FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-04-23

All entries: 37539

Number of unique PDB entries: 7791

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FMODB ID: K39Q3

Calculation Name: 4FKR-AB-MD335-md3_32ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: (8z)-8-{[(2,2-dioxido-1,3-dihydro-2-benzothiophen-5-yl)amino]methylidene}-6,8-dihydro-7h-[1,3]thiazolo[5,4-e]indol-7-one

ligand 3-letter code: 45K

PDB ID: 4FKR

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-08-30

Reference: K. Takaba et al., Protein-ligand binding affinity prediction of cyclin-dependent kinase-2 inhibitors by dynamically averaged fragment molecular orbital-based interaction energy, J. Comput. Chem., 43, 1362-1371, 2022.

DOI: 10.1002/jcc.26940

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2775
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -19479237.828095
FMO2-HF: Nuclear repulsion 19171603.687944
FMO2-HF: Total energy -307634.140151
FMO2-MP2: Total energy -308474.142526


3D Structure
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-135.648659-115.30323983.048946-34.156676-69.237689-0.025648


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-156.793-145.82138.641-59.483-90.136-0.002
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.003 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.74014.1820.1850.1850.0000.0000.0000.000
2A2GLU-1-0.66817.862-0.239-0.2390.0000.0000.0000.000
3A3ASN00.04614.259-0.008-0.0080.0000.0000.0000.000
4A4PHE00.02710.983-0.047-0.0470.0000.0000.0000.000
5A5GLN00.00212.974-0.005-0.0050.0000.0000.0000.000
6A6LYS10.86211.5270.3040.3040.0000.0000.0000.000
7A7VAL00.0138.8470.0360.0360.0000.0000.0000.000
8A8GLU-1-0.6806.019-2.890-2.8900.0000.0000.0000.000
9A9LYS10.8627.3220.8290.8290.0000.0000.0000.000
10A10ILE00.0192.626-5.257-0.3833.099-1.523-6.4500.012
11A11GLY00.0963.076-11.053-7.8061.179-1.685-2.741-0.010
12A12GLU-1-0.7684.1291.5801.928-0.0010.087-0.4330.000
13A13GLY00.0693.414-3.389-2.8340.016-0.345-0.226-0.003
14A14THR00.0045.4670.4170.4170.0000.0000.0000.000
15A15TYR0-0.0197.555-0.105-0.1050.0000.0000.0000.000
16A16GLY00.0887.8470.0630.0630.0000.0000.0000.000
17A17VAL0-0.0386.262-0.416-0.4160.0000.0000.0000.000
18A18VAL00.0012.638-2.314-0.2413.956-1.116-4.9150.005
19A19TYR0-0.0315.994-1.602-1.421-0.001-0.006-0.1740.000
20A20LYS10.8284.2045.7886.2390.000-0.035-0.4170.000
21A21ALA00.0246.789-0.145-0.1450.0000.0000.0000.000
22A22ARG10.8288.3931.0591.0590.0000.0000.0000.000
23A23ASN00.06110.8960.1110.1110.0000.0000.0000.000
24A24LYS10.85812.4310.2980.2980.0000.0000.0000.000
25A25LEU00.02415.7260.0190.0190.0000.0000.0000.000
26A26THR00.00113.1430.0140.0140.0000.0000.0000.000
27A27GLY00.03715.072-0.007-0.0070.0000.0000.0000.000
