THR	0	0.003	-0.003	50.304	0.002	0.002	0.000	0.000	0.000	0.000
281	A	282	ILE	0	-0.017	0.004	48.811	0.001	0.001	0.000	0.000	0.000	0.000
282	A	283	SER	0	0.046	0.026	52.644	-0.003	-0.003	0.000	0.000	0.000	0.000
283	A	284	GLY	0	0.037	0.005	55.623	0.002	0.002	0.000	0.000	0.000	0.000
284	A	285	ASP	-1	-0.900	-0.942	57.596	0.053	0.053	0.000	0.000	0.000	0.000
285	A	286	ASP	-1	-0.902	-0.945	54.104	0.069	0.069	0.000	0.000	0.000	0.000
286	A	287	VAL	0	-0.067	-0.031	52.254	0.003	0.003	0.000	0.000	0.000	0.000
287	A	288	ASP	-1	-0.778	-0.872	54.313	0.060	0.060	0.000	0.000	0.000	0.000
288	A	289	LEU	0	-0.005	-0.010	52.101	-0.003	-0.003	0.000	0.000	0.000	0.000
289	A	290	VAL	0	-0.009	0.015	51.031	0.004	0.004	0.000	0.000	0.000	0.000
290	A	291	SER	0	0.001	-0.014	47.822	-0.003	-0.003	0.000	0.000	0.000	0.000
291	A	292	ARG	1	0.832	0.934	46.250	-0.074	-0.074	0.000	0.000	0.000	0.000
292	A	293	LEU	0	-0.009	0.005	41.226	-0.002	-0.002	0.000	0.000	0.000	0.000
293	A	294	MET	0	0.008	0.030	41.483	0.004	0.004	0.000	0.000	0.000	0.000
294	A	295	PHE	0	-0.050	-0.053	33.263	0.003	0.003	0.000	0.000	0.000	0.000
295	A	296	MET	0	0.000	0.010	31.798	0.006	0.006	0.000	0.000	0.000	0.000
296	A	297	GLN	0	-0.048	-0.043	36.058	0.007	0.007	0.000	0.000	0.000	0.000
297	A	298	VAL	0	0.011	0.018	36.144	-0.004	-0.004	0.000	0.000	0.000	0.000
298	A	299	LEU	0	-0.003	-0.002	38.964	0.001	0.001	0.000	0.000	0.000	0.000
299	A	300	HIS	0	-0.015	-0.018	37.675	0.008	0.008	0.000	0.000	0.000	0.000
300	A	301	LYS	1	0.877	0.906	34.624	-0.148	-0.148	0.000	0.000	0.000	0.000
301	A	302	THR	0	-0.038	-0.026	38.526	0.000	0.000	0.000	0.000	0.000	0.000
302	A	303	TYR	0	0.066	0.018	40.668	-0.007	-0.007	0.000	0.000	0.000	0.000
303	A	304	ALA	0	-0.025	-0.004	38.960	0.006	0.006	0.000	0.000	0.000	0.000
304	A	305	GLY	0	0.053	0.045	38.870	-0.005	-0.005	0.000	0.000	0.000	0.000
305	A	306	THR	0	0.067	0.029	38.652	-0.002	-0.002	0.000	0.000	0.000	0.000
306	A	307	ALA	0	0.016	0.011	41.460	-0.005	-0.005	0.000	0.000	0.000	0.000
307	A	308	THR	0	-0.001	-0.012	43.045	-0.004	-0.004	0.000	0.000	0.000	0.000
308	A	309	ALA	0	0.036	0.022	44.458	-0.004	-0.004	0.000	0.000	0.000	0.000
309	A	310	CYS	0	-0.069	-0.019	45.326	-0.006	-0.006	0.000	0.000	0.000	0.000
310	A	311	THR	0	0.010	0.008	47.163	-0.003	-0.003	0.000	0.000	0.000	0.000
311	A	312	GLY	0	0.021	0.018	49.098	-0.003	-0.003	0.000	0.000	0.000	0.000
312	A	313	SER	0	0.020	-0.015	49.494	-0.003	-0.003	0.000	0.000	0.000	0.000
313	A	314	ALA	0	-0.011	-0.004	51.446	-0.003	-0.003	0.000	0.000	0.000	0.000
