FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-10-17

All entries: 77277

Number of unique PDB entries: 32023

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FMODB ID: YYVV2

Calculation Name: 4FKW-AB-MD341-md4_26ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: 2-methylpropyl (3z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1h-indole-5-carboxylate | acetyl group

Ligand 3-letter code: 62K | ACE

Ligand of Interest (LOI): LIG

Structure Source: PDB

PDB ID: 4FKW

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-09-12

Reference: K. Takaba et al., Protein-Ligand Binding Affinity Prediction of CDK2 Inhibitors by Dynamically Averaged FMO-based Interaction Energy, To be published.

DOI:

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
Remarks
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2656
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -18633570.37945
FMO2-HF: Nuclear repulsion 18335133.95147
FMO2-HF: Total energy -298436.427979
FMO2-MP2: Total energy -299253.828972


3D Structure Molmil
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-102.154554-75.97340685.956063-34.436181-77.701029-0.017254


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-170.219-158.051149.342-62.671-98.836-0.023
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.022 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.71813.524-0.418-0.4180.0000.0000.0000.000
2A2GLU-1-0.58716.5980.0200.0200.0000.0000.0000.000
3A3ASN00.02713.2930.0340.0340.0000.0000.0000.000
4A4PHE00.02210.584-0.146-0.1460.0000.0000.0000.000
5A5GLN00.04612.4680.1100.1100.0000.0000.0000.000
6A6LYS10.89911.639-1.558-1.5580.0000.0000.0000.000
7A7VAL00.0198.5320.0310.0310.0000.0000.0000.000
8A8GLU-1-0.6474.5957.7127.942-0.001-0.005-0.2240.000
9A9LYS10.8206.027-4.087-4.0870.0000.0000.0000.000
10A10ILE0-0.0362.498-3.1141.9807.959-2.634-10.4200.025
11A11GLY00.0782.607-3.053-0.9181.338-1.186-2.287-0.005
12A12GLU-1-0.7492.8351.5261.8570.7520.145-1.228-0.002
13A13GLY00.0592.565-2.683-1.3141.049-0.985-1.4330.001
14A14THR00.0262.9491.4220.5900.1031.076-0.3470.000
15A15TYR0-0.0066.095-0.185-0.1850.0000.0000.0000.000
16A16GLY00.0256.1680.2330.2330.0000.0000.0000.000
17A17VAL0-0.0434.868-0.386-0.3860.0000.0000.0000.000
18A18VAL0-0.0062.454-3.642-0.9733.640-1.336-4.9730.010
19A19TYR00.0315.3770.9161.261-0.001-0.010-0.3340.000
20A20LYS10.8805.219-0.182-0.1820.0000.0000.0000.000
21A21ALA0-0.0286.9420.2480.2480.0000.0000.0000.000
22A22ARG10.8588.6100.2240.2240.0000.0000.0000.000
23A23ASN0-0.04010.8660.3220.3220.0000.0000.0000.000
24A24LYS10.89412.4560.1050.1050.0000.0000.0000.000
25A25LEU00.02015.3900.0570.0570.0000.0000.0000.000
26A26THR0-0.00413.2500.0660.0660.0000.0000.0000.000