28A28GLU-1-0.70510.771-0.801-0.8010.0000.0000.0000.000
29A29VAL00.0116.3180.0400.0400.0000.0000.0000.000
30A30VAL0-0.0025.7410.0420.0420.0000.0000.0000.000
31A31ALA0-0.0182.904-1.1840.4520.558-0.582-1.6120.004
32A32LEU0-0.0334.782-0.823-0.635-0.001-0.013-0.1740.000
33A33LYS10.8141.905-23.613-26.33512.359-3.907-5.7300.043
34A34LYS10.7916.842-0.280-0.2800.0000.0000.0000.000
35A35ILE00.0338.2140.4480.4480.0000.0000.0000.000
36A36ARG10.84710.282-0.355-0.3550.0000.0000.0000.000
37A37LEU00.00412.873-0.064-0.0640.0000.0000.0000.000
38A38ASP-1-0.70214.5560.0140.0140.0000.0000.0000.000
39A39THR0-0.02215.8330.0290.0290.0000.0000.0000.000
40A40GLU-1-0.59818.4230.0050.0050.0000.0000.0000.000
41A41THR00.05920.1970.0060.0060.0000.0000.0000.000
42A42GLU-1-0.64722.637-0.056-0.0560.0000.0000.0000.000
43A43GLY00.01619.686-0.016-0.0160.0000.0000.0000.000
44A44VAL00.01316.5830.0160.0160.0000.0000.0000.000
45A45PRO00.07318.958-0.008-0.0080.0000.0000.0000.000
46A46SER00.02618.1190.0110.0110.0000.0000.0000.000
47A47THR00.01118.7910.0100.0100.0000.0000.0000.000
48A48ALA00.00320.2090.0100.0100.0000.0000.0000.000
49A49ILE0-0.00514.5040.0300.0300.0000.0000.0000.000
50A50ARG10.92314.891-0.048-0.0480.0000.0000.0000.000
51A51GLU-1-0.70613.4830.1050.1050.0000.0000.0000.000
52A52ILE00.0149.4680.0760.0760.0000.0000.0000.000
53A53SER00.01212.067-0.084-0.0840.0000.0000.0000.000
54A54LEU0-0.02113.157-0.046-0.0460.0000.0000.0000.000
55A55LEU0-0.0038.344-0.042-0.0420.0000.0000.0000.000
56A56LYS10.80712.5130.0490.0490.0000.0000.0000.000
57A57GLU-1-0.70215.404-0.088-0.0880.0000.0000.0000.000
58A58LEU00.03912.7110.0210.0210.0000.0000.0000.000
59A59ASN0-0.00112.434-0.131-0.1310.0000.0000.0000.000
60A60HIS00.05612.6310.0130.0130.0000.0000.0000.000
61A61PRO0-0.01712.297-0.084-0.0840.0000.0000.0000.000
62A62ASN00.04611.604-0.022-0.0220.0000.0000.0000.000
63A63ILE0-0.0328.8670.0990.0990.0000.0000.0000.000
64A64VAL00.0202.889-0.845-0.2380.088-0.133-0.5620.000
65A65LYS10.8546.3001.1731.1730.0000.0000.0000.000
66A66LEU00.0135.884-0.791-0.7910.0000.0000.0000.000
67A67LEU0-0.0147.4750.1540.1540.0000.0000.0000.000
68A68ASP-1-0.6929.476-0.164-0.1640.0000.0000.0000.000
69A69VAL00.01610.2040.0430.0430.0000.0000.0000.000
70A70ILE00.01411.721-0.013-0.0130.0000.0000.0000.000
71A71HIS00.02114.3800.0640.0640.0000.0000.0000.000
72A72THR00.00714.112-0.060-0.0600.0000.0000.0000.000
73A73GLU-1-0.66815.018-0.041-0.0410.0000.0000.0000.000
74A74ASN00.03118.1010.0240.0240.0000.0000.0000.000
75A75LYS10.81715.190-0.013-0.0130.0000.0000.0000.000
76A76LEU00.06312.224-0.013-0.0130.0000.0000.0000.000
77A77TYR0-0.00110.3560.0780.0780.0000.0000.0000.000
78A78LEU0-0.0086.967-0.117-0.1170.0000.0000.0000.000
79A79VAL00.0236.9380.1800.1800.0000.0000.0000.000
