FMODB

FMODB: The database of quantum mechanical data based on the FMO method

Last updated: 2025-07-23

All entries: 44592

Number of unique PDB entries: 7794

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FMODB ID: ZY6MN

Calculation Name: 4FKS-AB-MD340-md3_38ns

Preferred Name: Cyclin-dependent kinase 2

Target Type: SINGLE PROTEIN

Ligand Name: n-[(4-{[(z)-(7-oxo-6,7-dihydro-8h-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}phenyl)sulfonyl]acetamide

ligand 3-letter code: 46K

PDB ID: 4FKS

Chain ID: AB

ChEMBL ID: CHEMBL301

UniProt ID: P24941

Base Structure: MD

Registration Date: 2022-09-07

Reference: K. Takaba et al., Protein-ligand binding affinity prediction of cyclin-dependent kinase-2 inhibitors by dynamically averaged fragment molecular orbital-based interaction energy, J Comput Chem. 2022;43:1362-1371.

DOI: 10.1002/jcc.26940

Apendix: None


IFIE MAP

IFIE Diagram


Modeling method
Optimization MOE:Amber10:EHT
Restraint OptHLSolv
Protonation BaseStructure_original
Complement BaseStructure_original
Water Water molecules within 6 angstrom of a protein-ligand complex.
Procedure Manual calculation
FMO calculation
FMO method FMO2-MP2/6-31G(d)
Fragmentation Auto
Number of fragment 2687
LigandResidueName LIG
LigandFragmentNumber 299
LigandCharge
Software MIZUHO/ABINIT-MP 4.0
Total energy (hartree)
FMO2-HF: Electronic energy -18933336.037878
FMO2-HF: Nuclear repulsion 18632261.499625
FMO2-HF: Total energy -301074.538254
FMO2-MP2: Total energy -301897.858028


3D Structure
Snapshot
 
Ligand structure

LIG

ligand structure
Ligand Interaction
ligand interaction
Ligand binding energy (frag 299 : frag 1-298)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-92.979237-58.40665047.862350-21.519265-60.9156720.016231


Interactive mode: IFIE and PIEDA for fragment #299(A:299:LIG)


Summations of interaction energy for fragment #299(A:299:LIG)
IFIE [kcal/mol] PIEDA [kcal/mol] Charge transfer value [e]
IFIE SUMIFIE SUM at MP2 level. ESElectro static interaction energy. EXExchange-repulsion energy. CT+mixCharge transfer and mixing terms energy. DI(MP2)Dispersion energy. q(I=>J)Charge transfer value from I to J fragments.
-161.874-135.036120.981-56.982-90.843-0.015
Interaction energy analysis for fragmet #299(A:299:LIG)
Snapshot