27A27GLY00.06415.233-0.028-0.0280.0000.0000.0000.000
28A28GLU-1-0.67110.274-1.680-1.6800.0000.0000.0000.000
29A29VAL00.0056.3650.2030.2030.0000.0000.0000.000
30A30VAL0-0.0525.649-0.340-0.3400.0000.0000.0000.000
31A31ALA0-0.0172.587-0.5460.9131.210-0.752-1.9170.004
32A32LEU0-0.0104.566-0.979-0.684-0.001-0.018-0.2770.000
33A33LYS10.8191.956-24.714-24.9006.347-2.311-3.8510.032
34A34LYS10.8686.248-1.794-1.7940.0000.0000.0000.000
35A35ILE00.0187.3130.4590.4590.0000.0000.0000.000
36A36ARG10.73310.009-1.349-1.3490.0000.0000.0000.000
37A37LEU0-0.01912.262-0.035-0.0350.0000.0000.0000.000
38A38ASP-1-0.65815.9370.6940.6940.0000.0000.0000.000
39A39THR00.01518.362-0.040-0.0400.0000.0000.0000.000
40A40GLU-1-0.65921.9070.3810.3810.0000.0000.0000.000
41A41THR00.00018.083-0.012-0.0120.0000.0000.0000.000
42A42GLU-1-0.69920.0050.5010.5010.0000.0000.0000.000
43A43GLY00.04219.914-0.047-0.0470.0000.0000.0000.000
44A44VAL0-0.02215.1060.0870.0870.0000.0000.0000.000
45A45PRO00.09018.063-0.059-0.0590.0000.0000.0000.000
46A46SER00.00518.7300.0430.0430.0000.0000.0000.000
47A47THR0-0.02719.2350.0130.0130.0000.0000.0000.000
48A48ALA00.03614.4940.0480.0480.0000.0000.0000.000
49A49ILE0-0.01214.5190.0670.0670.0000.0000.0000.000
50A50ARG10.83216.041-0.335-0.3350.0000.0000.0000.000
51A51GLU-1-0.75712.3200.6940.6940.0000.0000.0000.000
52A52ILE00.0389.7690.0470.0470.0000.0000.0000.000
53A53SER0-0.00712.172-0.189-0.1890.0000.0000.0000.000
54A54LEU0-0.02714.497-0.107-0.1070.0000.0000.0000.000
55A55LEU0-0.0226.725-0.096-0.0960.0000.0000.0000.000
56A56LYS10.89110.977-0.039-0.0390.0000.0000.0000.000
57A57GLU-1-0.65912.719-0.174-0.1740.0000.0000.0000.000
58A58LEU0-0.04611.024-0.060-0.0600.0000.0000.0000.000
59A59ASN00.04311.528-0.296-0.2960.0000.0000.0000.000
60A60HIS00.10012.0430.0350.0350.0000.0000.0000.000
61A61PRO00.08211.761-0.207-0.2070.0000.0000.0000.000
62A62ASN0-0.03311.664-0.140-0.1400.0000.0000.0000.000
63A63ILE0-0.0158.3970.1710.1710.0000.0000.0000.000
64A64VAL00.0072.948-1.992-0.5660.349-0.425-1.3500.003
65A65LYS10.8845.9152.2662.2660.0000.0000.0000.000
66A66LEU0-0.0025.621-1.510-1.5100.0000.0000.0000.000
67A67LEU0-0.0026.8530.4440.4440.0000.0000.0000.000
68A68ASP-1-0.6568.6910.0120.0120.0000.0000.0000.000
69A69VAL0-0.0059.5380.0350.0350.0000.0000.0000.000
70A70ILE0-0.03211.457-0.028-0.0280.0000.0000.0000.000
71A71HIS00.01713.8490.1050.1050.0000.0000.0000.000
72A72THR00.02816.626-0.074-0.0740.0000.0000.0000.000
73A73GLU-1-0.57418.3960.7450.7450.0000.0000.0000.000
74A74ASN0-0.00720.2000.1290.1290.0000.0000.0000.000
75A75LYS10.84415.263-0.879-0.8790.0000.0000.0000.000
76A76LEU00.03112.631-0.117-0.1170.0000.0000.0000.000
77A77TYR0-0.0319.8420.2230.2230.0000.0000.0000.000