80A80PHE00.0182.780-1.3260.0260.198-0.324-1.225-0.001
81A81GLU-1-0.7014.134-1.865-1.2010.000-0.230-0.434-0.001
82A82PHE00.0112.067-19.538-13.1386.214-5.213-7.401-0.033
83A83LEU0-0.0091.767-9.809-14.46514.766-5.036-5.0750.035
84A84HIS00.0131.849-10.720-12.47710.671-3.817-5.097-0.030
85A85GLN00.0702.833-6.119-1.0424.532-2.797-6.8130.000
86A86ASP-1-0.6792.655-21.219-17.3081.766-0.537-5.140-0.022
87A87LEU00.0224.1611.6131.9660.002-0.031-0.3240.000
88A88LYS10.8486.7522.2132.2130.0000.0000.0000.000
89A89LYS10.8871.723-26.249-34.30617.055-4.561-4.4370.023
90A90PHE00.0645.2831.0181.153-0.001-0.002-0.1320.000
91A91MET00.0157.4310.1250.1250.0000.0000.0000.000
92A92ASP-1-0.7008.4502.0662.0660.0000.0000.0000.000
93A93ALA00.0337.1260.0090.0090.0000.0000.0000.000
94A94SER00.0229.232-0.213-0.2130.0000.0000.0000.000
95A95ALA00.03912.624-0.198-0.1980.0000.0000.0000.000
96A96LEU0-0.01914.724-0.131-0.1310.0000.0000.0000.000
97A97THR0-0.02214.762-0.056-0.0560.0000.0000.0000.000
98A98GLY00.02316.256-0.080-0.0800.0000.0000.0000.000
99A99ILE0-0.00113.0000.0700.0700.0000.0000.0000.000
100A100PRO00.05816.749-0.036-0.0360.0000.0000.0000.000
101A101LEU00.04519.811-0.041-0.0410.0000.0000.0000.000
102A102PRO00.01221.996-0.025-0.0250.0000.0000.0000.000
103A103LEU00.01314.852-0.038-0.0380.0000.0000.0000.000
104A104ILE0-0.06617.663-0.061-0.0610.0000.0000.0000.000
105A105LYS10.82518.745-0.026-0.0260.0000.0000.0000.000
106A106SER00.03019.057-0.036-0.0360.0000.0000.0000.000
107A107TYR0-0.03512.1870.0040.0040.0000.0000.0000.000
108A108LEU00.01316.234-0.038-0.0380.0000.0000.0000.000
109A109PHE00.00818.465-0.003-0.0030.0000.0000.0000.000
110A110GLN00.00415.193-0.062-0.0620.0000.0000.0000.000
111A111LEU00.02112.2050.0080.0080.0000.0000.0000.000
112A112LEU0-0.00815.4210.0330.0330.0000.0000.0000.000
113A113GLN00.06217.9540.0060.0060.0000.0000.0000.000
114A114GLY00.03014.2390.0050.0050.0000.0000.0000.000
115A115LEU0-0.00314.3750.0310.0310.0000.0000.0000.000
116A116ALA00.05515.7630.0250.0250.0000.0000.0000.000
117A117PHE0-0.01416.1260.0120.0120.0000.0000.0000.000
118A118CYS0-0.01513.9750.0140.0140.0000.0000.0000.000
119A119HIS0-0.01616.7290.0000.0000.0000.0000.0000.000
120A120SER00.03219.9120.0050.0050.0000.0000.0000.000
121A121HIS00.08417.121-0.004-0.0040.0000.0000.0000.000
122A122ARG10.83820.3700.0400.0400.0000.0000.0000.000
123A123VAL00.00516.2670.0150.0150.0000.0000.0000.000
124A124LEU00.01316.587-0.012-0.0120.0000.0000.0000.000
125A125HIS00.0568.645-0.128-0.1280.0000.0000.0000.000
126A126ARG10.84213.749-0.045-0.0450.0000.0000.0000.000
127A127ASP-1-0.6579.5100.1300.1300.0000.0000.0000.000
128A128LEU0-0.0159.7470.0140.0140.0000.0000.0000.000
129A129LYS10.9087.3020.3790.3790.0000.0000.0000.000