314	A	315	ALA	0	0.034	0.025	53.233	-0.003	-0.003	0.000	0.000	0.000	0.000
315	A	316	ARG	1	0.787	0.889	55.258	-0.061	-0.061	0.000	0.000	0.000	0.000
316	A	317	ILE	0	-0.039	-0.005	53.920	-0.002	-0.002	0.000	0.000	0.000	0.000
317	A	318	PRO	0	0.023	0.000	57.858	0.000	0.000	0.000	0.000	0.000	0.000
318	A	319	GLY	0	0.015	-0.001	61.115	-0.001	-0.001	0.000	0.000	0.000	0.000
319	A	320	THR	0	-0.032	-0.012	55.129	0.000	0.000	0.000	0.000	0.000	0.000
320	A	321	ILE	0	0.046	0.020	54.935	0.000	0.000	0.000	0.000	0.000	0.000
321	A	322	VAL	0	-0.026	-0.016	51.930	0.000	0.000	0.000	0.000	0.000	0.000
322	A	323	ASN	0	-0.033	-0.023	55.163	-0.002	-0.002	0.000	0.000	0.000	0.000
323	A	324	GLN	0	-0.052	-0.034	58.292	-0.001	-0.001	0.000	0.000	0.000	0.000
324	A	325	VAL	0	-0.049	-0.018	55.522	-0.001	-0.001	0.000	0.000	0.000	0.000
325	A	326	LEU	0	-0.066	-0.015	55.626	0.001	0.001	0.000	0.000	0.000	0.000
326	A	327	ARG	1	0.784	0.882	58.469	-0.058	-0.058	0.000	0.000	0.000	0.000
327	A	328	ASP	-1	-0.913	-0.966	60.131	0.048	0.048	0.000	0.000	0.000	0.000
328	A	329	THR	0	0.017	0.010	57.708	0.000	0.000	0.000	0.000	0.000	0.000
329	A	330	GLY	0	-0.027	-0.009	61.085	0.001	0.001	0.000	0.000	0.000	0.000
330	A	331	ASP	-1	-0.964	-0.990	63.454	0.047	0.047	0.000	0.000	0.000	0.000
331	A	332	GLU	-1	-0.897	-0.900	56.919	0.066	0.066	0.000	0.000	0.000	0.000
332	A	333	ASP	-1	-0.717	-0.873	55.846	0.060	0.060	0.000	0.000	0.000	0.000
333	A	334	THR	0	-0.147	-0.099	52.357	0.003	0.003	0.000	0.000	0.000	0.000
334	A	335	VAL	0	-0.017	-0.001	52.233	-0.002	-0.002	0.000	0.000	0.000	0.000
335	A	336	ARG	1	0.790	0.854	51.713	-0.060	-0.060	0.000	0.000	0.000	0.000
336	A	337	ILE	0	0.015	0.012	47.765	-0.003	-0.003	0.000	0.000	0.000	0.000
337	A	338	GLY	0	0.057	0.022	48.881	0.004	0.004	0.000	0.000	0.000	0.000
338	A	339	HIS	0	-0.008	-0.005	42.992	-0.001	-0.001	0.000	0.000	0.000	0.000
339	A	340	PRO	0	0.016	-0.003	43.192	-0.001	-0.001	0.000	0.000	0.000	0.000
340	A	341	ALA	0	-0.020	-0.007	41.913	0.000	0.000	0.000	0.000	0.000	0.000
341	A	342	GLY	0	-0.006	0.010	43.972	0.003	0.003	0.000	0.000	0.000	0.000
342	A	343	VAL	0	0.008	-0.008	46.976	-0.002	-0.002	0.000	0.000	0.000	0.000
343	A	344	ILE	0	-0.093	-0.035	42.971	0.006	0.006	0.000	0.000	0.000	0.000
344	A	345	PRO	0	0.014	0.015	46.920	-0.003	-0.003	0.000	0.000	0.000	0.000
345	A	346	VAL	0	-0.041	-0.027	47.600	0.004	0.004	0.000	0.000	0.000	0.000
346	A	347	VAL	0	0.015	0.015	49.426	-0.004	-0.004	0.000	0.000	0.000	0.000
347	A	348	SER	0	-0.011	-0.009	51.048	0.001	0.001	0.000	0.000	0.000	0.000