78A78LEU00.0166.157-0.215-0.2150.0000.0000.0000.000
79A79VAL0-0.0106.2760.0830.0830.0000.0000.0000.000
80A80PHE00.0122.243-3.637-0.8372.450-1.386-3.864-0.011
81A81GLU-1-0.6183.749-3.906-3.0050.001-0.289-0.614-0.001
82A82PHE0-0.0041.980-20.413-16.1098.342-5.385-7.261-0.042
83A83LEU00.0021.674-4.733-14.84319.944-5.645-4.1900.028
84A84HIS00.0021.934-16.343-15.6367.313-3.167-4.853-0.037
85A85GLN00.0503.292-4.320-1.4081.264-1.090-3.0850.000
86A86ASP-1-0.6313.228-6.364-3.7990.196-0.705-2.055-0.004
87A87LEU00.0244.4990.5970.8160.000-0.013-0.2050.000
88A88LYS10.8527.2480.2340.2340.0000.0000.0000.000
89A89LYS10.8792.057-0.436-3.78010.876-2.516-5.0160.019
90A90PHE00.0086.872-0.034-0.0340.0000.0000.0000.000
91A91MET00.0399.7170.1670.1670.0000.0000.0000.000
92A92ASP-1-0.6759.0370.2920.2920.0000.0000.0000.000
93A93ALA00.0038.6340.0510.0510.0000.0000.0000.000
94A94SER0-0.00410.644-0.021-0.0210.0000.0000.0000.000
95A95ALA00.02413.9700.0740.0740.0000.0000.0000.000
96A96LEU00.01615.9620.0700.0700.0000.0000.0000.000
97A97THR00.03516.5020.0160.0160.0000.0000.0000.000
98A98GLY00.02517.7160.0380.0380.0000.0000.0000.000
99A99ILE00.04914.418-0.060-0.0600.0000.0000.0000.000
100A100PRO00.00218.6240.0820.0820.0000.0000.0000.000
101A101LEU00.00321.370-0.050-0.0500.0000.0000.0000.000
102A102PRO00.07622.515-0.018-0.0180.0000.0000.0000.000
103A103LEU00.02315.321-0.018-0.0180.0000.0000.0000.000
104A104ILE0-0.01317.909-0.064-0.0640.0000.0000.0000.000
105A105LYS10.80719.4480.4610.4610.0000.0000.0000.000
106A106SER00.00017.8560.0290.0290.0000.0000.0000.000
107A107TYR0-0.00312.0130.0190.0190.0000.0000.0000.000
108A108LEU00.01216.4670.0190.0190.0000.0000.0000.000
109A109PHE00.05218.5970.0610.0610.0000.0000.0000.000
110A110GLN0-0.01315.630-0.055-0.0550.0000.0000.0000.000
111A111LEU0-0.02712.222-0.012-0.0120.0000.0000.0000.000
112A112LEU0-0.02515.9090.1040.1040.0000.0000.0000.000
113A113GLN00.03917.4930.0460.0460.0000.0000.0000.000
114A114GLY00.04314.4920.0220.0220.0000.0000.0000.000
115A115LEU00.04813.8000.1140.1140.0000.0000.0000.000
116A116ALA00.04116.2080.0830.0830.0000.0000.0000.000
117A117PHE0-0.00913.8130.0570.0570.0000.0000.0000.000
118A118CYS0-0.05313.9790.0720.0720.0000.0000.0000.000
119A119HIS00.06416.3400.0000.0000.0000.0000.0000.000
120A120SER00.00019.5210.0120.0120.0000.0000.0000.000
121A121HIS0-0.05216.617-0.033-0.0330.0000.0000.0000.000
122A122ARG10.76719.086-0.033-0.0330.0000.0000.0000.000
123A123VAL00.01913.5250.0540.0540.0000.0000.0000.000
124A124LEU00.01715.289-0.075-0.0750.0000.0000.0000.000
125A125HIS00.0176.7180.1360.1360.0000.0000.0000.000
126A126ARG10.85010.569-0.256-0.2560.0000.0000.0000.000
127A127ASP-1-0.6806.1640.7270.7270.0000.0000.0000.000