130A130PRO00.0717.973-0.065-0.0650.0000.0000.0000.000
131A131GLN0-0.0264.0240.5090.7590.000-0.017-0.2320.000
132A132ASN0-0.0663.101-3.903-2.7770.112-0.477-0.761-0.003
133A133LEU00.0344.8660.5080.763-0.001-0.008-0.2460.000
134A134LEU00.0062.686-5.396-3.0496.240-1.369-7.2180.007
135A135ILE00.0246.4150.5790.5790.0000.0000.0000.000
136A136ASN00.0416.931-0.386-0.3860.0000.0000.0000.000
137A137THR0-0.0109.5480.0160.0160.0000.0000.0000.000
138A138GLU-1-0.63412.302-0.275-0.2750.0000.0000.0000.000
139A139GLY00.06213.3510.0660.0660.0000.0000.0000.000
140A140ALA0-0.03711.6070.0060.0060.0000.0000.0000.000
141A141ILE0-0.01510.394-0.135-0.1350.0000.0000.0000.000
142A142LYS10.7057.1621.3571.3570.0000.0000.0000.000
143A143LEU0-0.0207.602-0.012-0.0120.0000.0000.0000.000
144A144ALA00.0262.852-1.034-0.2150.197-0.268-0.7480.001
145A145ASP-1-0.7173.8177.5568.2430.046-0.213-0.5190.000
146A146PHE00.0436.276-0.504-0.5040.0000.0000.0000.000
147A147GLY00.0459.447-0.030-0.0300.0000.0000.0000.000
148A148LEU0-0.0137.846-0.050-0.0500.0000.0000.0000.000
149A149ALA00.01912.246-0.063-0.0630.0000.0000.0000.000
150A150ARG10.73915.011-0.122-0.1220.0000.0000.0000.000
151A151ALA00.01215.912-0.031-0.0310.0000.0000.0000.000
152A152PHE0-0.05811.804-0.021-0.0210.0000.0000.0000.000
153A153GLY00.07916.668-0.028-0.0280.0000.0000.0000.000
154A154VAL0-0.04516.3590.0250.0250.0000.0000.0000.000
155A155PRO00.04014.638-0.022-0.0220.0000.0000.0000.000
156A156VAL0-0.00616.347-0.015-0.0150.0000.0000.0000.000
157A157ARG10.71717.180-0.044-0.0440.0000.0000.0000.000
158A158THR0-0.00613.0640.0220.0220.0000.0000.0000.000
159A159TYR00.00015.2050.0290.0290.0000.0000.0000.000
160A160THR00.01116.3830.0000.0000.0000.0000.0000.000
161A161HIS00.04218.6470.0150.0150.0000.0000.0000.000
162A162GLU-1-0.66015.610-0.010-0.0100.0000.0000.0000.000
163A163VAL00.03616.836-0.027-0.0270.0000.0000.0000.000
164A164VAL0-0.02711.661-0.029-0.0290.0000.0000.0000.000
165A165THR00.04911.724-0.136-0.1360.0000.0000.0000.000
166A166LEU00.00413.532-0.022-0.0220.0000.0000.0000.000
167A167TRP00.00315.229-0.005-0.0050.0000.0000.0000.000
168A168TYR0-0.06011.7500.0460.0460.0000.0000.0000.000
169A169ARG10.85014.7660.0230.0230.0000.0000.0000.000
170A170ALA00.04217.5740.0040.0040.0000.0000.0000.000
171A171PRO00.10920.8790.0040.0040.0000.0000.0000.000
172A172GLU-1-0.73723.9020.0110.0110.0000.0000.0000.000
173A173ILE0-0.02619.2700.0030.0030.0000.0000.0000.000
174A174LEU00.00120.4850.0030.0030.0000.0000.0000.000
175A175LEU00.00923.8430.0030.0030.0000.0000.0000.000
176A176GLY00.02025.7370.0010.0010.0000.0000.0000.000
177A177CYS0-0.03526.6910.0010.0010.0000.0000.0000.000
178A178LYS10.83326.362-0.027-0.0270.0000.0000.0000.000
179A179TYR00.06527.0540.0010.0010.0000.0000.0000.000