IFIE Diagram

Base fragment(s) of PIEDA/IFIE
Single fragment Multi fragments
Fragment list
Charge [e] FCHARGE : 0 / q_Mulliken : -0.014 / q_NPA : ******
Distance from base fragment(s) [Å]
Dist
Interaction energy by IFIE and PIEDA
[kcal/mol]
| Total | > | ES | > | EX | >
| CT+mix | > | DI(MP2) | >
Fragment charge [e]
FCHARGE q_Mulliken
q_NPA q(I=>J)
Residue
Res #    RES   
Sort
Graph Options
X Axis Label
Y Axis Max Y Axis Min
Display   
frag_NumFragment number. ChainChain species. Res #Residue number. RES3-letter code of amino acid residue, ligand and solvent molecule. FCHARGEFormal charge [e]. q_MullikenFragment charge evaluated by Mulliken charge [e]. q_NPAFragment charge evaluated by natural population analysis(NPA) charge [e]. DISTDistance from Ligand [Å]. TotalIFIE at MP2 level [kcal/mol]. ESElectro static interaction energy by PIEDA [kcal/mol]. EXExchange-repulsion energy by PIEDA [kcal/mol]. CT+mixCharge transfer and mixing terms energy by PIEDA [kcal/mol]. DI(MP2)Dispersion energy by PIEDA [kcal/mol]. q(I=>J)Charge transfer value from I to J fragmens [e].
1A1MET10.75613.7940.1130.1130.0000.0000.0000.000
2A2GLU-1-0.63817.066-0.114-0.1140.0000.0000.0000.000
3A3ASN00.08116.665-0.034-0.0340.0000.0000.0000.000
4A4PHE00.00611.263-0.046-0.0460.0000.0000.0000.000
5A5GLN0-0.00812.7310.0160.0160.0000.0000.0000.000
6A6LYS10.88110.970-0.129-0.1290.0000.0000.0000.000
7A7VAL00.0409.6810.1270.1270.0000.0000.0000.000
8A8GLU-1-0.6775.137-0.516-0.397-0.001-0.002-0.1160.000
9A9LYS10.8424.500-1.715-1.607-0.001-0.019-0.0890.000
10A10ILE00.0032.1840.3974.6338.214-3.566-8.8830.006
11A11GLY00.0662.674-6.011-5.5211.1060.822-2.419-0.014
12A12GLU-1-0.6305.1051.2001.4410.000-0.018-0.2230.000
13A13GLY00.0425.473-1.170-1.1700.0000.0000.0000.000
14A14THR0-0.0166.5480.2080.2080.0000.0000.0000.000
15A15TYR00.0018.241-0.113-0.1130.0000.0000.0000.000
16A16GLY00.0669.0270.0440.0440.0000.0000.0000.000
17A17VAL0-0.0137.739-0.225-0.2250.0000.0000.0000.000
18A18VAL00.0192.937-2.3340.1151.482-0.727-3.2040.003
19A19TYR00.0056.183-0.917-0.9170.0000.0000.0000.000
20A20LYS10.8285.1364.8644.8640.0000.0000.0000.000
21A21ALA00.0187.0920.4460.4460.0000.0000.0000.000
22A22ARG10.8389.4150.8120.8120.0000.0000.0000.000
23A23ASN00.00311.8630.1520.1520.0000.0000.0000.000
24A24LYS10.85413.8770.2410.2410.0000.0000.0000.000
25A25LEU0-0.02817.3290.0410.0410.0000.0000.0000.000
26A26THR00.05915.2940.0180.0180.0000.0000.0000.000
27A27GLY00.04215.7980.0060.0060.0000.0000.0000.000
28A28GLU-1-0.71111.651-0.774-0.7740.0000.0000.0000.000
29A29VAL00.0006.7770.0290.0290.0000.0000.0000.000
30A30VAL0-0.0016.3380.1020.1020.0000.0000.0000.000
31A31ALA00.0162.568-1.1770.2590.878-0.594-1.7200.004
32A32LEU0-0.0384.676-0.666-0.375-0.001-0.016-0.2740.000
33A33LYS10.8073.957-5.045-4.1280.009-0.288-0.6380.001
34A34LYS10.8586.508-0.181-0.1810.0000.0000.0000.000
35A35ILE0-0.0207.5690.1780.1780.0000.0000.0000.000
36A36ARG10.87011.029-0.067-0.0670.0000.0000.0000.000
37A37LEU00.03714.6840.0100.0100.0000.0000.0000.000
38A38ASP-1-0.73617.746-0.007-0.0070.0000.0000.0000.000
39A39THR0-0.01416.413-0.002-0.0020.0000.0000.0000.000
40A40GLU-1-0.64019.173-0.007-0.0070.0000.0000.0000.000
41A41THR00.01422.754-0.003-0.0030.0000.0000.0000.000
42A42GLU-1-0.70022.860-0.020-0.0200.0000.0000.0000.000
43A43GLY00.04020.394-0.005-0.0050.0000.0000.0000.000
44A44VAL00.02416.0130.0100.0100.0000.0000.0000.000