128A128LEU0-0.0197.163-0.047-0.0470.0000.0000.0000.000
129A129LYS10.8894.978-0.337-0.3370.0000.0000.0000.000
130A130PRO00.0117.289-0.187-0.1870.0000.0000.0000.000
131A131GLN00.0182.274-0.6650.3942.613-0.961-2.710-0.007
132A132ASN0-0.0602.583-4.526-2.2240.852-1.097-2.056-0.013
133A133LEU00.0214.3660.5780.8220.000-0.022-0.2210.000
134A134LEU0-0.0222.762-4.545-2.2816.651-1.422-7.4930.008
135A135ILE00.0475.7340.7360.7360.0000.0000.0000.000
136A136ASN00.0926.028-1.106-1.1060.0000.0000.0000.000
137A137THR0-0.0108.3970.1220.1220.0000.0000.0000.000
138A138GLU-1-0.71010.867-1.550-1.5500.0000.0000.0000.000
139A139GLY00.06812.9990.2330.2330.0000.0000.0000.000
140A140ALA00.01412.2870.1980.1980.0000.0000.0000.000
141A141ILE0-0.01410.135-0.297-0.2970.0000.0000.0000.000
142A142LYS10.7737.2972.9382.9380.0000.0000.0000.000
143A143LEU00.0218.468-0.052-0.0520.0000.0000.0000.000
144A144ALA00.0163.414-1.222-0.2380.184-0.368-0.8010.003
145A145ASP-1-0.6842.1252.6496.4032.469-2.032-4.1900.004
146A146PHE0-0.0393.611-1.471-1.1860.0580.103-0.4460.002
147A147GLY00.0667.2550.0460.0460.0000.0000.0000.000
148A148LEU0-0.0406.683-0.114-0.1140.0000.0000.0000.000
149A149ALA00.0699.596-0.257-0.2570.0000.0000.0000.000
150A150ARG10.82011.319-0.692-0.6920.0000.0000.0000.000
151A151ALA00.03113.016-0.140-0.1400.0000.0000.0000.000
152A152PHE0-0.01411.450-0.090-0.0900.0000.0000.0000.000
153A153GLY00.07114.332-0.113-0.1130.0000.0000.0000.000
154A154VAL00.02113.2330.1350.1350.0000.0000.0000.000
155A155PRO00.0109.063-0.063-0.0630.0000.0000.0000.000
156A156VAL0-0.00811.468-0.091-0.0910.0000.0000.0000.000
157A157ARG10.79310.595-0.732-0.7320.0000.0000.0000.000
158A158THR00.0146.6300.0470.0470.0000.0000.0000.000
159A159TYR0-0.0127.084-0.025-0.0250.0000.0000.0000.000
160A160THR0-0.0409.014-0.022-0.0220.0000.0000.0000.000
161A161HIS00.00110.896-0.028-0.0280.0000.0000.0000.000
162A162GLU-1-0.68710.9310.8530.8530.0000.0000.0000.000
163A163VAL00.03910.6680.0250.0250.0000.0000.0000.000
164A164VAL0-0.0307.1060.0370.0370.0000.0000.0000.000
165A165THR0-0.0029.604-0.057-0.0570.0000.0000.0000.000
166A166LEU00.00711.0930.0050.0050.0000.0000.0000.000
167A167TRP0-0.01012.711-0.037-0.0370.0000.0000.0000.000
168A168TYR0-0.03011.080-0.078-0.0780.0000.0000.0000.000
169A169ARG10.78612.196-0.407-0.4070.0000.0000.0000.000
170A170ALA00.06615.104-0.035-0.0350.0000.0000.0000.000
171A171PRO00.03618.2740.0310.0310.0000.0000.0000.000
172A172GLU-1-0.71920.7940.0960.0960.0000.0000.0000.000
173A173ILE00.00715.6810.0060.0060.0000.0000.0000.000
174A174LEU0-0.03417.6840.0320.0320.0000.0000.0000.000
175A175LEU00.00520.8020.0090.0090.0000.0000.0000.000
176A176GLY00.01822.705-0.005-0.0050.0000.0000.0000.000
177A177CYS0-0.07922.0530.0090.0090.0000.0000.0000.000