348	A	349	ILE	0	0.025	0.024	52.906	-0.002	-0.002	0.000	0.000	0.000	0.000
349	A	350	VAL	0	-0.005	-0.013	53.731	0.001	0.001	0.000	0.000	0.000	0.000
350	A	351	LYS	1	0.872	0.930	56.272	-0.050	-0.050	0.000	0.000	0.000	0.000
351	A	352	ASP	-1	-0.938	-0.975	59.229	0.043	0.043	0.000	0.000	0.000	0.000
352	A	353	GLY	0	-0.009	-0.002	57.759	-0.002	-0.002	0.000	0.000	0.000	0.000
353	A	354	LYS	1	0.901	0.937	54.549	-0.045	-0.045	0.000	0.000	0.000	0.000
354	A	355	VAL	0	0.027	0.011	49.831	-0.001	-0.001	0.000	0.000	0.000	0.000
355	A	356	GLU	-1	-0.874	-0.910	51.919	0.053	0.053	0.000	0.000	0.000	0.000
356	A	357	LYS	1	0.843	0.929	51.239	-0.063	-0.063	0.000	0.000	0.000	0.000
357	A	358	ALA	0	0.040	0.019	47.610	-0.002	-0.002	0.000	0.000	0.000	0.000
358	A	359	ALA	0	-0.001	0.021	46.684	0.004	0.004	0.000	0.000	0.000	0.000
359	A	360	LEU	0	-0.009	-0.006	42.176	-0.002	-0.002	0.000	0.000	0.000	0.000
360	A	361	ILE	0	0.035	0.029	43.571	0.003	0.003	0.000	0.000	0.000	0.000
361	A	362	ARG	1	0.837	0.902	38.630	-0.123	-0.123	0.000	0.000	0.000	0.000
362	A	363	THR	0	0.075	0.038	36.752	-0.003	-0.003	0.000	0.000	0.000	0.000
363	A	364	ALA	0	-0.013	-0.002	33.119	0.005	0.005	0.000	0.000	0.000	0.000
364	A	365	ARG	1	0.930	0.958	28.494	-0.254	-0.254	0.000	0.000	0.000	0.000
365	A	366	ARG	1	0.872	0.928	24.503	-0.312	-0.312	0.000	0.000	0.000	0.000
366	A	367	ILE	0	-0.120	-0.073	25.446	-0.013	-0.013	0.000	0.000	0.000	0.000
367	A	368	MET	0	-0.005	-0.008	17.794	0.001	0.001	0.000	0.000	0.000	0.000
368	A	369	GLU	-1	-0.836	-0.888	20.724	0.376	0.376	0.000	0.000	0.000	0.000
369	A	370	GLY	0	0.005	-0.001	16.788	0.017	0.017	0.000	0.000	0.000	0.000
370	A	371	TYR	0	-0.033	-0.029	11.934	0.027	0.027	0.000	0.000	0.000	0.000
371	A	372	VAL	0	0.044	0.037	13.054	0.097	0.097	0.000	0.000	0.000	0.000
372	A	373	TYR	0	-0.031	-0.025	6.606	0.337	0.337	0.000	0.000	0.000	0.000
373	A	374	VAL	0	0.057	0.033	9.179	-0.278	-0.278	0.000	0.000	0.000	0.000
374	A	375	GLU	-1	-0.795	-0.884	8.194	0.637	0.637	0.000	0.000	0.000	0.000
375	A	376	LYS	1	0.885	0.919	2.595	-0.090	0.522	0.480	-0.384	-0.708	0.003
376	A	377	ALA	0	0.028	0.010	8.472	-0.088	-0.088	0.000	0.000	0.000	0.000
377	A	378	LYS	1	0.803	0.892	10.673	-0.215	-0.215	0.000	0.000	0.000	0.000
378	A	379	LEU	0	-0.008	-0.001	10.971	0.033	0.033	0.000	0.000	0.000	0.000
379	A	380	VAL	0	-0.059	-0.002	11.298	-0.017	-0.017	0.000	0.000	0.000	0.000

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Interactive mode: IFIE and PIEDA for fragment #1(A:2:SER)