45A45PRO00.00117.430-0.012-0.0120.0000.0000.0000.000
46A46SER0-0.00919.7680.0020.0020.0000.0000.0000.000
47A47THR00.02619.897-0.002-0.0020.0000.0000.0000.000
48A48ALA00.00615.3320.0050.0050.0000.0000.0000.000
49A49ILE0-0.03615.6110.0060.0060.0000.0000.0000.000
50A50ARG10.77016.5970.0900.0900.0000.0000.0000.000
51A51GLU-1-0.69414.414-0.004-0.0040.0000.0000.0000.000
52A52ILE0-0.0029.8470.0480.0480.0000.0000.0000.000
53A53SER00.05510.1850.0280.0280.0000.0000.0000.000
54A54LEU00.03112.289-0.063-0.0630.0000.0000.0000.000
55A55LEU00.0145.180-0.017-0.0170.0000.0000.0000.000
56A56LYS10.7899.8470.3140.3140.0000.0000.0000.000
57A57GLU-1-0.66111.379-0.252-0.2520.0000.0000.0000.000
58A58LEU0-0.02411.990-0.003-0.0030.0000.0000.0000.000
59A59ASN00.02811.803-0.111-0.1110.0000.0000.0000.000
60A60HIS00.04112.0680.0330.0330.0000.0000.0000.000
61A61PRO00.05711.565-0.085-0.0850.0000.0000.0000.000
62A62ASN00.02011.200-0.030-0.0300.0000.0000.0000.000
63A63ILE0-0.0248.4340.1060.1060.0000.0000.0000.000
64A64VAL0-0.0092.168-1.552-0.8011.841-0.719-1.8730.005
65A65LYS10.8795.5780.8230.8230.0000.0000.0000.000
66A66LEU0-0.0446.224-0.607-0.6070.0000.0000.0000.000
67A67LEU00.0317.3970.3690.3690.0000.0000.0000.000
68A68ASP-1-0.6749.138-0.228-0.2280.0000.0000.0000.000
69A69VAL00.0279.815-0.059-0.0590.0000.0000.0000.000
70A70ILE00.00512.1310.0270.0270.0000.0000.0000.000
71A71HIS00.08714.0650.0320.0320.0000.0000.0000.000
72A72THR00.04416.775-0.008-0.0080.0000.0000.0000.000
73A73GLU-1-0.58719.362-0.076-0.0760.0000.0000.0000.000
74A74ASN00.00020.2660.0140.0140.0000.0000.0000.000
75A75LYS10.81815.5870.0340.0340.0000.0000.0000.000
76A76LEU0-0.00511.939-0.025-0.0250.0000.0000.0000.000
77A77TYR0-0.00910.1960.0390.0390.0000.0000.0000.000
78A78LEU0-0.0116.001-0.077-0.0770.0000.0000.0000.000
79A79VAL00.0116.5560.0550.0550.0000.0000.0000.000
80A80PHE00.0192.698-3.538-0.8391.808-1.042-3.464-0.009
81A81GLU-1-0.5764.022-1.099-0.6470.000-0.081-0.3700.000
82A82PHE0-0.0122.410-12.124-5.9932.097-3.298-4.929-0.017
83A83LEU0-0.0331.837-6.697-10.48511.821-3.544-4.4890.028
84A84HIS00.1022.208-14.600-12.1732.953-1.646-3.734-0.025
85A85GLN00.0392.750-8.654-3.7224.253-2.719-6.4660.004
86A86ASP-1-0.6852.238-12.829-9.5352.077-0.533-4.838-0.021
87A87LEU00.0273.8751.6171.9610.013-0.042-0.3140.000
88A88LYS10.8436.8800.8450.8450.0000.0000.0000.000
89A89LYS10.8582.529-14.741-13.2863.135-1.088-3.5010.013
90A90PHE00.0085.8590.1610.1610.0000.0000.0000.000
91A91MET0-0.0368.794-0.141-0.1410.0000.0000.0000.000
92A92ASP-1-0.6258.1961.8511.8510.0000.0000.0000.000
93A93ALA0-0.0218.507-0.062-0.0620.0000.0000.0000.000
94A94SER00.03010.528-0.231-0.2310.0000.0000.0000.000
95A95ALA00.06113.618-0.136-0.1360.0000.0000.0000.000
96A96LEU0-0.01315.355-0.091-0.0910.0000.0000.0000.000
97A97THR00.01616.379-0.014-0.0140.0000.0000.0000.000
98A98GLY00.05917.489-0.062-0.0620.0000.0000.0000.000
99A99ILE0-0.02014.3860.0440.0440.0000.0000.0000.000
100A100PRO00.01517.513-0.028-0.0280.0000.0000.0000.000
101A101LEU00.07420.031-0.027-0.0270.0000.0000.0000.000
102A102PRO0-0.00821.523-0.020-0.0200.0000.0000.0000.000
103A103LEU00.01514.466-0.019-0.0190.0000.0000.0000.000
104A104ILE00.00817.312-0.048-0.0480.0000.0000.0000.000
105A105LYS10.82718.4190.0400.0400.0000.0000.0000.000
106A106SER00.03617.470-0.014-0.0140.0000.0000.0000.000
107A107TYR0-0.00111.757-0.006-0.0060.0000.0000.0000.000