178A178LYS10.88221.681-0.246-0.2460.0000.0000.0000.000
179A179TYR0-0.01022.5430.0240.0240.0000.0000.0000.000
180A180TYR00.03417.321-0.032-0.0320.0000.0000.0000.000
181A181SER00.04821.814-0.001-0.0010.0000.0000.0000.000
182A182THR00.03119.4040.0270.0270.0000.0000.0000.000
183A183ALA0-0.00119.414-0.022-0.0220.0000.0000.0000.000
184A184VAL00.00716.049-0.019-0.0190.0000.0000.0000.000
185A185ASP-1-0.69713.6790.2430.2430.0000.0000.0000.000
186A186ILE0-0.03915.512-0.064-0.0640.0000.0000.0000.000
187A187TRP00.07916.690-0.048-0.0480.0000.0000.0000.000
188A188SER0-0.04312.400-0.008-0.0080.0000.0000.0000.000
189A189LEU00.00914.194-0.052-0.0520.0000.0000.0000.000
190A190GLY00.04915.383-0.067-0.0670.0000.0000.0000.000
191A191CYS0-0.05214.854-0.014-0.0140.0000.0000.0000.000
192A192ILE00.01010.882-0.022-0.0220.0000.0000.0000.000
193A193PHE00.00714.988-0.035-0.0350.0000.0000.0000.000
194A194ALA00.06418.454-0.009-0.0090.0000.0000.0000.000
195A195GLU-1-0.61313.837-0.233-0.2330.0000.0000.0000.000
196A196MET00.01514.355-0.015-0.0150.0000.0000.0000.000
197A197VAL00.00118.349-0.020-0.0200.0000.0000.0000.000
198A198THR00.01920.4600.0490.0490.0000.0000.0000.000
199A199ARG10.78717.9600.4610.4610.0000.0000.0000.000
200A200ARG10.81217.2990.1520.1520.0000.0000.0000.000
201A201ALA00.04714.728-0.037-0.0370.0000.0000.0000.000
202A202LEU00.01616.2660.0200.0200.0000.0000.0000.000
203A203PHE00.02817.4680.0140.0140.0000.0000.0000.000
204A204PRO00.03116.4230.0350.0350.0000.0000.0000.000
205A205GLY00.09216.657-0.009-0.0090.0000.0000.0000.000
206A206ASP-1-0.67016.5910.4130.4130.0000.0000.0000.000
207A207SER00.01617.7790.0350.0350.0000.0000.0000.000
208A208GLU-1-0.64518.2720.2970.2970.0000.0000.0000.000
209A209ILE0-0.04120.220-0.027-0.0270.0000.0000.0000.000
210A210ASP-1-0.65421.0250.1770.1770.0000.0000.0000.000
211A211GLN0-0.02916.9720.0020.0020.0000.0000.0000.000
212A212LEU0-0.00420.322-0.026-0.0260.0000.0000.0000.000
213A213PHE00.01022.930-0.020-0.0200.0000.0000.0000.000
214A214ARG10.77420.690-0.118-0.1180.0000.0000.0000.000
215A215ILE00.02819.959-0.023-0.0230.0000.0000.0000.000
216A216PHE00.03623.790-0.016-0.0160.0000.0000.0000.000
217A217ARG10.82326.277-0.121-0.1210.0000.0000.0000.000
218A218THR00.02323.112-0.009-0.0090.0000.0000.0000.000
219A219LEU0-0.00624.486-0.023-0.0230.0000.0000.0000.000
220A220GLY00.08727.592-0.009-0.0090.0000.0000.0000.000
221A221THR0-0.03528.9630.0050.0050.0000.0000.0000.000
222A222PRO00.03928.372-0.013-0.0130.0000.0000.0000.000
223A223ASP-1-0.63830.9500.0310.0310.0000.0000.0000.000
224A224GLU-1-0.71233.9900.0290.0290.0000.0000.0000.000
225A225VAL00.01635.871-0.004-0.0040.0000.0000.0000.000
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