180A180TYR0-0.00220.8550.0020.0020.0000.0000.0000.000
181A181SER00.08823.5910.0000.0000.0000.0000.0000.000
182A182THR00.06220.7010.0050.0050.0000.0000.0000.000
183A183ALA0-0.01020.804-0.003-0.0030.0000.0000.0000.000
184A184VAL0-0.02417.979-0.005-0.0050.0000.0000.0000.000
185A185ASP-1-0.68515.9340.0490.0490.0000.0000.0000.000
186A186ILE0-0.07117.418-0.021-0.0210.0000.0000.0000.000
187A187TRP00.06019.118-0.005-0.0050.0000.0000.0000.000
188A188SER0-0.03414.5030.0040.0040.0000.0000.0000.000
189A189LEU00.01915.619-0.036-0.0360.0000.0000.0000.000
190A190GLY00.06317.000-0.007-0.0070.0000.0000.0000.000
191A191CYS0-0.05317.2350.0190.0190.0000.0000.0000.000
192A192ILE00.01112.0340.0100.0100.0000.0000.0000.000
193A193PHE0-0.01415.8220.0280.0280.0000.0000.0000.000
194A194ALA00.04319.1920.0300.0300.0000.0000.0000.000
195A195GLU-1-0.68913.7820.0360.0360.0000.0000.0000.000
196A196MET0-0.05115.0320.0760.0760.0000.0000.0000.000
197A197VAL00.01317.8860.0440.0440.0000.0000.0000.000
198A198THR00.02920.1730.0200.0200.0000.0000.0000.000
199A199ARG10.84017.195-0.355-0.3550.0000.0000.0000.000
200A200ARG10.87917.577-0.224-0.2240.0000.0000.0000.000
201A201ALA0-0.01017.029-0.044-0.0440.0000.0000.0000.000
202A202LEU0-0.00318.8820.0270.0270.0000.0000.0000.000
203A203PHE00.04120.2780.0170.0170.0000.0000.0000.000
204A204PRO00.01918.725-0.028-0.0280.0000.0000.0000.000
205A205GLY00.05119.2710.0240.0240.0000.0000.0000.000
206A206ASP-1-0.66819.5230.0540.0540.0000.0000.0000.000
207A207SER00.07921.7470.0010.0010.0000.0000.0000.000
208A208GLU-1-0.69221.2800.0170.0170.0000.0000.0000.000
209A209ILE00.02522.979-0.001-0.0010.0000.0000.0000.000
210A210ASP-1-0.64924.6900.0720.0720.0000.0000.0000.000
211A211GLN0-0.02619.663-0.002-0.0020.0000.0000.0000.000
212A212LEU00.00022.873-0.001-0.0010.0000.0000.0000.000
213A213PHE0-0.00725.6060.0020.0020.0000.0000.0000.000
214A214ARG10.87423.521-0.102-0.1020.0000.0000.0000.000
215A215ILE00.00623.0000.0040.0040.0000.0000.0000.000
216A216PHE00.00926.4830.0030.0030.0000.0000.0000.000
217A217ARG10.85327.333-0.078-0.0780.0000.0000.0000.000
218A218THR0-0.02625.9150.0130.0130.0000.0000.0000.000
219A219LEU0-0.06427.0780.0000.0000.0000.0000.0000.000
220A220GLY00.10430.2440.0000.0000.0000.0000.0000.000
221A221THR00.00931.379-0.001-0.0010.0000.0000.0000.000
222A222PRO0-0.01030.198-0.001-0.0010.0000.0000.0000.000
223A223ASP-1-0.63832.5470.0260.0260.0000.0000.0000.000
224A224GLU-1-0.67535.6690.0160.0160.0000.0000.0000.000
225A225VAL00.02236.763-0.002-0.0020.0000.0000.0000.000
226A226VAL0-0.00332.734-0.001-0.0010.0000.0000.0000.000
227A227TRP0-0.07927.638-0.003-0.0030.0000.0000.0000.000
228A228PRO00.04934.1840.0020.0020.0000.0000.0000.000
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