108A108LEU0-0.00316.026-0.021-0.0210.0000.0000.0000.000
109A109PHE00.02618.5600.0040.0040.0000.0000.0000.000
110A110GLN0-0.01714.685-0.040-0.0400.0000.0000.0000.000
111A111LEU0-0.01211.7060.0010.0010.0000.0000.0000.000
112A112LEU0-0.01815.2410.0260.0260.0000.0000.0000.000
113A113GLN00.07017.760-0.006-0.0060.0000.0000.0000.000
114A114GLY00.06814.3750.0000.0000.0000.0000.0000.000
115A115LEU00.00214.7670.0190.0190.0000.0000.0000.000
116A116ALA00.06016.2330.0150.0150.0000.0000.0000.000
117A117PHE0-0.00114.9650.0070.0070.0000.0000.0000.000
118A118CYS0-0.02814.4590.0090.0090.0000.0000.0000.000
119A119HIS00.03117.1590.0000.0000.0000.0000.0000.000
120A120SER00.02320.0250.0100.0100.0000.0000.0000.000
121A121HIS0-0.00418.5590.0070.0070.0000.0000.0000.000
122A122ARG10.80720.1800.0800.0800.0000.0000.0000.000
123A123VAL0-0.02916.5910.0110.0110.0000.0000.0000.000
124A124LEU0-0.02216.489-0.008-0.0080.0000.0000.0000.000
125A125HIS00.0438.389-0.159-0.1590.0000.0000.0000.000
126A126ARG10.84213.0210.0550.0550.0000.0000.0000.000
127A127ASP-1-0.7309.848-0.150-0.1500.0000.0000.0000.000
128A128LEU00.0219.911-0.016-0.0160.0000.0000.0000.000
129A129LYS10.8357.7980.4550.4550.0000.0000.0000.000
130A130PRO00.0548.330-0.070-0.0700.0000.0000.0000.000
131A131GLN00.0264.978-0.067-0.0670.0000.0000.0000.000
132A132ASN0-0.0873.302-4.403-3.4310.056-0.377-0.651-0.001
133A133LEU00.0214.8750.7280.978-0.001-0.007-0.2430.000
134A134LEU0-0.0402.708-6.468-3.1545.858-1.640-7.5320.005
135A135ILE00.0225.8260.7280.7280.0000.0000.0000.000
136A136ASN0-0.0195.828-0.613-0.6130.0000.0000.0000.000
137A137THR00.0247.8780.0880.0880.0000.0000.0000.000
138A138GLU-1-0.63810.647-0.437-0.4370.0000.0000.0000.000
139A139GLY00.05912.6000.0640.0640.0000.0000.0000.000
140A140ALA00.01211.1710.0560.0560.0000.0000.0000.000
141A141ILE00.0049.723-0.107-0.1070.0000.0000.0000.000
142A142LYS10.7266.7420.9220.9220.0000.0000.0000.000
143A143LEU00.0327.413-0.032-0.0320.0000.0000.0000.000
144A144ALA00.0402.894-1.189-0.1360.265-0.375-0.9430.002
145A145ASP-1-0.7114.8350.8600.8600.0000.0000.0000.000
146A146PHE00.0196.427-0.431-0.4310.0000.0000.0000.000
147A147GLY00.0739.741-0.058-0.0580.0000.0000.0000.000
148A148LEU0-0.0409.537-0.075-0.0750.0000.0000.0000.000
149A149ALA00.01512.381-0.046-0.0460.0000.0000.0000.000
150A150ARG10.80414.545-0.020-0.0200.0000.0000.0000.000
151A151ALA00.01816.505-0.021-0.0210.0000.0000.0000.000
152A152PHE0-0.02014.281-0.014-0.0140.0000.0000.0000.000
153A153GLY00.12718.073-0.014-0.0140.0000.0000.0000.000
154A154VAL0-0.04615.5410.0160.0160.0000.0000.0000.000
155A155PRO00.01511.505-0.006-0.0060.0000.0000.0000.000
156A156VAL00.08014.612-0.028-0.0280.0000.0000.0000.000
157A157ARG10.80115.0870.0420.0420.0000.0000.0000.000
158A158THR00.04210.6460.0510.0510.0000.0000.0000.000
159A159TYR00.01810.1340.0070.0070.0000.0000.0000.000
160A160THR0-0.04013.2380.0140.0140.0000.0000.0000.000
161A161HIS00.00615.3510.0160.0160.0000.0000.0000.000
162A162GLU-1-0.70513.766-0.245-0.2450.0000.0000.0000.000
163A163VAL00.01514.786-0.033-0.0330.0000.0000.0000.000
164A164VAL00.03911.412-0.095-0.0950.0000.0000.0000.000
165A165THR00.02513.0820.0410.0410.0000.0000.0000.000
166A166LEU00.04514.384-0.029-0.0290.0000.0000.0000.000
167A167TRP0-0.06614.7560.0080.0080.0000.0000.0000.000
168A168TYR0-0.02712.585-0.033-0.0330.0000.0000.0000.000
169A169ARG10.84712.5500.1730.1730.0000.0000.0000.000
170A170ALA00.04118.3240.0040.0040.0000.0000.0000.000
171A171PRO00.00721.5860.0030.0030.0000.0000.0000.000
172A172GLU-1-0.66823.909-0.050-0.0500.0000.0000.0000.000
173A173ILE0-0.02019.4090.0040.0040.0000.0000.0000.000
174A174LEU0-0.01521.5220.0030.0030.0000.0000.0000.000
175A175LEU0-0.00724.6620.0050.0050.0000.0000.0000.000
176A176GLY00.05626.7050.0030.0030.0000.0000.0000.000
177A177CYS0-0.11825.5180.0030.0030.0000.0000.0000.000
178A178LYS10.85024.8680.0220.0220.0000.0000.0000.000
179A179TYR00.02725.2210.0020.0020.0000.0000.0000.000
180A180TYR00.04919.445-0.001-0.0010.0000.0000.0000.000
181A181SER0-0.01022.3880.0020.0020.0000.0000.0000.000
182A182THR00.00420.2850.0010.0010.0000.0000.0000.000
183A183ALA00.05021.171-0.006-0.0060.0000.0000.0000.000
184A184VAL0-0.02818.182-0.005-0.0050.0000.0000.0000.000
185A185ASP-1-0.72215.918-0.036-0.0360.0000.0000.0000.000
186A186ILE0-0.04617.248-0.021-0.0210.0000.0000.0000.000
187A187TRP00.08119.327-0.004-0.0040.0000.0000.0000.000
188A188SER0-0.02514.8540.0000.0000.0000.0000.0000.000
189A189LEU00.02714.795-0.030-0.0300.0000.0000.0000.000
190A190GLY00.02916.617-0.009-0.0090.0000.0000.0000.000
191A191CYS0-0.03017.0080.0160.0160.0000.0000.0000.000
192A192ILE00.02612.1020.0010.0010.0000.0000.0000.000
193A193PHE0-0.04615.9500.0140.0140.0000.0000.0000.000
194A194ALA00.06718.9910.0230.0230.0000.0000.0000.000
195A195GLU-1-0.70514.398-0.219-0.2190.0000.0000.0000.000
196A196MET0-0.00914.5850.0380.0380.0000.0000.0000.000
197A197VAL00.03316.8590.0430.0430.0000.0000.0000.000
198A198THR0-0.02419.9060.0310.0310.0000.0000.0000.000
199A199ARG10.81716.950-0.190-0.1900.0000.0000.0000.000
200A200ARG10.81416.995-0.084-0.0840.0000.0000.0000.000
201A201ALA00.01317.191-0.031-0.0310.0000.0000.0000.000
202A202LEU0-0.00918.7020.0320.0320.0000.0000.0000.000
203A203PHE00.01619.9670.0210.0210.0000.0000.0000.000
204A204PRO00.04519.337-0.019-0.0190.0000.0000.0000.000
205A205GLY00.08419.8160.0250.0250.0000.0000.0000.000
206A206ASP-1-0.68919.976-0.057-0.0570.0000.0000.0000.000
207A207SER00.04421.383-0.012-0.0120.0000.0000.0000.000
208A208GLU-1-0.60622.921-0.049-0.0490.0000.0000.0000.000
209A209ILE00.02023.8610.0010.0010.0000.0000.0000.000
210A210ASP-1-0.66924.572-0.014-0.0140.0000.0000.0000.000
211A211GLN0-0.04420.6010.0040.0040.0000.0000.0000.000
212A212LEU00.04123.8600.0000.0000.0000.0000.0000.000
213A213PHE00.01726.7210.0040.0040.0000.0000.0000.000
214A214ARG10.83923.4360.0060.0060.0000.0000.0000.000
215A215ILE0-0.02523.2690.0030.0030.0000.0000.0000.000
216A216PHE00.02626.6980.0030.0030.0000.0000.0000.000
217A217ARG10.80229.022-0.011-0.0110.0000.0000.0000.000
218A218THR0-0.01526.4160.0100.0100.0000.0000.0000.000
219A219LEU0-0.01827.324-0.003-0.0030.0000.0000.0000.000
220A220GLY00.09230.1170.0000.0000.0000.0000.0000.000
221A221THR00.00931.946-0.004-0.0040.0000.0000.0000.000
222A222PRO00.00431.6470.0010.0010.0000.0000.0000.000
223A223ASP-1-0.56233.885-0.009-0.0090.0000.0000.0000.000
224A224GLU-1-0.66136.965-0.018-0.0180.0000.0000.0000.000
225A225VAL00.03238.612-0.001-0.0010.0000.0000.0000.000
226A226VAL0-0.02233.998-0.001-0.0010.0000.0000.0000.000
227A227TRP0-0.04328.487-0.003-0.0030.0000.0000.0000.000
228A228PRO00.04434.8360.0010.0010.0000.0000.0000.000
229A229GLY00.04834.4510.0010.0010.0000.0000.0000.000
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